An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents

作     者：Sangaraiah Nagarajan Poovan Shanmugavelan Murugan Sathishkumar Ramasamy Selvi Alagusundaram Ponnuswamy Hariharan Harikrishnan Vellasamy Shanmugaiah 

作者机构：Department of Organic ChemistrySchool of ChemistryMadurai Kamaraj University Department of Microbial TechnologySchool of Biological SciencesMadurai Kamaraj University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2014年第25卷第3期

页      面：419-422页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：the UGC (BSR) and DST-PURSE for financial support Department of Science and Technology, New Delhi, India for funds under the IRHPA program for the purchase of a NMR spectrometer 

主　　题：Water promotedAntibacterial1 2 3-TriazolePyrimidine 

摘      要：An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz, water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.