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Central corneal regularization (CCR): an alternative approach in keratoconus treatment

Eye and Vision 2019年第1期6卷 338-344页

作者： Giulio Mulè Shihao Chen Jia Zhang Wen Zhou vasileios selimis Aleksandar Stojanovic Ioannis M.Aslanides iVis Trento Center San Camillo HospitalTrentoItaly Eye Hospital Wenzhou Medical UniversityWenzhouChina SynsLaser Kirurgi AS Skippergata 7TromsoNorway Emmetropia Mediterranean Eye Institute Plateia Eleftherias 44Heraklion71201 CreteGreece

Background:To evaluate the safety and efficacy of an approach that combines corneal customized transepithelial therapeutic ablation to treat irregular corneal optics and accelerated corneal collagen cross-linking(CXL)to strengthen the corneal tissue and stop the progression of *** transepithelial therapeutic ablation applied a novel concept named central corneal regularization(CCR)which could correct the corneal morphological irregularities and the eye’s spherocylindrical refractive error with minimal stromal tissue ***:Retrospective *** that underwent CCR combined with CXL were evaluated preoperatively and up to 12 months postoperatively for visual acuity,subjective refraction,corneal haze,pachymetry and maximum keratometry(Kmax).Results:Twenty four eyes of 24 patients with a mean age of 28.92±9.88 years were *** mean spherical equivalent(SE)refractive error changed from−0.74±1.17 D preoperatively to−1.05±1.52 D at 12 months *** mean uncorrected distance visual acuity(UDVA)and corrected distance visual acuity(CDVA)*** eye lost lines of CDVA,21 had a mean improvement of 3.21 *** mean cylinder error and Kmax value dropped from−3.06±1.83 D and 51.38±3.29 D to−1.04±0.80 D and 48.70±2.58 D,*** mean haze score at 3,6 and 12 months was 0.56,0.19 and 0.06,***:CCR combined with CXL offers promising results as a safe and effective treatment in keratoconic patients.

关键词： Central corneal regularization Corneal collagen cross-linking Transepithelial Excimer laser Keratoconus

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5-year efficacy of all surface laser ablation with cross-linking(ASLA-XTRA)for the treatment of myopia

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Eye and Vision 2020年第1期7卷 294-299页

作者： Ioannis M.Aslanides Farhad Hafezi Shihao Chen Hatch Mukherjee vasileios selimis Ilias Maragkos Nanji Lu George Kymionis Emmetropia Mediterranean Eye Institute Plateia Eleftherias 44Heraklion71201 CreteGreece Eye Hospital Wenzhou Medical UniversityWenzhouChina Center for Applied Biotechnology and Molecular Medicine University of ZurichDietikon/ZurichSwitzerland ELZA Institute Dietikon/ZurichSwitzerland USC Roski Eye Institute University of Southern CaliforniaCaliforniaLos AngelesUSA Faculty of Medicine University of GenevaGenevaSwitzerland Essex County Hospital EssexUK Athens Medical School University of AthensAthensGreece Faculty of Biology and Medicine Jules Gonin Eye HospitalUniversity of LausanneLausanneSwitzerland

Background:The purpose of our study is to examine the long(5-year)efficacy of the all surface laser ablation(ASLA)combined with accelerated cross-linking(CXL)for the treatment of myopia without the use of mitomycin-C(MMC).Methods:This retrospective study consisted of 202 eyes of 118 myopic(SD:2.41,range:−1.50 to−12.75 D)patients(44 males,74 females).Mean age was 28.50 years(SD:6.45,range:18 to 51 years)that underwent ASLA with accelerated CXL for the treatment of their ***:The patients underwent routine postoperative assessment on the 1st,3rd,7th day and in the 1st,3rd,6th and 12th month,30th month(±6 months),4th and 5th *** mean spherical equivalent(SEq)refractive error changed from−6.41±2.41 D preoperatively to−0.02±0.53 D at 5 years *** haze score was 0.18,0.25 and 0.28 at 1,3 and 6 months *** 12 months after the treatment,no eyes had significant corneal haze and in all the following postoperative time intervals the haze traces were ***:ASLA combined with accelerated CXL(ASLA-XTRA)appears to be safe,efficacious and offering very good refractive *** potential additional benefits of this modality are the stabilizing effect of the refraction and its sterilization effect on the treated cornea without the potential side effects of MMC.

关键词： Refractive surgery Transepithelial PRK ASLA Cross-linking CXL ASLA-XTRA

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