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Shared(epi)genomic background connecting neurodegenerative diseases and type 2 diabetes

World Journal of Diabetes 2020年第5期11卷 155-164页

作者： valerio caputo Andrea Termine Claudia Strafella Emiliano Giardina Raffaella Cascella Department of Biomedicine and Prevention Tor Vergata UniversityRome 00133Italy Molecular Genetics Laboratory UILDM Santa Lucia FoundationRome 00142Italy Experimental and Behavioral Neurophysiology Laboratory Santa Lucia FoundationRome 00142Italy Department of Biomedical Sciences Catholic University Our Lady of Good CounselTirana 1000Albania

The progressive aging of populations has resulted in an increased prevalence of chronic pathologies,especially of metabolic,neurodegenerative and movement *** particular,type 2 diabetes(T2D),Alzheimer’s disease(AD)and Parkinson’s disease(PD)are among the most prevalent age-related,multifactorial pathologies that deserve particular attention,given their dramatic impact on patient quality of life,their economic and social burden as well the etiopathogenetic mechanisms,which may overlap in some ***,the existence of common triggering factors reflects the contribution of mutual genetic,epigenetic and environmental features in the etiopathogenetic mechanisms underlying T2D and AD/*** this subject,this review will summarize the shared(epi)genomic features that characterize these complex *** particular,genetic variants and gene expression profiles associated with T2D and AD/PD will be discussed as possible contributors to determine the susceptibility and progression to these ***,potential shared epigenetic modifications and factors among T2D,AD and PD will also be ***,this review shows that findings from genomic studies still deserves further research to evaluate and identify genetic factors that directly contribute to the shared ***,a common epigenetic background still needs to be investigated and *** evidences discussed in this review underline the importance of integrating largescale(epi)genomic data with additional molecular information and clinical and social background in order to finely dissect the complex etiopathogenic networks that build up the“disease interactome”characterizing T2D,AD and PD.

关键词： Type 2 diabetes Alzheimer’s disease Parkinson’s disease Metabolism Neurodegeneration Neuroinflammation Genetic variants Epigenomic background Disease interactome

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