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An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents

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Chinese Chemical Letters 2014年第3期25卷 419-422页

作者： Sangaraiah Nagarajan Poovan Shanmugavelan Murugan Sathishkumar Ramasamy Selvi Alagusundaram Ponnuswamy Hariharan Harikrishnan vellasamy shanmugaiah Department of Organic Chemistry School of ChemistryMadurai Kamaraj University Department of Microbial Technology School of Biological SciencesMadurai Kamaraj University

An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz, water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.

关键词： Water promotedAntibacterial1 2 3-TriazolePyrimidine

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Isolation and characterisation of mesenchymal stem cells derived from human placenta tissue

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World Journal of Stem Cells 2012年第6期4卷 53-61页

作者： Shalini vellasamy Pratheep Sandrasaigaran Sharmili Vidyadaran Elizabeth George Rajesh Ramasamy Immunology Laboratory Department of Pathology Faculty of Medicine and Health Sciences Universiti Putra Malaysia Haematology Unit Department of Pathology Faculty of Medicine and Health Sciences Universiti Putra Malaysia

AIM: To explore the feasibility of placenta tissue as a reliable and efficient source for generating mesenchymal stem cells (MSC). METHODS: MSC were generated from human placenta tissue by enzymatic digestion and mechanical dissociation. The placenta MSC (PLC-MSC) were characterized for expression of cell surface markers, embryonic stem cell (ECS) gene expression and their differentiation ability into adipocytes and osteocytes. The immunosuppressive properties of PLC-MSC on resting and phytohemagglutinin (PHA) stimulated allogenic T cells were assessed by means of cell proliferation via incorporation of tritium thymidine (3H-TdR). RESULTS: The generated PLC-MSC appeared as spindle-shaped cells, expressed common MSC surface markers and ESC transcriptional factors. They also differen-tiated into adipogenic and osteogenic lineages when induced. However, continuous cultivation up to passage 15 caused changes in morphological appearance and cellular senescence, although the stem cell nature of their protein expression was unchanged. In terms of their immunosuppressive properties, PLC-MSC were unable to stimulate resting T cell proliferation; they inhibited the PHA stimulated T cells in a dose dependent manner through cell to cell contact. In our study, MSC generated from human placenta exhibited similar mesenchymal cell surface markers; MSC-like gene expression pattern and MSC-like differentiation potential were comparable to other sources of MSC. CONCLUSION: We suggest that placenta tissues can serve as an alternative source of MSC for future experimental and clinical studies.

关键词： Mesenchymal Stem Cell Placenta Immunophenotyping Immunomodulation Growth Kinetics

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Depression, Anxiety and Stress among Undergraduate Students: A Cross Sectional Study

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Open Journal of Epidemiology 2015年第4期5卷 260-268页

作者： Choon Khim Teh Choon Wei Ngo Rashidatul Aniyah binti Zulkifli Rammiya vellasamy Kelvin Suresh Melaka Manipal Medical College Melaka Malaysia

Background: The prevalence of moderate to extremely severe level of depression, anxiety and stress among undergraduate students in Malaysia was ranging from 13.9% to 29.3%, 51.5% to 55.0% and 12.9% to 21.6% respectively. Medical students have been shown to be more inclined to emotional disorders, especially stress and depression, as compared to their non-medical peers. Therefore, the objective of this cross-sectional study was to determine the prevalence of depression, anxiety and stress among undergraduate students in Melaka Manipal Medical College. Methods: Self-administered questionnaires consisted of 3 sections: demographic data, socioeconomic data and DASS 21 questions. Data processing was performed using Microsoft Excel 2010. The psychological status was categorized according to the presence or absence of depression, anxiety and stress. The data were analyzed using Epi InfoTM 7.1.4 and SPSS. Student’s t-test, Fisher Exact and Chi-square test were used to analyze the associations. P-value of <0.05 was considered as statistically significant. Multiple logistic regression was used to calculate the adjusted Odd Ratio. Results: A total of 397 undergraduates participated in this study. The prevalence of the depression, anxiety and stress, ranging from moderate to extremely severe, was 30.7%, 55.5%, and 16.6% respectively. Multiple logistic regression shows significant associations between relationship status, social life and total family income per month with depression. Only ethnicity has been shown to be significantly associated with anxiety. There are significant associations between ethnicity and total family income per month with stress. No other factors have been found to be significantly associated. Conclusion: Depression, anxiety and stress have a high detrimental effect to individual and society, which can lead to negative outcomes including medical dropouts, increased suicidal tendency, relationship and marital problems, impaired ability to work effectivel

关键词： Prevalence Depression Anxiety Stress Undergraduates Melaka Manipal Medical College

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Diversity of endophytic fungi from the ornamental plant-Adenium obesum

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Studies in Fungi 2016年第1期1卷 34-42页

作者： Meenatchi A Ramesh V Bagyalakshmi Kuralarasi R shanmugaiah V Rajendran A Department of Botany Virudhunagar Hindhu Nadar Senthikumara Nadar CollegeVirudhunagar-626001 Department of Botany Vivekananda CollegeTiruvedakam WestMadurai-625234 Department of Microbial Technology School of Biological SciencesMadurai Kamaraj UniversityMadurai-625021Tamil NaduIndia1

Endophytic fungi live internally in apparently healthy and asymptomatic *** are ubiquitous;no study has yet shown the existence of a plant species without *** species diversity is another characteristic of endophytic *** is quite common for endophyte surveys to find assemblages consisting of more than 30species per host plant *** the present study,179 isolates were obtained from leaf,stem,and tissues of Adenium obesum collected from Virudhunagar,*** endophytic fungi were identified based on the colony morphology and sporulating *** sp.(28.5%),Aspergilus breviceps(30%),Colletotrichum gloeosporioides(23%)and Scorpulariopsis brevicalis(17%)were the most dominant *** colonization frequency was higher in the winter *** hymanaeae was isolated from leaf tissues during the summer and winter *** was the predominant genus isolated from all of leaf,stem and bark tissues of Adenium obesum.

关键词： Adenium obesum colonization frequency endophytes seasonality

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