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Bilateral benign reactive lymphoid hyperplasia of the conjunctiva: a case treated with oral doxycycline and review of the literature

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Eye and Vision 2019年第1期6卷 219-228页

作者： Olga Klavdianou Georgios Kondylis vasileios Georgopoulos Sotiria Palioura National and Kapodistrian University of Athens School of Medicine AthensGreece Cornea Service Athens Vision Eye Institute328-330 Syngrou AveKallithea17673 AthensGreece

Background:To report a case of bilateral benign reactive lymphoid hyperplasia(BRLH)of the conjunctiva treated with oral doxycycline and perform review of the literature evaluating the presentation,treatment and risk of transformation to *** presentation:A case report is described and review of the literature from January 1975 to January 2019 was performed.A 30-year-old man presented with bilateral enlarging fleshy pink medial canthal conjunctival *** biopsy revealed *** doxycycline was initiated(100 mg two times a day)for a total of 2 *** lesions decreased in size significantly at the patient’s two-month follow up *** residual lesion in the right eye was excised along with an adjacent pterygium and the patient has been free of recurrence for the past 1.5 *** lesion in the left eye has remained stable in size after cessation of the oral doxycycline.A total of 235 cases of conjunctival BRLH were identified in our literature *** mean age at diagnosis was 35.2 years(range,5 to 91 years).BRLH lesions were unilateral in 75%of patients and bilateral in 25%of *** patients(2.9%)had a concurrent Epstein-Barr virus(EBV)infection at the time of lesion *** most common treatments were surgical excision(155/235 or 65.9%)and corticosteroids(30/235 or 12.7%),while 14%(33/235)of the patients were observed and 4.6%(11/235)received external beam radiotherapy *** occurred in ten patients(10/235 or 4.2%),of whom five had undergone surgical excision alone,two excision followed by external beam radiotherapy,one excision and oral corticosteroids,one radiotherapy alone and one had been treated with topical ***,only 2 of the 235 reported cases(0.8%)developed malignancy,one localized to the conjunctiva and one ***:Benign reactive lymphoid hyperplasia is one of the lymphoproliferative disorders of the conjunctiva and ocular *** literature review shows that m

关键词： Conjunctival lymphoma Conjunctival biopsy High resolution anterior segment optical coherence tomography Conjunctival tumor Conjunctival lymphoid lesion Atypical lymphoid hyperplasia

Removal of toxic elements from aqueous environments using nano zero-valent iron-and iron oxide-modified biochar:a review

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Biochar 2022年第1期4卷 779-799页

作者： Sabry M.Shaheen Ahmed Mosa Natasha Hamada Abdelrahman Nabeel Khan Niazi vasileios Antoniadis Muhammad Shahid Hocheol Song Eilhann E.Kwon Jörg Rinklebe Laboratory of Soil-and Groundwater-Management Institute of Foundation EngineeringWater-and Waste-ManagementSchool of Architecture and Civil EngineeringUniversity of WuppertalPauluskirchstraße 742285 WuppertalGermany Department of Arid Land Agriculture Faculty of MeteorologyEnvironmentand Arid Land AgricultureKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Soil and Water Sciences Faculty of AgricultureUniversity of KafrelsheikhKafr El-Sheikh 33516Egypt Soils Department Faculty of AgricultureMansoura UniversityMansoura 35516Egypt Department of Environmental Sciences COMSATS University IslamabadVehari CampusVehari 61100Pakistan Soil Science Dept. Faculty of AgricultureCairo UniversityGiza 12613Egypt Institute of Soil and Environmental Sciences University of Agriculture FaisalabadFaisalabad 38040Pakistan Department of Agriculture Crop Production and Rural Environment University of ThessalyFytokou Street38446VolosGreece Department of Environment Energy and GeoinformaticsUniversity of SejongGuangjin-GuSeoul 05006Republic of Korea Department of Earth Resources and Environmental Engineering Hanyang UniversitySeoul 04763Republic of Korea

Biochar(BC)has gained attention for removal of toxic elements(TEs)from aqueous media;however,pristine biochar often exhibits low adsorption ***,various modification strategies in BC have been developed to improve its removal capability against *** zero-valent iron(nZVI)and iron oxides(FeOx)have been used as sorbents for TE ***,these materials are prone to agglomeration and also expensive,which make their usage limited for large-scale *** nZVI technical demerits could be resolved by the development of BC-based composite sorbents through the loading of nZVI or FeOx onto BC *** zero-valent iron modified BC(nZVIBC),FeOx-modified BC(FeOxBC)have attracted attention for their capability in removing pollutants from the aqueous ***,a potential use of nZVIBC and FeOxBC for TE removal from aqueous environments has not been well-realized or *** such,this article reviews:(i)the preparation and characterization of nZVIBC and FeOxBC;(ii)the capacity of nZVIBC and FeOxBC for TE retention in line with their physicochemical properties,and(iii)TE removal mechanisms by nZVIBC and *** nZVI and FeOx in BC increases its sporptive capability of TEs due to surface modifications in morphology,functional groups,and elemental *** combined effects of BC and nZVI,FeOx or Fe salts on the sorption of TEs are complex because they are very specific to *** review identified significant opportunities for research and technol-ogy advancement of nZVIBC and FeOxBC as novel and effective sorbents for the remediation of TEs contaminated water.

关键词： Feedstock Engineered biochar Toxic metal(loid)s Biosorption Wastewater remediation

Preoperative Management of Cataract Surgery Candidates: An Evaluation of Their Perception and Preferences

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Open Journal of Ophthalmology 2013年第3期3卷 90-92页

作者： Evgenia Kanonidou vasileios Konidaris Christina Kanonidou Leonidas Papazisis Department of Ophthalmology General Hospital of Veria Veria Greece.

Purpose: To assess the primary visual disability in patients with cataract and to evaluate their preference regarding the visual outcome after surgery. Materials and Methods: 120 patients (66 males, mean age 76.3 years, mean best corrected visual acuity 5.2/10 binocularly) participated. Perception regarding the primary visual disability related to cataract and preference of visual outcome after surgery were assessed by a questionnaire. All study procedures adhered to the principles outlined in the Declaration of Helsinki for research involving human subjects, and all participants gave written informed consent before their participation. Results: 74 patients (61.6%) had difficulty in distant vision, 5 (4.2%) in near vision, 17 (14.2%) mentioned blurred vision, 14 (11.7%) difficulty in driving especially at night, 7 (5.8%) complained about monocular diplopia and 3 (2.5%) about anisometropia. All mentioned that they preferred to obtain clear distant and near vision after cataract surgery. Conclusions: There was an interesting variety in visual disability related to cataract. The difficulty in distant vision was the primary visual deficit in the majority of the patients and the preference for clear distant and near vision was the desired postoperative visual outcome.

关键词： Cataract Visual Outcome Visual Disability Quality of Life

Automated global delineation of human settlements from 40 years of Landsat satellite data archives

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Big Earth Data 2019年第2期3卷 140-169页

作者： Christina Corbane Martino Pesaresi Thomas Kemper Panagiotis Politis Aneta J.Florczyk vasileios Syrris Michele Melchiorri Filip Sabo Pierre Soille European Commission Joint Research CentreIspraItaly Arhs Developments S.A. Luxembourg Engineering S.p.a RomaItaly Arhs Developments Italia S.r.l. MilanoItaly

This paper presents the analysis of Earth Observation data records collected between 1975 and 2014 for assessing the extent and temporal evolution of the built-up surface in the frame of the Global Human Settlement Layer *** scale of the information produced by the study enables the assessment of the whole continuum of human settlements from rural hamlets to *** study applies enhanced processing methods as compared to the first production of the GHSL baseline *** major improvements include the use of a more refined learning set on built-up areas derived from Sentinel-1 data which allowed testing the added-value of incremental learning in big data ***,the new features of the GHSL built-up grids and the methods are described and compared with the previous ones using a reference set of building footprints for 277 areas of *** results show a gradual improvement in the accuracy measures with a gain of 3.6% in the balanced accuracy,between the first production of the GHSL baseline and the latest GHSL multitemporal built-up grids.A validation of the multitemporal component is also conducted at the global scale establishing the reliability of the built-up layer across time.

关键词： Built-up area landsat global human settlement layer machine learning validation

Assessment of the Most Common Pterygium Symptoms Leading to the Decision for Its Surgical Removal

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Open Journal of Ophthalmology 2013年第3期3卷 68-69页

作者： vasileios Konidaris Evgenia Kanonidou Christina Kanonidou Leonidas Papazisis Department of Ophthalmology General Hospital of Veria Veria Greece.

Purpose: Pterygium is a benign growth of conjunctival tissue frequently related to chronic sunlight exposure and hot and dry climate. Purpose of this study was to evaluate the predominant symptoms in patients with pterygium leading to its surgical removal decision. Methods: 31 patients (19 males, 12 females), mean age 48.75 years old (SD 8.5), with primary pterygium and no other eye disease participated in the study. The predominant symptoms caused by the pterygium were assessed using a questionnaire. Results: The predominant symptoms associated with the pterygium were: discomfort/feeling of foreign body in 31 patients (100%), redness in 23 (74%), increased lacrimation in 17 (55%), aesthetic reasons in 12 (39%), visual disturbance (astigmatism/extension of the pterygium to the optical axis) in 4 (13%). In one case, despite the absence of annoying symptoms, surgical excision was proposed due to the atypical appearance of pterygium. For younger patients, the predominant reason for choosing surgical removal was that the patients are not content with external appearance caused by pterygium and in contrast lacrimation was the predominant reason for the older. In most patients, visual disturbance was not a significant cause although astigmatism in eyes with pterygium was 3.51 D (SD 1.82) and 0.95 D (SD 0.78) in healthy eyes respectively. Discussion: The main symptom in patients with pterygium is foreign body sensation;meanwhile aesthetic consideration and increased lacrimation are the main reasons leading to surgical removal decision for younger and older patients, respectively.

关键词： Pterygium Pterygium Surgery Astigmatism

Sudden cardiac death in patients with rheumatoid arthritis

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World Journal of Cardiology 2017年第7期9卷 562-573页

作者： Sherry Masoud Phang Boon Lim George D Kitas vasileios Panoulas Cardiology Department Imperial College Healthcare NHS Trust Hammersmith Hospital Arthritis Research UK Epidemiology Unit University of Manchester National Heart and Lung Institute ImperiaCollege London Department of Cardiology Royal Brompton and Harefield NHS Foundation Trust Harefield Hospital

An increased cardiovascular morbidity and mortality, including the risk of sudden cardiac death(SCD), has been shown in patients with rheumatoid arthritis(RA). Abnormalities in autonomic markers such as heart rate variability and ventricular repolarization parameters, such as QTc interval and QT dispersion, have been associated with sudden death in patients with RA. The interplay between these parameters and inflammation that is known to exist with RA is of growing interest. In this article, we review the prevalence and predictors of SCD in patients with RA and describe the potential underlying mechanisms, which may contribute to this. We also review the impact of biologic agents on arrhythmic risk as well as cardiovascular morbidity and mortality.

关键词： Sudden death Rheumatoid arthritis Cardiovascular QT Autonomic nervous system Arrhythmia

Phylogenetic analysis of the five internal genes and evolutionary pathways of the Greek H3N8 equine influenza virus

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Natural Science 2012年第11期4卷 839-847页

作者： Maria Bountouri vasileios Ntafis Eirini Fragkiadaki Theo Kanellos Eftychia Xylouri Department of Anatomy and Physiology of Farm Animals Faculty of Animal Science and Aquaculture Agricultural University of Athens Athens Greece Department of Anatomy and Physiology of Farm Animals Faculty of Animal Science and Aquaculture Agricultural University of Athens Athens Greece Pfizer Animal Health Biologicals Development Sandwich UK

To amplify the NS, NP, PB1, PB2 and PA internal genes of two equine H3N8 influenza A viruses isolated in Greece in 2003 and 2007 five primer pairs were designed. The derived sequences were analysed from a phylogenetic point of view and compared with the evolutionary patters of the HA and NA proteins. Comparison of nucleotide sequences of the five internal genes of the Greek strains showed high similarity (99.3% - 99.7%) to strains isolated from outbreaks in Europe and Asia during 2002-2008. A total of 11 amino acid substitutions of the surface protein NA and the RNP complex proteins were identified in the Greek strains compared to those of progenitor viruses circulating up to 2003. These substitutions were repeated in Chinese and Mongolian isolates from outbreaks in 2007-2008. Notably NS1 protein did not acquired amino acid substitutions and moreover, a stop codon introduced at position 220 was stably maintained in the Greek strains. Phylogenetic trees of the five internal genes did not show the same separation in clades. Greek strains classified them into the American sublineage (as for the PA) Florida clade II (as for the NP, NS1 and PB1) and among Chinese strains of 2007-2008 outbreaks (as for the PB2). Additionally, evolutionary profiles of these internal proteins, except PB2, indicated a parallel evolution fashion to the HA protein, suggesting the possible occurrence of genetic reassortment between H3N8 viruses of district evolutionary lineages. In conclusion, phylogenetic analysis of the internal genes reported in this study could establish a candidate framework for future scientific communications on the phylogenetic diversity and evolution of the equine influenza viruses.

关键词： Equine Influenza Internal Genes Evolution Pathways

Single injection of platelet-rich plasma as a novel treatment of carpal tunnel syndrome

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Neural Regeneration Research 2015年第11期10卷 1856-1859页

作者： Michael Alexander Malahias Elizabeth O.Johnson George C.Babis vasileios S.Nikolaou Second Department of Orthopedics Athens University Department of Anatomy School of Medicine Athens University

Both in vitro and in vivo experiments have confirmed that platelet-rich plasma has therapeutic effects on many neuropathies, but its effects on carpal tunnel syndrome remain poorly understood. We aimed to investigate whether single injection of platelet-rich plasma can improve the clinical symptoms of carpal tunnel syndrome. Fourteen patients presenting with median nerve injury who had suffered from mild carpal tunnel syndrome for over 3 months were included in this study. Under ultrasound guidance, 1-2 m L of platelet-rich plasma was injected into the region around the median nerve at the proximal edge of the carpal tunnel. At 1 month after single injection of platelet-rich plasma, Visual Analogue Scale results showed that pain almost disappeared in eight patients and it was obviously alleviated in three patients. Simultaneously, the disabilities of the arm, shoulder and hand questionnaire showed that upper limb function was obviously improved. In addition, no ultrasonographic manifestation of the carpal tunnel syndrome was found in five patients during ultrasonographic measurement of the width of the median nerve. During 3-month follow-up, the pain was not greatly alleviated in three patients. These findings show very encouraging mid-term outcomes regarding use of platelet-rich plasma for the treatment of carpal tunnel syndrome.

关键词： nerve regeneration carpal tunnel syndrome platelet-rich plasma ultrasound guidance pilot study neural regeneration

Role of fetuin A in the diagnosis and treatment of joint arthritis

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World Journal of Orthopedics 2017年第6期8卷 461-464页

作者： Eleni Pappa Despina S Perrea Spiridon Pneumaticos vasileios S Nikolaou Laboratory of Experimental Surgery "N.S.Christeas" National and Kapodistrian University of AthensSchool of Medicine 3~(rd) Department of Orthopaedics KAT HospitalNational and Kapodistrian University of AthensSchool of Medicine 2~(nd) Department of Orthopaedics Agia Olga HospitalNational and Kapodistrian University of AthensSchool of Medicine

Osteoarthritis is a slowly progressive disease which includes the intervention of several cytokines, macrophage metalleinoproteinases reaction, leading to the degradation of the local cartilage but also having an impact on the serum acute phase proteins(APPs). Subsequently, biomarkers seem to be essential to estimate its progression and the need for any surgical intervention such as total arthroplasty, but also can be used as therapeutic agents. Recently, among APPs, fetuin A drew attention regarding its possible anti-inflammatory role in animal models but also as a therapeutic agent in the inflammatory joint disease in clinical trials. In contrast with other APPs such as C-reactive protein, fetuin A appears to be lower in the serum of patients with degenerative joint disease in comparison with the healthy ones, and also acts as an antagonist of the anti-proliferative potential of transforming growth factor-b(TGF-b) cytokines. Because of its lower serum levels in arthritis, an unregulated binding of TGF-b and bone morphogenetic proteins takes place leading to further arthritic lesions. The purpose of the present review is to assess the current evidence regarding the multipotent role of the alpha-2-HSglycoprotein or as also known Fetuin-a in animal models but also as a biomarker of the degenerative joint arthritis in clinical trials.

关键词： Fetuin A Arthritis Alpha-2-HS-glycoprotein Bone morphogenetic protein Inflammation Glycoprotein Treatment