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Evaluation of activities of daily living following pseudophakic presbyopic correction

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Eye and Vision 2017年第1期4卷 6-13页

作者： Georgios Labiris panagiota Ntonti Maria patsiamanidi Haris Sideroudi Kimon Georgantzoglou vassilios p.kozobolis Department of Ophthalmology University Hospital of Alexandroupolis68100 DraganaAlexandroupolisGreece Eye Institute of Thrace AlexandroupolisGreece

Background:pseudophakic presbyopic correction is among the prevalent methods for regaining near vision *** purpose of this study is to compare the impact of pseudophakic monovision correction and multifocal lens implantation on the performance in a series of activities of daily living(ADL)of presbyopic ***:An ADL research framework(10 ADLs)was constructed and validated in a sample of patients divided into three validation groups according to their near visual ***-two participants that underwent mini-monovision(MoG)cataract extraction and 60 that underwent bilateral multifocal lenses implantation(MfG)populated study groups and addressed the *** uncorrected distant(BdUVA)and near(BnUVA)visual acuity were associated with ADL scores and with subjective satisfaction using the VF-14 ***:Test-retest reliability[all Intraclass Correlations Coefficients(ICC)>0.90]and construct validity(all ppsychometric performance of the ADL *** study groups presented comparable mean ADL scores(p=0.07)however,MoG patients had lower performance in demanding ADLs(p=0.02).ADL scores demonstrated significant correlation with BnUVA(r^(2)=−0.67,ppprovide sufficient near vision capacity for the majority of activities of daily ***,only multifocal lens implantation can address demanding near vision tasks.

关键词： Cataract presbyopia Monovision Multifocal intraocular lenses Activities of daily living

Liquefaction for cataract extraction

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 306-311页

作者： Georgios Labiris Aspasia Toli Damaskini polychroni Maria Gkika Dimitrios Angelonias vassilios p.kozobolis Department of Ophthalmology University Hospital of Alexandroupolis Eye Institute of Thrace Democritus University

A systematic review of the recent literature regarding the implementation of the liquefaction in cataract surgery and its short-term and long-term outcomes in various parameters that affect the quality of patients＂ life, including visual rehabilitation and possible complications was performed based on the pubMed, Medline, Nature and the American Academy of Ophthalmology databases in November 2013 and data from 14 comparative studies were included in this narrative review. Liquefaction is an innovative technology for cataract extraction that uses micropulses of balanced salt solution to liquefy the lens nucleus. Most studies reported that liquefaction is a reliable technology for mild to moderate cataracts, while fragmentation difficulties may be encountered with harder nuclei.

关键词： Aqualase liquefaction cataract extraction endothelium corneal thermal injury

Retinal capillary plexus in parkinson’s disease using optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 131-136页

作者： Ioannis Giachos Spyridon Doumazos Anastasia Tsiogka Konstantina Manoli George Tagaris Tryfon Rotsos vassilios kozobolis Ioannis Iliopoulos Marilita Moschos First Department of Ophthalmology National and Kapodistrian University of Athens Medical SchoolAthens 11527Greece Department of Neurology General Hospital of Athens“Georgios Gennimatas”Athens 11527Greece Department of Ophthalmology Faculty of MedicineSchool of Health SciencesUniversity of PatrasPatras 26504Greece Neurology Department Democritus University of ThraceAlexandroupolis 68100Greece

AIM:To evaluate the alterations of the retinal microvasculature and foveal avascular zone in patients with parkinson’s disease(pD)using optical coherence tomography angiography(OCT-A).METHODS:A retrospective study of pD patients examined in the Ophthalmology Department of the General Hospital of Athens,“Georgios Gennimatas”from March 2021 to March 2022 was *** 44 patients with pD were included and 18 healthy controls were examined,hence a total of 124 eyes were enrolled in the *** foveal and parafoveal superficial and deep capillary plexus vascular density(fSCp-VD,fDCp-VD,pSCp-VD,pDCp-CD)and foveal avascular zone(FAZ)were quantified with *** coherence tomography(OCT)was used to measure macular *** statistical analysis was conducted by using a mixed effect linear regression ***:After adjustment for age and gender,the mean parafoveal superficial capillary plexus vascular density(pSCp-VD)and mean parafoveal deep capillary plexus vascular density(pDCp-VD)were significantly decreased in individuals with pD(pp-VD didn’t approach statistical *** FAZ area and perimeter were significantly decreased(ppproach statistical *** retinal thickness(CRT)was significantly decreased in individuals with pD(pporal retinal thickness(TRT)was decreased(p=0.025)by-11μm(95%CI-22,-1.5)while nasal retinal thickness(NRT)only approached statistical significance(p=0.066).CONCLUSION:The mean pSCp-VD,pDCp-VD,CRT and TRT are significantly decreased and FAZ is altered in individuals with *** findings can be potentially used as biomarkers for the diagnosis and evaluation of early pD.

关键词： parkinson’s disease optical coherence tomography angiography retinal vascular density foveal avascular zone

Modified deep sclerectomy combined with Ex-pRESS filtration device versus trabeculectomy for primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 728-732页

作者： vassilios kozobolis Georgios D.panos Aristeidis Konstantinidis Miguel Teus Georgios Labiris Department of Ophthalmology University General Hospital of Alexandroupolis School of Medicine Democritus University of Thrace Alexandroupolis Eastem Macedonia and ThraceGR-68100 Greece Eye Institute of Thrace School of Medicine Democritus University of Thrace Alexandroupolis Eastern Macedonia and Thrace GR-68100 Greece Glaucoma Laser Eye Center Athens GR-10674 Greece Department of Ophthalmology School of MedicineUniversity of Alcala Madrid ES-28801 Spain

AIM：To compare the efficacy of modified deep sclerectomy combined with Ex-pRESS shunt versus trabeculectomy in primary open angle glaucoma. METHODS：This is a prospective cohort comparative single-center study. Forty-nine eyes of 49 patients were enrolled in the study. patients were randomly divided into two groups. Group A（22 patients） underwent classic trabeculectomy and group B（27 patients） underwent modified deep sclerectomy combined with insertion of Ex-pRESS model p50 drainage device. RESULTS：Mean age was 69±7y in group A and 64±8y in group B（p=0.03）. The mean reduction was 11.1±5.7 mm Hg in group A compared to 15.8±5.7 mm Hg in group B at 6mo（p=0.006）, and 9.8±4.9 mm Hg and 15.4±4.7 mm Hg respectively at 1y（p=0.0001）. Regarding the postoperative glaucoma medication, significant difference was observed between the two groups（in favour of group B） only at 6mo（p=0.017）. At the end of the follow-up period complete success rate in group A was 68.2% compared to 92.6% in group B（χ^2 test, p=0.07） and qualified success rate was 100% in both ***：Modified deep sclerectomy combined with Ex-pRESS shunt may provide comparable IOp reduction with fewer complications in management of primary open angle glaucoma.

关键词： modified deep sclerectomy Ex-pRESSdrainage device trabeculectomy glaucoma

Imaging of filtering blebs after implantation of the Ex-pRESS shunt with the use of the Visante optical coherence tomography

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 492-495页

作者： Aristeidis Konstantinidis Georgios D panos Magdalini Triantafylla Georgios Labiris Efthimia Tsaragli Zisis Gatzioufas vassilios kozobolis Department of Ophthtalmology University Hospital of Alexandroupolis & Eye Institute of Thrace Department of Ophthtalmology Geneva University Hospitals Faculty of Medicine University of Geneva

AIM: To analyze the features of the filtering blebs following implantation of the Ex-pRESS glaucoma device(model p-50) with the aid of the Visante anterior segment optical coherence tomography(AS-OCT)METHODS: Five patients with open angle glaucomas were included in the study. They all underwent implantation of the Ex-pRESS device under a scleral flap. The surgical procedure was augmented with the use of mitomycin C subconjunctivally. The filtering blebs were analyzed with the Visante AS-OCT with the scans taken along the axis of the implantation of the glaucoma ***: All filtering blebs were graded as diffuse functioning. The morphological characteristics of the blebs were similar to those of the *** the use of the Ex-pRESS implant tend to form a characteristic episcleral lake at the site of the plate of the implant. CONCLUSION: The use of the Ex-pRESS implant produces filtering blebs similar to those of the trabeculectomy with the formation of a characteristic episcleral lake at the site of the plate of the implant.

关键词： Ex-pRESS glaucoma optical coherence tomography

Impact of polyethylene glycol 400/propylene glycol/hydroxypropyl-guar and 0.1%sodium hyaluronate on postoperative discomfort following cataract extraction surgery:a comparative study

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Eye and Vision 2017年第1期4卷 59-65页

作者： Georgios Labiris panagiota Ntonti Haris Sideroudi vassilios kozobolis Department of Ophthalmology University Hospital of Alexandroupolis68100 DraganaAlexandroupolisGreece Eye Institute of Thrace AlexandroupolisGreece

Background:Universal postoperative guidelines for cataract extraction surgery are yet to be *** tears are gaining popularity as an additional integral component of the postoperative *** primary objective of this study was to explore the impact of two prevalent artificial tear preparations on postoperative discomfort following cataract extraction ***:A total of 180 patients that underwent cataract extraction surgery were randomly divided into three groups according to their postoperative regime:a)Study group 1(SG1)received a fixed combination of tobramycin and dexamethasone(FCTD)quid for 3 weeks and,additionally polyethylene glycol 400/propylene glycol/hydroxypropyl-guar quid,for 6 weeks,b)Study group 2(SG2)received FCTD quid for 3 weeks and,additionally 0.1%sodium hyaluronate provided in the COMOD^(®)device quid,for 6 weeks,and,c)Control Group(CG)received only FCTD quid for 3 *** following indexes were evaluated at three postoperative checkpoints:1)Subjective discomfort index(SDI)derived from four direct 10-scale Likert-type questions that were addressed to the patient and pertained to:a)foreign body sensation(FBS),b)blinking discomfort(BD),c)stinging sensation(SS),d)tearing sensation(TS),2)Tear break-up time(TBUT),3)Central corneal thickness(CCT)and,4)Central Corneal Sensitivity(CCS).Results:Both groups showed increased CCT values at the first examination point and reduced CCS values at all examination ***,both SGs had better TBUT times at all examination points compared to CG(CG:8.86±1.08,SG1:9.59±1.45,CG2:9.45±1.33,pparameters,at all examination ***:polyethylene glycol 400/propylene glycol/hydroxypropyl-guar and 0.1%sodium hyaluronate provided

关键词： Cataract postoperative regimen Artificial tears Surface discomfort index Systane Hylocomod

LASER DEEp SCLERECTOMY: 24 MONTHS FOLLOW-Up

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国际眼科杂志 2003年第1期3卷 39-40页

作者： E.V.Christodoulakis V.p.kozobolis I.G.pallikaris Department of Ophthalmology University of Crete Vardinoyannion Eye Institute of Crete (Veic)Department of Ophthalmology University of CreteVardinoyannion Eye Institute of Crete (Veic) and De-partment of Ophthalmology University of Thrace GreeceDepartment of Ophthalmology University of Crete Vardinoyannion Eye Institute of Crete (Veic)

purpose: To study and to evaluate, prospectively the effectiveness and the safety of the Deep sclerectomy when it is performed with the assistance of the Erbium: Yag laser in eyes with primary open angle glaucoma patients and Methods: Forty eyes of 40 patients with primary open angle glaucoma (pOAG) or pseu-doexfoliative glaucoma (pG) were enrolled consecutively to un-

关键词：激光深层巩膜切除术随访疗效安全性

EXFOLIATION SYNDROME AND MOR-pHOLOGICAL AppEARANCE OF CON-JUNCTIVAL GOBLETS CELLS

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国际眼科杂志 2003年第1期3卷 25-26页

作者： V.p.kozobolis I.Naoumidou E.Christodoulakis I.G.pallikaris Uni-versity of Crete Vardinoyannion Eye Institute and University of Thrace GreeceUniversity of CreteVardinoyannion Eye InstituteUniversity of CreteVardinoyannion Eye InstituteUniversity of CreteVardinoyannion Eye Institute

purpose: To study the conjunctival Goblet Cells in patients with pseudoexfoliation compared to the control group. Methods: Conjunctival tissue was obtained at the end of uneventful cataract surgical procedure in 40 patients with pseudoexfoliation from the inferior and nasal part of the conjunctiva. The results were compared to an equal control group. Light microscopy, electron microscopy and histochemistry were performed. Results: 1)

关键词：假磷片样脱皮综合征结膜杯状细胞形态学特征结缔组织病理变化

假性剥脱综合征的结膜杯状细胞形态学和泪膜稳定性研究

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 41-42页

作者：张晓光 kozobolis V.p Christodoulakis E.V Naoumidi I.I E.V.Christodoulakis Department of Ophthalmolog yHeraklion Universi ty HospitalPOBox 220871003HeraklionCreteGreece

Background:Tear secretion and tear film stability seem to be influenced by pseudoexfoliation syndrome (pEX).Histopathological evaluation of conjunctival goblet cells in pEX patients might explain the influ ence on tear film ***:In a prospective,c ross-sectional study,40eyes of 40patients with pEX(study group)had mea-surement of Schirmer test with anesthesia and break-up time prior to cataract *** th e end of an uneventful operation,a 1×1.5mm sample of conju nctival tissue was obtained and light and electron microscopy were *** were compared with a control *** evaluation was *** imary outcome mea-sures included Schirmer test with an esthesia,break-up time,goblet cell density and morphological character of conjunctiva and conjunctival goble t ***:Both Schirmer test and break-up time valu es were significantly lower(p=0.01and p=0.001)in the pEX patients(mean 10.6mm and 8.6s respectively)than in the control group(13.4mm and 12.3s respectively).The number of goblet cells in patients wi th pEX compared with the control group showed no statisti cally significant differ-ence(p=0.66).Use of trichrome stain revealed sig nif-icant differences in the staining pr operties of goblet cells between patients with pEX and contro *** electron mi-croscopy,typical pseudoexfoliati on filaments were found in the connective tissue of conjunctiv a of pEX ***-markable changes of mucin pockets in the study group were also noticed;they had extremely irregular distribu-tion,various forms of size and appearance and even com-plete ***:pseudoexfoliation seems to alter basic features of goblet cell morphology,thus af-fecting tear film *** studies are necessary to determine the exact mechanism.

关键词：结膜杯状细胞剥脱综合征泪膜稳定性白内障手术破膜时间泪液分泌表皮剥脱结膜组织组织学评价试验测量