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It's all about timing, early treatment with hyperbaric oxygen therapy and corticosteroids is essential in acute acoustic trauma

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Journal of.Otology 2021年第4期16卷 237-241页

作者： A.B.Bayoumy R.P.Weenink E.Lvan der Veen f.S.Besseling-Hansen A.D.M.Hoedemaeker f.J.Mde Jong M.Hvan der Laan R.Swenker R.Avan Hulst J.Ade Ru Department of.Otolaryngology Central Military HospitalMinistry of DefenseUtrechtthe Netherlands Department of.Anesthesiology and Department of.Hyperbaric Medicine Amsterdam University Medical CentersLocation AMCAmsterdamthe Netherlands Department of.Otolaryngology-Head and Neck Surgery University Medical Centre UtrechtUtrechtthe Netherlands Diving Medical Centre Royal Netherlands NavyMinistry of DefenseDen Helderthe Netherlands

Background: Acute acoustic trauma (AAT) is an acute hearing impairment caused by intense noiseimpact. The current management strategy f.r AAT with substantial hearing loss in the Dutch militaryis the combination therapy with corticosteroids and hyperbaric oxygen therapy (HBOT). In a previousstudy, early initiation of.the combination therapy was associated with better outcomes. Theref.re, weperf.rmed a new analysis to assess the dif.erence in hearing outcome between patients in whomcombination therapy was started within two days, versus af.er more than two ***: A retrospective analysis was perf.rmed on military patients diagnosed with AAT with substantial hearing loss who presented between f.bruary 2018 and March 2020. Absolute and relativehearing improvement between f.rst and last audiograms were calculated f.r all af.ected f.equencies(def.ned as loss of. 20 dB on initial audiogram). We also determined the amount of.patients whorecovered to the level of.Dutch military requirement, and perf.rmed speech discrimination ***: In this analysis, 30 male patients (49 ears) with AAT were included. The median age was 24.5years (IQR 23e29). The median time to initiation of.therapy with corticosteroids and HBOT were one andtwo days, respectively. HBOT was started within two days in 31 ears, and af.er more than two days in 18ears. The mean absolute and relative hearing gains were 18.8 dB (SD 14.6) and 46.8% (SD 31.3) on allaf.ected f.equencies. The 100% discrimination/speech perception level improved f.om 64.0 dB to 51.7 dB(gain 12.3 dB ± 14.1). There was signif.cantly more improvement in absolute and relative hearingimprovement when HBOT was started in 2 days, compared to >2 ***: Our analysis shows results in f.vor of.early initiation ( 2 days) of.the combination treatmentof.HBOT and corticosteroids in patients with AAT.

关键词： Hyperbaric oxygen therapy Acute acoustic trauma Hearing loss Corticosteroids Blast injury Noise-induced hearing loss

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北祁连东部两类Ⅰ型花岗岩定年及其地质意义

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岩石学报 2004年第3期20卷 425-432页

作者：吴才来杨经绥杨宏仪 Joseph L.W00den 史仁灯陈松永郑秋光中国地质科学院地质研究所北京100037 成功大学斯坦福大学

北祁连东部早古生代地层中产出两种特征不同的I型花岗岩类,其一以井子川岩体为代表,暗色矿物以角闪石为主,稀土总量为90×10^(-6)～106×10^(-6),轻重稀土比值小于8,锆石的SHRIMP年龄为464±15Ma,岩体形成的构造环境类似于岛弧;其二是... 详细信息

北祁连东部早古生代地层中产出两种特征不同的I型花岗岩类,其一以井子川岩体为代表,暗色矿物以角闪石为主,稀土总量为90×10^(-6)～106×10^(-6),轻重稀土比值小于8,锆石的SHRIMP年龄为464±15Ma,岩体形成的构造环境类似于岛弧;其二是以黄羊河岩体为代表,暗色矿物以黑云母为主,稀土总量为214×10^(-6)～250×10^(-6),轻重稀土比值大于8,锆石的LA-ICP-MS年龄为383±6 Ma,岩体形成于碰撞后环境。

关键词：北祁连东部两种类型花岗岩锆石定年

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Controlling the gelation temperature of.biomimetic polyisocyanides

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Chinese Chemical Letters 2018年第2期29卷 281-284页

作者： Paul H.J. Kouwer Paula de Almeida Onno ven den Boomen Zaskia H. Eksteen-Akeroyd Roel Hammink Maarten Jaspers Stijn Kragt Mathijs f.J. Mabesoone RoelandJ.M. Nolte Alan E. Rowan Martin G.T.A. Rutten Vincent A.A. Le Sage Daniel C. Schoenmakers Chengf.n Xing Jialiang xu Institute f.r Molecules and Materials Radboud University Nijmegen 6525 A J The Netherlands

Thermosensitive polymers show an entropy-driven transition f.om a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conf.rmation. The transition at the lower critical solution temperature（LCST） is of.en sharp, which allows f.r a wide range of.smart material *** the LCST, oligo（ethylene glycol）-substituted polyisocyanides（PICs） f.rm sof. hydrogels, composed of.polymer bundles similar to biological gels, such as actin, f.brin and intermediate f.laments. Here, we show that the LCST of.PICs strongly depends linearly on the length of.the ethylene glycol（EG） tails; every EG group increases the LCSTand thus the gelation temperature by nearly 30 ℃. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 ℃ and 60 ℃and, consequently, tune the mechanical properties of.the PIC gels.

关键词： Smart materials Lower critical solution temperature Polyisocyanides Mechanical properties Biomimetic polymers

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生后早期使用别嘌呤醇不能改善出生时严重窒息患儿的短期预后

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世界核心医学期刊文摘（儿科学分册） 2006年第A10期2卷 19-20页

作者： Benders M.J.N.L. bos A.f. Rademaker C.M.A. 贺莉 Department of.Neonatology Wilhelmina Children' s Hospital University Medical Center PO Box 85090 3508 AB Utrecht NetherlandsDr.

Objective: To investigate whether postnatal allopurinol would reduce f.ee radical induced reperf.sion/reoxygenation injury of.the brain in severely asphyxiated neonates. Method: In an interim analysis of.a randomised, double blind, placebo controlled study, 32 severely asphyxiated inf.nts were given allopurinol or a vehicle within f.ur hours of.birth. Results: The analysis showed an unaltered (high) mortality and morbidity in the inf.nts treated with allopurinol. Conclusion: Allopurinol treatment started postnatally was too late to reduce the early reperf.sion induced f.ee radical surge. Allopurinol administration to the f.tus with (imminent) hypoxia via the mother during labour may be more ef.ective in reducing f.ee radical induced post- asphyxial brain damage.

关键词：窒息患儿别嘌呤醇生时再灌注损伤大脑损伤孕母急性缺氧再氧合随机化安慰剂对照

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视网膜血管直径与脑卒中的风险:来自鹿特丹的研究

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 6-7页

作者： Ikram M.K. De Jong f.J. bos M.J. 桑延智 The Netherlands Institute f.r Neurosciences KNAWMeibergdreef 471105 BA AmsterdamNetherlands Dr.P.T.V.M.

Background:Retinal vessels may provide inf.rmation on cerebral vascular pathology,because they share many f.atures with cerebral vessels.A smaller ratio of.the retinal arteriolar-to-venular diameters reportedly predicts the risk of.*** is unclear if.this is due to arteriolar narrowing or venular ***:To investigate whether smaller arteriolar or larger venular diameters are related to the risk of.stroke and cerebral ***:This study was based on the prospective population-based Rotterdam Study and included 5,540 participants of.55 years or over,who had gradable f.ndus transparencies and were f.ee of.stroke at baseline(1990 to 1993).f.r each participant,retinal arteriolar and venular diameters were measured on digitized images of.one ***-up f.r f.rst-ever stroke was complete until January 1,***:Af.er a mean f.llow-up of.8.5 years,411 participants had a stroke,of.whom 259 had cerebral *** venular diameters were associated with an increased risk of.stroke(hazard ratio HR adjusted f.r age and sex per SD increase:1.12 95% CI:1.02 to 1.24)and cerebral inf.rction(HR:1.15 95% CI:1.02 to 1.29).Smaller arteriolar diameters were neither related to the risk of.stroke(HR per SD decrease:1.02 95% CI:0.93 to 1.13)nor to the risk of.cerebral inf.rction(HR:1.02 95% CI:0.90 to 1.15).Af.er additional adjustment f.r other cardiovascular risk f.ctors,the results did not ***:Larger retinal venular diameters are associated with an increased risk of.stroke and cerebral *** role of.venules in cerebrovascular disease warrants f.rther exploration.

关键词：脑卒中发作视网膜血管血管直径鹿特丹风险脑血管病变心血管危险因素随访研究

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Cryo-EM structures of.cytotoxin VacA f.om Helicobacter pylori

Cryo-EM structures of cytotoxin VacA from Helicobacter pylor...

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第六届全国冷冻电子显微学与结构生物学专题研讨会

作者： Hua-wei ZHANG Kai-ming ZHANG Shan-shan LI Grigore D.Pintilie Tung-Chung MOU Yuan-zhu GAO Qin-f.n ZHANG Henry van den BEDEM Michael f.SCHMID Shannon Wing Ngor Au Wah Chiu The Chinese University of.Hong Kong Stanf.rd University University of.Montana Sun Yat-sen University

＜正＞Helicobacter pylori colonizes human stomach and is the primary risk f.ctor f.r many gastric diseases including gastric cancer. The pathogenesis of.H. pylori depends on several virulence f.ctors including cytotoxin VacA. VacA is secreted through type V secretion system and exists as various water-soluble oligomeric states in vitro. VacA can bind to mammalian cell membrane and be internalized through endocytosis. Dif.erent cellular events such as cell vacuolation and

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Environmental and biological f.ctors af.ecting the abundance of.Prosopis f.exuosa saplings in the central-west Monte of.Argentina

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f.rest Ecosystems 2022年第1期9卷 103-110页

作者： Cappa f.M. Campos V.E. Barri f.R. Ramos L. Campos C.M. INTERBIODES(Interacciones Biologicas del Desierto) Facultad Ciencias ExactasFísicas y Naturales(Universidad Nacional de San Juan)San JuanArgentina CIGEOBIO-CONICET(Centro de Investigaciones de la Geosf.ra y Biosf.ra Consejo Nacional de Investigaciones Científicas y Tecnicas)San JuanArgentina Instituto de Diversidad y Ecología Animal CONICET–UNCCordobaArgentina IADIZA Instituto Argentino de Investigaciones de las Zonas AridasUniversidad Nacional de CuyoGobierno de MendozaCONICETMendozaArgentina

Background:Trees and f.rests in drylands help mitigate the challenges through provision of.economic products and vital environmental services such as habitat f.r biodiversity,prevention of.erosion and desertif.cation,regulation of.water,microclimate,and soil *** condition and changes in dry f.rests can be assessed by using ecological indicators able to quantif. spatial and temporal changes in *** of.the ways to determine the condition of.the f.rest is to study the dominant tree species and its *** study aimed to assess whether the abundance of.Prosopis f.exuosa saplings is af.ected by environmental and biological ***:To evaluate the f.rst variables we used data f.om remote sensing such as satellite images and Aster Global Digital Model(GDEM).The second set of.variables was about exotic and native ungulates and we used f.ces of.these animals and camera traps to take *** f.und that sapling abundance related positively to sandy substrates and negatively to Wetness *** the other hand,in relation to biological variables,the abundance of.saplings was positively af.ected by density of.adult trees and by number of.seeds dispersed by equines,but space use by Lama guanicoe had a negative relationship with *** research shows that *** saplings are benef.ted f.om sandy substrates and the conditions around adult *** addition to this,we f.und that exotic ungulates in low densities have neutral(***)or positive(***)ef.ects on sapling ***:Based on these f.ndings,we conclude that regeneration of.the population of.*** in our study area has no major *** addition,we corroborated that the presence of.exotic and domestic ungulates in low densities does not have deleterious consequences f.r saplings of.the dominant tree,***.

关键词： bos primigenius taurus Dry f.rests Equines Exotic and domestic ungulates Lama guanicoe Prosopis f.exuosa Remote sensing Saplings Seed dispersal

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齐次线性微分方程解取小函数的点的收敛指数

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南昌大学学报（理科版） 2010年第6期34卷 532-535页

作者：邓中书南昌大学期刊社江西南昌330047

研究齐次线性微分方程f.k)+Ak-1(z)f.k-1)+…+A0(z)f.0解取小函数的点的收敛指数,并用二阶收敛指数估计无穷级解的增长率。

关键词：微分方程小函数收敛指数

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肠套叠水压灌肠复位法的成功与症状持续时间的关系

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世界核心医学期刊文摘（儿科学分册） 2006年第A3期2卷 35-36页

作者： van den Ende E.D. Allema J.H. Hazebroek f.W.J. Breslau P.J. 王一飞 Department of.Surgery Red Cross and Juliana Children' s Hospital Sportlaan 600 2566 MJ The Hague Netherlands

Background: It is widely believed that hydrostatic reduction of.intussusception is less successf.l in children with prolonged symptoms prior to presentation. Aim: To prospectively evaluate success in relation to duration of.symptoms. Methods: Prospective study in which children, regardless of.symptom duration, underwent an attempt at hydrostatic reduction. Results: Of.113 children presenting with intussusception, 16 had peritonitis and required immediate laparotomy. A hydrostatic reduction was attempted in 97 and was successf.l in 77 (79% ). There were 26 successf.l reductions with symptoms f.r 12-24 hours (81% ), and 21 with symptoms >24 hours (75% ). Conclusion: The success rate with hydrostatic reduction was not signif.cantly inf.uenced by symptom duration.

关键词：水压灌肠复位症状持续时间合并腹膜炎时间相关

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不同生长期金荞麦营养成分含量及消化率测定研究

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草业学报 2016年第8期25卷 107-117页

作者：韩勇邓蓉刁其玉中国农业科学院饲料研究所北京100190 贵州省畜牧兽医研究所贵州贵阳550005

为系统地测定分析不同生长期金荞麦的常规营养成分、氨基酸、微量元素含量及其回肠末端消化率,本研究用3头安装"T"型瘘管,并做回-直肠吻合切除盲肠的巴克夏-驯养野猪-高坡黑猪(巴-野-高)三元杂交生长猪作为试验动物,采用3×3拉丁方试验... 详细信息

为系统地测定分析不同生长期金荞麦的常规营养成分、氨基酸、微量元素含量及其回肠末端消化率,本研究用3头安装"T"型瘘管,并做回-直肠吻合切除盲肠的巴克夏-驯养野猪-高坡黑猪(巴-野-高)三元杂交生长猪作为试验动物,采用3×3拉丁方试验设计开展消化试验。结果表明,分枝期、孕蕾期和初花期金荞麦OM、CP、EE、Ca、P、Cf.量分别为88.59%、22.72%、2.34%、1.05%、0.39%、13.51%,89.10%、20.57%、1.69%、1.25%、0.42%、15.50%和89.63%、17.54%、1.37%、1.29%、0.46%、19.75%;EAA、NEAA和TAA含量分别为9285、7982、6244mg/100g,14334、10810、9320mg/100g和23619、18792、15564mg/100g。随着生长期的后延,营养成分含量显著降低,在体和离体消化率也随着生长期的后延而显著降低。分枝期与孕蕾期间营养成分含量差异显著(Pf.量升高较慢,营养成分消化率下降也较慢;从孕蕾期到初花期,金荞麦CP、EE、EAA及TAA下降较快,Cf.量升高也较快,营养成分消化率下降也较快。以分枝期、孕蕾期和初花期体外法测定常规营养成分及微量元素消化率值为自变量,以对应的动物饲养试验回肠末端表观消化率值为因变量建立的回归方程拟合度好,可用于推算对应的回肠末端表观消化率。本实验证明,金荞麦营养丰富、消化率高,必需氨基酸比例高、适合动物消化吸收。孕蕾期为金荞麦适宜收割期,在适宜收割期内,收割时间点应选择孕蕾后期。

关键词：肉猪体外法表观消化率标准消化率生长期

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