Role of PTX3 and complement modulation in the tumor microenvironment

作     者：GIUSEPPE STEFANO NETTI FEDERICA SPADACCINO VALERIA CATALANO GIUSEPPE CASTELLANO GIOVANNI STALLONE ELENA RANIERI 

作者机构：Clinical Pathology Unit and Center for Molecular MedicineDepartment of Medical and Surgical SciencesUniversity of FoggiaFoggia71122Italy NephrologyDialysis and Renal Transplant UnitDepartment of Clinical Sciences and Community HealthFondazione IRCCS Ca’Granda-OspedaleMaggiore Policlinico-University of MilanMilan20122Italy Nephrology Dialysis and Transplantation UnitAdvanced Research Center on Kidney Aging(A.R.K.A.)Department of Medical and Surgical SciencesUniversity of FoggiaFoggia71122Italy 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2022年第46卷第10期

页      面：2235-2239页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by grant funding from University of Foggia(University Research Projects 2019“PRA 2019”granted to G.S.N. 2019).The funders had no role in study design data collection and analysis decision to publish or preparation of the manuscript.The contents are solely the responsibility of the author and do not necessarily represent the official views of the University of Foggia 

主　　题：Pentraxin-3 Complement system Tumor microenvironment Prostate cancer Renal cell carcinoma 

摘      要：Pentraxin-3(PTX3),the prototype of long pentraxins,seems to influence complement system(CS)***3 and CS sustain carcinogenesis,enriching tumor microenvironment(TME)with pro-inflammatory molecules promoting angiogenesis in prostate cancer(PC)and renal cell carcinoma(RCC).Furthermore,cancer cells overexpress complement regulatory proteins,such as CD46,CD55 and CD59,which negatively affect complement pathways for support cancer cells *** viewpoint aims to elucidate the ambivalent role of PTX3 and the CS in the context of tumor microenvironment(TME).