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Physical model simulation of rock-support interaction for the tunnel in squeezing ground

Journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 82-92页

作者： Ketan arora Marte Gutierrez Ahmadreza Hedayat Civil and Environmental Engineering Colorado School of MinesGoldenCO80401USA

The existence of squeezing ground conditions can lead to significant challenges in designing an adequate support system for *** empirical,observational and analytical methods have been suggested over the years to design support systems in squeezing ground conditions,but all of them have some *** this study,a novel experimental setup having physical model for simulating the tunnel boring machine(TBM)excavation and support installation process in squeezing clay-rich rocks is *** observations are made to understand better the interaction between the support and the squeezing *** physical model included a large true-triaxial cell,a miniature TBM,laboratoryprepared synthetic test specimen with properties similar to natural mudstone,and an instrumented cylindrical aluminum support *** were conducted at realistic in situ stress levels to study the time-dependent three-dimensional tunnel support *** tunnel was excavated using the miniature TBM in the cubical rock specimen loaded in the true-triaxial cell,after which the support was *** confining stress was then increased in stages to values greater than the rock’s unconfined compressive strength.A model for the time-dependent longitudinal displacement profile(LDP)for the supported tunnel was proposed using the tunnel convergence measurements at different times and stress *** LDP formulation was then compared with the unsupported model to calculate the squeezing amount carried by the *** increase in thrust in the support was backcalculated from an analytical solution with the assumption of linear elastic *** on the test results and case studies,a recommendation to optimize the support requirement for tunnels in squeezing ground is proposed.

关键词： Squeezing ground Tunnel support system Longitudinal displacement profile Rock-support interaction

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Recent progress in contact, mobility, and encapsulation engineering of InSe and GaSe

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InfoMat 2021年第6期3卷 662-693页

作者： Himani arora Artur Erbe Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany Faculty of Physics and Center for Advancing Electronics Dresden Technische Universität DresdenDresdenGermany

The field of two-dimensional(2D)materials has stimulated considerable interest in the scientific *** to quantum confinement in one direction,intriguing properties have been reported in 2D materials that cannot be observed in their bulk *** advent of semiconducting 2D materials with a broad range of electronic properties has provided fascinating opportunities to design and configure next-generation *** such emerging class is the family of III-VI monochalcogenides,the two prominent members of which are indium selenide(InSe)and gallium selenide(GaSe).In contrast to transition metal dichalcogenides,their high intrinsic mobility and the availability of a direct bandgap at small thicknesses have attracted researchers to investigate the underlying physical phenomena as well as their technological ***,the sensitivity of InSe and GaSe to environmental influences has limited their exploitation in functional *** lack of methods for their scalable synthesis further hinders the realization of their *** review article outlines recent advancements in the synthesis and understanding of the charge transport properties of InSe and GaSe for their integration into technological applications.A detailed summary of the improvements in the device structure by optimizing extrinsic factors such as bottom substrates,metal contacts,and device fabrication schemes is ***,various encapsulation techniques that have been proven effective in preventing the degradation of InSe and GaSe layers under ambient conditions are thoroughly ***,this article presents an outlook on future research ventures with respect to ongoing developments and practical viability of these materials.

关键词： 2D materials 2D transistors electronic properties gallium selenide indium selenide vdW semiconductors

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Biological therapy for ulcerative colitis

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Gastroenterology Report 2015年第2期3卷 103-109页

作者： Zubin arora Bo Shen Department of Internal Medicine the Cleveland Clinic FoundationClevelandOHUSA Department of Gastroenterology and Hepatology the Cleveland Clinic FoundationClevelandOHUSA

Ulcerative colitis(UC)is a major form of inflammatory bowel disease(IBD)*** understanding of the pathogenesis of UC has led to the development of novel therapeutic agents that target specific mediators of the inflammatory cascade.A number of biological agents have been approved by the *** and Drug Administration(FDA)for the treatment of UC and several more are currently in various phases of drug *** commonly used agents include TNFa antagonists(***,adalimumab,and golimumab)and anti-integrin agents(vedolizumab).These biological agents have profoundly influenced the management of UC patients,especially those with refractory *** paper reviews the currently available knowledge and evidence for the use of various biological agents in the treatment of UC.

关键词： ulcerative colitis biological therapy TNFαantagonists anti-integrin agents

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Modeling oblique load carrying capacity of batter pile groups using neural network,random forest regression and M5 model tree

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Frontiers of Structural and Civil Engineering 2019年第3期13卷 674-685页

作者： Tanvi SINGH Mahesh PAL V.K.arora Department of Civil Engineering National Institute of TechnologyKurukshetraHaryana 136119India

M5 model tree,random forest regression(RF)and neural network(NN)based modelling approaches were used to predict oblique load carrying capacity of batter pile groups using 247 laboratory experiments with smooth and rough pile *** length(L),angle of oblique load(a),sand density(ρ),number of batter piles(B),and number of vertical piles(V)as input and oblique load(Q)as output was *** suggest improved performance by RF regression for both pile groups.M5 model tree provides simple linear relation which can be used for the prediction of oblique load for field data *** developed using RF regression approach with smooth pile group data was found to be in good agreement for rough piles *** based approach was found performing equally well with both smooth and rough *** analysis using all three modelling approaches suggest angle of oblique load(a)and number of batter pile(B)affect the oblique load capacity for both smooth and rough pile groups.

关键词： batter piles oblique load test neural network M5 model tree random forest regression ANOVA

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Using hybrid models to predict blood pressure reactivity to unsupported back based on anthropometric characteristics

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Frontiers of Information Technology & Electronic Engineering 2015年第6期16卷 474-485页

作者： Gurmanik KAUR Ajat Shatru arora Vijender Kumar JAIN Sant Longowal Institute of Engineering and Technology Deemed University Punjab 148106 India

Accurate blood pressure （BP） measurement is essential in epidemiological studies, screening programmes, and research studies as well as in clinical practice for the early detection and prevention of high BP-related risks such as coronary heart disease, stroke, and kidney failure. Posture of the participant plays a vital role in accurate measurement of BP. Guidelines on measurement of BP contain recommendations on the position of the back of the participants by advising that they should sit with supported back to avoid spuriously high readings. In this work, principal component analysis （PCA） is fused with forward stepwise regression （SWR）, artificial neural network （ANN）, adaptive neuro-fuzzy inference system （ANFIS）, and the least squares support vector machine （LS-SVM） model for the prediction of BP reactivity to an unsupported back in norrnotensive and hypertensive participants. PCA is used to remove multi-collinearity among anthropometric predictor variables and to select a subset of components, termed ＇principal components＇（PCs）, from the original dataset. The selected PCs are fed into the proposed models for modeling and testing. The evaluation of the performance of the constructed models, using appropriate statistical indices, shows clearly that a PCA-based LS-SVM （PCA-LS-SVM） model is a promising approach for the prediction of BP reactivity in comparison to others. This assessment demonstrates the importance and advantages posed by hybrid models for the prediction of variables in biomedical research studies.

关键词： Blood pressure (BP) Principal component analysis (PCA) Forward stepwise regression Artificial neural network(ANN) Adaptive neuro-fuzzy inference system (ANFIS) Least squares support vector machine (LS-SVM)

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Natural polysaccharides for ulcerative colitis: A general overview

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Asian Pacific Journal of Tropical Biomedicine 2023年第5期13卷 185-194页

作者： Akshita arora Nitin Sharma Dipti Kakkar Department of Pharmaceutics ISF College of PharmacyMogaPunjabIndia Institute of Nuclear Medicine and Allied Sciences Ministry of DefenceBrig SK Mazumder MargDelhiIndia

Ulcerative colitis is a colonic disease characterized by the disruption of the mucosal epithelial layer and inflammation. For the treatment of this disease, various chemotherapeutic agents are ***, the toxicities associated with chemotherapeutics greatly hamper treatment. Polysaccharide from natural resources is emerging as a potentially therapeutic substance with comparative minimum adverse effects. In this article, we are discussing polysaccharide from diverse sources(plants, edible mushrooms,and algae) which are being used in the treatment of ulcerative colitis. These polysaccharides exert their therapeutic action on ulcerative colitis through several mechanisms, including suppression of inflammatory cascades NF-κB, MAPK, IL-6/JAK2/STAT3,preventing the release of certain inflammatory mediators, modulating the intestinal microbiome, maintaining the integrity of intestinal barriers, and regulating the certain inflammatory markers. The present review compiles the role of different polysaccharides being used successfully in the management/treatment of ulcerative *** emphasis was given to explaining the biomolecular pathway.

关键词： Ulcerative colitis Polysaccharide Colon Inflammatory bowel disease Phytochemicals

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Enhanced cavitation erosion resistance of a friction stir processed high entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2020年第10期27卷 1353-1362页

作者： Rakesh B.Nair H.S.arora Harpreet Singh Grewal Surface Science and Tribology Lab Department of Mechanical EngineeringShiv Nadar UniversityGautam Buddha NagarUttar Pradesh 203207India

Friction stir processing of an Al0.1CoCrFeNi high entropy alloy(HEA)was performed at controlled cooling conditions(ambient and liquid submerged).Microstructural and mechanical characterization of the processed and as-cast HEAs was evaluated using electron backscatter diffraction,micro-hardness testing and *** under the submerged cooling condition showed elongated grains(10μm)with fine equiaxed grains(2μm)along the boundary compared to the coarser grain(~2 mm)of as-cast *** hardness showed remarkable improvements with four(submerged cooling condition)and three(ambient cooling condition)times that of as-cast HEA(HV^150).The enhanced hardness is attributed to the significant grain refinement in the processed *** erosion behavior was observed for samples using an ultrasonication *** of the HEAs showed better cavitation erosion resistance than the stainless steel *** sample processed under a submerged liquid condition showed approximately 20 and 2 times greater erosion resistance than stainless steel 316L and ascast HEA,*** enhanced erosion resistances of the processed HEAs correlate to their increased hardness,resistance to plasticity,and better yield strength than the as-cast *** surface of the tested samples showed nucleation and pit growth,and plastic deformation of the material followed by fatigue-controlled disintegration as the primary material removal mechanism.

关键词： cavitation erosion microstructure mechanical properties surface engineering

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Investigation of 58Ni(n, p)58Co reaction cross-section with covariance analysis

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Chinese Physics C 2024年第2期48卷 78-90页

作者： Akash Hingu S.Mukherjee Siddharth Parashari arora Sangeeta A.Gandhi Mahima Upadhyay Mahesh Choudhary Sumit Bamal Namrata Singh G.Mishra Sukanya De Saurav Sood Sajin Prasad G.Saxena Ajay Kumar R.G.Thomas B.K.Agrawal K.Katovsky A.Kumar Department of Physics Faculty of ScienceThe M.S.University of BarodaVadodara 390002India Faculty of Electrical Engineering and Communication Brno University of TechnologyBrnoCzech Republic Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.32Zagreb 10000Croatia Department of Physics University Institute of SciencesChandigarh UniversityGharuanMohali 140413PunjabIndia Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei National Institute for Physics and Nuclear Engineering Măgurele 077125Romania Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Physics(H&S) Government Women Engineering CollegeAjmer 305002India Saha Institute of Nuclear Physics Kolkata 700064India Homi Bhabha National Institute Anushakti NagarMumbai 400094India

The excitation function of the 58Ni(n,p)58Co reaction was measured using the well-established neutron activation technique andγ-ray *** in the energy range of 1.7 to 2.7 MeV were generated using the 7Li(p,n)*** neutron flux was measured using the standard 115In(n,n’)115mIn monitor *** results of the neutron spectrum averaged cross-section of 58Ni(n,p)58Co reactions were compared with existing cross-section data available in the EXFOR data library as well as with various evaluated data libraries such as ENDF/B-VIII.0,JEFF-3.3,JENDL-4.0,and *** calculations were performed using the nuclear reaction code *** nuclear level density(NLD)models were tested,and their results were compared with the present *** NLDs were also obtained through the spectral distribution method(SDM).The cross-section results,along with the absolute errors,were obtained by investigating the uncertainty propagation and using the covariance *** forγ-ray true coincidence summing,low-energy background neutrons,andγ-ray self attenuation were *** experimental cross-section obtained in the present study is consistent with previously published experimental data,evaluated libraries,and theoretical calculations carried out using the TALYS code.

关键词： nuclear reactions (n,p)reaction cross-section measurement covariance analysis nuclear level density

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Mutation D614G increases SARS-CoV-2 transmission

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1075-1076页

作者： Prerna arora Stefan Pohlmann Markus Hoffmann Infection Biology Unit German Primate CenterGottingenGermany Faculty of Biology and Psychology Georg-August-University GottingenGottingenGermany

It has been unclear why SARS-CoV-2 with a D614G mutation in the spike protein became dominant early in the COVID-19 pandemic.A recent study by Hou et *** in Science shows that D614G increases SARS-CoV-2 spread in cult... 详细信息

关键词： 4G D61 spread

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Tunnels in squeezing clay-rich rocks

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Underground Space 2021年第4期6卷 432-445页

作者： Ketan arora Marte Gutierrez Ahmadreza Hedayat Caichu Xia Civil and Environmental Engineering Colorado School of MinesGoldenCO 80401USA Geotechnical Engineering Tongji UniversityShanghai 200092China

Squeezing ground conditions,which can lead to severe loads in tunnels,have historically been associated with the presence of clay minerals in the *** the years,many methodologies have been proposed to predict squeezing in tunnels based on tunnel depth,in situ stress,ground mineralogy,and ground strength and deformation *** paper presents a comprehensive review of methodologies to predict tunnel squeezing in clay-rich rocks.A new methodology is proposed where ground conditions and squeezing potential are assessed based on the Stress History and Normalized Soil Engineering Properties(SHANSEP)approach adapted to clayrich rocks,Peck’s stability number and Hoek&Brown’s(1997)Geological Strength Index(GSI).A squeezing number S is suggested to classify ground conditions based on the level of squeezing that the ground may experience in response to ***,it is demonstrated that by combining the proposed classification system and an existing classification system for ground squeezing condition,an accurate estimate of tunnel strain can also be *** proposed method is applied to four case studies of tunnels in squeezing ground in shale and mudstone.

关键词： Squeezing ground High in situ stress Critical strain Clay-rich rocks Mudrock Shale Tunnels

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