Evaluating role of bone marrow-derived stem cells in dry age-related macular degeneration using multifocal electroretinogram and fundus autofluorescence imaging

作     者：Atul Kumar Neha Midha Sujata Mohanty Annu Chohan Tulika Seth Varun Gogia Shikha Gupta 

作者机构：Dr.Rajendra Prasad Centre for Ophthalmic SciencesAll India Institute of Medical Sciences Stem Cell FacilityAll India Institute of Medical Sciences Department of HematologyAll India Institute of Medical Sciences 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2017年第10卷第10期

页      面：1552-1558页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：dry age-related macular degeneration multifocal electroretinogram stem cells fimdus autofluorescence imaging 

摘      要：AIM：To evaluate the role of bone marrow-derived stem cells in the treatment of advanced dry age-related macular degeneration（AMD）using multifocal electroretinogram（mf-ERG）and fundus autofluorescence ***：Thirty patients（60 eyes）with bilateral central geographic atrophy（GA）were *** eye of each patient received autologous bone marrow-derived hematopoietic stem cells（BM-HSCs）（group 1）and the fellow eye with better visual acuity served as control（group2）.The effect of stem cell therapy was determined in terms of visual acuity,amplitude and implicit time in mf-ERG and size of GA on fundus autofluorescence *** tests were performed at presentation and first,third and sixth month follow *** events（if any）were also ***：At 6mo follow-up there was no statistically significant improvement in median log MAR best corrected visual acuity（BCVA）in either ***-ERG revealed significant improvement in amplitude and implicit time in the intervention group.A significant decrease was also noted in greatest linear dimension（GLD）of GA in the eyes receiving stem cells[6.78±2.60 mm at baseline to 6.56±2.59 mm at 6mo（P=0.021）].However,no such improvement was noted in the control ***：Electrophysiological and anatomical improvement in the intervention group sheds light on the therapeutic role of *** studies are required to determine the stage of disease at which the maximal benefit can be achieved and to standardize the dose andfrequency of stem cell injection.