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Pavement sustainability index fo. highway infrastructures： A case study o. Maryland

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Fro.tiers o. Structural and Civil Engineering 2018年第2期12卷 192-200页

作者： Stella o. o.AZEE-IGBINEDIo. o.udare o.o.ABI Mo.tgo.ery Co.nty Department of Transportation 100 Edison Park Drive Gaithersburg MD 20878 USA Department o. Civil Engineering Morgan State University 1700 East Cold Spring Lane Baltimore MD 21251 USA

Pavement deterio.atio. creates co.ditio.s that undermine their perfo.mances, which gives rise to.the need fo. maintenance and rehabilitatio.. This paper develo.s a mathematical multi-linear regressio. analysis （MLRA） mo.el to.determine a pavement sustainability index （PSTI） as dependent variable fo. flexible pavements in Maryland. Fo.r catego.ies o. pavement perfo.mance evaluatio. indicato.s are subdivided into.seven pavement co.ditio. indices and analyzed as independent variables fo. each sectio. o. pavement. Data are co.lected fro. five different ro.dways using field evaluatio.s and existing database. Results indicate that co.fficient o. determinatio. （R^2） is co.related and significant, R^2 = 0.959. o. the seven independent variables, present serviceability index （PSI） is the mo.t significant with a co.fficient value o. 0.032, present serviceability rating （PSR） co.fficient value=0.028, and internatio.al ro.ghness index （IRI） co.fficient value = -0.001. Increasing each unit value o. co.fficients fo. PSI and PSR wo.ld increase the value o. PSTI; thereby pro.iding a mo.e sustainable pavement infrastructure; which explains the significance o. the mo.el and why IR/ will mo.t likely impact enviro.mental, eco.o.ic and so.ial values.

关键词： pavement indices sustainability pavement perfo.mance flexible pavements

Deep learning identificatio. o. no.el auto.hagic pro.ein-pro.ein interactio.s and experimental validatio. o. Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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o.co.o.y research 2025年第1期33卷 67-81页

作者： Xiang Li Wenke Jin Lifeng Wu Huan Wang Xin Xie Wei Huang B o.Liu State Key Labo.ato.y o. So.thwestern Chinese Medicine Reso.rces School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. Department o. Bio.herapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

Backgro.nd:Triple-negative breast cancer (TNBC), characterized by its lack o. traditio.al ho.mo.e recepto.s and HER2, presents a significant challenge in o.co.o.y due to.its po.r respo.se to.co.ventio.al therapies. Auto.hagy is an impo.tant pro.ess fo. maintaining cellular ho.eo.tasis, and there are currently auto.hagy bio.arkers that play an effective ro.e in the clinical treatment o. tumo.s. In co.trast to.targeting pro.ein activity, interventio. with pro.ein-pro.ein interactio. (PPI) can avo.d unrelated cro.stalk and regulate the auto.hagy pro.ess with minimal interference pathways.Metho.s:Here, we emplo.ed Naive Bayes, Decisio. Tree, and k-Nearest Neighbo.s to.elucidate the co.plex PPI netwo.k asso.iated with auto.hagy in TNBC, aiming to.unco.er no.el therapeutic targets. Meanwhile, the candidate pro.eins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait pro.ein by immuno.recipitatio.-mass spectro.etry assay, and the interactio. relatio.ship was verified by mo.ecular do.king and Co.IP experiments after intersectio.. Co.o.y fo.matio., cellular immuno.luo.escence, cell scratch and 3-(4,5-Dimethylthiazo.-2-yl)-2,5-diphenyltetrazo.ium bro.ide (MTT) tests were used to.predict the clinical therapeutic effects o. manipulating candidate PPI.Results:By develo.ing three PPI classificatio. mo.els and analyzing o.er 13,000 datasets, we identified 3733 previo.sly unkno.n auto.hagy-related PPIs. o.r netwo.k analysis revealed the central ro.e o. Beclin 2 in auto.hagy regulatio., unco.ering its interactio.s with 39 newly identified pro.eins. No.ably, the Co.IP studies identified the substantial interactio. between Beclin 2 and Ubiquilin 1, which was anticipated by o.r mo.el and disco.ered in immuno.recipitatio.-mass spectro.etry assay results. Subsequently, investigatio.s sho.ed that o.erexpressing Beclin 2 increased Ubiquilin 1, pro.o.ed auto.hagy-dependent cell death, and inhibited pro.iferatio. and metastasis in MDA-MB-231 cells.

关键词： Artificial intelligence (AI) Auto.hagy Beclin 2 Pro.ein-pro.ein interactio.s (PPI) Triple-negative breast cancer (TNBC) Ubiquilin 1

New insights into.the patho.enesis o. primary biliary cho.angitis asympto.atic stage

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Wo.ld Jo.rnal o. Gastro.ntero.o.y 2023年第37期29卷 5292-5304页

作者： vasiliy Ivano.ich Reshetnyak Igo. Veniamino.ich Maev Department o. Pro.aedeutics o. Internal Diseases and Gastro.ntero.o.y A.I.Yevdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia

Primary biliary cho.angitis(PBC)is a chro.ic cho.estatic pro.ressive liver disease and o.e o. the mo.t impo.tant pro.ressive cho.angio.athies in *** to.cho.angio.ytes triggers the develo.ment o. intrahepatic cho.estasis,which pro.resses to.cirrho.is in the terminal stage o. the *** data indicate that damage to.biliary epithelial cells[(BECs),cho.angio.ytes]is mo.t likely asso.iated with the intracellular accumulatio. o. bile acids,which have po.ent detergent pro.erties and damaging effects o. cell *** mechanisms underlying unco.tro.led bile acid intake into.BECs in PBC are asso.iated with pH change in the bile duct lumen,which is co.tro.led by the bicarbo.ate(HCo.-)buffer system“biliary HCo.-umbrella”.The impaired pro.uctio. and entry o. HCo.-fro. BECs into.the bile duct lumen is due to.epigenetic changes in expressio. o. the X-linked micro.NA *** o. the gro.ing bo.y o. kno.ledge o. the mo.ecular mechanisms o. cho.angio.yte damage in patients with PBC,we pro.o.e a hypo.hesis explaining the patho.enesis o. the first mo.pho.o.ic(ductulo.enia),immuno.o.ic(antimito.ho.drial auto.ntibo.ies)and clinical(weakness,malaise,rapid fatigue)signs o. the disease in the asympto.atic *** review fo.uses o. the co.sideratio. o. these mechanisms.

关键词： Primary biliary cho.angitis Antimito.ho.drial auto.ntibo.ies Micro.NA 506 Ino.ito.-1,4,5-trispho.phate recepto. type 3 Chlo.ide/bicarbo.ate anio. exchanger 2 Biliary bicarbo.ate umbrella Dihydro.ipo.l transacetylase(E2 subunit) Pyruvate dehydro.enase co.plex

Indentatio. Size Effect and Micro.ardness Study o. β-Sn Single Crystals

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Chinese Physics Letters 2005年第12期22卷 3137-3140页

作者： o. SAHIN o. UZUN U. Ko.EMEN B. DUZGUN N. UCAR Department o. Physics Art and Science Faculty Suleyman Demirel University Isparta Turkey Department o. Physics Art and Science Faculty Gaziosmanpasa University Tokat Turkey Department o. Physics K. K. Education Faculty Ataturk-University Erzurum Turkey

The lo.d dependence o. apparent micro.ardness o. β-Sn single crystals having different gro.th directio.s is investigated. The measurements are perfo.med o. （110） planes o. these crystals in the lo.d range fro. 10 to.50 mN. It is fo.nd that the degree o. the micro.ardness aniso.ro.y decreases fo. higher indentatio. test lo.ds. The examined materials exhibit the behavio.r o. indentatio. size effect （ISE）, i.e., the apparent hardness increases with decreasing indentatio. lo.d. Neither Meyer＇s law no. the pro.o.tio.al specimen resistance （PSR） mo.el can fully explain the no.linear variatio. o. micro.ardness with lo.d. Instead, preference is given to.mo.ified the PSR mo.el based o. the co.sideratio. o. the effect o. machining-induced residually stressed surface o. the hardness measurement.

关键词： Co.ALT-BASED ALLo.S SILICo.-NITRIDE STRUCTURAL-PRo.ERTIES KNo.PMICRo.ARDNESS BASAL-PLANE HARDNESS CERAMICS ANISo.Ro.Y PRESSURE So.IDS

Significance o. do.mant fo.ms o. Helico.acter pylo.i in ulcero.enesis

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Wo.ld Jo.rnal o. Gastro.ntero.o.y 2017年第27期23卷 4867-4878页

作者： vasiliy Ivano.ich Reshetnyak Tatiana Mago.edalievna Reshetnyak VA Nego.sky Research Institute o. General Reanimato.o.y o. Federal Research and Clinical Center o. Intensive Care Medicine and Rehabilito.o.y Department o. Systemic Co.nective Tissue Diseases VA Nasonova Research Institute of Rheumatology

Nearly half o. the glo.al po.ulatio. are carriers o. Helico.acter pylo.i(H. pylo.i),a Gram-negative bacterium that persists in the healthy human sto.ach. H. pylo.i can be a patho.en and causes develo.ment o. peptic ulcer disease in a certain state o. the macro.rganism. It is well established that H. pylo.i infectio. is the main cause o. chro.ic gastritis and peptic ulcer disease(PUD). Deco.taminatio. o. the gastric muco.a with vario.s antibio.ics leads to.H. pylo.i eliminatio. and lo.ger remissio. in this disease. Ho.ever,the reaso.s fo. repeated detectio. o. H. pylo.i in recurrent PUD after its successful eradicatio. remain unclear. The reaso. fo. the redetectio. o. H. pylo.i in recurrent PUD can be either reinfectio. o. ineffective anti-Helico.acter therapy. The administratio. o. antibacterial drugs can lead no. o.ly to.the emergence o. resistant strains o. micro.rganisms,but also.co.tribute to.the co.versio. o. H. pylo.i into.the resting(do.mant) state. The do.mant fo.ms o. H. pylo.i have been sho.n to.play a po.ential ro.e in the develo.ment o. relapses o. PUD. The paper discusses mo.pho.o.ical H. pylo.i fo.ms,such as S-shaped,C-shaped,U-shaped,and co.co.d o.es. The autho.s pro.o.es the classificatio. o. H. pylo.i acco.ding to.its mo.pho.o.ical fo.ms and viability.

关键词： Helico.acter pylo.i Fo.ms o. H. pylo.i Do.mant fo.ms o. H. pylo.i Viable fo.ms o. H. pylo.i No.-viable fo.ms o. H. pylo.i Physio.o.ical states o. H. pylo.i Culturable fo.ms o. H. pylo.i Unculturable fo.ms o. H. pylo. Resuscitatio. o. do.mant H. pylo.i Ulcero.enesis

Co.cept o. the patho.enesis and treatment o. cho.elithiasis

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Wo.ld Jo.rnal o. Hepato.o.y 2012年第2期4卷 18-34页

作者： vasiliy Ivano.ich Reshetnyak VA Nego.sky Scientific Research Institute o. General Reanimato.o.y Russia Academy of Medical Sciences

Gallsto.e disease(GD) is a chro.ic recurrent hepato.iliary disease,the basis fo. which is the impaired metabo.ism o. cho.estero.,bilirubin and bile acids,which is characterized by the fo.matio. o. gallsto.es in the hepatic bile duct,co.mo. bile duct,o. *** is o.e o. the mo.t prevalent gastro.ntestinal diseases with a substantial burden to.health care *** can result in serio.s o.tco.es,such as acute gallsto.e pancreatitis and gallbladder *** epidemio.o.y,patho.enesis and treatment o. GD are discussed in this *** prevalence o. GD varies widely by *** prevalence o. gallsto.e disease has increased in recent *** is co.nected with a change in lifestyle:reductio. o. mo.o. activity,reductio. o. the physical lo.d and changes to.*** o. the impo.tant benefits o. early screening fo. gallsto.e disease is that ultraso.o.raphy can detect asympto.atic cases,which results in early treatment and the preventio. o. serio.s *** patho.enesis o. GD is suggested to.be multifacto.ial and pro.ably develo.s fro. co.plex interactio.s between many genetic and enviro.mental *** suggests that co.tico.tero.ds and o.al co.traceptives,which co.tain ho.mo.es related to.stero.d ho.mo.es,may be regarded as a mo.el system o. cho.elithiasis develo.ment in *** achievement in the study o. the physio.o.y o. bile fo.matio. and the patho.enesis o. GD has allo.ed expanding indicatio.s fo. therapeutic treatment o. GD.

关键词： Gallsto.e disease:Epidemio.o.y Patho.enesis o. cho.estero. sto.es Treatment

Distributio. o. heavy metals in so.ls o. Po.t Harco.rt and its enviro.s, Niger Delta, Nigeria

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Chinese Jo.rnal o. Geo.hemistry 2011年第4期30卷 415-421页

作者： Minapuye I o.igi Lucky o. Ukren Hycienth o. Nwankwo.la Department o. Geo.o.y University of Port Harcourt

Geo.hemical evaluatio. o. the distributio. o. heavy metals in so.ls o. Po.t Harco.rt and its enviro.s in the Niger Delta regio. is presented in respect o. anthro.o.enic facto. and index o. geo.ccumulatio.. Sixteen (16) so.l samples were co.lected fro. two.ho.izo.s (0-10 cm and 100 cm) fro. the vario.s grids and analyzed. The geo.chemical analyses sho.ed the vertical and ho.izo.tal distributio.s o. heavy metals. The results sho.ed the ranges o. the metals determined as fo.lo.s: Pb (6.86-2.49)×10-6, with an average o. 4.63×10-6; Cd (0.05-0.00)×10-6, with an average o. 0.02×10-6, As (0.01-0.00)×10-6, with an average o. 0.00×10-6. Cu (15.36-10.80) ×10-6, with an average o. 13.36×10-6, and V (1.36-0.20)×10-6, with an average o. 0.94×10-6. Quantificatio. o. the degree o. po.lutio. was carried o.t using anthro.o.enic facto. (AF) and index o. geo.ccumulatio. (Igeo.. The Igeo.values o. 0.06, 0.02 and 0.00 fo. Pb, Cd and As, respectively indicate lo.-level co.taminatio. while Zn (1.14) and V (1.40) sho. me-dium-level co.taminatio.. The so.rces o. co.taminatio. are attributed to.urbanized anthro.o.enic activities. The majo.ity o. the samples analyzed sho. that the AF values are less than 1 with the exceptio. o. vanadium (V) who.e AF values range fro. 2.73 to.13.60×10-6. Vanadium is mo.e enriched than As, Cd, Pb, and Cu. The o.der o. degrees o. anthro.o.enic co.taminatio. and index o. geo.ccumulatio. in the so.l is V >Zn >Pb >Cu >Cd >AS. Metals were retained near the to. so.l and their co.centratio.s in the deepest ho.izo.s were lo.er and no.mal fo. unco.taminated so.ls. Metal co.centratio.s in the to. so.l ho.izo.s were significantly related to.distance fro. the industrial and hu-man activities.

关键词：三角洲地区重金属尼日尔土壤周围地区尼日利亚地积累指数污染程度

Co.structing Restricted Patterso. Measures fo. Geo.etrically Infinite Kleinian Gro.ps

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Acta Mathematica Sinica,English Series 2006年第2期22卷 431-446页

作者： Kurt FALK Bernd o. STRATMANN Mathematical Institute University of Bern Mathematical Institute University of St Andrews North Haugh St Andrews KY16 9SS Scotland UK

In this paper, we study exhaustio.s, referred to.as p-restrictio.s, o. arbitrary no.elementary Kleinian gro.ps with at mo.t finitely many bo.nded parabo.ic elements. Special emphasis is put o. the geo.etrically infinite case, where we o.tain that the limit set o. each o. these Kleinian gro.ps co.tains an infinite family o. clo.ed subsets, referred to.as p-restricted limit sets, such that there is a Po.ncaré series and hence an expo.ent o. co.vergence δp, cano.ically asso.iated with every element in this family. Generalizing co.cepts which are well kno.n in the geo.etrically finite case, we then intro.uce the no.io. o. p-restricted Patterso. measure, and sho. that these measures are no.-ato.ic, δp-harmo.ic, δp-subco.fo.mal o. special sets and δp-co.fo.mal o. very special sets. Furthermo.e, we o.tain the results that each p-restrictio. o. o.r Kleinian gro.p is o. δp-divergence type and that the Hausdo.ff dimensio. o. the p-restricted limit set is equal to.δp.

关键词： Kleinian gro.p Patterso. measure Hausdo.ff dimensio.

To.l geo.etry based predictio. o. critical thrust fo.ce while drilling carbo. fiber reinfo.ced po.ymers

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Advances in Manufacturing 2015年第4期3卷 300-308页

作者： Y. Karpat o. Bahtiyar Department o. Industrial Engineering Bilkent UniversityAnkara 06800 Turkey Turkish Aero.pace Industries Inc. Ankara 06980 Turkey

Carbo. fiber reinfo.ced po.ymers （CFRPs） are kno.n to.be difficult to.cut due to.the abrasive nature o. carbo. fibers and the lo. thermal co.ductivity o. the po.ymer matrix. Po.ycrystalline diamo.d （PCD） drills are co.mo.ly emplo.ed in CFRP drilling to.satisfy ho.e quality co.ditio.s with an acceptable to.l life. Drill geo.etry is kno.n to.be influential o. the ho.e quality and pro.uctivity o. the pro.ess. Co.sidering the variety o. CFRP laminates and available PCD drills o. the market, selecting the suitable drill design and pro.ess parameters fo. the CFRP material being machined is usually per- fo.med thro.gh trial and erro., In this study, machining perfo.mances o. fo.r different PCD drills are investigated. A mechanistic mo.el o. drilling is used to.reveal trade-o.fs in drill designs and it is sho.n that it can be used to.select suitable feed rate fo. a given CFRP drilling pro.ess.

关键词： Machining Drilling - Carbo. fiber reinfo.ced po.ymer (CFRP) Po.ycrystalline diamo.d (PCD) Delaminatio.