Bilateral benign reactive lymphoid hyperplasia of the conjunctiva: a case treated with oral doxycycline and review of the literature

作     者：Olga Klavdianou Georgios Kondylis Vasileios Georgopoulos Sotiria Palioura Olga Klavdianou;Georgios Kondylis;Vasileios Georgopoulos;Sotiria Palioura

作者机构：National and Kapodistrian University of Athens School of MedicineAthensGreece Cornea ServiceAthens Vision Eye Institute328-330 Syngrou AveKallithea17673 AthensGreece 

出 版 物：《Eye and Vision》 (眼视光学杂志（英文）)

年 卷 期：2019年第6卷第1期

页      面：219-228页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Conjunctival lymphoma Conjunctival biopsy High resolution anterior segment optical coherence tomography Conjunctival tumor Conjunctival lymphoid lesion Atypical lymphoid hyperplasia 

摘      要：Background:To report a case of bilateral benign reactive lymphoid hyperplasia(BRLH)of the conjunctiva treated with oral doxycycline and perform review of the literature evaluating the presentation,treatment and risk of transformation to *** presentation:A case report is described and review of the literature from January 1975 to January 2019 was performed.A 30-year-old man presented with bilateral enlarging fleshy pink medial canthal conjunctival *** biopsy revealed *** doxycycline was initiated(100 mg two times a day)for a total of 2 *** lesions decreased in size significantly at the patient’s two-month follow up *** residual lesion in the right eye was excised along with an adjacent pterygium and the patient has been free of recurrence for the past 1.5 *** lesion in the left eye has remained stable in size after cessation of the oral doxycycline.A total of 235 cases of conjunctival BRLH were identified in our literature *** mean age at diagnosis was 35.2 years(range,5 to 91 years).BRLH lesions were unilateral in 75%of patients and bilateral in 25%of *** patients(2.9%)had a concurrent Epstein-Barr virus(EBV)infection at the time of lesion *** most common treatments were surgical excision(155/235 or 65.9%)and corticosteroids(30/235 or 12.7%),while 14%(33/235)of the patients were observed and 4.6%(11/235)received external beam radiotherapy *** occurred in ten patients(10/235 or 4.2%),of whom five had undergone surgical excision alone,two excision followed by external beam radiotherapy,one excision and oral corticosteroids,one radiotherapy alone and one had been treated with topical ***,only 2 of the 235 reported cases(0.8%)developed malignancy,one localized to the conjunctiva and one ***:Benign reactive lymphoid hyperplasia is one of the lymphoproliferative disorders of the conjunctiva and ocular *** literature review shows that m