Shared(epi)genomic background connecting neurodegenerative diseases and type 2 diabetes

作     者：Valerio Caputo Andrea Termine Claudia Strafella Emiliano Giardina Raffaella Cascella 

作者机构：Department of Biomedicine and PreventionTor Vergata UniversityRome 00133Italy Molecular Genetics Laboratory UILDMSanta Lucia FoundationRome 00142Italy Experimental and Behavioral Neurophysiology LaboratorySanta Lucia FoundationRome 00142Italy Department of Biomedical SciencesCatholic University Our Lady of Good CounselTirana 1000Albania 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2020年第11卷第5期

页      面：155-164页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100204[医学-神经病学] 10[医学] 

主　　题：Type 2 diabetes Alzheimer’s disease Parkinson’s disease Metabolism Neurodegeneration Neuroinflammation Genetic variants Epigenomic background Disease interactome 

摘      要：The progressive aging of populations has resulted in an increased prevalence of chronic pathologies,especially of metabolic,neurodegenerative and movement *** particular,type 2 diabetes(T2D),Alzheimer’s disease(AD)and Parkinson’s disease(PD)are among the most prevalent age-related,multifactorial pathologies that deserve particular attention,given their dramatic impact on patient quality of life,their economic and social burden as well the etiopathogenetic mechanisms,which may overlap in some ***,the existence of common triggering factors reflects the contribution of mutual genetic,epigenetic and environmental features in the etiopathogenetic mechanisms underlying T2D and AD/*** this subject,this review will summarize the shared(epi)genomic features that characterize these complex *** particular,genetic variants and gene expression profiles associated with T2D and AD/PD will be discussed as possible contributors to determine the susceptibility and progression to these ***,potential shared epigenetic modifications and factors among T2D,AD and PD will also be ***,this review shows that findings from genomic studies still deserves further research to evaluate and identify genetic factors that directly contribute to the shared ***,a common epigenetic background still needs to be investigated and *** evidences discussed in this review underline the importance of integrating largescale(epi)genomic data with additional molecular information and clinical and social background in order to finely dissect the complex etiopathogenic networks that build up the“disease interactomecharacterizing T2D,AD and PD.