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Evaluating role of bone marrow-derived stem cells in dry age-related macular degeneration using multifocal electroretinogram and fundus autofluorescence imaging

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1552-1558页

作者： Atul Kumar Neha Midha Sujata Mohanty Annu Chohan Tulika Seth varun gogia Shikha Gupta Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences Stem Cell Facility All India Institute of Medical Sciences Department of Hematology All India Institute of Medical Sciences

AIM：To evaluate the role of bone marrow-derived stem cells in the treatment of advanced dry age-related macular degeneration（AMD）using multifocal electroretinogram（mf-ERG）and fundus autofluorescence ***：Thirty patients（60 eyes）with bilateral central geographic atrophy（GA）were *** eye of each patient received autologous bone marrow-derived hematopoietic stem cells（BM-HSCs）（group 1）and the fellow eye with better visual acuity served as control（group2）.The effect of stem cell therapy was determined in terms of visual acuity,amplitude and implicit time in mf-ERG and size of GA on fundus autofluorescence *** tests were performed at presentation and first,third and sixth month follow *** events（if any）were also ***：At 6mo follow-up there was no statistically significant improvement in median log MAR best corrected visual acuity（BCVA）in either ***-ERG revealed significant improvement in amplitude and implicit time in the intervention group.A significant decrease was also noted in greatest linear dimension（GLD）of GA in the eyes receiving stem cells[6.78±2.60 mm at baseline to 6.56±2.59 mm at 6mo（P=0.021）].However,no such improvement was noted in the control ***：Electrophysiological and anatomical improvement in the intervention group sheds light on the therapeutic role of *** studies are required to determine the stage of disease at which the maximal benefit can be achieved and to standardize the dose andfrequency of stem cell injection.

关键词： dry age-related macular degeneration multifocal electroretinogram stem cells fimdus autofluorescence imaging

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Evaluation of fundus autofluorescence patterns in age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1779-1784页

作者： Pradeep Venkatesh Pradeep Sagar Rohan Chawla varun gogia Rajpal Vohra Yog Raj Sharma Department of Ophthalmology Dr. Rajendra Prasad Centre for Ophthalmic SciencesAll India Institute of Medical Sciences

AIM： To study the various morphological patterns of fundus autofluorescence （FAF） images in patients with age-related macular degeneration （AMD） in Indian ***： Totally 179 eyes of 104 patients with clinical diagnosis of AMD were recruited into the study. Autofluorescence images were captured using confocal scanning laser ophthalmoscope and the patterns of FAF were ***： Of 179 eyes, 27 （15.08%） were early AMD, 58 （32.41%） were intermediate AMD, 94 eyes （52.51%） were late AMD. Of 94 eyes with late AMD, 79 （84.04%） were neovascular AMD and 15 （15.96%） were central geographic atrophy. In eyes with early and intermediate AMD, 9 patterns of FAF were noted. Six patterns （normal, minimal change, focal increased, patchy increased, linear, reticular） were similar to that in the published classification. Two patterns （lacelike and speckled） described in the published classification were not found. Three new patterns （focal hypo-fluorescence, patchy hypo-fluorescence, mixed focal hypo-fluorescence and hyper-fluorescence） were detected. In eyes with neovascular AMD, 6 morphological patterns of FAF were noted. Two patterns （mixed hypo-fluorescence and hyper-fluorescence, central hypo-fluorescence with hyper-fluorescent rim） were similar to that in published classification. Two patterns （normal, near normal or normal background fluorescence in the centre of hypo-fluorescent area） described in the published classification were not found. Four new patterns （minimal change, hypo-fluorescent patch, central hypo-fluorescence with surrounding reticular, bull’s eye） were recognized. In eye with central geographic atrophy 5 morphological patterns were noted and these were similar to that in published ***： Phenotypic differences in the pattern of FAF exist in the study population compared to existing classification systems.

关键词： age-related macular degeneration fundus autofluorescence lipofuscin choroidal neovascularization

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Exploring the efficacy of natural products in alleviating Alzheimer’s disease

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Neural Regeneration Research 2019年第8期14卷 1321-1329页

作者： Prajakta Deshpande Neha gogia Amit Singh Department of Biology University of Dayton Dayton OH USA Premedical Program University of Dayton Dayton OH USA Center for Tissue Regeneration and Engineering at Dayton (TREND) University of Dayton Dayton OH USA The Integrative Science and Engineering Center University of Dayton Dayton OH USA Center for Genomic Advocacy (TCGA) Indiana State University Terre Haute IN USA

Alzheimer’s disease(hereafter AD) is a progressive neurodegenerative disorder that affects the central nervous system. There are multiple factors that cause AD, viz., accumulation of extracellular Amyloid-beta 42 plaques, intracellular hyper-phosphorylated Tau tangles, generation of reactive oxygen species due to mitochondrial dysfunction and genetic mutations. The plaques and tau tangles trigger aberrant signaling, which eventually cause cell death of the neurons. As a result, there is shrinkage of brain, cognitive defects, behavioral and psychological problems. To date, there is no direct cure for AD. Thus, scientists have been testing various strategies like screening for the small inhibitor molecule library or natural products that may block or prevent onset of AD. Historically, natural products have been used in many cultures for the treatment of various diseases. The research on natural products have gained importance as the active compounds extracted from them have medicinal values with reduced side effects, and they are bioavailable. The natural products may target the proteins or members of signaling pathways that get altered in specific diseases. Many natural products are being tested in various animal model systems for their role as a potential therapeutic target for AD, and to address questions about how these natural products can rescue AD or other neurodegenerative disorders. Some of these products are in clinical trials and results are promising because of their neuroprotective, anti-inflammatory, antioxidant, anti-amyloidogenic, anticholinesterase activities and easy availability. This review summarizes the use of animal model systems to identify natural products, which may serve as potential therapeutic targets for AD.

关键词： Alzheimer’s disease amyloid-beta 42 natural products Lunasin neuroprotective anti-inflammation antioxidant Drosophila cell death neurodegeneration

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Microstructural observations on the terminal penetration of long rod projectile

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Defence Technology（防务技术） 2017年第6期13卷 413-421页

作者： Krushna Kumbhar P.Ponguru Senthil A.K.gogia Armour Design and Development Division Defence Metallurgical Research LaboratoryHyderabad 500058India

Present study focuses on the terminal penetration of tungsten heavy alloy(WHA) long rod penetrator impacted against armour steel at an impact velocity of 1600 m/s. The residual penetrator and armour steel target recovered after the ballistic test have been characterized using optical microscope, scanning electron microscope(SEM) and electron probe micro analyzer(EPMA). Metallurgical changes in target steel and WHA remnant have been analysed. Large shear stresses and shear localization have resulted in local failure and formation of erosion products. Severe plastic deformation acts as precursor for formation of adiabatic shear band(ASB) induced cracks in target steel. Recovered WHA penetrator remnant also exhibits severe plastic deformation forming localized shear bands, ASB induced cracks and shock induced cracks.

关键词： Long rod projectile Terminal penetration Shear localization Adiabatic shear band Tungsten heavy alloy Armour steel

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Hippo signaling:bridging the gap between cancer and neurodegenerative disorders

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Neural Regeneration Research 2021年第4期16卷 643-652页

作者： Neha gogia Anuradha Venkatakrishnan Chimata Prajakta Deshpande Aditi Singh Amit Singh Department of Biology University of DaytonDaytonOHUSA Medical Candidate University of Toledo College of Medicine and Life SciencesToledoOHUSA Premedical Program University of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA The Integrative Science and Engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

During development,regulation of organ size requires a balance between cell proliferation,growth and cell *** of these fundamental processes can cause a variety of *** cell proliferation results in cancer whereas excessive cell death results in neurodegenerative *** signaling pathways known-to-date have a role in growth *** them,evolutionarily conserved Hippo signaling pathway is unique as it controls both cell proliferation and cell death by a variety of mechanisms during organ sculpture and ***,a complex process of progressive death of neuronal population,results in fatal disorders with no available cure to *** normal development,cell death is required for sculpting of an ***,aberrant cell death in neuronal cell population can result in neurodegenerative *** pathway has gathered major attention for its role in growth regulation and cancer,however,other functions like its role in neurodegeneration are also emerging *** review highlights the role of Hippo signaling in cell death and neurodegenerative diseases and provide the information on the chemical inhibitors employed to block Hippo *** Hippo mediated cell death mechanisms will aid in development of reliable and effective therapeutic strategies in future.

关键词： animal models cell death mechanisms cell-signaling chemical inhibitors Drosophila eye Hippo pathway neurodegeneration neurological diseases therapeutic targets

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An experimental investigation of wire electrical discharge machining of hot-pressed boron carbide

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Defence Technology（防务技术） 2015年第4期11卷 344-349页

作者： Ravindranadh BOBBILI V.MADHU A.K.gogia Defence Metallurgical Research Laboratory

The present work discusses the experimental study on wire-cut electric discharge machining of hot-pressed boron *** effects of machining parameters,such as pulse on time(TON),peak current(IP),flushing pressure(FP) and spark voltage on material removal rate(MRR)and surface roughness(R_a) of the material,have been *** parameters are found to have an effect on the surface integrity of boron carbide machined *** rate of brass wire increases with rise in input energy in machining of hot-pressed boron *** surfaces of machined samples were examined using scanning electron microscopy(SEM).The influence of machining parameters on mechanism of MRR and R_a was *** was demonstrated that higher TON and peak current deteriorate the surface finish of boron carbide samples and result in the formation of large craters,debris and micro *** generation of spherical particles was noticed and it was attributed to surface tension of molten ***-ridges were also observed on the surface due to protrusion of molten material at higher discharge energy levels.

关键词：电火花加工碳化硼热压制实验扫描电子显微镜材料去除率表面粗糙度电火花线切割

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Neural network modeling to evaluate the dynamic flow stress of high strength armor steels under high strain rate compression

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Defence Technology（防务技术） 2014年第4期10卷 334-342页

作者： Ravindranadh BOBBILI V.MADHU A.K.gogia Defence Metallurgical Research Laboratory Hyderabad 500058 India

An artificial neural network(ANN) constitutive model is developed for high strength armor steel tempered at 500 C, 600 C and 650 C based on high strain rate data generated from split Hopkinson pressure bar(SHPB) experiments. A new neural network configuration consisting of both training and validation is effectively employed to predict flow stress. Tempering temperature, strain rate and strain are considered as inputs, whereas flow stress is taken as output of the neural network. A comparative study on Johnsone Cook(Je C) model and neural network model is performed. It was observed that the developed neural network model could predict flow stress under various strain rates and tempering temperatures. The experimental stressestrain data obtained from high strain rate compression tests using SHPB, over a range of tempering temperatures(500e650 C), strains(0.05e0.2) and strain rates(1000e5500/s) are employed to formulate Je C model to predict the high strain rate deformation behavior of high strength armor steels. The J-C model and the back-propagation ANN model were developed to predict the high strain rate deformation behavior of high strength armor steel and their predictability is evaluated in terms of correlation coefficient(R) and average absolute relative error(AARE). R and AARE for the Je C model are found to be 0.7461 and 27.624%, respectively, while R and AARE for the ANN model are 0.9995 and 2.58%, respectively. It was observed that the predictions by ANN model are in consistence with the experimental data for all tempering temperatures.

关键词：人工神经网络模型高应变率高强度装甲钢流变应力可预测性压缩评估

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Prediction of flow stress of 7017 aluminium alloy under high strain rate compression at elevated temperatures

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Defence Technology（防务技术） 2015年第1期11卷 93-98页

作者： Ravindranadh BOBBILI B.RAMAKRISHNA V.MADHU A.K.gogia Defence Metallurgical Research Laboratory

An artificial neural network(ANN) constitutive model and JohnsoneC ook(Je C) model were developed for 7017 aluminium alloy based on high strain rate data generated from split Hopkinson pressure bar(SHPB) experiments at various temperatures. A neural network configuration consists of both training and validation, which is effectively employed to predict flow stress. Temperature, strain rate and strain are considered as inputs, whereas flow stress is taken as output of the neural network. A comparative study on Johnsone Cook(Je C) model and neural network model was performed. It was observed that the developed neural network model could predict flow stress under various strain rates and temperatures. The experimental stressestrain data obtained from high strain rate compression tests using SHPB over a range of temperatures(25 e300 C), strains(0.05e0.3) and strain rates(1500e4500 s 1) were employed to formulate JeC model to predict the flow stress behaviour of 7017 aluminium alloy under high strain rate loading. The JeC model and the back-propagation ANN model were developed to predict the flow stress of 7017 aluminium alloy under high strain rates, and their predictability was evaluated in terms of correlation coefficient(R) and average absolute relative error(AARE). R and AARE for the J-C model are found to be 0.8461 and 10.624%, respectively, while R and AARE for the ANN model are 0.9995 and 2.58%, respectively. The predictions of ANN model are observed to be in consistent with the experimental data for all strain rates and temperatures.

关键词： Aluminium alloy Artificial neural network Johnson-Cook model

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Isolated Major Aortopulmonary Collateral Artery Causing Heart Failure: Transcatheter Occlusion of Mapcas Using Amplatzer Vascular Plugs and Amplatzer Piccolo Occluders

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World Journal of Cardiovascular Diseases 2023年第11期13卷 701-709页

作者： Vakhtang Khelashvili Iuri Fkhkadze Tengiz Shiryaev Omar gogia Congenital Heart Disease Department The Jo Ann University Hospital European University Tbilisi Georgia

Major aortopulmonary collateral arteries (MAPCAs) are congenital vessels that arise from the aorta or its first-order branches and are distally connected to the pulmonary arterial vasculature, thereby providing pulmonary blood flow. MAPCAs are often associated with cyanotic congenital heart disease with decreased pulmonary blood flow. Isolated MAPCAs are rare in patients without congenital heart disease with structurally normal hearts. Sometimes, isolated congenital MAPCAs can occur without any lung disease. Isolated MAPCAs represent the occurrence of collaterals in the absence of underlying heart disease, which commonly presents as heart failure, recurrent respiratory tract infection, and pulmonary artery hypertension. We report a rare case of congestive heart failure in a 6-year-old patient with dual arterial supply to an otherwise normal right lung, with a normal bronchial tree, and a structurally normal heart. The patient was successfully managed by the closure of collaterals by Amplatzer vascular plugs II (AVPII) and Amplatzer Piccolo Occluders.

关键词： Isolated Major Aortopulmonary Collateral Artery Amplatzer Vascular Plugs Amplatzer Piccolo Occluder Mapcas Transcatheter Closure

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Circumflex Coronary Artery Fistulae Draining into Right Atrium: A Case Report

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World Journal of Cardiovascular Diseases 2023年第4期13卷 220-227页

作者： Vakhtang Khelashvili Iuri Fkhkadze Nona Grdzelishvili Tengiz Shiryaev Omar gogia Congenital Heart Disease Department The Jo Ann University Hospital European University Tbilisi Georgia

Coronary artery fistula (CAF) is an anomaly making a coronary artery communicate with a heart cavity or a great vessel, thus bypassing the myocardial capillary bed. CAF is frequently diagnosed as an incidental finding. Herein, we present the case of a 4-year-old boy. He was referred for a pediatric cardiology assessment due to a continuous murmur at the middle sternal border. Echocardiogram showed dilated left coronary artery and an abnormal diastolic flow in the right atrium. The right-sided chambers were slightly enlarged, but ventricular contractility was normal. CAF was suspected. Angiography and CT confirmed the diagnosis of coronary fistula from the circumflex coronary artery to the right atrium. Successful transcatheter closure with an Amplatzer PiccoloOccluder was performed with complete occlusion.

关键词： Coronary Artery Fistula Circumflex Coronary Artery Congenital Heart Disease

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