检索结果-南通市图书馆

Change of photosensitizer fluorescence at its diffusion in viscous liquid flow

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health sciences 2016年第2期9卷 25-30页

作者： valeriya s.Maryakhina vyacheslav v.Gun'kov Orenburg state University 13 Pobedy st. Orenburg 460018Russia

In this paper,the mathematical model of distribution of the injected compound in biological liquid flow has been *** is considered that biological liquid contains a few phases such as water,peptides and *** injected compound(for example,photosensitizer)can interact with peptides and *** the time,viscosity of the biological liquid depends on pathology present in *** obtained distribution of the compound connects on changes of its fluorescence spectra which are registered during fluorescent diagnostics of *** is obtained that the curves do not have monotonic *** is a sharp curves decline in the first few seconds after *** of curves rises after *** is especially pronounced for wavelength 590 nm and 580 nm(near the"transparency window"of biological tissues).Time of inflection point shifts from 8.4 s to 6.9 s for longer ***,difference between curves is little for di®erent viscosity means of the biological ***,additional pathology present in organism does not impact to the results of in vivo biomedical investigations.

关键词： Fluorescence diffusion biomedical diagnostics photosensitizer viscosity

Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第4期15卷 586-596页

作者： Alisa A.shaimardanova valeriya v.s.lovyeva Daria s.Chulpanova victoria James Kristina v.Kitaeva Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia shemyakin-Ovchinnikov Institute of Bioorganic Chemistry The Russian Academy of SciencesMoscowRussia school of veterinary Medicine and science University of NottinghamSutton Bonington CampusLeicestershireUK

Extracellular vesicles,including exosomes and microvesicles,play a fundamental role in the activity of the nervous system,participating in signal transmission between neurons and providing the interaction of central nervous system with all body *** many neurodegenerative diseases,neurons pack toxic substances into vesicles and release them into the extracellular space,which leads to the spread of misfolded neurotoxic *** contents of neuron-derived extracellular vesicles may indicate pathological changes in the central nervous system,and the analysis of extracellular vesicle molecular content contributes to the development of non-invasive methods for the diagnosis of many central nervous system *** vesicles of neuronal origin can be isolated from various biological fluids due to their ability to cross the blood-brain ***,the diagnostic potential of almost all toxic proteins involved in nervous system disease pathogenesis,specificallyα-synuclein,tau protein,superoxide dismutase 1,FUs,leucine-rich repeat kinase 2,as well as some synaptic proteins,has been well *** attention is paid to extracellular RNAs mostly associated with extracellular vesicles,which are important in the onset and development of many neurodegenerative *** on parental cell type,extracellular vesicles may have different therapeutic properties,including neuroprotective,regenerative,and *** to nano size,biosafety,ability to cross the blood-brain barrier,possibility of targeted delivery and the lack of an immune response,extracellular vesicles are a promising vehicle for the delivery of therapeutic substances for the treatment of neurodegenerative diseases and drug delivery to the *** review describes modern approaches of diagnosis and treatment of central nervous system diseases using extracellular vesicles.

关键词： biomarkers cell-mediated therapy central nervous system diseases diagnosis exosomes extracellular RNAs extracellular vesicles microRNAs microvesicles neurodegenerative diseases

Genotypic diversity and genotype identity of resident species drive community composition

在线全文

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2020年第2期13卷 224-232页

作者： věroslava Hadincová Hana skálová Zuzana Münzbergová Department of Population Ecology Institute of BotanyAcademy of Sciences of the Czech RepublicCzech Republic Department of Botany Faculty of ScienceCharles UniversityCzech Republic Department of Invasion Ecology Institute of BotanyAcademy of Sciences of the Czech RepublicCzech Republic

Aims species-rich plant communities are more resistant to *** the past decade it was demonstrated that genetic variation also has many ecological *** our study we aimed to test whether the patterns of response to the genetic diversity of a resident species differ between colonizing species of different growth forms and whether the response is affected by soil *** We established experimental stands of a common grass,Festuca rubra,harbouring three levels of genetic diversity(1,6 or 18 clonal genotypes,referred to as genotypic diversity)under two soil nutrient *** the fourth year after the stands were established,we sowed a mixture of four colonizers into the stands:a stoloniferous legume(Trifolium repens),a broad-leaf tussock grass(Anthoxanthum odoratum),a largerosette forb(Plantago lanceolata)and a small-rosette forb(Campanula rotundifolia).We observed species establishment and growth over 3 *** tested whether colonization success depended on genotypic diversity,specific Festuca genotypes,soil nutrients and colonizer growth *** Findings The colonization success and biomass of the colonizers were significantly affected by the genotypic diversity and the genotype identity of the resident clonal *** response,however,differed between the *** strongest response to the genotypic diversity of the resident species was observed in the tussock grass with a growth form and architecture similar to the resident *** large-rosette species responded in early stages of growth whereas the stoloniferous legume did not respond at *** intraspecific genotypic diversity and genotype identity of the resident species play an important role in the assembly of plant communities.

关键词： clonal grass biodiversity effects colonization

Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第1期17卷 122-129页

作者： Alisa A.shaimardanova Daria s.Chulpanova valeriya v.s.lovyeva Aleksandr M.Aimaletdinov Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia

Tay-sachs disease and sandhoff disease are severe hereditary neurodegenerative disorders caused by a deficiency ofβ-hexosaminidase A(HexA)enzyme,which results in the accumulation of GM2 gangliosides in the nervous system *** this work,we analyzed the efficacy and safety of cell-mediated gene therapy for sandhoff disease and sandhoff disease using a bicistronic lentiviral vector encoding cDNA of HexAα-andβ-subunit genes separated by the nucleotide sequence of a P2A peptide(HEXA-HEXB).The functionality of the bicistronic construct containing the HEXA-HEXB genetic cassette was analyzed in a culture of HEK293T cells and human umbilical cord blood mononuclear cells(hUCBMCs).Our results showed that the enzymatic activity of HexA in the conditioned medium harvested from genetically modified HEK293T-HEXA-HEXB and hUCBMCs-HEXA-HEXB was increased by 23 and 8 times,respectively,compared with the conditioned medium of native *** blot analysis showed that hUCBMCs-HEXA-HEXB secreted both completely separated HEXA and HEXB proteins,and an uncleaved protein containing HEXA+HEXB linked by the P2A *** injection of genetically modified hUCBMCs-HEXA-HEXB to laboratory Wistar rats was carried out,and the HexA enzymatic activity in the blood plasma of experimental animals,as well as the number of live cells of immune system organs(spleen,thymus,bone marrow,lymph nodes)were determined.A significant increase in the enzymatic activity of HexA in the blood plasma of laboratory rats on days 6 and 9(by 2.5 and 3 times,respectively)after the administration of hUCBMCsHEXA-HEXB was *** the same time,the number of live cells in the studied organs remained ***,the functionality of the bicistronic genetic construct encoding cDNA of the HEXA and HEXB genes separated by the nucleotide sequence of the P2A peptide was shown in vitro and in *** hypothesize that due to the natural ability of hUCBMCs to overcome biological barriers,such a strategy can rest

关键词： bicistronic vector cell-mediated gene therapy GM2 gangliosidosis P2A peptide sandhoff disease Tay-sachs disease umbilical cord blood mononuclear cells β-hexosaminidase

Features of structure of external layer of murine hair at different stages of malignant tumor development

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health sciences 2015年第3期8卷 3-8页

作者： valeriya s.Maryakhina Larisa s.scheglova Ksenia A.Anenkova Institute of Micro-and Nanotechnologies Orenburg state University 13 Pobedy st. Orenburg 460018Russia Molecular Physics Department M.v.Lomonosov Moscow state University 1 Leninskiye Gory Moscow 119991Russia

In the paper,the results of experimental investigations on the diferences of wool structure ofhealthy mice and mice with malignant tumor(s)are *** is shown that destruction ofwool structure happens during pathology *** of cells of external wool layerand their thickness decrease when the tumor capsule *** is seen even when thetumor is *** obtained results can be used to improve optical techniques of biomedicaldiagnostics of cancer diseases.

关键词： Breast cancer hair optical biomedical diagnost ics atomic force microscopy dynamiclight scattering

Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová sushil Kumar singh vojtech vozda Ludek vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal sam M.vinko Alessandro Forte Thomas Gawne Thomas Campbell shenyuan Ren YuanFeng shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand sven Toleikis Katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of surface and Plasma science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DEsY Photon science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLAsH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

Facile synthesis of Amino Acid Decorated Water-soluble Fullerene Derivatives with Anti-influenza Activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第15期41卷 1803-1808页

作者： valeriya s.Bolshakova Ekaterina O.sinegubova Yana L.Esaulkova Alexander s.Peregudov Ekaterina A.Khakina Nikita A.slesarenko Alexander F.shestakov vladimir v.Zarubaev Pavel A.Troshin Olga A.Kraevaya Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of RAs Academician Semenov ave.1Chernogolovka142432Russia Higher Chemical College of RAs D.1.Mendeleev University of Chemical Technology of RussiaMiusskaya square 9Moscow125047Russia st.Petersburg Pasteur Institute Mira st.14St.Petersburg197101Russia A.N.Nesmeyanov Institute of Organoelement compounds of RAs Vavylova St.28B-334Moscow119991Russia National Research University Higher school of Economics Vavylova St.7Moscow101000Russia Department of Fundamental Physics&Chemical Engineering M.V.Lomonosov Moscow State UniversityLeninskie Gory 1/51Moscow119991Russia Zhengzhou Research Institute Harbin Institute of TechnologyLongyuan East 7th 26Jinshui DistrictZhengzhouHenan 450003China Harbin Institute of Technology West Dazhi Street 92Nan Gang DistrictHarbinHeilongjiang 150001China

Comprehensive summary Herein,we present a facile synthesis of amide-type water-soluble fullerene derivatives decorated with five residues of amino *** compared to the previously developed approaches,the proposed method enables usage of a broad range of amino acids,including those unstable under Friedel-Crafts reaction ***,it is fully tolerant to the nature of the sixth addend X in C60R5X precursor compounds and allows one to obtain fullerene derivatives with X=Cl,H,*** synthesized amide-type water-soluble fullerene derivatives demonstrated promising antiviral activities against rimantadine-resistant influenzaА/Puerto Rico/8/34(Н1N1)virus in vitro.

关键词： Fullerenes Amino acids Regioselectivity Water-solublel Influenza Antiviral

solar-driven CO_(2) conversion to methane and methanol using different nanostructured Cu_(2)O-based catalysts modified with Au nanoparticles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini Lilian D.Moura Torquato Juliana Fde Brito Gustavo A.Andolpho Mateus A.Gonçalves Leonardo D.De Angelis Lucas D.Germano susana I.Córdoba de Torresi Teodorico C.Ramalho Maria v.Boldrin Zanoni são Paulo state University(UNEsP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of Molecular Modelling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil Department of Chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto de Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work describes the use of TiO_(2)nanotubes-based electrodes(TNT)modified with Cu_(2)O nanostructures and gold nanoparticles for the photoelectroreduction of CO_(2)to produce value-added compounds.A thin layer of polydopamine was used as both an adherent agent and an electron transfer mediator,due to itsπ-conjugated electron *** highest production yield was achieved using a TNT@PDA/Nc/Au40%electrode,with Faradaic efficiencies of 47.4%(110.5μM cm^(-2))and 27.8%(50.4μM cm^(-2))for methanol and methane,*** performance of the photoelectrodes was shown to be Cu_(2)O facet-dependent,with cubic structures leading to greater conversion of CO_(2)to methanol(43%)and methane(27%),compared to the octahedral morphology,while a higher percentage of metallic gold on the nanostructured Cu_(2)O surface was mainly important for *** functional theory(DFT)calculations supported these findings,attributing the superior photoelectrocatalytic performance of the TNT@PDA/Nc/Au40%electrode for CH4generation to the formation of an OCH3intermediate bonded to Au *** using isotope-labeling and analysis by gas chromatograph-mass(GC-Ms)demonstrated that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and13CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polydopamine CO_(2) photoelectroreduction DFT calculations

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 Tev with the ATLAs detector

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht s.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.s. Acharya C. Adam Bourdarios L. Adamczyk s.v. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.s. Ahmed s. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.v. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy s. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali s. Ali s.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei s.P. Amor Dos santos K.R. Amos v. Ananiev C. Anastopoulos T. Andeen J.K. Anders s.Y. Andrean A. Andreazza s. Angelidakis A. Angerami A.v. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal s.J. Arbiol val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin s. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai s. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos s. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten s. Auricchio A.D. Auriol v.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey v.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta v. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay s. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-s. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAs Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAs Collaboration,using √s=13 Tev proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAs *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 Gev and 2 Tev and for multiple tagger working points.

关键词： ATLAs JET QUARK GLUON TAGGING