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Advances in parkinson's Disease 2016年第4期5卷 67-72页

作者： Lisette Bazán-Rodríguez Mayela Rodríguez-Violante Amin Cervantes-Arriaga Guillermo parra-López Diego Cruz-Fino Francisco pascasio-Astudillo vanessa Alatriste-Booth Clinical Laboratory of Neurodegenerative Diseases National Institute of Neurology and Neurosurgery Mexico City Mexico Movement Disorders Clinic National Institute of Neurology and Neurosurgery Mexico City Mexico Sleep Disorders Unit National Institute of Neurology and Neurosurgery Mexico City Mexico

purpose: Rapid eye movement sleep behavior disorder (RBD) and impulse control disorders (ICDs) are common in subjects with parkinson’s disease. The association between these two conditions has been contradictory. The aim of this study is to analyze the association between these two non-motor symptoms. Methods: Consecutive subjects with parkinson’s disease attending the Movement Disorders Outpatient Clinic were included. The presence of ICDs was assessed using the Questionnaire for Impulse Control Disorders Rating Scale. RBD was diagnosed by an overnight, single night polysomnography. Results: Fifty-five consecutive subjects with parkinson’s disease were included. The prevalence of ICDs and related behaviors was 23.6% (ICD in 14.5% and related behaviors in 9.1%). RBD was diagnosed in 47.2% of the patients. No differences were found in the frequency of ICDs and related behaviors when comparing subjects with and without RBD (23% versus 24.1%, p = 0.926, respectively). Conclusion: No association between the presence of RBD and the frequency of ICDs in subjects with parkinson’s disease was found.

关键词： parkinson’s Disease Impulse Control Disorders REM Sleep Behavior Disorder

predictors of nodal metastasis in sinonasal squamous cell carcinoma:A national cancer database analysis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第2期6卷 137-141页

作者： Viran J.Ranasinghe vanessa C.Stubbs Danielle C.Reny Ramie Fathy Jason A.Brant Jason G.Newman Department of Otorhinolaryngology e Head and Neck Surgery University of PennsylvaniaPhiladelphiaPAUnited States perelman School of Medicine University of PennsylvaniaPhiladelphiaPAUnited States

Objective:We present the largest population based study of sinonasal squamous cell carcinoma(SCC)to identify risk factors for presentation with nodal ***:The National Cancer Database(NCDB)was used for this *** codes corresponding to the nasal cavity and paranasal sinuses and histology codes representing SCC malignancy were *** regression analysis was performed to identify factors associated with presentation with nodal ***:6448 cases met inclusion *** metastasis at presentation was seen in 13.2%of patients,with the sinus subsite(19.3%)being a significant risk factor for nodal metastasis at presentation when compared to the nasal cavity(7.9%).Logistic regression analysis showed black,uninsured and Medicaid patients were more likely than white and privately insured patients,respectively,to present with nodal ***:In sinonasal SCC,the sinus subsite has a significantly increased risk of nodal metastasis compared to the nasal *** race,uninsured and Medicaid patients are more likely to have nodal metastasis at presentation.

关键词： Squamous cell carcinoma National cancer database Nodal metastasis Maxillary sinus Nasal cavity

Insights into CODE-DE–Germany’s Copernicus data and exploitation platform

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Big Earth Data 2019年第4期3卷 338-361页

作者： Tobias Storch Christoph Reck Stefanie Holzwarth Bert Wiegers Nico Mandery Ulrich Raapea Christian Strobl Rouven Volkmann Martin Böttcher Andreas Hirner Johanna Senft Nicolae plesia Thomas Kukuk Stephan Meissl Jens-Rainer Felske Thomas Heege vanessa Keuck Michael Schmidt Helmut Staudenrausch Earth Observation Center(EOC) German Aerospace Center(DLR)WeßlingGermany T-Systems SfR GmbH BonnGermany Brockmann Consult GmbH GeesthachtGermany GAF AG MunichGermany EOX IT Services GmbH ViennaAustria Werum Software&Systems AG LüneburgGermany EOMAp GmbH&Co.KG SeefeldGermany programme Strategy Space R&D German Aerospace Center(DLR)CologneGermany Space Administration German Aerospace Center(DLR)BonnGermany

This article presents and analyses the modular architecture and capabilities of CODE-DE(Copernicus Data and Exploitation platform–Deutschland,***),the integrated German operational environment for accessing and processing Copernicus data and products,as well as the methodology to establish and operate the *** March 2017,CODE-DE has been online with access to Sentinel-1 and Sentinel-2 data,to Sentinel-3 data shortly after this time,and since March 2019 with access to Sentinel-5p *** products are available and accessed by 1,682 registered users as of March *** this period 654,895 products were downloaded and a global catalogue was continuously updated,featuring a data volume of 814 TByte based on a rolling archive concept supported by a reload mechanism from a long-term *** November 2017,the element for big data processing has been operational,where registered users can process and analyse data themselves specifically assisted by methods for value-added product *** 195,467 core and 696,406 memory hours,982,948 products of different applications were fully automatically generated in the cloud environment and made available as of March *** features include an improved visualization of available Sentinel-2 products,which are presented within the catalogue client at full 10 m resolution.

关键词： Big earth data big data processing online data access Sentinel Copernicus CODE-DE collaborative ground segment

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以汉语为母语失歌症者对音乐音高的加工

以汉语为母语失歌症者对音乐音高的加工

第四届中国音乐家协会音乐心理学学会学术研讨会

作者：蒋存梅 Jeff p.Hamm vanessa K.Lim Ian J.Kirk 杨玉芳上海师范大学音乐学院中科院心理研究所奥克兰大学心理学系

在调性音乐中,对音高的知觉直接影响着个体对调性音乐的创作、表演以及欣赏活动。先天性失歌症（Congenital amusia,简称失歌症）是一种对音乐音高变化的加工障碍。无法识别音乐音高细微变化是失歌症音高障碍的核心。已有研究表明,声调... 详细信息

在调性音乐中,对音高的知觉直接影响着个体对调性音乐的创作、表演以及欣赏活动。先天性失歌症（Congenital amusia,简称失歌症）是一种对音乐音高变化的加工障碍。无法识别音乐音高细微变化是失歌症音高障碍的核心。已有研究表明,声调语言背景对个体音乐音高的加工具有积极影响。然而,我们在前期研究中发现,以汉语为母语的失歌症者在加工旋律轮廓存在障碍。该结果暗示,声调语言背景似乎不能弥补失歌症的音高障碍。那么,这种对旋律轮廓加工的障碍是否也出现在以汉语为母语失歌症者对音乐音高分辨上?如果是的话,失歌症者是否存在音高加工的促进效应?为了考察这些问题,本实验通过两个纯音配对的分辨任务探讨失歌症者对音高差异的辨别能力。同时,本实验还通过由四个纯音组成序列的分辨任务考察失歌症者对音高加工是否存在促进效应。本实验包含11个失歌症者和11个控制组被试。在两音配对实验中,刺激材料包含80对纯音。其中40对包含相同的两个音,另外40对包含不同的两个音。第一个音的频率值包括以下几种:C3（131Hz）、C4（262Hz）、C5（523Hz）和C6（1047Hz）。在不同音高配对中,音高的变化发生在第二个音。它们可能比第一个高或低0.5个半音、1个半音、1.5个半音、2.0个半音和2.5个半音。刺激以伪随机的顺序呈现。在四音序列任务中,80个刺激也以伪随机的顺序呈现。音高变化距离和方向与两音配对任务相似。二者之间主要的不同在于,在四音序列中,音高变化出现在第三个音。这种音高变化意味着,作为知觉的参考音,第一个音被重复两次。实验结果表明,以汉语为母语失歌症者不仅显示出对两音配对的分辨障碍,而且对四音序列的分辨也低于正常被试。同时,尽管失歌症者对四音序列的加工优于两音分辨,但这种提高并不意味着促进效应,而是来源于额外的参考音以及更多的音高变化线索。本结果暗示,声调语言背景似乎不能弥补失歌症者对音高辨别的缺陷。

关键词：先天失歌症细微音高分辨障碍提高声调语言背景

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大熊猫取食竹笋期间的昼夜活动节律和强度

生态学报 2011年第10期31卷 2655-2661页

作者：张晋东 vanessa HULL 黄金燕周世强李仁贵刘巅黄炎李德生徐卫华张和民刘建国欧阳志云中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085 绵阳师范学院四川绵阳621000 Center For Systems Integration and Sustainability Department of Fisheries and WildlifeMichigan State UniversityEast LansingMI48823USA 中国保护大熊猫研究中心四川汶川623006

采用内置记录活动水平传感器的GpS项圈研究了卧龙自然保护区3只野生大熊猫春季取食竹笋期间的昼夜活动节律和强度,并分析了太阳辐射、温度因子对大熊猫活动节律与强度的影响。3只大熊猫的平均活动率为68.05%,受孕雌性大熊猫的活动率(70.... 详细信息

采用内置记录活动水平传感器的GpS项圈研究了卧龙自然保护区3只野生大熊猫春季取食竹笋期间的昼夜活动节律和强度,并分析了太阳辐射、温度因子对大熊猫活动节律与强度的影响。3只大熊猫的平均活动率为68.05%,受孕雌性大熊猫的活动率(70.86%)和活动强度(范围:0—255;水平方向/垂直方向,23.82±0.30/17.63±0.22)均比其它两只大熊猫(70.55%,14.71±0.17/13.52±0.15;62.76%,17.74±0.23/13.61±0.18)高。大熊猫有3次活动高峰,分别出现在6:00—7:00,18:00—21:00和23:00—3:00,一个明显的活动低谷,出现在9:00—12:00。大熊猫白天的活动率(68.32%)和活动强度(19.59±0.20/15.45±0.15)比夜间(67.67%,17.63±0.19/14.21±0.15)高。大熊猫的活动强度与太阳辐射之间存在显著负相关(r=-0.822,p<0.001),与空气温度之间不存在显著的相关性。

关键词：大熊猫(Ailuropoda melanoleuca) GpS项圈活动强度活动节律卧龙自然保护区

Clinical, psycho-Social and Metabolic profile of Women with Hirsutism in Yaounde

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Open Journal of Endocrine and Metabolic Diseases 2022年第11期12卷 225-237页

作者： Francine Mendane Ekobena Martine Claude Etoa Etoga Laurence Carole Ngo Yon Mesmin Dehayem Sandrine Ongnesseck Nengom Eliane Ngassam vanessa Balla Eugène Sobngwi Jean Claude Mbanya Internal Medicine Essos Hospital Centre Yaoundé Cameroon Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon National Obesity Centre Diabetes and Metabolic Diseases Unit Yaoundé Central Hospital Yaoundé Cameroon Faculty of Medicine and pharmaceutical Sciences University of Douala Douala Cameroon Regional Hospital of Nkongsamba Nkongsamba Cameroon

Background: Hirsutism is a clinical situation in Cameroon which is poorly elucidated due to a paucity of clinical and biological data;hence our interest in this study. The aim of this work was to describe the clinical, psycho-social and metabolic profile of women with hirsutism in Yaoundé. Materials and Methods: This was a descriptive cross-sectional study carried out from May 2013 to December 2013. participants were recruited by announcement through social media. Our study included women at least 18 years old, not in menopausal, not pregnant, not breastfeeding, with hirsutism regardless of severity. They were assessed through an interrogation, anthropometric parameters, a physical examination using the modified Ferriman and Gallwey score, the measurement of fasting capillary blood glucose and a lipid profile. The psycho-social assessment was carried out using a pre-designed questionnaire on the participant’s perception and daily experience with hirsutism. The metabolic syndrome was established according to the criteria of the International Diabetes Federation of 2005 and the National Cholesterol Education program-third adult treatment panel of 2001. Results: We recruited 60 women aged 27.6 ± 7.0 years. The median Ferriman and Gallwey score was 12. The mean duration of evolution was 9 years. A family history of hirsutism was found in 88.8% of the participants, especially in the mother. Signs of virilization were found in 3.3% of the participants. Association was found between menstrual cycle abnormalities and severity of hirsutism (p = 0.023). psycho-socially, 58.8% of women found hirsutism normal. The metabolic syndrome was found in 21.7% and 18.3% according to the IDF and NCEp-ATp III, respectively. Conclusion: Hirsutism in our context seems normal to most of our participants. It is, however, associated with menstrual irregularities, signs of virilization and metabolic syndrome. As a result, hirsutism merits further study on a large-scale with emphasis on etiology

关键词： Hirsutism hyperandrogenism Yaoundé Ferriman and Gallwey

A Model for the Risk of Microcephaly Induced by the Zika Virus (ZIKV)

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Open Journal of Modelling and Simulation 2016年第3期4卷 109-117页

作者： Dalia M. Muñoz pizza Anibal Muñoz Loaiza John F. Arredondo Montoya Oscar A. Manrique vanessa Abello Sossa Carlos A. Abello Muñoz Steven Raigosa Hans Meyer Contreras Irma pérez Contreras Maria E. Cardenas perea Miguel A. Enríquez Grupo de Modelación Matemática en Epidemiología (GMME) Facultad de Educación Universidad del Quindío Quindío Colombia Facultad de Medicina Benemérita Universidad Autónoma de Puebla Puebla México

It has been introduced and analyzed a mathematical model based on integral equations, which turns into a dynamical system of non-linear differential equations to account for the risk of microcephaly incidence caused by the Zika virus. A specific pregnant women susceptible group has been accounted for. The epidemic threshold (basic reproduction number) has been obtained by implementing the next generation matrix method. A sensitivity analysis with respect to each parameter has been applied to that threshold. Finally, the incidence to the exposure is obtained by performing several system simulations.

关键词： Model Microcephaly Zika Virus Basic Reproduction Number Sensitivity Analysis

Comparative Study of the Complications of pedicular Screw Fixation Techniques in the Thoracolumbar Spine: A Systematic Review

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Open Journal of Orthopedics 2023年第8期13卷 343-353页

作者： vanessa Cavazana Takata João Vitor Lois Balestrieri pedro Bastos Neto Rodrigo Eduardo Souza Garcia Idiberto José Zotarelli Filho Luis Fernando Ricci Boer Fabiano Morais Nogueira FAMERp-Faculty of Medicine of Sã o José do Rio Preto Orthopedics and Traumatology at Hospital de Base S&atildeo José do Rio Preto S&atildeo Paulo Brazil ABRAN-Brazilian Association of Nutrology Catanduva Sao Paulo Brazil Clinical Research and Biostatistical Department College of Palliative Medicine of Sri Lanka Colombo Sri Lanka

Introduction: The use of pedicle screws increases postoperative stability and consolidation of arthrodesis. pedicle arthrodesis is currently the standard treatment for the thoracolumbar spine, presenting the best fusion and stiffness rates, and among its main indications is the possibility of better correction of spine deformities in the thoracic and lumbar region. However, due to different definitions and the lack of a control group, many of these studies have limited comparative analysis, resulting in the scarcity of comparative studies with standardized methodology. Objective: It was to analyze, through a systematic review, the safety and efficacy of instrumentation with pedicle screws in the spine which have been questioned, despite its wide use for stabilization of the spine, comparing the complications present in the insertion techniques of pedicle screws. Methods: The rules of the Systematic Review-pRISMA were followed. The literary search process was carried out from January to March 2023. A bibliographic search was carried out in MEDLINE, pubMed, and Scielo for articles produced between 2001 and 2023. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. The Cohen test (Funnel plot) and The Heterogeneity Test (Chi-Square Test – Xp>2p>) were performed, with p Results and Conclusion: A total of 134 articles were found. A total of 67 articles were evaluated in full and 12 were selected to compose the results of this systematic review. According to the GRADE instrument, most studies (Xp>2p> = 90.2% > 50%) followed a controlled clinical study model and had a good methodological design, with p poor positioning of pedicle screws is the most common cause of complications. The surgeon’s skills and the length and diameter of the pedicle screw can also affect the different modes of placement. Robotic computer assistance has the potential to reduce th

关键词： pedicular Arthrodesis Complications Spinal Instrumentation

Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia

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World Journal of Gastrointestinal Endoscopy 2017年第2期9卷 61-69页

作者： Justin M Gomez James T patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang Division of Gastroenterology and Hepatology University of Virginia Division of Biostatistics and Epidemiology University of Virginia Department of pathology University of Virginia

AIMTo determine which clinical factors might be associated with gastric intestinal metaplasia (IM) in a North American population. METHODSpathology and endoscopy databases at an academic medical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. patient demographics, insurance status, and other clinical factors were reviewed. RESULTSFour hundred and sixty-eight patients with gastric IM (mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM (mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology (OR = 2.05, p = 0.051). Gastric IM was associated with histologic findings of chronic gastritis (OR = 2.56, p p = 0.015), gastric dysplasia (OR = 6.11, p = 0.038), and gastric cancer (OR = 6.53, p = 0.027). Histologic findings of Barrett’s esophagus (OR = 0.28, p = 0.003) and esophageal dysplasia (OR = 0.11, p = 0.014) were inversely associated with gastric IM. Tobacco use (OR = 1.73, p = 0.005) was associated with gastric IM. CONCLUSIONpatients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy (EGD). patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable.

关键词： Gastric Intestinal metaplasia Atrophic gastritis Biopsies Esophagogastroduodenoscopy

Antimalarial Activity of an Alkaloid Mixture Isolated from the Tender Leaves of the Nectandra membranacea （Laureaceae）

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Journal of Life Sciences 2018年第3期12卷 134-140页

作者： vanessa Bagnarello-Madrigal Daniela Rodríguez-Chaves Javier Alpizar-Cordero Alonso Calvo-Vargas Maribel Cordero-Villalobos Misael Chinchilla-Carmona Idalia Valerio-Campos Ronald Sánchez -porras Departamento de Química Universidad de Ciencias Médicas (UCIMED) San José 10108 Costa Rica Departamento de Investigación Básica Universidad de Ciencias Médicas (UCIMED) San José 10108 Costa Rica Sección de Biología Sede Occidente Universidad de Costa Rica San José 10108 Costa Rica

Despite the breadth of knowledge about malaria, its transmission, preventive measures and available treatments and its difficulty in controlling the vector and the rapid spread of resistance to current drugs, there is a stimulus to develop new research looking for active molecules. The phytochemical studies of the active extract confirmed the presence of alkaloids, flavonoids, coumarins, tannins, reducing compounds, anthocyanins, terpenes, triterpenes and steroids. In the present work, it was possible to isolate a mixture of isoquinolinic alkaloids from the tender leaves of Nectandra membranacea （Laureaceae） with antimalarial activity. The mixture composed of （-） - gliazovine and （＋） - aplogliazovine showed an IC50 value of 32.18 μg/mL against the p. berghei NK65 strain. It is important to continue with these studies and their chemical components isolated from N. membranacea that could be used as an alternative the treatment of malaria.

关键词： Malaria Nectandra membranacea alkaloids phytochemical screening Laureaceae.