Natural polysaccharides for ulcerative colitis: A general overview

作     者：Akshita Arora Nitin Sharma Dipti Kakkar Akshita Arora;Nitin Sharma;Dipti Kakkar

作者机构：Department of PharmaceuticsISF College of PharmacyMogaPunjabIndia Institute of Nuclear Medicine and Allied SciencesMinistry of DefenceBrig SK Mazumder MargDelhiIndia 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2023年第13卷第5期

页      面：185-194页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Ulcerative colitis Polysaccharide Colon Inflammatory bowel disease Phytochemicals 

摘      要：Ulcerative colitis is a colonic disease characterized by the disruption of the mucosal epithelial layer and inflammation. For the treatment of this disease, various chemotherapeutic agents are ***, the toxicities associated with chemotherapeutics greatly hamper treatment. Polysaccharide from natural resources is emerging as a potentially therapeutic substance with comparative minimum adverse effects. In this article, we are discussing polysaccharide from diverse sources(plants, edible mushrooms,and algae) which are being used in the treatment of ulcerative colitis. These polysaccharides exert their therapeutic action on ulcerative colitis through several mechanisms, including suppression of inflammatory cascades NF-κB, MAPK, IL-6/JAK2/STAT3,preventing the release of certain inflammatory mediators, modulating the intestinal microbiome, maintaining the integrity of intestinal barriers, and regulating the certain inflammatory markers. The present review compiles the role of different polysaccharides being used successfully in the management/treatment of ulcerative *** emphasis was given to explaining the biomolecular pathway.