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A Three-Dimensional Multi-scale Plasticity Model for Metal-Intermetallic Laminate Composites Containing Phases of the L12 Structure

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Acta Metallurgica Sinica(English Letters) 2018年第12期31卷 1265-1271页

作者： Yana D.Lipatnikova vladimir A.Starenchenko Yuliya v.solov'eva Larisa A.valuiskaya Tomsk State University of Architecture and Building Solyanaya Sq.2TomskRussia 634003 Siberian State Medical University 2 Moskovsky traktTomskRussia 634055

A three-dimensional plasticity model was developed and applied to metal-intermetallic laminate composites containingphases of the L12 structure. A multi-scale approach that combined the methods of continuum mechanics and dislocationkinetics was used. This model takes account of the different mechanisms of self-locking superdislocations, the dislocationsand the dislocation walls＇ density storage for each type of layer at the micro-scale. At the meso-scale, the solutions to thedislocation kinetics equations, in the form of stress-strain curves, were used to create the properties of a three-dimensionalrepresentative element. The numerical simulation study of the macroscopic deformation was carried out with the finiteelement method using the dynamic model of continuum mechanics, which included the classical conservation laws,constitutive equations and the equation of state. It was shown that the simulation results generated using this model were ingood agreement with the mechanical tests conducted on the single crystals of the L12 structure. The model provides anexcellent description of the high-temperature plastic strain superlocalization effect of single crystal intermetallics of theLI2 structure. This paper describes the numerical results of the study of the tension and compression tests of metal-intermetallic laminate composites containing phases of the L12 structure. The model allows the description of the dis-tribution of the accumulated plastic strain inhomogeneities and is capable of predicting the strengthening properties andplastic behaviour of the metal-intermetallic laminate composites containing phases of the L12 structure.

关键词： Plasticity model Metal-intermetallic laminate composites Layered composites L12 structure Tension Compression

Neuromorphic nanocluster networks:Critical role of the substrate in nano-link formation

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Nano Research 2023年第7期16卷 10500-10506页

作者： Wenkai Wu Alexey v.verkhovtsev Theodoros Pavloudis Andrey v.solov’yov Richard E.Palmer Nanomaterials Lab Faculty of Science and EngineeringSwansea UniversityBay CampusFabian WaySA18ENSwanseaUK MBN Research Center Altenhöferallee 360438 Frankfurt am MainGermany School of Physics Faculty of SciencesAristotle University of ThessalonikiGR-54124 ThessalonikiGreece

Atomic cluster-based networks represent a promising architecture for the realization of neuromorphic computing systems,which may overcome some of the limitations of the current computing *** formation and breakage of links between the clusters are of utmost importance for the functioning of these computing *** paper reports the results of molecular dynamics simulations of synapse(bridge)formation at elevated temperature and thermal breaking processes between 2.8 nmsized Au1415 clusters deposited on a carbon substrate,a model ***,we find that the bridge formation process is driven by the diffusion of gold atoms along the substrate,no matter how small the gap between the clusters *** complementary simulations of the bridge breaking process reveal the existence of a threshold bias voltage to activate bridge rupture via Joule *** results provide an atomistic-level understanding of the fundamental dynamical processes occurring in neuromorphic cluster arrays.

关键词： atomic-switch network nanoclusters nanoparticles(NPs) clusters on surfaces synapse neuromorphics molecular dynamics(MD)

Change of photosensitizer fluorescence at its diffusion in viscous liquid flow

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Journal of Innovative Optical Health Sciences 2016年第2期9卷 25-30页

作者： valeriya S.Maryakhina vyacheslav v.Gun'kov Orenburg State University 13 Pobedy st. Orenburg 460018Russia

In this paper,the mathematical model of distribution of the injected compound in biological liquid flow has been *** is considered that biological liquid contains a few phases such as water,peptides and *** injected compound(for example,photosensitizer)can interact with peptides and *** the time,viscosity of the biological liquid depends on pathology present in *** obtained distribution of the compound connects on changes of its fluorescence spectra which are registered during fluorescent diagnostics of *** is obtained that the curves do not have monotonic *** is a sharp curves decline in the first few seconds after *** of curves rises after *** is especially pronounced for wavelength 590 nm and 580 nm(near the"transparency window"of biological tissues).Time of inflection point shifts from 8.4 s to 6.9 s for longer ***,difference between curves is little for di®erent viscosity means of the biological ***,additional pathology present in organism does not impact to the results of in vivo biomedical investigations.

关键词： Fluorescence diffusion biomedical diagnostics photosensitizer viscosity

Septic arthritis of the hand:Current issues of etiology,pathogenesis,diagnosis,treatment

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World Journal of Orthopedics 2022年第7期13卷 622-630页

作者： Konstantin v Lipatov Arthur Asatryan George Melkonyan Aleksandr D Kazantcev Ekaterina I solov'eva Urii E Cherkasov Department of General Surgery Institute of Clinical Medicine named after N.V.SklifosovskySechenov First Moscow State Medical University(Sechenov University)Moscow 119021Russia Wound and Wound Infection Surgery State Budgetary Institution“City Clinical Hospital named after S.S.Yudin of Moscow Healthcare Department”Moscow 115446Russia Department of General Surgery Physician of The Hospital for War Veterans No 3Moscow 129336Russia Department of General Surgery I.M.Sechenov First Moscow State Medical UniversityMoscow 119048Russia

Septic arthritis of the hand is a serious disease that often results in dysfunction of the joint or even the need to perform amputation of the *** rank second in the frequency of occurrence after lesions of the knee *** points concerning the etiology,the timing of the development of cartilage destruction and the development of osteomyelitis,approaches to surgical treatment,the duration of antibiotic therapy,and the start of rehabilitation measures remain the subject of numerous *** on a search in the PubMed,Web of Science and Google Scholar databases down to 1990-2021,publications on septic arthritis of the hand were found and *** following inclusion criteria were used in our review:(1) Septic arthritis of the hand;(2) Published in a peer review journal;(3) Written in English;and(4) Full text version *** were excluded if they met any of the following criteria:(1) Letters;(2) Articles published in abstract form only;and(3) Cadaveric *** arthritis of the hand was characterized by the most frequent damage to the joints of the index and middle fingers(> 50% of cases).Up to 90% of cases,the infection enters the joint as a result of penetrating trauma,animal bites,*** aureus became the most frequently isolated microorganism(30%-55%),and its polyantibiotic-resistant form Methicillin-resistant Staphylococcus aureus was found,according to various sources,from 0% to 73% among all isolated Staphylococcus *** arthritis,Pasteurella multocida(6%-11%) is often isolated as a result of animal *** cartilage destruction in the experiment developed within 24-48 h after *** clinical studies,the development of osteomyelitis was noted when treatment was delayed by more than 10 d.X-ray data during the first two weeks were *** of surgical treatment of septic *** and surgical treatment,and with the development of osteomyelitis,the implementation of arthro

关键词： Septic arthritis Hand Staphylococcus aureus Metacarpophalangeal joint Interphalangeal joint Rehabilitation

Effectiveness of negative pressure wound therapy in complex surgical treatment of necrotizing fasciitis of the upper limb

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World Journal of Orthopedics 2024年第11期15卷 1015-1022页

作者： Konstantin v Lipatov Arthur Asatryan George Melkonyan Aleksandr D Kazantcev Ekaterina I solov’eva Denis v Krivikhin Irina v Gorbacheva Urii E Cherkasov Department of General Surgery Institute of Clinical Medicine named after N.V.SklifosovskySechenov First Moscow State Medical University(Sechenov University)Moscow 119021Russia Department of General Surgery Wound and Wound Infection SurgeryState Budgetary Institution“City Clinical Hospital named after S.S.Yudin of Moscow Healthcare Department”Moscow 115446Russia Department of General Surgery Physician of The Hospital for War Veterans No 3Moscow 129336Russia Department of General Surgery I.M.Sechenov First Moscow State Medical UniversityMoscow 119048Russia

BACKGROUND Necrotizing fasciitis(NF)of the upper extremities is a severe surgical pathology,and the incidence of this disease has been steadily increasing in recent *** treatment is accompanied by the formation of extensive wounds,which can be treated with significant *** recent years,negative pressure wound therapy(NPWT)has proven to be highly *** is also promising for the treatment of *** To explore the effectiveness of NPWT in the treatment of NF of the upper *** The results of the treatment of 36 patients with NF of the upper extremities in two groups(NPWT group and control group;2022−2023)were retrospectively *** the NPWT group,the NPWT method(120 mmHg;constant mode)was used after surgical *** number of vacuum-assisted dressings in patients ranged from 1 to 3,depending on the dynamics of the wound *** duration of fixation of one bandage was up to 2−3 *** the control group,conventional methods of local wound treatment were *** following indicators were analyzed:The treatment delay,the prevalence of inflammation,the microbial landscape,the number of debridements,the duration of wound preparation for surgical closure,and the nature of skin plastic *** Most patients experienced a significant treatment delay[4 d,interquartile range(IQR):2–7 d],which led to the spread of the pathological process to the forearm and *** most common pathogens were Staphylococcus aureus(14;38.9%)and Streptococcus pyogenes(22;61.1%).The average number of debridements per patient was 5(IQR:3–7),with no difference between *** average time to prepare wounds for surgical closure was 11±4 d in the NPWT group and 29±10 d(P=0.00001)in the control *** the NPWT group,the wounds were more often closed with local tissues(15;83.3%),and in the control group,split-thickness skin grafts were more often used(4;50%).CONCLUSION The predominant isolation of Staphylococcus aureus and/or Strep

关键词： Necrotizing fasciitis Upper limb Negative pressure wound therapy vacuum-assisted closure Surgical treatment

Septic arthritis of the hand: From etiopathogenesis to surgical treatment

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World Journal of Orthopedics 2022年第11期13卷 993-1005页

作者： Konstantin v Lipatov Arthur Asatryan George Melkonyan Aleksandr D Kazantcev Ekaterina I solov’eva Irina v Gorbacheva Alexander S vorotyntsev Andrey Y Emelyanov General Surgery Department Institute of Clinical Medicine named after N.V.SklifosovskySechenov First Moscow State Medical University(Sechenov University)Moscow 119021Russia General Surgery Department State Budgetary Institution“City Clinical Hospital named after S.S.Yudin of Moscow Healthcare Department”Moscow 115142Russia General Surgery Department The Hospital for War Veterans N3Moscow 129336Russia General Surgery Department I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia

BACKGROUND Septic arthritis of the hand,which is the second most common after damage of the knee joint,remains one of the leading causes of temporary *** inflammation can cause dysfunction of the joint,and in the most severe cases,the need for amputation of the finger may *** results of their treatment today,especially from a functional point of view,cannot be considered *** surgical treatment is extremely important in septic arthritis of the hand,as it helps to prevent cartilage destruction and the development of *** To explore the features of the course of septic arthritis of the hand as well as approaches to surgical treatment and its results,depending on the nature of the damage to the articular *** The results of the treatment of 170 patients with septic arthritis of the hand,which were treated in the period of 2020-2021,were *** of the interphalangeal and metacarpophalangeal joints(MCP)of fingers 1,2,and 3 was more often noted in 147(81.6%)*** most common cause of arthritis was a penetrating injury as a result of household trauma(101,59.4%),animal bite(30,17.6%),and clenched fist injury(15,8.8%).Septic arthritis with contiguous osteomyelitis was observed in 98(54.4%)*** treatment was completed with drainage and irrigation of the *** mobilization was used to restore *** patients with osteomyelitis,it was aimed at the formation of *** was not ***-term results of treatment were assessed in 142(83.5%)patients within 1 mo to 12 mo after discharge from the hospital[the median was 7 mo(IQR:4-9)].RESULTS The most commonly isolated organism was Staphylococcus aureus(35.3%).The median treatment delay in patients without osteomyelitis was 5 d(IQR:4-7);for septic arthritis with contiguous osteomyelitis,it was 14 d(IQR:5-21).Radiography for osteomyelitis within 2 wk was uninformative:41.2%of diagnoses.A single surgical treatment was

关键词： Septic arthritis Osteomyelitis Hand Surgical treatment Neoarthrosis

Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

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Neural Regeneration Research 2020年第4期15卷 586-596页

作者： Alisa A.Shaimardanova valeriya v.solovyeva Daria S.Chulpanova victoria James Kristina v.Kitaeva Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry The Russian Academy of SciencesMoscowRussia School of veterinary Medicine and Science University of NottinghamSutton Bonington CampusLeicestershireUK

Extracellular vesicles,including exosomes and microvesicles,play a fundamental role in the activity of the nervous system,participating in signal transmission between neurons and providing the interaction of central nervous system with all body *** many neurodegenerative diseases,neurons pack toxic substances into vesicles and release them into the extracellular space,which leads to the spread of misfolded neurotoxic *** contents of neuron-derived extracellular vesicles may indicate pathological changes in the central nervous system,and the analysis of extracellular vesicle molecular content contributes to the development of non-invasive methods for the diagnosis of many central nervous system *** vesicles of neuronal origin can be isolated from various biological fluids due to their ability to cross the blood-brain ***,the diagnostic potential of almost all toxic proteins involved in nervous system disease pathogenesis,specificallyα-synuclein,tau protein,superoxide dismutase 1,FUS,leucine-rich repeat kinase 2,as well as some synaptic proteins,has been well *** attention is paid to extracellular RNAs mostly associated with extracellular vesicles,which are important in the onset and development of many neurodegenerative *** on parental cell type,extracellular vesicles may have different therapeutic properties,including neuroprotective,regenerative,and *** to nano size,biosafety,ability to cross the blood-brain barrier,possibility of targeted delivery and the lack of an immune response,extracellular vesicles are a promising vehicle for the delivery of therapeutic substances for the treatment of neurodegenerative diseases and drug delivery to the *** review describes modern approaches of diagnosis and treatment of central nervous system diseases using extracellular vesicles.

关键词： biomarkers cell-mediated therapy central nervous system diseases diagnosis exosomes extracellular RNAs extracellular vesicles microRNAs microvesicles neurodegenerative diseases

Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses

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Neural Regeneration Research 2022年第1期17卷 122-129页

作者： Alisa A.Shaimardanova Daria S.Chulpanova valeriya v.solovyeva Aleksandr M.Aimaletdinov Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia

Tay-Sachs disease and Sandhoff disease are severe hereditary neurodegenerative disorders caused by a deficiency ofβ-hexosaminidase A(HexA)enzyme,which results in the accumulation of GM2 gangliosides in the nervous system *** this work,we analyzed the efficacy and safety of cell-mediated gene therapy for Sandhoff disease and Sandhoff disease using a bicistronic lentiviral vector encoding cDNA of HexAα-andβ-subunit genes separated by the nucleotide sequence of a P2A peptide(HEXA-HEXB).The functionality of the bicistronic construct containing the HEXA-HEXB genetic cassette was analyzed in a culture of HEK293T cells and human umbilical cord blood mononuclear cells(hUCBMCs).Our results showed that the enzymatic activity of HexA in the conditioned medium harvested from genetically modified HEK293T-HEXA-HEXB and hUCBMCs-HEXA-HEXB was increased by 23 and 8 times,respectively,compared with the conditioned medium of native *** blot analysis showed that hUCBMCs-HEXA-HEXB secreted both completely separated HEXA and HEXB proteins,and an uncleaved protein containing HEXA+HEXB linked by the P2A *** injection of genetically modified hUCBMCs-HEXA-HEXB to laboratory Wistar rats was carried out,and the HexA enzymatic activity in the blood plasma of experimental animals,as well as the number of live cells of immune system organs(spleen,thymus,bone marrow,lymph nodes)were determined.A significant increase in the enzymatic activity of HexA in the blood plasma of laboratory rats on days 6 and 9(by 2.5 and 3 times,respectively)after the administration of hUCBMCsHEXA-HEXB was *** the same time,the number of live cells in the studied organs remained ***,the functionality of the bicistronic genetic construct encoding cDNA of the HEXA and HEXB genes separated by the nucleotide sequence of the P2A peptide was shown in vitro and in *** hypothesize that due to the natural ability of hUCBMCs to overcome biological barriers,such a strategy can rest

关键词： bicistronic vector cell-mediated gene therapy GM2 gangliosidosis P2A peptide Sandhoff disease Tay-Sachs disease umbilical cord blood mononuclear cells β-hexosaminidase

Features of structure of external layer of murine hair at different stages of malignant tumor development

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 3-8页

作者： valeriya S.Maryakhina Larisa S.Scheglova Ksenia A.Anenkova Institute of Micro-and Nanotechnologies Orenburg State University 13 Pobedy st. Orenburg 460018Russia Molecular Physics Department M.v.Lomonosov Moscow State University 1 Leninskiye Gory Moscow 119991Russia

In the paper,the results of experimental investigations on the diferences of wool structure ofhealthy mice and mice with malignant tumor(s)are *** is shown that destruction ofwool structure happens during pathology *** of cells of external wool layerand their thickness decrease when the tumor capsule *** is seen even when thetumor is *** obtained results can be used to improve optical techniques of biomedicaldiagnostics of cancer diseases.

关键词： Breast cancer hair optical biomedical diagnost ics atomic force microscopy dynamiclight scattering