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Pharmacological activity,phytochemical analysis and toxicity of methanol extract of Etlingera elatior(torch ginger) flowers

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Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 769-774页

作者： Subramanion Jo Thy Lachumy Sreenivasan Sasidharan velio sumathy Zakaria Zuraini School of Distance Education Universiti Sains MalaysiaMinden 11800Pulau PinangMalaysia Institute for Research in Molecular Medicine(INFORMM) Universiti Sains MalaysiaMinden 11800Pulau PinangMalaysia

Objective:To elucidate its pharmacological activities and medicinal potential of extract of Etlingera elatior（***）.Methods:Phytochemical screening of the flower extract was done to determine the phytochemical in the *** pharmacological study included the determination of antimicrobial activity and minimum inhibitory concentration（MIC） of metabolic flower *** antimicrobial activity of the extract was tested against medically important bacterial,yeast and fungal *** from that,the methanolic extract of *** flower was further tested in vivo toxicity using the brine shrimp lethality ***,the flower extract was qualitatively screened for their free radical scavenging activity by 2,2-diphenyl-1- picrylhydrazyl radical（DPPH） ***:The extract was effective on tested microorganisms and MIC values were in the range of 1.563-50.000 mg/*** brine shrimp lethality test exhibited no significant toxicity(LC50= 2.52 mg/mL) against Artemia *** *** flower extract with high LC50 value signified that this plant is not toxic to *** the phytochemical screening of the flower extract revealed the presence of the following compounds: flavonoids,terpenoids,saponin,tannins and carbohydrates whereas,alkaloids,anthraquinone and reducing sugars were *** concentration of the flower extract required for 50% inhibition of DPPH radical scavenging effect(IC50) were 9.14 mg/mL and 8.08 mg/mL for butylated hydroxytoluene 8.08 mg/***:These findings indicate that the extract of *** flower possesses pharmacological properties and potential to develop natural products based pharmaceuticals products.

关键词： Etlingera elatior Pharmacological activity Phytochemical analysis Artemia salina

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