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sharing Culture and Belonging Through Cross-Cultural collaborative Painting

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Journal of Literature and Art studies 2014年第6期4卷 483-488页

作者： vanessa Maree Barbay Australian National University Canberra Australia

The topic of this paper is animals in painting and the investigative process undertaken by the artist vanessa Barbay during her practice--led Ph.D.. Her aim was to discover a way to present deceased animals that retained their agency as individuals by challenging the objectifying nature of representation. The foundation of this method was the collaboration between artist and dead animal subjects through harnessing the natural decomposition of the subject in order to generate their image. A related stream of Barbay＇s research was learning about the art and culture of Kunwinjku speaking artists living in Kunbarlanja Western Amhem Land where artists have painted images of animals on rock shelters and on bark from ancient through to contemporary times. The significance of their form of animal representation is a mythopoeic relationship between locally found pigments and animal bodies. Paintings are considered as collaboration between matter, subject, and artist, which Barbay extends in her current work centred on collaborative painting involving more than one artist.

关键词： painting animals pigments Kunwinjku shroud decomposition

RAGs-TO-RICHEs TALE OF A CITY:shenzhen is evolving from the world’s factory into an innovative center with a thriving cultural scene

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China Report AsEAN 2020年第12期5卷 40-42页

作者： [Indonesia]vanessa Intan 不详

The immense crowds,the technicolor buildings,the labyrinthine markets...No,we are not in *** are in *** sprawling megalopolis in south China’s Guangdong Province is often touted as China’s silicon Valley,but unlike ... 详细信息

关键词： RICH center innovative

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Complex diseases demand novel treatment strategies: understanding drug combination

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Drug Combination Therapy 2022年第2期4卷 5-16页

作者： Renata siqueira de Mello vanessa Fernandes Arnaud-sampaio Lucas Ferreira Maciel vanessa de sá Talita Glaser Henning Ulrich Claudiana Lameu Departamento de Bioquímica Instituto de QuímicaUniversidade de São PauloSPBrazil

For many multigene or multifactorial diseases,the one-drug therapy for inhibiting a defined molecular target is often less effective than combined ***,drug combination therapies are multitargeted,so the mechanisms or even interactions are often *** drug-drug interactions may promote alteration of pharmacokinetic or pharmacodynamic activities of one drug by another *** interactions may change the expected effect of medications through polymorphisms that alter the expression or activity of the drug-mediated enzyme and the cell signaling cascade,such as drug-gene interactions and drug-drug-gene *** number of possible existing interactions requires appropriate methods of *** this review,we summarized combination therapies for cancer,as well as for viral,cardiovascular,and neurological ***,we also highlight known methodologies,such as in vitro methods based on Loewe’s and Bliss’s pioneer models and in silico methods based on online available *** more elaborate methods and reliable results,multitarget therapies through drug combinations may increasingly benefit patients suffering from complex diseases.

关键词： drug combinations multitarget therapy combination therapy drug-drug interaction in vitro in silico methods and models

HVOF-sprayed HAp/s53P4 BG composite coatings on an AZ31 alloy for potential applications in temporary implants

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Journal of Magnesium and Alloys 2024年第1期12卷 345-360页

作者： Carlos A.Poblano-salas John Henao Astrid L.Giraldo-Betancur Paola Forero-sossa Diego German Espinosa-Arbelaez Jorge A.González-sánchez Luis R.Dzib-Pérez susana T.Estrada-Moo Idelfonso E.Pech-Pech CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-Cinvestav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Universidad Tecnológica de Querétaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIDEsI Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Center for Corrosion Research Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bioactive thermal spray coatings produced via high-velocity oxygen fuel spray(HVOF)from hydroxyapatite(HAp)and bioactive glasses(BG)have the potential to be employed on temporary implants due to the ability of both HAp and BG to dissolve and promote osseointegration,considering that both phases have different reaction and dissolution rates under in-vitro *** the present work,75%***-25%wt.s53P4 bioactive glass powders were HVOF-sprayed to obtain HAp/s53P4 BG composite coatings on a bioresorbable AZ31 *** study is focused on exploring the effect of the stand-off distance and fuel/oxygen ratio variation as HVOF parameters to obtain stable structural coatings and to establish their effect on the phases and microstructure produced in those *** characterization techniques,such as scanning electron microscopy,X-ray diffraction,and Fourier transform infrared spectroscopy,were employed to characterize relevant structural and microstructural properties of the composite *** results showed that thermal gradients during coating deposition must be managed to avoid delamination due to the high temperature achieved(max 550℃)and the differences in coefficients of thermal *** was also found that both spraying distance and oxygen/fuel ratio allowed to keep the hydroxyapatite as the main phase in the *** addition,in-vitro electrochemical studies were performed on the obtained HAp/s53P4 BG composite coatings and compared against the uncoated AZ31 *** results showed a significant decrease in hydrogen evolution(at least 98%)when the bioactive coating was applied on the Mg alloy during evaluation in simulated body fluid(sBF).

关键词： Coatings Composites Thermal spray Temporary implants Hydrogen evolution

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烟碱和大脑功能障碍(英文)

Acta Pharmacologica sinica 2000年第2期21卷 3-10页

作者： stefan MIHAILEsCU,René DRUCKER-colíN Departamento de Fisiología Facultad de Medicina Departamento de Fisiología Facultad de Medicina Depto de Neurociencias Instituto de Fisiología Celular Universidad Nacional Autónoma de México Míxico

During the last decade, brain nicotinic acetylcholine receptors were extensively characterized from electrophys-iological and pharmacological points of view. These receptors play important roles in memory and cognition and participate in the pathogenesis of several brain disorders (Parkinson's and Alzheimer's diseases, Tourette's syndrome, schizophrenia, depression, attention deficit disorder) . In the same diseases, clinical studies showed that nicotine had beneficial effects, both as therapeutic and prophylactic agent. This review presents recent data concerning the structure and properties of neuronal nicotinic receptors, their involvement in the pathogenesis of various brain disorders and the beneficial effects of nicotine as therapeutic agent.

关键词：烟碱烟碱受体帕金森病阿尔采末病多动秽语综合征轻微脑损伤综合征抑郁症精神分裂症

sARs-CoV-2 infection in free-ranging white-tailed deer

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四川生理科学杂志 2021年第10期43卷 1834-1834页

作者： vanessa L Hale Veterinary Preventive Medicine The Ohio State University College of Veterinary Medicine Columbus OH USA

Humans have infected a wide range of animals with sARs-CoV-2 viruses1-5,but the establishment of a new natural animal reservoir has not been ***,we document that free-ranging white-tailed deer(Odocoileus virginianus)are highly susceptible to infection with sARs-CoV-2 virus,are exposed to a range of viral diversity from humans,and are capable of sustaining transmission in ***-CoV-2 virus was detected by rRT-PCR in more than one-third(129/360,35.8%)of nasal swabs obtained from Odocoileus virginianus in northeast Ohio(UsA)during January-March *** in 6 locations were infected with 3 sARs-CoV-2 lineages(B.1.2,B.1.582,B.1.596).The B.1.2 viruses,dominant in humans in Ohio at the time,infected deer in four *** deer-to-deer transmission of B.1.2,B.1.582,and B.1.596 viruses was observed,allowing the virus to acquire amino acid substitutions in the spike protein(including the receptor-binding domain)and ORF1 that are infrequently seen in humans.

关键词： white infection free

植物激素和抗生素调节的转基因火炬松愈伤组织的生长和分化(英文)

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Acta Genetica sinica 2002年第2期29卷 166-174页

作者：唐巍罗晓艳 vanessa samuels 北卡罗来纳州立大学生物技术组北卡罗来纳大学细胞和发育生物学系

包含质粒载体pBI12 1的农杆菌菌株LBA4 4 0 4被用于转化火炬松的成熟合子胚。质粒载体pBI12 1含有胭脂碱合成酶基因的启动子驱动的新霉素磷酸转移酶基因 (nptⅡ )和花椰菜花叶病毒的 35s启动子驱动的GUs基因。器官发生的转基因愈伤组织... 详细信息

包含质粒载体pBI12 1的农杆菌菌株LBA4 4 0 4被用于转化火炬松的成熟合子胚。质粒载体pBI12 1含有胭脂碱合成酶基因的启动子驱动的新霉素磷酸转移酶基因 (nptⅡ )和花椰菜花叶病毒的 35s启动子驱动的GUs基因。器官发生的转基因愈伤组织和转基因的再生植株已经获得 ,并经GUs组织化学染色、聚合酶链式反应和southern杂交分析证实。植物激素 (BA IBA)和抗生素对转基因愈伤组织的生长和分化的影响被研究。 5 0 0mg L羧苄青霉素和2mg LBA、0 .5mg LIBA的组合导致转基因愈伤组织的生长增加 5 4 .2 % ,分化增加 4 5 .7%。 5 0 0mg LClaforan和 2mg LBA、0 .5mg LIBA的组合导致转基因愈伤组织的生长增加 4 0 .8% ,分化增加 38.7%。高浓度的植物激素和抗生素降低了转基因愈伤组织的生长和分化。实验结果有助于建立一个高效的农杆菌介导的火炬松遗传转化系统 ,也有助于未来针叶树的遗传转化研究。

关键词：火炬松农杆菌遗传转化植物激素抗生素 GUs基因 southern杂交愈伤组织生长分化

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Historical perspective of cell transplantation in Parkinson's disease

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World Journal of Transplantation 2017年第3期7卷 179-192页

作者： Alejandra Boronat-García Magdalena Guerra-Crespo René Drucker-colín Departamento de Neuropatología Molecular Instituto de Fisiología CelularUniversidad Nacional Autónoma de México

Cell grafting has been considered a therapeutic approach for Parkinson's disease(PD) since the 1980 s. The classical motor symptoms of PD are caused by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to a decrement in dopamine release in the striatum. Consequently, the therapy of celltransplantation for PD consists in grafting dopamineproducing cells directly into the brain to reestablish dopamine levels. Different cell sources have been shown to induce functional benefits on both animal models of PD and human patients. However, the observed motor improvements are highly variable between individual subjects, and the sources of this variability are not fully understood. The purpose of this review is to provide a general overview of the pioneering studies done in animal models of PD that established the basis for the first clinical trials in humans, and compare these with the latest findings to identify the most relevant aspects that remain unanswered to date. The main focus of the discussions presented here will be on the mechanisms associated with the survival and functionality of the transplants. These include the role of the dopamine released by the grafts and the capacity of the grafted cells to extend fibers and to integrate into the motor circuit. The complete understanding of these aspects will require extensive research on basic aspects of molecular and cellular physiology, together with neuronal network function, in order to uncover the real potential of cell grafting for treating PD.

关键词： Parkinson’s disease Cell replacement Animal models Nigrostriatal pathway striatum Dopaminergic loss

An Assessment of Water Quality Parameters at the Cerrillos Reservoir, Ponce, Puerto Rico in the Aftermath of Hurricane Maria

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Journal of Water Resource and Protection 2022年第1期14卷 35-49页

作者： Yashira Marie sánchez-colón Javier Alejandro Chévere-Del Río Nichole Marie sánchez-Guzmán Fred Charles schaffner Public Health Program Ponce Health Sciences University Ponce Puerto Rico Puerto Rico Department of Health San Juan Puerto Rico school of science and Technology Universidad Ana G Méndez Gurabo Campus Gurabo Puerto Rico

Maintaining the water quality of lakes and reservoirs is part of the 2030 Agenda for sustainable Development, an initiative promoted by the United Nations, including anthropogenic and natural factors that may influence water quality. The water reservoirs of Puerto Rico were built in watersheds to provide runoff control and for primary uses. The Cerrillos Reservoir is one of the largest water reservoirs in southern Puerto Rico, and is used as a source of potable water and for recreational activities. After hurricane Maria, in september 2017, many communities were without public water service and have obtained their drinking water from local rivers or their tributaries, without filtration or purification treatment. This research explored the physical-chemical parameters of Cerrillos Reservoir’s surface water from May 2018 to January 2019. The objective of the present study is to assess seasonal variations in surface water quality with respect to physical (temperature, turbidity, and conductivity), chemical (nutrient concentrations: (Phosphorus (P) (soluble Reactive Phosphorus, phosphate, or orthophosphate) and Nitrogen (N) (nitrate, nitrite, and ammonia)), pH, and dissolved oxygen), and biological (total coliforms and Escherichia coli) parameters. Results suggest that Cerrillos Reservoir did not exceed the parameters of temperature, turbidity, conductivity, pH and DO, established by the Puerto Rico Department of Natural and Environmental Resources (PRDNER). The reservoir showed a stable trophic state in relation to inorganic phosphorus and nitrogen as N and P concentrations did not increase sufficiently to disrupt this ecosystem. However, total coliforms exceeded the maximum parameter (23 MPN/100mL - 994 MPN/100mL) established for the Puerto Rico Department of Natural and Environmental Resources and are likely to be the results of the disruption caused by hurricane Maria.

关键词： Cerrillos Reservoir Water Quality Puerto Rico Post Hurricane Maria