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Clinical Efficacy of Inhaled Nitric Oxide in Preventing the Progression of Moderate to Severe COVID-19 and Its Correlation to Viral Clearance:Results of a Pilot Study

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Infectious Microbes & Diseases 2022年第1期4卷 26-33页

作者： Merlin Moni Thushara Madathil Dipu T.Sathyapalan Veena Menon Georg Gutjahr Fabia Edathadathil Deepthi Sureshkumar Preetha Prasanna Soumya Jose Roshni Jerome Ajai Krishnan Indulekha C.L.Pillai geetha Kumar Bipin Nair Victor Nizet Aveek Jayant Department of Medicine Division of Infectious DiseasesAmrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia Department of Cardiac Anaesthesiology Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia Clinical Virology Laboratory Amrita Institute of Medical SciencesAmrita Vishwa VidyapeethamKochiKeralaIndia Center for Research in Analytics and Technologies for Education(CREATE) Amrita Vishwa VidyapeethamAmritapuriKollamKeralaIndia Department of Infection Control and Epidemiology Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia School of Medicine Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia School of Biotechnology Amrita Vishwa VidyapeethamAmritapuriKollamKeralaIndia Skaggs School of Pharmacy and Pharmaceutical Sciences University of CaliforniaSan DiegoLa JollaCaliforniaUSA Department of Pediatrics University of CaliforniaSan DiegoLa JollaCaliforniaUSA

Hypoxic patients with coronavirus disease 2019(COVID-19)are at high risk of adverse *** nitric oxide(iNO)has shown anti-viral and immunomodulatory effects in ***,in vivo evidence of efficacy in hypoxic COVID-19 is *** open label feasibility study was conducted at a single referral center in South India and evaluated the effectiveness of repurposed iNO in improving clinical outcomes in COVID-19 and its correlation with viral *** recruited hypoxemic COVID-19 patients and allocated them into treatment(iNO)and control groups(1:1).Viral clearance on day 5 favored the treatment group(100%vs 72%,P<0.01).The speed of viral clearance as adjudged by normalized longitudinal cycle threshold(Ct)values was positively impacted in the treatment *** proportion of patients who attained clinical improvement,defined as a≥2-point change on the World Health Organization ordinal scale,was higher in the iNO cohort(n=11,79%)as compared to the control group(n=4,36%)(odds ratio 6.42,95%confidence interval 1.09–37.73,P=0.032).The proportion of patients progressing to mechanical ventilation in the control group(4/11)was significantly higher than in the treatment group(0/14).The all-cause 28-day mortality was significantly different among the study arms,with 36%(4/11)of the patients dying in the control group while none died in the treatment *** numbers needed to treat to prevent an additional poor outcome of death was estimated to be *** study demonstrates the putative role of repurposed iNO in hypoxemic COVID-19 patients and calls for extended validation.

关键词： nitric oxide COVID-19 antiviral activity WHO ordinal scale

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Transformation of User Interface to Activity Models and Assessing Performance of WA/WS

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Journal of Software Engineering and Applications 2019年第5期12卷 101-126页

作者： Ch. Ram Mohan Reddy D. Evangelin geetha R. V. Raghvendra Rao T. V. Suresh Kumar B.M.S College of Engineering Bengaluru India Ramaiah Institute of Technology Bengaluru India

Quality of Service is an important attribute of a software system. In retrospect, performance assessment based on user interaction with the system has given a better understanding of underlying disciplines of the product. In this paper, we capture user interaction with the prototype/User Interface (UI). An approach for developing activity model from the user interface model is presented using workflows and functional elements. A methodology is proposed to transform UI into activity diagram. The approach is validated by an experimental setup using Amazon service. The performance of Amazon service is assessed using activity based performance prediction methodology, and the simulation results are obtained using SMTQA.

关键词： Web Services Software Performance Engineering Web Applications Software Size Estimation Activity Based Performance Prediction Unified Modeling Language

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胡椒愈伤组织的离体诱导

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世界热带农业信息 1993年第4期 21-23页

作者： C.K.geetha 成翠兰

本文详述利用胡椒植株各部位的外殖体诱导愈伤组织的情况。

关键词：愈伤组织诱导愈伤外殖体根段离体培养体细胞变异无性繁殖喀拉拉邦激动素器官形成

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能力建设辐射防护的可持续教育与培训

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国际原子能机构通报 2001年第1期43卷 12-15页

作者： PATRICIA WIELAND geetha SADAGOPAN KHAMMAR MRABIT TONY WRIXON 安全协调科核安全司安全协调科核安全司辐射监测和防护科核安全司辐射安全科

电离辐射在世界各地医疗、工业、农业和研究领域的应用继续增加。随着应用的不断增加,在所有这些领域中,更加需要合格而训练有素的人员。在第一线负责核、辐射、运输或放射性废物安全的人员应充分了解与辐射防护有关的概念,熟悉辐射源... 详细信息

电离辐射在世界各地医疗、工业、农业和研究领域的应用继续增加。随着应用的不断增加,在所有这些领域中,更加需要合格而训练有素的人员。在第一线负责核、辐射、运输或放射性废物安全的人员应充分了解与辐射防护有关的概念,熟悉辐射源的安全使用。其他类型人员,即使不直接和电离辐射源打交道,也需要培训,以便能够履行职责。

关键词： IAEA 辐射防护教育培训可持续性辐射安全

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Kinetics of Anaerobic Digestion of Water Hyacinth,Poultry Litter,Cow Manure and Primary Sludge:A Comparative Study

Kinetics of Anaerobic Digestion of Water Hyacinth,Poultry Li...

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2012 2nd International Conference on Biotechnology and Environment Management

作者： Srinidhi Adiga Ramya R. Shankar B.B. Jagadish H.Patil geetha C.R. R V College of Engineering Acharya Institute of Technology Sapthagiri College of Engineering

Global depletion of energy supply due to the continuing over-utilization is a major problem of the present and future world *** is estimated that the fossil fuels will be exhausted in the next few *** today s energy demanding life style,there is always a need for exploring and exploiting new sources of energy which are renewable as well as *** digestion is a technology that utilizes various organic wastes（animal manure,energy crops and industrial wastes） to produce biofuel methane,which holds promise for the future while simultaneously addressing ecological and agrochemical *** the present study,kinetics of anaerobic digestion of dry water hyacinth,poultry litter,cow manure and primary sludge were undertaken in 250 ml biodigesters with 7% total solids and 60 days retention time and modified Gompertz equation was tested for its *** kinetic parameters viz.,biogas yield potential（P）,the maximum biogas production rate（Rm） and the duration of lag phase（λ） were estimated for each *** digester fed with poultry litter produced maximum biogas（0.39 l（g VS）-1） and kinetic parameters P,Rm and λ were 0.3904 l（g VS）-1;0.0165 l（g VS）-1d-1 and 8.7498 days respectively.

关键词： Anaerobic digestion Biogas Modified Gompertz equation Kinetic parameters Mesophilic range

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Development and Rapid Intensification of Tropical Cyclone OCKHI(2017)over the North Indian Ocean

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Journal of Atmospheric Science Research 2020年第3期3卷 13-22页

作者： geetha B Balachandran S India Meteorological Department ChennaiIndia

Tropical Cyclone OCKHI over the North Indian Ocean during 2017 underwent dramatic development and rapid intensification very close to the land-Sri Lanka,extreme South Indian coast and Lakshadweep area during its initial developmental stage and caused extensive damages over these *** examining the physical and structural mechanism involved in such development,it is observed that the initial development was associated with axi-symmetrisation of the vortex that could be associated with Vortex Rossby waves near the *** with the expulsion of high vorticity from the centre during asymmetry mixing,there was outward propagation of eddy angular momentum flux in the lower levels that strengthened a low level anticyclone to the northeast of the TC centre which in turn enhanced the cyclonic inflow near the TC *** rapid intensification phase was associated with vertical non-uniform heating with upper and lower tropospheric warming associated with latent heat release in *** the mature phase,the system sustained‘very severe’intensity even under increasing vertical shear and lower ocean heat flux under the influence of a break in the sub tropical ridge to the north of the system centre that enhanced the poleward outflow in the upper troposphere.

关键词： Tropical cyclone Ockhi Asymmetry Eddy flux convergence Heat and moisture budget

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伴发牙髓病变的牙周骨内缺损治疗一例报告

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中国口腔医学继续教育杂志 2011年第3期14卷 179-184页

作者： geetha Ari Anii Kumar K Thyagarajan Ramakrishnan 王宪娥（译）徐莉（审）不详北京大学口腔医学院修复科北京市中关村南大街22号 100081

牙周治疗的目的消除牙周组织的炎症．而牙髓治疗是为了解决牙髓及根尖组织的疾病。长久以来．研究人员及临床医师一直认为牙髓与其周围的牙周组织关系密切。本报告介绍了PRF（富含血小板纤维蛋白）凝胶在牙周骨内缺损合并根尖病变中的... 详细信息

牙周治疗的目的消除牙周组织的炎症．而牙髓治疗是为了解决牙髓及根尖组织的疾病。长久以来．研究人员及临床医师一直认为牙髓与其周围的牙周组织关系密切。本报告介绍了PRF（富含血小板纤维蛋白）凝胶在牙周骨内缺损合并根尖病变中的应用。病变牙首先进行了根管治疗，然后是牙周治疗。为使根尖病变及骨内缺损尽早愈合，联合应用了PRF凝胶、羟磷灰石、引导性组织再生膜。1年后．治疗效果良好．根尖病变，疼痛及肿胀都消失了．牙齿稳固性增加．影像学显示有足够的支持骨。

关键词：引导性组织再生:骨内缺损牙周一牙髓联合病变 periobone—G 富含血小板纤维蛋白

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Organ at Risk Doses during High Dose Rate Intracavitary Brachytherapy for Cervical Cancer: A Dosimetric Study

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2018年第4期7卷 472-478页

作者： N. V. Vinin Joneetha Jones V. T. Ajas geetha Muttath C. A. Suja E. K. Nabeel Yahiya P. N. Shoaib Nawaz Arun P. Narendran P. Shimjith Department of Radiation Oncology Malabar Cancer Centre Thalassery Kerala India

Background: Treatment of Cervical cancer includes a combination of external beam radiotherapy (EBRT) with intracavitary brachytherapy (ICBT). ICBT helps to boost radiation dose to primary disease. Organs like rectum, bladder, sigmoid and small bowel lie close to the cervix region and these organs receive dose from EBRT as well as ICBT and we want to know the dose to these organ at risk (OAR). Materials & Methods: Dosimetric details of 174 ICBT applications done in 58 patients were retrospectively analysed. All patients received EBRT dose of 50.4 Gy in 28 fractions. All patients had ICBT, three sessions with 7 Gy prescribed to point A. Dosimetric data including dose to right and left point A and dose to OARs were recorded from Oncentra Planning System. Results: Mean dose to point A on right side was 6.89 Gy and left side was 6.91 Gy. Mean D2cc dose to rectum, bladder, sigmoid and small bowel was 3.5 Gy, 5.25 Gy, 4.75 Gy and 4.2 Gy respectively. Mean EQD2 dose combining EBRT and ICBT in point A was 78.7 Gy on right side and 79 Gy on left side. Mean EQD2 doses to D2cc of rectum, bladder, sigmoid and small bowel was 62 Gy, 74.4 Gy, 70.5 Gy and 66.5 Gy respectively. Conclusion: From the results of this dosimetric study it is evident that OARs like rectum, sigmoid, bladder & bowel are receiving only acceptable doses of radiation using point A prescribed CT based ICBT planning. Hence with regards to OAR doses, CT based ICBT planning with dose prescribed to point A is a feasible option.

关键词： Intracavitary Brachytherapy Carcinoma Cervix Organ at Risk High Dose Rate Brachytherapy

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阿肖克·金君瓦拉

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科技纵览 2015年第5期 23-23页

作者： geetha Rao

阿肖克·金君瓦拉（Ashok Jhunjhunwala）和他的团队于2005年左右第一次在南印度的农村地区帮忙安装一台ATM机，那时当地的村民们并不喜欢那台机器：他们认为ATM机吐出的崭新纸币有可能会被当作假钱，而那些有污损的却被视为不容置疑的... 详细信息

阿肖克·金君瓦拉（Ashok Jhunjhunwala）和他的团队于2005年左右第一次在南印度的农村地区帮忙安装一台ATM机，那时当地的村民们并不喜欢那台机器：他们认为ATM机吐出的崭新纸币有可能会被当作假钱，而那些有污损的却被视为不容置疑的真钞，原因是它们曾一直在流通。

关键词：金 ATM机农村地区

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沙棘叶子提取物对白化病白鼠由铬诱导氧化胁迫的抗氧化活性评估

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陕西林业科技 2006年第1期30卷 90-94页

作者：郭海赵明 S.geetha M.Sai Ram S.S.Mongia Virendra Singh G.Ilavazhagan R.C.Sawhney 水利部沙棘开发管理中心北京100038 香港中文大学生物系生理联合科学预防研究所 H.P.农业大学

本研究报道沙棘(胡颓子科)对雄性白化病白鼠由铬诱导氧化胁迫的抗氧化活性。氧化胁迫通过对小白鼠进行强制性喂养30 d,以浓度为30 m g/kg的铬相对体重比例的重铬酸钾盐实现。铬促使体重下降,而却明显增加了器官与体重比例。铬处理明显... 详细信息

本研究报道沙棘(胡颓子科)对雄性白化病白鼠由铬诱导氧化胁迫的抗氧化活性。氧化胁迫通过对小白鼠进行强制性喂养30 d,以浓度为30 m g/kg的铬相对体重比例的重铬酸钾盐实现。铬促使体重下降,而却明显增加了器官与体重比例。铬处理明显减少了谷胱甘肽的降低,增加了丙二醛和肌氨酸磷酸激酶的水平;而且它还加强了血清中谷氨酸草酰乙酸转移酶和谷氨酸丙酮酸转移酶的浓度。用不同剂量的沙棘叶子提取物(乙醇提取)对保护铬元素诱导的氧化胁迫进行了评估,结果表明叶子提取物在浓度为100到250 m g/kg铬与体重比的情况下可以明显保护动物避免由铬所诱导的氧化伤害。

关键词：沙棘铬氧化胁迫抗氧化剂

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