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Role of PTX3 and complement modulation in the tumor microenvironment

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BIOCELL 2022年第10期46卷 2235-2239页

作者： GIUSEPPE STEFANO NETTI FEDERICA SPADACCINO valeria CATALANO GIUSEPPE CASTELLANO GIOVANNI STALLONE ELENA RANIERI Clinical Pathology Unit and Center for Molecular Medicine Department of Medical and Surgical SciencesUniversity of FoggiaFoggia71122Italy Nephrology Dialysis and Renal Transplant UnitDepartment of Clinical Sciences and Community HealthFondazione IRCCS Ca’Granda-OspedaleMaggiore Policlinico-University of MilanMilan20122Italy Nephrology Dialysis and Transplantation Unit Advanced Research Center on Kidney Aging(A.R.K.A.)Department of Medical and Surgical SciencesUniversity of FoggiaFoggia71122Italy

Pentraxin-3(PTX3),the prototype of long pentraxins,seems to influence complement system(CS)***3 and CS sustain carcinogenesis,enriching tumor microenvironment(TME)with pro-inflammatory molecules promoting angiogenesis in prostate cancer(PC)and renal cell carcinoma(RCC).Furthermore,cancer cells overexpress complement regulatory proteins,such as CD46,CD55 and CD59,which negatively affect complement pathways for support cancer cells *** viewpoint aims to elucidate the ambivalent role of PTX3 and the CS in the context of tumor microenvironment(TME).

关键词： Pentraxin-3 Complement system Tumor microenvironment Prostate cancer Renal cell carcinoma

Dual stimuli-responsive polyurethane-based hydrogels as smart drug delivery carriers for the advanced treatment of chronic skin wounds

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Bioactive Materials 2021年第9期6卷 3013-3024页

作者： Rossella Laurano Monica Boffito Michela Abrami Mario Grassi Alice Zoso valeria Chiono Gianluca Ciardelli Politecnico di Torino Mechanical and Aerospace Engineering DepartmentCorso Duca degli Abruzzi 2410129TorinoItaly Universitàdegli Studi di Trieste Department of Engineering and ArchitectureVia Alfonso Valerio 6/134127TriesteItaly

The design of multi-stimuli-responsive vehicles for the controlled and localized release of drugs is a challenging issue increasingly catching the attention of many research groups working on the advanced treatment of hard-to-close *** this work,a thermo-and pH-responsive hydrogel(P-CHP407)was prepared from an ad hoc synthesized amphiphilic poly(ether urethane)(CHP407)exposing a significant amount of-COOH groups(8.8±0.9 nmol/g_(polymer)).The exposure of acid moieties in P-CHP407 hydrogel led to slightly lower initial gelation temperature(12.1◦C vs.14.6◦C,respectively)and gelation rate than CHP407 hydrogel,as rheologically *** hydrogel characterization by Low Field NMR(LF-NMR)spectroscopy suggested that the presence of carboxylic groups in P-CHP407 caused the formation of bigger micelles with a thicker hydrated shell than CHP407 hydrogels,as further proved by Dynamic Light Scattering *** addition,P-CHP407 hydrogel showed improved capability to change its internal pH compared to CHP407 one when incubated with an alkaline buffer(pH 8)(e.g.,pH_(change_5min)=3.76 and 1.32,respectively).Moreover,LF-NMR characterization suggested a stronger alkaline-pH-induced interaction of water molecules with micelles exposing-COOH ***,the hydrogels were found biocompatible according to ISO 10993 and able to load and release Ibuprofen:delivery kinetics of Ibuprofen was enhanced by P-CHP407 hydrogels at alkaline pH,suggesting their potential use as smart delivery systems in the treatment of chronic infected wounds.

关键词： Stimuli-responsive hydrogel Drug delivery system pH-triggered release Advanced wound treatment Polyurethane hydrogel LF-NMR characterization

Custom-design of intrinsically antimicrobial polyurethane hydrogels as multifunctional injectable delivery systems for mini-invasive wound treatment

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Engineered Regeneration 2021年第1期2卷 263-278页

作者： Rossella Laurano valeria Chiono Chiara Ceresa Letizia Fracchia Alice Zoso Gianluca Ciardelli Monica Boffito Mechanical and Aerospace Engineering Department Politecnico di TorinoCorso Duca degli Abruzzi 24Torino 10129Italy Department of Pharmaceutical Sciences Universitadel Piemonte Orientale A.AvogadroLargo Guido Donegani 2Novara 28100Italy

Effective management of hard-to-close skin wounds is a challenging issue due to several co-morbidities in affected ***,infections represent a major obstacle in wound *** design of efficient wound treatments thus represents an urgent *** drug delivery hydrogels with intrinsic antimicrobial and antifungal properties were herein designed for perspective application in the mini-invasive treatment of hard-to-close ***,an amphiphilic polyurethane was synthesized from Poloxamer■407 macrodiol and N-Boc diethanolamine chain extender(DHP407,M_(w)=33 kDa).Chain-extension reaction step was optimized to maximize the formation of-NH groups along the polymer chains(4.5×10^(20)±1.8×10^(19)-NH groups/g polymer),after Boc-caging group removal(D-DHP407).DHP407 and D-DHP407 water-based solutions were thermosensitive with slightly different Critical Micellar Concentration(17.5μg/mL vs.19.7μg/mL)and cluster hydrodynamic diameter(235.6±19.9 nm vs.260.1±20.5 nm),and similar Critical Micellar Temperature(22.5℃ vs.23.1℃).A polyurethane solution concentration(15%w/V)was selected by tube-inverting test and rheological analysis showing injectability,as evidenced by sol-to-gel transition at 27.7±0.6℃ for DHP407 and 29.7±0.6℃ for D-DHP407,within few minutes,at similar gelation ***407 and D-DHP407 hydrogels showed controlled release of Bovine Serum Albumin(BSA)model protein(1 mg/mL),with no burst *** released from DHP407 and D-DHP407 hydrogels at 24 h was 33.7±5.0% and 24.6±1.2%,respectively.D-DHP407 hydrogel was biocompatible and able to support NIH-3T3 cell ***,D-DHP407 hydrogel showed intrinsic antifungal and antibacterial activity against *** and Gram-positive *** and Gram-negative *** bacteria,injectability and capability to retain shape post-injection,making it promising for future use in the management of hard-to-close skin wounds.

关键词： Antimicrobial poly(ether urethane)s Drug delivery systems Injectable formulations Antibiotic-free treatments Wound healing Thermosensitive hydrogels

Current role of hepatopancreatoduodenectomy for the management of gallbladder cancer and extrahepatic cholangiocarcinoma:A systematic review

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 625-637页

作者： Alessandro Fancellu valeria Sanna Giulia Deiana Chiara Ninniri Davide Turilli Teresa Perra Alberto Porcu Department of Medical Surgical and Experimental SciencesUniversity of SassariSassari 07100Italy Unit of Oncology AOU SassariSassari 07100Italy Unit of Radiology AOU SassariSassari 07100Italy

BACKGROUND Hepatopancreatoduodenectomy(HPD)is the simultaneous combination of hepatic resection,pancreaticoduodenectomy,and resection of the entire extrahepatic biliary *** is not a universally accepted due to high mortality and morbidity rates,as well as to controversial survival *** To evaluate the current role of HPD for curative treatment of gallbladder cancer(GC)or extrahepatic cholangiocarcinoma(ECC)invading both the hepatic hilum and the intrapancreatic common bile *** A systematic literature search using the PubMed,Web of Science,and Scopus databases was performed to identify studies reporting on HPD,using the following keywords:‘Hepatopancreaticoduodenectomy’,‘hepatopancreatoduodenectomy’,‘hepatopancreatectomy’,‘pancreaticoduodenectomy’,‘hepatectomy’,‘hepatic resection’,‘liver resection’,‘Whipple procedure’,‘bile duct cancer’,‘gallbladder cancer’,and‘cholangiocarcinoma’.RESULTS This updated systematic review,focusing on 13 papers published between 2015 and 2020,found that rates of morbidity for HPD have remained high,ranging between 37.0%and 97.4%,while liver failure and pancreatic fistula are the most serious ***,perioperative mortality for HPD has decreased compared to initial experiences,and varies between 0%and 26%,although in selected center it is well below 10%.Long term survival outcomes can be achieved in selected patients with R0 resection,although 5–year survival is better for ECC than *** The present review supports the role of HPD in patients with GC and ECC with horizontal spread involving the hepatic hilum and the intrapancreatic bile duct,provided that it is performed in centers with high experience in hepatobiliarypancreatic *** use of preoperative portal vein embolization,and preoperative biliary drainage in patients with obstructive jaundice,represent strategies for decreasing the occurrence and severity of postoperative *** is advisable to develop internationa

关键词： Hepatopancreatoduodenectomy Extrahepatic cholangiocarcinoma Gallbladder cancer Survival Morbidity Mortality

Safety and efficacy of a docetaxel-5FU-oxaliplatin regimen with or without trastuzumab in neoadjuvant treatment of localized gastric or gastroesophageal junction cancer: A retrospective study

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World Journal of Gastrointestinal Oncology 2019年第8期11卷 634-641页

作者： valeria Basso David Orry Jean Fraisse Julie Vincent Audrey Hennequin Leila Bengrine Francois Ghiringhelli Department of Surgery Centre Georges Francois LeclercDijon 21000France Department of Medical Oncology Centre Georges Francois LeclercDijon 21000France

BACKGROUND Triplet chemotherapy,with docetaxel-5FU-oxaliplatin FLOT regimen recently became the standard perioperative treatment for localized gastric cancer(GC).An adapted regimen called TeFOX was recently tested in metastatic setting and gave promising *** To determine safety and efficacy of TeFOX perioperative *** This monocentric retrospective study aims to test efficacy and safety of the perioperative TeFOX regimen given alone or in combination with trastuzumab in patients with localized *** consist in docetaxel(50 mg/m^2)with oxaliplatin 85 mg/m^2 and and leucovorin(400mg/m^2^)5 FU bolus(400mg/m^2)on day 1,followed by continuous infusion of 5FU for 46h(2400mg/m^2)every 2 *** Thirty-three consecutive patients were included in this retrospective *** patients have a gastroesophageal junction cancer and 11 have a *** follow-up of surviving patients was 32 mo.R0 resection was obtained in 30(91)*** patients(36)had a pathological complete response and 8(24)patients a nearly complete pathological *** OS and PFS were not reached at data base *** have observed 6 metastatic relapses and 1 localized *** relapse was observed in patients with pathological complete *** most common grade 3-4 adverse events were peripheral neuropathy(21)and asthenia(20).CONCLUSION TeFOX regimen could be safely administrated in perioperative treatment of localized *** and the FLOT regimen have comparable efficacy and safety profiles.

关键词： Gastric cancer Neoadjuvant chemotherapy TeFOX Retrospective study

Anastomotic leakage in rectal cancer surgery:Retrospective analysis of risk factors

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World Journal of Clinical Cases 2022年第36期10卷 13321-13336页

作者： Giuseppe Brisinda Maria Michela Chiarello Gilda Pepe Maria Cariati valeria Fico Paolo Mirco Valentina Bianchi Department of Medical and Surgical Sciences Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Surgery UniversitàCattolica S CuoreRome 00168Italy Department of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Emergency Surgery and Trauma Center Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Surgery Azienda Sanitaria Provinciale di CrotoneCrotone 88900Italy

BACKGROUND Anastomotic leakage(AL)after restorative surgery for rectal cancer(RC)is associated with significant morbidity and *** To ascertain the risk factors by examining cases of AL in rectal surgery in this retrospective cohort *** To identify risk factors for AL,a review of 583 patients who underwent rectal resection with a double-stapling colorectal anastomosis between January 2007 and January 2022 was ***,demographic and operative features,intraoperative outcomes and oncological characteristics were *** The incidence of AL was 10.4%,with a mean time interval of 6.2±2.1 *** mortality was 0.8%.Mortality was higher in patients with AL(4.9%)than in patients without leak(0.4%,P=0.009).Poor bowel preparation,blood transfusion,median age,prognostic nutritional index<40 points,tumor diameter and intraoperative blood loss were identified as risk factors for *** of anastomosis,number of stapler cartridges used to divide the rectum,diameter of circular stapler,level of vascular section,T and N status and stage of disease were also correlated to AL in our *** diverting ileostomy did not reduce the leak rate,while the use of the transanastomic tube significantly *** Clinical,surgical and pathological factors are associated with an increased risk of *** adversely affects the morbidity and mortality of RC patients.

关键词： Anastomosis Leak Anterior resection Morbidity Mortality Rectal surgery

The western Durkan Complex(Makran Accretionary Prism,SE Iran):A Late Cretaceous tectonically disrupted seamounts chain and its role in controlling deformation style

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Geoscience Frontiers 2021年第3期12卷 503-527页

作者： Edoardo Barbero Luca Pandolfi Morteza Delavari Asghar Dolati Emilio Saccani Rita Catanzariti valeria Luciani Marco Chiari Michele Marroni Dipartimento di Fisica e Scienze della Terra Universitàdi FerraraVia Saragat 144123 FerraraItaly Dipartimento di Scienze della Terra Universitàdi PisaVia S.Maria 5356126 PisaItaly Istituto di Geoscienze e Georisorse CNRPisaVia G.Moruzzi 156124 PisaItaly Faculty of Earth Sciences Kharazmi UniversityShahid Mofatteh St.43TehranIran Istituto di Geoscienze e Georisorse CNRFirenzeVia La Pira 450121 FirenzeItaly

The Durkan Complex is a key tectonic element of the Makran accretionary prism(SE Iran)and it has been interpreted as representing a continental margin *** present here a multidisciplinary study of the western Durkan Complex,which is based on new geological,stratigraphic,biostratigraphic data,as well as geochemical data of the volcanic and meta-volcanic rocks forming this *** data show that this complex consists of distinct tectonic slices showing both non-metamorphic and very low-grade metamorphic deformed *** and biostratigraphic data allow us to recognize three types of ***-Ⅰis composed by a Coniacian-early Campanian pelagic succession with intercalation of pillow lavas and minor volcaniclastic ***-Ⅱsuccession includes a volcanic sequence passing to a volcano-sedimentary sequence with Cenomanian pelagic limestones,followed by a hemipelagic *** succession is characterized by abundant mass-transport ***-Ⅲsuccession includes volcanic and volcano-sedimentary sequences,which are stratigraphically covered by a Cenomanian platform *** latter is locally followed by a hemipelagic *** volcanic rocks in the different successions show alkaline geochemical affinity,suggesting an origin from an oceanic within-plate *** new results indicate that the western Durkan Complex represents fragments of seamounts tectonically incorporated in the Makran accretionary wedge during the latest Late *** propose that incorporation of seamounts in the frontal prism caused a shortening of the whole convergent margin and possibly contributed to controlling the deformation style in the Makran Accretionary Wedge during Late Cretaceous-Paleocene times.

关键词： Tectonically disrupted seamounts Makran Late Cretaceous Iran Neo-Tethys

Therapeutic strategies in Crohn’s disease in an emergency surgical setting

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World Journal of Gastroenterology 2022年第18期28卷 1902-1921页

作者： Maria Michela Chiarello Gilda Pepe valeria Fico Valentina Bianchi Giuseppe Tropeano Gaia Altieri Giuseppe Brisinda Department of Surgery San Giovanni in Fiore HospitalAzienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Emergency Surgery and Trauma Center Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Surgery Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Medical and Surgical Science UniversitàCattolica del Sacro CuoreRome 00168Italy

Crohn’s disease(CD)remains a chronic,incurable disorder that presents unique challenges to the *** factors must be considered to allow development of an appropriate treatment *** therapy often precedes or complements the surgical *** indications for operative management of CD include acute and chronic disease complications and failed medical *** surgery comes into play when patients are refractory to medical treatment if they have an obstructive *** colitis,acute obstruction,perforation,acute abscess,or massive hemorrhage represent indications for emergency *** patients are generally in critical conditions and present with intra-abdominal sepsis and a preoperative status of immunosuppression and malnutrition that exposes them to a higher risk of complications and mortality.A multidisciplinary team including surgeons,gastroenterologists,radiologists,nutritional support services,and enterostomal therapists are required for optimal patient care and decision *** of each emergency should be individualized based on patient age,disease type and duration,and patient goals of ***,the recurrent nature of disease mandates that we continue searching for innovative medical therapies and operative techniques that reduce the need to repeat surgical *** this review,we aimed to discuss the acute complications of CD and their treatment.

关键词： Crohn’s disease Intestinal obstruction Free perforation Intra-abdominal sepsis Perineal sepsis Acute bleeding

The Epidemiology of Recurrent Violence and Its Relationship with Sentence Time in the Romanian Juvenile Prison System: A Two-Year Cohort Study

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Open Journal of Epidemiology 2022年第1期12卷 12-30页

作者： Carmen-valeria Baias Faculty of Integral Medicine University EurAka Therwil Switzerland

Background: Research suggests that a small number of persistent violent offenders are responsible for a majority of prison violence and tend to behave violently to a disproportionate amount. However, literature on patterns of violence in juvenile prisoners is limited. Method: In order to explore how subjects engage in violence while incarcerated in the juvenile prison system, the authors will examine both proximal and distal predictors of violent behavior among juveniles in custody. This study adds to the current empirical research by longitudinally examining dynamic risk factors of recurrent violent behavior across a population of juvenile prisoners (Mage = 16.21;94.8% male) in custody in the Romanian juvenile justice system, starting from their entry date until the end of the follow-up period (Me = 2 years). Results: Results from a series of repeated aggressive events survival analyses show evidence of a long-term deleterious association between pre-incarceration risk factors and poor developmental trajectory associated with violence. Adherence to destructive conduct in prison was consistently influenced by low ability to cope with the prison environment, although education level and family factors also mattered. Implications for prison professionals and forensic practitioners are presented. Conclusion: Recurring aggressive behavior is frequent for individuals who experience complex adverse experiences during childhood, suggesting that screening youths upon their admission into juvenile justice settings should include an assessment of their basic self-regulation needs. A greater focus on longitudinal studies may help improve the screening process and also follow the progress of each juvenile to warrant the efficacy of preventive programs in self-harm, according to their emerging needs.

关键词： Violence Risk-Assessment Repeated Events Analysis Juveniles Prison System