视网膜血管直径与脑卒中的风险:来自鹿特丹的研究

作     者：Ikram M.K. De Jong F.J. Bos M.J. 桑延智 

作者机构：The Netherlands Institute for NeurosciencesKNAWMeibergdreef 471105 BA AmsterdamNetherlands Dr.P.T.V.M. 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2006年第2卷第9期

页      面：6-7页

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：脑卒中发作 视网膜血管 血管直径 鹿特丹 风险 脑血管病变 心血管危险因素 随访研究 

摘      要：Background:Retinal vessels may provide information on cerebral vascular pathology,because they share many features with cerebral vessels.A smaller ratio of the retinal arteriolar-to-venular diameters reportedly predicts the risk of *** is unclear if this is due to arteriolar narrowing or venular ***:To investigate whether smaller arteriolar or larger venular diameters are related to the risk of stroke and cerebral ***:This study was based on the prospective population-based Rotterdam Study and included 5,540 participants of 55 years or over,who had gradable fundus transparencies and were free of stroke at baseline(1990 to 1993).For each participant,retinal arteriolar and venular diameters were measured on digitized images of one ***-up for first-ever stroke was complete until January 1,***:After a mean follow-up of 8.5 years,411 participants had a stroke,of whom 259 had cerebral *** venular diameters were associated with an increased risk of stroke(hazard ratio HR adjusted for age and sex per SD increase:1.12 95% CI:1.02 to 1.24)and cerebral infarction(HR:1.15 95% CI:1.02 to 1.29).Smaller arteriolar diameters were neither related to the risk of stroke(HR per SD decrease:1.02 95% CI:0.93 to 1.13)nor to the risk of cerebral infarction(HR:1.02 95% CI:0.90 to 1.15).After additional adjustment for other cardiovascular risk factors,the results did not ***:Larger retinal venular diameters are associated with an increased risk of stroke and cerebral *** role of venules in cerebrovascular disease warrants further exploration.