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现代生物医学进展 2017年第27期17卷 I0002-I0002页

作者： David Sulzer, Francesca Garretti, Ellen Kanter, Julian Agin-liebes, Elizabeth Phillips, Simon Mallal David Sulzer, Roy N. Alcalay, lucien Cote, Christopher liong, Elizabeth Phillips, Simon Mallal David Sulzer Curtis McMurtrey, William H. Hildebrand Xiaobo Mao, valina l. dawson, Ted M. dawson Xiaobo Mao, valina l. dawson, Ted M. dawson valina l. dawson valina l. dawson, Ted M. dawson Ted M. dawson Carla Oseroff, John Pham, John Sidney, Myles B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Bjoern Peters, April Frazier, Cecilia S. lindestam Arlehamn, Alessandro Sette Elizabeth Phillips, Simon Mallal Departments of Psychiatry Columbia University Division of Molcular Therapeutics New York State Psychiatric Institute New York New York 10032 USA Department of Neurology Columbia University New York New York 10032 USA Department of Pharmacology Columbia University New York New York 10032 USA Department of Microbiology and Immunology University of Oklahoma Oklahoma City Oklahoma 73104 USA Neuroregeneration and Stem Cell Program Institute for Cell Engineering and the Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Adrienne Helis Malvin Medical Research Foundation New Orleans Louisiana 70130-2685 USA Department of Physiology Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Department of Pharmacology & Molecular Sciences Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Division of Vaccine Discovery La Jolla Institute for Allergy and Immunology La Jolla California 92037 USA Institute for Immunology and Infectious Diseases Murdoch University Perth Western Australia 6150 Australia Vanderbilt University School of Medicine Nashville Tennessee 37235 USA

帕金森病是一种神经退行性疾病。这种疾病的一种关键特征是受损的a-突触核蛋白（alpha-synuclein）在帕金森病患者体内的一种被称作多巴胺能神经元的脑细胞中堆积。在一项新的研究中，来自美国哥伦比亚大学医学中心和拉荷亚过敏症与免... 详细信息

帕金森病是一种神经退行性疾病。这种疾病的一种关键特征是受损的a-突触核蛋白（alpha-synuclein）在帕金森病患者体内的一种被称作多巴胺能神经元的脑细胞中堆积。在一项新的研究中，来自美国哥伦比亚大学医学中心和拉荷亚过敏症与免疫学研究所等研究机构的研究人员发现首个直接的证据证实自身免疫反应在帕金森病中发挥着作用。

关键词：自身免疫疾病帕金森病神经退行性疾病多巴胺能神经元哥伦比亚大学免疫反应研究人员研究机构

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Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart lanham Andrew Rawlings Marta Roldo Gianluca Tozzi Jonathan I.dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for life Nano-and Neuro-Science(ClN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(lAB)by blending human bone-ECM(B)with nanoclay(l,laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

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Science:研究鉴定出导致脑细胞死亡的罪魁祸首

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现代生物医学进展 2017年第4期17卷 I0001-I0001页

作者： Yingfei Wang Ran An George K Umanah Hyejin Park Kalyani Nambiar Stephen M Eacker BongWoo Kim lei Bao Maged M Harraz Calvin Chang Rong Chen Jennifer E Wang TaeIn Kam Jun Seop Jeong Zhi Xie Stewart Neifert Jiang Qian Shaida A Andrabi Seth Blackshaw Heng Zhu Hongjun Song Guoli Ming valina l dawson Ted M dawson Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. tdawson@jhmi.edu vdawson1@jhmi.edu yingfei.wang@utsouthwestern.edu. Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Pathology University of Texas Southwestern Medical Center Dallas TX 75390 USA. Department of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas TX 75390 USA. Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Neurology of Huashan Hospital State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China. Adrienne Helis Malvin Medical Research Foundation New Orleans LA 70130-2685 USA. Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Center for High-Throughput Biology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Department of Physiology Johns Hopkins University School of Medicine Baltimore MD 21205 USA.

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋... 详细信息

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋白。即一种通过切割细胞的DNA给予致命性打击的蛋白。他们说，这一发现潜在地为开发预防、阻止或削弱这一过程的药物打开新的大门。相关研究结果发表在Science期刊上。

关键词：细胞死亡脑损伤神经退行性疾病鉴定阿尔茨海默病分子事件研究人员致命性

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Card7 mediates lRRK2 induced toxicity

Card7 mediates LRRK2 induced toxicity

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： W.Smith valina dawson Ted dawson Christopher A.Ross Department of Neurology 1st HospitalSunyat-Sen University Division of Neurobiology Johns Hopkins UniversityBaltimoreMaryland21205 USA

＜正＞Parkinson’s disease is a neurodegenerative disease characterized by loss of dopaminergic neurons and presence of lewy *** in leucine-rich repeat kinase-2（lRRK2） cause familiar PD and some sporadic PD. lRRK2 also is component of lewy *** used four lRRK2 bait-constructs to screen human substantial negra library in the yeast two-hybrid system,resulting in the identification of a positive interaction cDNAs clone using the lRR domain as a bait,which has 97%homology with human ***7 protein belongs to caspase recruitment domain（CARD） family and is widely detected in human tissues,with rich expression in ***7 contains a card at the carboxyl terminus,a pyrin domain at N-terminus,a putative nucleotide binding site（YACHT or NACHT） and a putative regulatory domain containing multiple leucine-rich repeats（lRR）.Card7 regulates apoptosis and inflammatory *** loss is a key feature of both familial and sporadic *** share similar programmed cell death pathways with other mammalian cell *** containing the death domain,such as members of CARD family of proteins including Card7,play a pivotal role in signaling events that regulate *** study suggested that overexpression of card7 in Hela cells and primary cerebellar granule neurons enhanced caspase-3 activity and induced *** further confirm the interaction of Card7 with lRRK2,card7 and lRRK2 were co-transfected into HEK293T *** found that Card7 co-immunopercipated with both wild type and mutant *** PD-linked mutant G2019S-lRRK2 increased Card7 interaction with ***,co-immunocytochemical studies of HEK293T cells co-expressing Card7 and lRRK2 showed that both proteins expressed in cytosol and partially co-localization with *** map the Card7 binding domain with lRRK2,we co-transfected various Card7 truncated constructs with ***2 predominantly interacted with YACHT and lRR domain of *** explore the role of ca

关键词： lRRK2 Card7 toxicity protein interaction

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land use and dingo baiting are correlated with the density of kangaroos in rangeland systems

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Integrative Zoology 2023年第2期18卷 299-315页

作者： Stuart J.dawson Tracey l.KREPlINS Malcolm S.KENNEDY Juanita RENWICK Mark A.COWAN Patricia A.FlEMING Terrestrial Ecosystem Science and Sustainability Harry Butler InstituteMurdoch UniversityMurdochAustralia Department of Primary Industries and Regional Development(present address) South PerthAustralia Department of Primary Industries and Regional Development NorthamAustralia Queensland Department of Environment and Science Australia Queensland Department of Environment and Science MoggillAustralia Department of Biodiversity Conservation and AttractionsWoodvaleAustralia

Rangelands worldwide have been subject to broadscale modiﬁcation,such as widespread predator control,intro-duction of permanent livestock water and altered vegetation to improve *** Australia,these landscape changes have resulted in kangaroos(*** macropods)populations increasing over the past 200 ***-garoos are a key contributor to total grazing pressure and in conjunction with livestock and feral herbivores have been linked to land *** used 22 years of aerial survey data to investigate whether the density of 3 macropod species in the southern rangelands of Western Australia was associated with:(i)land use,including type of livestock,total livestock,density of feral goats,type of land tenure,and kangaroo commercial harvest effort;(ii)predator management,including permitted dingo control effort,estimated dingo abundance,and presence of the State Barrier Fence(a dingo exclusion fence);and(iii)environmental variables:ruggedness,rainfall,fractional cover,and total standing dry *** kangaroos(Osphranter rufus)were most abundant inﬂat,open vegetation,on pastoral land,where area permitted for dingo control was high,and numbers were positively associated with antecedent rainfall with a 12-month *** grey kangaroos(Macropus fuliginosus)were most abundant onﬂat,agricultural land,but less abundant in areas with high permitted dingo ***(Osphranter robustus)were most abundant in rugged pastoral land with open vegetation,where permitted dingo control was *** environmental variables are key drivers of landscape productivity and kangaroo populations,anthropogenic factors such as land use and permitted dingo control are strongly associated with kangaroo abundance.

关键词： herbivores livestock macropods overgrazing rangelands total grazing pressure

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纺织品喷墨印花(二)——墨滴形成和喷射原理及纺织品喷墨印花的发展

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印染 2005年第2期31卷 41-42,51页

作者： T l dawson 英国独立顾问

6 DOD喷墨印花机液滴的形成6.1喷嘴口显然,油墨喷射管道的出口尺寸和形状起着重要作用,决定了液滴的大小/体积、速度、射出的角度和墨滴形成的密度.喷管壁最常用的材料是镀镍(以获得一种收敛的锥形孔)或放电加工或微穿孔的不锈钢(一种... 详细信息

6 DOD喷墨印花机液滴的形成6.1喷嘴口显然,油墨喷射管道的出口尺寸和形状起着重要作用,决定了液滴的大小/体积、速度、射出的角度和墨滴形成的密度.喷管壁最常用的材料是镀镍(以获得一种收敛的锥形孔)或放电加工或微穿孔的不锈钢(一种柱形的孔).近期,为了满足小液滴的趋势,广泛应用了聚酰亚胺薄层的准分子激光刻蚀加工.

关键词：喷射印花数码机理印花机发展

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纺织品喷墨印花(一)——墨滴形成和喷射原理及纺织品喷墨印花的发展

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印染 2005年第1期31卷 46-48页

作者： T l dawson

综述用于纺织品的喷墨印花机的发展。介绍各类喷墨印花机 ,如连续喷墨、压电喷墨和热泡喷墨各系统喷头结构及各自液滴的特征 ;分析了在DOD喷墨花机中液滴形成的过程以及喷射在纺织品上的效果。最后 ,展望了数码喷墨印花的发展前景 ,以... 详细信息

综述用于纺织品的喷墨印花机的发展。介绍各类喷墨印花机 ,如连续喷墨、压电喷墨和热泡喷墨各系统喷头结构及各自液滴的特征 ;分析了在DOD喷墨花机中液滴形成的过程以及喷射在纺织品上的效果。最后 ,展望了数码喷墨印花的发展前景 ,以及其它数码技术 ,如静电印刷术、电子照相术用于纺织工业的可行性。

关键词：喷射印花数码机理印花机发展

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Cloning and expression of SlC10A4,a putative organic anion transport protein

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World Journal of Gastroenterology 2006年第42期12卷 6797-6805页

作者： Patrick l Splinter Konstantinos N lazaridis Paul A dawson Nicholas F laRusso The Center for Basic Research in Digestive Disease Division of Gastroenterology and Hepatology Mayo Medical School Clinic and Foundation Rochester Minnesota 55905 United States Department of Internal Medicine-Gastroenter-ology Wake Forest University School of Medicine Winston-Salem North Carolina 27157 United States

AIM: To determine if novel bile acid transporters may be expressed in human tissues. METHODS: SlC10A1 (NTCP) was used as a probe to search the NCBI database for homology to previously uncharacterized ESTs. The homology search identified an EST (termed SlC10A4) that shares sequence identity with SlC10A1 and SlC10A2 (ASBT). We performed Northern blot analysis and RT-PCR to determine the tissue distribution of SlC10A4. SlC10A4 was cloned in frame with an epitope tag and overexpressed in CHO cells to determine cellular localization and functional analysis of bile acid uptake. RESUlTS: Northern analysis revealed that SlC10A4 mRNA is ubiquitously expressed in human tissues with the highest levels of mRNA expression in brain, placenta, and liver. In SlC10A4-transfected CHO cells, immunoblotting analysis and immunofluorescence staining demonstrated a 49-kDa protein that is expressed at the plasma membrane and intracellular compartments. Functional analysis of SlC10A4 showed no significant taurocholate uptake in the presence of sodium when compared to untransfected CHO cells. CONClUSION: To date, we have shown that this protein has no capacity to transport taurocholate relative to SlC10A1; however, given its ubiquitous tissue distribution, it may play a more active role in transporting other endogenous organic anions.

关键词： SlC10A4 Bile acid transport Biliaryepithelium Taurocholate Plasma membrane

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Physician versus Patient Perception of Physician Hospital Discharge Communication: A Preliminary Study

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Open Journal of Internal Medicine 2014年第4期4卷 101-107页

作者： Michael J. Maniaci Michael G. Heckman Nancy l. dawson Division of Hospital Internal Medicine Mayo Clinic Jacksonville USA The Biostatistics Unit Mayo Clinic Jacksonville USA

Background: Physician discharge instructions are critical to patient care because they are the link transitioning the hospital care plan to the home. We hypothesize that physician perception of discharge instructions communication is better than patient perception. Objective: In a preliminary study, to compare patient and physician perception of communication at discharge. Design: Observational, survey-based. Setting: 330-bed adult teaching hospital. Participants: Surveys were mailed to 100 patients discharged home and 49 internal medicine physicians responsible for those patients’ care. Each physician had between 1 and 4 patients surveyed. Measurements: Patients and physicians received anonymous 5-item questionnaires concerning physician communication at discharge. Patient surveys inquired about their physicians’ communication at the specific physician encounter, while physician surveys asked about the physicians’ overall self-perception of discharge communication skills. Results: Completed questionnaires were returned by 59 patients and 40 physicians. Physicians reported a noticeably better perception of communication than their patients regarding spending adequate time reviewing the discharge plan (83% vs. 61%, P = 0.027), speaking slowly enough to understand (98% vs. 80%, P = 0.013), using wording that could be easily understood (100% vs. 68%, P P = 0.008). Perception of discharge communication improved with physician experience for several survey items. Conclusions: This study provides evidence suggesting that physician perception of communication at discharge is better than patient perception. Future studies of larger sample size and direct patient-physician pairing focusing on patient satisfaction and outcomes are needed.

关键词： Communication Patient Discharge Questionnaire

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Erbium-doped TeO2-coated Si3N4 waveguide amplifiers with 5 dB net gain

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Photonics Research 2020年第2期8卷 127-134页

作者： HENRY C.FRANKIS HAMIDU M.MBONDE dawson B.BONNEVIllE CHENGlIN ZHANG RICHARD MATEMAN ARNE lEINSE JONATHAN D.B.BRADlEY Department of Engineering Physics Mc Master UniversityHamilton L8S 4L7Canada lioni X International BV Enschede AL 7500The Netherlands

We demonstrate 5dB net gain in an erbium-doped tellurium-oxide-coated silicon nitride *** amplifier design leverages the high refractive index and high gain in erbium-doped tellurite glass as well as the ultralow losses and mature,reliable,and low-cost fabrication methods of silicon nitride waveguide *** show that the waveguide platform demonstrates low background propagation losses of 0.25dB/cm based on a ring resonator device with a Q factor of 1.3×10^6 at 1640 *** measure 5dB peak net gain at 1558 nm and>3dB of net gain across the C band in a 6.7 cm long waveguide for 35 m W of launched 1470 nm pump *** per unit length of 1.7 and 1.4dB/cm is measured in a 2.2 cm long waveguide for 970 and 1470 nm pump wavelengths,*** simulations predict that>10dB gain can be achieved across the C band simply by optimizing waveguide length and fiber-chip *** results demonstrate a promising approach for the monolithic integration of compact erbium-doped waveguide amplifiers on silicon nitride chips and within silicon-based photonic integrated circuits.

关键词： waveguide pump amplifiers

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