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Impact of X-radiation in the management of COVID-19 disease

World Journal of Radiology 2022年第7期14卷 219-228页

作者： Aishwarya T A Divya K Mohan K Nandhini Venkateswarlu Raavi venkatachalam perumal Department of Human Genetics Sri Ramachandra Institute of Higher Education and Research(Deemed to be University)PorurChennai 600116Tamil NaduIndia Department of Cell Biology and Molecular Genetics Sri Devaraj Urs Academy of Higher Education and Research(Deemed to be University)TamakaKolar 563103KarnatakaIndia

Coronaviruses are a diverse group of viruses that infect both animals and *** though the existence of coronavirus and its infection to humans is not new,the 2019-novel coronavirus(nCoV)caused a major burden to individuals and society i.e.,anxiety,fear of infection,extreme competition for hospitalization,and more importantly financial *** nCoV infection/disease diagnosis was based on non-specific signs and symptoms,biochemical parameters,detection of the virus using reverse-transcription polymerase chain reaction(RTPCR),and X-ray-based *** review focuses on the consolidation of potentials of X-ray-based imaging modality[chest-X radiography(CXR)and chest computed tomography(CT)]and low-dose radiation therapy(LDRT)for screening,severity,and management of COVID-19 *** studies suggest that CXR contributed significantly toward initial rapid screening/diagnosis and CT-imaging to monitor the disease *** chest CT has high sensitivity up to 98%and low specificity for diagnosis and severity of COVID-19 disease compared to ***,LDRT compliments drug therapy in the early recovery/Less hospital stays by maintaining the physiological parameters better than the drug therapy *** the results undoubtedly demonstrated the evidence that X-ray-based technology continues to evolve and play a significant role in human health care even during the pandemic.

关键词： Corona virus COVID-19 infection COVID-19 disease X-rays Computed tomography Low dose radiotherapy

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Radiation signature on exposed cells: Relevance in dose estimation

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World Journal of Radiology 2015年第9期7卷 266-278页

作者： venkatachalam perumal Tamizh Selvan Gnana Sekaran Venkateswarlu Raavi Safa Abdul Syed Basheerudeen Karthik Kanagaraj Amith Roy Chowdhury Solomon FD Paul Department of Human Genetics College of BiomedicalSciences Technology and Research Sri Ramachandra University

The radiation is considered as a double edged sword, as its beneficial and detrimental effects have been demonstrated. The potential benefits are being exploited to its maximum by adopting safe handling of radionuclide stipulated by the regulatory agencies. While the occupational workers are monitored by personnel monitoring devices, for general publics, it is not a regular practice. However, it can be achieved by using biomarkers with a potential for the radiation triage and medical management. An ideal biomarker to adopt in those situations should be rapid, specific, sensitive, reproducible, and able to categorize the nature of exposure and could provide a reliable dose estimation irrespective of the time of the exposures. Since cytogenetic markers shown to have many advantages relatively than other markers, the origins of various chromosomal abnormalities induced by ionizing radiations along with dose-response curves generated in the laboratory are presented. Current status of the gold standard dicentric chromosome assay, micronucleus assay, translocation measurement by fluorescence insitu hybridization and an emerging protein marker the g-H2 AX assay are discussed with our laboratory data. With the wide choice of methods, an appropriate assay can be employed based on the net.

关键词： Biomarker Dicentric chromosomes Micronucleus Fluor

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Chromium detoxification mechanism induced growth and antioxidant responses in vetiver(Chrysopogon zizanioides(L.) Roberty)

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Journal of Central South University 2019年第2期26卷 489-500页

作者： AN Wen-hui LI Wai-chin WU Chuan School of Metallurgy and Environment Central South University Plant Genetic Engineering and Molecular Biology Lab Department of Biotechnology Periyar University Department of Science and Environmental Studies The Education University of Hong Kong Department of Biology Western Kentucky University Department of Marine Science University of Calcutta

This study investigated the chromium(Cr)detoxification mechanism-induced changes in growth and antioxidant defence enzyme activities in Chrysopogon *** growth decreased by 36.8%and 45.0%in the shoots and roots,respectively,in the 50 mg/L Cr *** accumulation was higher in root(9807μg/g DW)than in shoots(8730μg/g DW).Photosynthetic pigments and malondialdehyde content increased up to the 30 mg/L Cr treatment,whereas they declined at higher *** activity of superoxide dismutase(SOD),catalase(CAT)and peroxidase(POX)were increased significantly with increasing of Cr dose but slightly declined at higher *** banding patterns revealed the expression of multiple bands for SOD,CAT and POX enzymes,and the band intensity decreased at high doses of Cr *** results indicate that higher Cr doses increased the oxidative stress by over production of reactive oxygen species(ROS)in vetiver that had potential tolerance mechanism to Cr as evidenced by enhanced level of antioxidative enzymes,photosynthetic pigments,MDA ***,vetiver has evolved a mechanism for detoxification and accumulates higher concentration of toxic *** study provides a better understanding of how vetiver detoxifies Cr.

关键词： chromium Chrysopogon zizanioides detoxification mechanism antioxidant enzymes phytoremediation

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