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Retrospective review of total neoadjuvant therapy

World Journal of gastrointestinal Oncology 2019年第10期11卷 857-865页

作者： Laila Babar veli Bakalov Stephen Abel Obaid Ashraf gene grant Finley Moses S Raj kristina Lundeen Dulabh k Monga Alexander V kirichenko Rodney E Wegner Department of Internal Medicine Allegheny General HospitalPittsburghPA 15212United States Department of Radiation Oncology Allegheny General HospitalPittsburghPA 15212United States Department of Medical Oncology Allegheny General HospitalPittsburghPA 15212United States

BACkgROUND Neoadjuvant chemoradiotherapy(nCRT)followed by resection and postoperative multi-agent chemotherapy(maChT)is the standard of care for locally advanced rectal *** this approach,maChT administration can be delayed for several months,leading to concern for distant *** counteract this,a novel treatment approach known as total neoadjuvant therapy(TNT)has gained popularity,in which patients receive both maChT and nCRT prior to *** utilized the National Cancer Database to examine temporal trends in TNT usage,and any potential effect on *** To study the temporal trends in the usage of TNT and evaluate its efficacy compared to neoadjuvant *** We queried the National Cancer Database for patients with locally advanced rectal cancer,Stage II-III,from 2004-2015 treated with nCRT or *** was defined as maChT initiated≥90 d prior to nCRT *** survival was calculated from the date of diagnosis to the date of last contact or death using kaplan-Meier curves to present the cumulative probability of survival,with logrank statistics to assess *** cox regression was used to identify predictors of survival and propensity score analysis accounted for *** We identified 9066 eligible patients,with 8812 and 254 patients receiving neoadjuvant chemoradiation followed by maChT and TNT,*** involvement,stage III disease,and treatment in recent years were predictive of TNT *** was greater use of TNT with more advanced stage,specifically>1 node involved(odds ratio[OR]=2.88,95%confidence interval[CI]:2.11-3.93,Pge III disease(OR=2.88,95%CI:2.11-3.93,Pgreater increase from 2013 to 2015(OR=6.62,95%CI:3.57-12.25,P<0.01).Both the TNT and neoadjuvant chemoradiation arms had a similar 5-year survival at 76%and 78%*** analysis with propensity score de

关键词： Total neoadjuvant therapy Neoadjuvant chemoradiation Multi-agent chemotherapy Locally advanced rectal cancer National cancer database Colorectal cancer Retrospective review gastrointestinal oncology Temporal trends Surgical excision

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kinetics of thermal decomposition of hydrated minerals associated with hematite ore in a fluidized bed reactor

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International Journal of Minerals,Metallurgy and Materials 2017年第3期24卷 229-239页

作者： P.C. Beuria S.k. Biswal B.k. Mishra g.g. Roy Institute of Minerals and Materials Technology Council of Scientific & Industrial Research Bhubaneswar-751013 India Indian Institute of Technology Kharagpur-721302 India

The kinetics of removal of loss on ignition(LOI) by thermal decomposition of hydrated minerals present in natural iron ores(i.e.,kaolinite,gibbsite,and goethite) was investigated in a laboratory-scale vertical fluidized bed reactor(FBR) using isothermal methods of kinetic *** in the FBR in batch processes were carried out at different temperatures(300 to 1200°C) and residence time(1 to 30 min) for four different iron ore samples with various LOIs(2.34wt% to 9.83wt%).The operating velocity was maintained in the range from 1.2 to 1.4 times the minimum fluidization velocity(Umf).We observed that,below a certain critical temperature,the FBR did not effectively reduce the LOI to a desired level even with increased residence *** results of this study indicate that the LOI level could be reduced by 90% within 1 min of residence time at 1100°*** kinetics for low-LOI samples(kinetics is characterized by a lower activation energy(diffusion-controlled physical moisture removal),followed by a higher activation energy(chemically controlled removal of LOI).In the case of high-LOI samples,three different kinetics mechanisms prevail at different temperature *** temperature up to 450°C,diffusion kinetics prevails(removal of physical moisture);at temperature from 450 to 650°C,chemical kinetics dominates during removal of matrix *** temperatures greater than 650°C,nucleation and growth begins to influence the rate of removal of LOI.

关键词： thermal decomposition fluidized beds kinetic analysis hydrated iron ore activation energy

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Study on kinetics of thermal decomposition of low LOI goethetic hematite iron ore

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International Journal of Mining Science and Technology 2017年第6期27卷 1031-1036页

作者： Beuria P.C. Biswal S.k. Mishra B.k. Roy g.g. Mineral Processing Department CSIR–Institute of Minerals and Materials TechnologyBhubaneswar 751013India Indian Institute of Technology Kharagpur 721302India

In the present study, the kinetics of thermal decomposition of hydrated minerals associated in natural hematite iron ores has been investigated in a fixed bed system using isothermal methods of kinetic analysis. Hydrated minerals in these hematite iron ores are kaolinite, gibbsite and goethite, which contribute to the loss on ignition(LOI) during thermal decomposition. Experiments in fixed bed have been carried out at variable bed depth(16, 32, 48 and 64 mm),temperature(400-1200 ℃) and residence time(30,45, 60 and 75 min) for iron ore samples. It is observed that beyond a certain critical bed depth(16 mm), 100% removal of LOI is not found possible even at higher temperature and higher residence time. Most of the solid-state reactions of isothermal kinetic analysis have been used to analyze the reaction mechanism. The raw data are modified to yield fraction reacted "α" versus time and used for developing various forms of "α" functions.f(α) is the inverse of first derivative of g(α) with respect to α. The study demonstrates that decomposition of hydrated mineral in hematite follows the chemical *** estimated activation energy values in all the experimental situations are found to high, of the order of 60 kJ/mol, reinstating that the reactions are indeed controlled by moving phase boundary and random nucleation.

关键词： Loss on ignition goethite kaolinite gibbsite Roasting Pellet feed kinetic analysis

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An in situ monitoring method for PECVD process equipment condition

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Plasma Science and Technology 2019年第6期21卷 15-22页

作者： g kANg S AN k kIM S HONg Department of Electronic Engineering Myongji University Yongin 17058 Republic of Korea

A key to successful consistent plasma processing is maintaining a consistent process chamber condition over a certain production *** alleviate the concern,in situ process monitoring sensors are employed to investigate the plasma chamber conditions of both the deposition step with direct plasma and the cleaning step with a remote plasma *** situ sensors are optical emission spectroscopy (OES),optical plasma monitoring sensors (OPMS),voltage current probes (Ⅵ-probes),and self-plasma OES (SP-OES).During the deposition,we perform the monitoring of a plasma condition associated with the applied RF power via OES,OPMS,and a Ⅵ-*** the chamber cleaning step using a remote plasma system does not allow plasma monitoring through the sidewall because the plasma is not formed in the process chamber,thus we employed SP-OES to monitor the by-product gas chemistry during the chamber cleaning process *** monitoring results with some useful applications,such as arc detection,part failure detection,and cleaning process chemistry analysis,are presented in this *** use of in situ sensors with proper combination can help to understand the plasma process better,to achieve more precise control of plasma processing.

关键词： in situ monitoring sensor advanced equipment control

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Prediction of wall deposition behaviour in a pilot-scale spray dryer using deposition correlations for pipe flows

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 301-312页

作者： kOTA k. LANgRISH T.A.g. School of Chemical and Biomolecular Engineering University of Sydney Sydney Australia

The particle deposition behaviour of skim milk, water and maltodextrin in the conical section of a pilot-scale spray dryer was predicted using simple correlations for particle depositions in pipes. The predicted particle deposition fluxes of these materials were then compared with the measured deposition fluxes. The predicted particle deposition regimes of the spray dryer were expected to be in the diffusional and mixed (diffusional and inertial) regimes, but the experimental results suggested that the particle deposition was mainly in the inertial regime. Therefore, using the pipe correlations for predicting deposition in a pilot-scale spray dryer suggests that they do not sufficiently represent the actual deposition behaviour. This outcome indicates that a further study of particle flow patterns needs to be carried out using numerical simulations (computational fluid dynamics, CFD) in view of the additional geometrical complexity of the spray dryer.

关键词： Spray dryer Pipe correlations Particle deposition

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ANTIBACTERIAL POLY(D,L-LACTIDE)(PDLLA)FIBROUS MEMBRANES MODIFIED WITH QUATERNARY AMMONIUM MOIETIES

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Chinese Journal of Polymer Science 2010年第4期28卷 581-588页

作者：李新松 k.g.Neoh School of Chemistry and Chemical Engineering Southeast University Department of Chemical and Biomolecular Engineering National University of Singapore

Antibacterial poly（D,L-lactide）（PDLLA） fibrous membranes were developed via electrospinning, followed by surface modification which involved plasma pretreatment, UV-induced graft copolymerization of 4-vinylpyridine （4VP） and quaternization of the grafted pyridine groups with hexylbromide. The success of modification with quaternized pyridinium groups on the PDLLA fibrous membranes was ascertained by X-ray photoelectron spectroscopy （XPS）. The antibacterial activities of these membranes were assessed against gram-positive Staphylococcus aureus （S. aureus） and gram-negative Escherichia coli （E. coli）. The PDLLA fibrous membranes modified with quatemized pyridinium groups showed antibacterial efficiency against both bacteria as high as 99.999%. The results demonstrated that the antibacterial activity was based on the interaction of the positive charge of pyridinium group and negatively charged cell membrane of bacteria, resulting in loss of membrane permeability and cell leakage.

关键词： Poly(D,L-lactide) Antibacterial Electrospinning Surface modification

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Intestinal obstruction due to phytobezoars: An update

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World Journal of Clinical Cases 2015年第8期3卷 721-726页

作者： Enis Dikicier Fatih Altintoprak Orhan veli Ozkan Orhan Yagmurkaya Mustafa Yener Uzunoglu Department of general Surgery Research and Educational Hospital Sakarya University Department of general Surgery Faculty of Medicine Sakarya University Department of general Surgery Research and Educational HospitalSakarya University

The term bezoar refers to an intraluminal mass in the gastrointestinal system caused by the accumulation of indigestible ingested materials, such as vegetables, fruits, and hair. Bezoars are responsible for 0.4%-4% of cases of mechanical intestinal obstruction. The clinical findings of bezoar-induced ileus do not differ from those of mechanical intestinal obstruction due to other causes. The appearance and localization of bezoars can be established with various imaging methods. Treatment of choice depends on the localization of the bezoar which makes the clinical findings.

关键词： Phytobezoar Intestinal obstruction Ileus

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Scaling of residual displacements in terms of elastic and inelastic spectral displacements for existing SDOF systems

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Earthquake Engineering and Engineering Vibration 2020年第1期19卷 71-85页

作者： M.g.Harikrishnan Vinay k.gupta Department of Civil Engineering Indian Institute of Technology Kanpur

Structures undergoing inelastic displacements during earthquake ground motions are known to sustain some amount of residual displacements, which may make them unusable or unsafe. In this study an attempt is made to estimate residual displacements for elastic-perfectly-plastic single-degree-of-freedom oscillators with a given lateral strength ratio. It is observed in the case of a class of ground motions that there are no trends in the dependence of residual displacement on the temporal features of the ground motion, and thus any estimation of residual displacements should be carried out only in the statistical sense. Statistical estimation of residual displacement spectrum via normalization with respect to inelastic or elastic spectral displacements is considered, and it is found that normalization with respect to inelastic spectral displacements is preferable. Expressions for residual displacement spectra are proposed for both types of normalizations and for the givenlateral-strength-ratio type oscillators.

关键词： residual displacement spectrum lateral strength ratio elastic-perfectly-plastic oscillator inelastic displacement spectrum elastic displacement spectrum horizontal ground motions

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World Journal of gastrointestinal Pathophysiology 2014年第3期5卷 228-238页

作者： veli Yazsz Division of Rheumatology Department of Internal MedicineMedical SchoolAkdeniz University

Behet's disease(BD) is a chronic inflammatory condition with multisystem involvement. Approximately 10%-15% of patients present with gastrointestinal involvement. Involved sites and the endoscopic view usually resemble Crohn's disease(CD). In addition to intestinal involvement, oral mucosa, the eyes, skin, and joints are commonly affected. No pathognomonic laboratory test is available for the diagnosis of either disease. Management approaches are also similar in various aspects. Differentiating BD from CD is highly challenging. In this article, the similarities and differences between BD and CD in terms of epidemiology, etiopathogenesis, clinical and imaging findings, and histopathological and therapeutic approaches are reviewed.

关键词： Behcet’s disease Crohn’s disease

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Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers

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Chinese Journal of Cancer 2012年第6期31卷 266-280页

作者： gökçe güllü Sevgi karabulut Mustafa Akkiprik Department of Medical Biology School of MedicineDMarmara University

Insulin-like growth factor-bindin g proteins (IgFBPs) are critical regulators of the mitogenic activity of insulin-like growth factors (IgFs). IgFBP5, one of these IgFBPs, has special structural features, including a nuclear transport domain, heparin-binding motif, and IgF/extracellular matrix/acid-labile subunit-binding sites. Furthermore, IgFBP5 has several functional effects on carcinogenesis and even normal cell processes, such as cell growth, death, motility, and tissue remodeling. These biological effects are sometimes related with IgF (IgF-dependent effects) and sometimes not (IgF-independent effects). The functional role of IgFBP5 is most likely determined in a cell-type and tissue-type specific manner but also depends on cell context, especially in terms of the diversity of interacting proteins and the potential for nuclear localization. Clinical findings show that IgFBP5 has the potential to be a useful clinical biomarker for predicting response to therapy and clinical outcome of cancer patients. In this review, we summarize the functional diversity and clinical importance of IgFBP5 in different types of cancers.

关键词：胰岛素样生长因子结合蛋白临床价值组织类型癌症患者细胞外基质 IgFs 生物标志物有丝分裂

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