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New Stability Indicating Method for Quantification of Impurities in Amlodipine and Benazepril Capsules by Validated HPLC

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American Journal of Analytical Chemistry 2013年第12期4卷 715-724页

作者： Rama Joga Venkata Eranki Gopichand Inti venkatasubramanian jayaraman Raghuram Pannala Sudhakar Rao Vidiyala Jadi Sree Ramulu Department of Chemistry Sri Krishnadevaraya University Anantapur India Quality & Analytical Development Department InvaGen Pharmaceuticals Inc. Hauppauge USA Quality & Analytical Development Department InvaGen Pharmaceuticals Inc. Hauppauge USA Department of Chemistry Sri Krishnadevaraya University Anantapur India Quality Assurance Department ScieGen Pharmaceuticals Inc. Hauppauge USA

A stability indicating LC method was developed for the simultaneous determination of Amlodipine and Benazepril capsules in pharmaceutical dosage form. Efficient chromatographic separation was achieved on Symmetry C18 stationary phase with simple combination of amobile phase containing 750 mL of DI Water, 250 mL of Acetonitrile and 2 mL of Octylamine into suitable container with adjusted pH to 2.50 ± 0.05 with the aid of Ortho phosphoric acid delivered in an isocratic mode and quantification was carried out using UV detection at 240 nm at a flow rate of 1.0 mL·min-1 with an injection volume of 20 μl and ambient column temperature. This method is capable to detect both the drug components of Amlodipine and Benazepril in presence of their degradation products (Amlodipine Imp-A and Benazepril Impurity-C) with a detection level of 0.05%. Amlodipine/Benazepril in their combination drug product were exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the samples were analysed. Peak homogeneity data of Amlodipine and Benazeprilis were obtained using PDA detector, in the stressed sample chromatograms, demonstrating the specificity. The method shows excellent linearity over a range of 0.05%-2.0% for Amlodipine, Amlodipine Impurity-A and 0.05%-5.0% for Benazepril and Benazepril Impurity-C. The correlation coefficient for Amlodipine and Benazepril is 1. The relative standard deviation was always less than 2%. The proposed method was found to be suitable and accurate for quantitative determination and the stability study of Amlodipine and Benazepril in pharmaceutical preparations. The developed HPLC method was validated with respect to linearity & range, accuracy, precision and robustness.

关键词： Column Liquid Chromatography Method Validation Stability Indicating Study Amlodipine and Benazepril

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T-bet in the spot light： roles in distinct T-cell fate determination

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Cellular & Molecular Immunology 2013年第4期10卷 289-291页

作者： Sundararajan jayaraman Department of Surgery University of IllinoisCollege of Medicine Peoria IL USA

The transcription factor T-bet was originally described to be important for the differentiation of the CD4＋ Thl subset. More recent investigations implicate T-bet in the lineage commitment of a variety of innate immu... 详细信息

关键词： Innate lymphoid cells T-bet T helper cell subsets

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Loss of TCR responsiveness during thymic education imprints the ＇innate＇ signature on γδ T cells

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Cellular & Molecular Immunology 2014年第4期11卷 323-325页

作者： Sundararajan jayaraman Department of Surgery University of Illinois College of Medicine Peoria IL USA

T cells expressing γδ determinants are considered innate-like and deviate from the classical αβ T cells in many aspects, including the rapid production of lymphokines following the recognition of ＇naked＇ antigen...

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Of ethnicity, environment, and microbiota

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Cellular & Molecular Immunology 2019年第2期16卷 106-108页

作者： Sundararajan jayaraman Department of Surgery University of Illinois College of Medicine at PeoriaPeoriaILUSA

Elie Metchnikoff’s lecture illustrated that‘men were free from microbes at birth and within tenth and seventeenth hour of birth the surface of skin,mucous membranes,respiratory passages,and more abundantly the digestive organs became peopled with microbes derived from the air or water’.1 It is interesting to note that the revised ratio of human cells to the number of bacteria in the body is 1:1,which is further tipped towards the human cell mass following each defecation.

关键词： organs respiratory revised

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Synergistic effect of flavonoids combined with antivenom on neutralisation of Naja naja venom

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Asian Pacific Journal of Tropical Biomedicine 2021年第7期11卷 298-307页

作者： Srimathi Raghavan Gurunathan jayaraman School of Biosciences and Technology Vellore Institute of TechnologyVellore 632014India

Objective:To evaluate the neutralizing effects of flavonoids on snake venom toxicity by stand-alone and combinatorial ***:Synthetic flavonoids were assessed,either individually or in combination with antivenom,for their neutralization of phospholipase A_(2)(PLA_(2)),protease,antioxidant(DPPH)assay and hemotoxic *** docking studies were performed to understand possible binding of flavonoids with Naja naja venom PLA_(2).In vivo studies were carried out to confirm the neutralisation effects using a mouse ***,inhibition of PLA_(2) was monitored using combinatorial ***:Among the flavonoids used,quercetin and naringenin inhibited PLA_(2)(56%and 45%),protease(71%and 64%),DPPH scavenging(69.0%and 77.5%)and hemotoxic(70%)*** docking studies indicated that the flavonoids bind to the substrate-binding site of PLA_(2)(Cys44 and Tyr63).In vivo studies showed a reduction in the venom toxicity level in the presence of ***,combinatorial studies using the mixture of flavonoid and anti-venom revealed the possibility of synergistic effect(up to 32%enhancement)in neutralising the venom ***:These flavonoids can be used as additives for the treatment of snake bites,which may exert synergistic effects in combination with antivenom and decrease the post-therapeutic effects caused by excessive use of antivenom.

关键词： Flavonoid Anti-venom Snake bite Combinatorial Synergistic Naja naja

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Effect of Process Parameters on Tensile Strength of Friction Stir Welded Cast LM6 Aluminium Alloy Joints

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Journal of Materials Science & Technology 2009年第5期25卷 655-664页

作者： M.jayaraman R.Sivasubramanian V.Balasubramanian Department of Mechatronics Engineering Kongu Engineering CollegeErodeTamil NaduIndia Department of Mechanical Engineering Coimbatore Institute of TechnologyCoimbatoreTamil NaduIndia Centre for Materials Joining&Research(CEMAJOR) Department of Manufacturing EngineeringAnnamalai UniversityAnnamalainagarTamil NaduIndia

This paper reports the effect of friction stir welding （FSW） process parameters on tensile strength of cast LM6 aluminium alloy. Joints were made by using different combinations of tool rotation speed, welding speed and axial force each at four levels. The quality of weld zone was investigated using macrostructure and microstructure analysis. Tensile strength of the joints were evaluated and correlated with the weld zone hardness and microstructure. The joint fabricated using a rotational speed of 900 r/min, a welding speed of 75 mm/min and an axial force of 3 kN showed superior tensile strength compared with other joints. The tensile strength and microhardness of the welded joints for the optimum conditions were 166 MPa and 64.8 Hv respectively.

关键词： LM6 aluminium alloy Friction stir welding Tool rotation speed Welding speed Axial force Tensile strength

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AEECA for Reliable Communication to Enhance the Network Life Time for WSN

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Intelligent Automation & Soft Computing 2023年第2期35卷 1705-1719页

作者： Ganesh jayaraman V R Sarma Dhulipala Department of Computer Science&Engineering Anjalai Ammal Mahalingam Engineering CollegeKovilvenniTamil NaduIndia Department of Physics Anna UniversityBIT CampusTiruchirappalliTamil NaduIndia

Nowadays,wireless sensor networks play a vital role in our day to day *** communication is preferred for many sensing applications due its convenience,ﬂexibility and *** sensors to sense the environmental factor are versatile and send sensed data to central station *** cluster based protocols are provided an optimal solution for enhancing the lifetime of the sensor *** this paper,modiﬁed K-means++algorithm is used to form the cluster and cluster head in an efﬁcient way and the Advanced Energy-Efﬁcient Cluster head selection Algorithm(AEECA)is used to calculate the weighted fac-tor of the transmission path and effective data collection using gateway *** experimental results show the proposed algorithm outperforms the existing routing algorithms.

关键词： Wireless sensor network reliable communication energy management energy clustering sensors base station gateway node

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Husbandry practices and gut health outcomes in weaned piglets:A review

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Animal Nutrition 2017年第3期3卷 205-211页

作者： Balachandar jayaraman Charles M.Nyachoti Department of Animal Sciences University of Manitoba

The immediate post-weaning period is one of the most stressful phases in a pig's life, and during this period, piglets are usually exposed to environmental, social and psychological stressors which have direct or indirect effects on gut health and overall growth performance. In this review, the impact of husbandry practices on gut health outcomes and performance of piglets is discussed. Husbandry practices in the swine barn generally include nutrition and management practices, maintenance of hygienic standards and disease prevention protocols, and animal welfare considerations. Poor husbandry practices could result in reduced feed intake, stress and disease conditions, and consequently affect gut health and performance in weaned piglets. Reduced feed intake is a major risk factor for impaired gut structure and function and therefore a key goal is to maximize feed intake in newly weaned piglets. In weaned piglets, crowding stress could reduce pig performance, favor the proliferation of pathogenic bacteria resulting in diarrhea, stimulate immune responses and interfere with beneficial microbial activities in the gut. Sanitation conditions in the swine barn plays an important role for optimal piglet performance, because unclean conditions reduced growth performance, shifted nutrient requirements to support the immune system and negatively affected the gut morphology in weaned piglets. Appropriate biosecurity measures need to be designed to prevent disease entry and spread within a swine operation,which in turn helps to keep all pigs and piglets healthy. Collectively, husbandry practices relating to feeding and nutrition, animal welfare, biosecurity and disease prevention are important determinants of gut health and piglet performance. Thus, it is suggested that adopting high husbandry practices is a critical piece in strategies aimed at raising pigs without the use of in-feed antibiotics.

关键词： Gut health Husbandry practices Weaned piglets

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Laparoscopic pancreatectomy: Indications and outcomes

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World Journal of Gastroenterology 2014年第39期20卷 14246-14254页

作者： Shuyin Liang Usmaan Hameed Shiva jayaraman Division of General Surgery University of Toronto Toronto ON M6R1B5 Canada Division of General Surgery HPB Service St.Joseph’s Health Centre Toronto Toronto ON M6R1B5 Canada

The application of minimally invasive approaches to pancreatic resection for benign and malignant diseases has been growing in the last two decades. Studies have demonstrated that laparoscopic distal pancreatectomy (LDP) is feasible and safe, and many of them show that compared to open distal pancreatectomy, LDP has decreased blood loss and length of hospital stay, and equivalent post-operative complication rates and short-term oncologic outcomes. LDP is becoming the procedure of choice for benign or small low-grade malignant lesions in the distal pancreas. Minimally invasive pancreaticoduodenectomy (MIPD) has not yet been widely adopted. There is no clear evidence in favor of MIPD over open pancreaticoduodenectomy in operative time, blood loss, length of stay or rate of complications. Robotic surgery has recently been applied to pancreatectomy, and many of the advantages of laparoscopy over open surgery have been observed in robotic surgery. Laparoscopic enucleation is considered safe for patients with small, benign or low-grade malignant lesions of the pancreas that is amenable to parenchyma-preserving procedure. As surgeons’ experience with advanced laparoscopic and robotic skills has been growing around the world, new innovations and breakthrough in minimally invasive pancreatic procedures will evolve.

关键词： Laparoscopy Distal pancreatectomy Pancreaticoduodenectomy Robotic pancreatectomy Enucleation

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Recognition and Anticipation of Diabetic Foot Ulcer in Type Ⅱ Diabetic Patients using Multi-layered Fuzzy Model

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Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 13-23页

作者： Sai Surya Varshith Nukala Jayashree jayaraman Vijayashree jayaraman Rishi Raghu School of Computer Science and Engineering Vellore Institute of TechnologyVellore 632014Tamil NaduIndia

Diabetes mellitus is associated with foot ulcers,which frequently pave the way to lower-extremity ***,trauma,deformity,high plantar pressures,and peripheral vascular disease are the most common underlying *** 15%of diabetic patients are affected by diabetic foot ulcer in their lifetime.64 million people are affected by diabetics in India and 40000 amputations are done every *** ulcers are evaluated and classified in a systematic and thorough manner to assist in determining the best course of *** paper proposes a novel model which predicts the threat of diabetic foot ulcer using independent agents for various input values and a combination of fuzzy expert *** proposed model uses a classification system to distinguish between each fuzzy framework and its *** on the severity levels necessary prevention,treatment,and medication are *** the results of all the fuzzy frameworks derived from its constituent parameters,a risk-specific medication is *** work also has higher accuracy when compared to other related models.

关键词： diabetic ulcer typeⅡdiabetic fuzzy model

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