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陶瓷表面Mo-Ni-Si金属化及其与Ag的润湿性研究（英文）

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稀有金属材料与工程 2018年第3期47卷 759-765页

作者：赵三团张相召刘桂武 valenza fabrizio Muolo Maria Luigia 乔冠军 Passerone Alberto 西安交通大学金属材料强度国家重点实验室陕西西安710049 江苏大学江苏镇江212013 Institute for Energetics and Interphases IENI-CNRGenoa 16149Italy 河南科技大学河南洛阳471003

采用真空熔烧工艺在SiC陶瓷表面制备了3种化学成分的Mo-Ni-Si金属化涂层,研究了涂层的相组成和涂层/SiC陶瓷界面的微结构。通过座滴法实验考察了纯Ag在SiC 陶瓷涂层上的润湿与铺展特性,分析和讨论了Ag/金属化SiC陶瓷体系的界面行为。结... 详细信息

采用真空熔烧工艺在SiC陶瓷表面制备了3种化学成分的Mo-Ni-Si金属化涂层,研究了涂层的相组成和涂层/SiC陶瓷界面的微结构。通过座滴法实验考察了纯Ag在SiC 陶瓷涂层上的润湿与铺展特性,分析和讨论了Ag/金属化SiC陶瓷体系的界面行为。结果表明,该金属化涂层主要由Mo_5Si_3、MoSi_2、Ni_2Si、NiSi_2和MoNiSi组成,同时随着涂层中Mo金属由20%增加至40% (摩尔分数),位于涂层表面的具有四方结构的MoSi_2晶粒逐渐消失。Ag对Mo20-Ni32-Si48、Mo30-Ni28-Si42、Mo40-Ni24-Si36金属化SiC陶瓷在1000℃保温30min后对应的最终接触角分别为45°,79°和85°,该结果与Ag滴和3种Mo-Ni-Si涂层之间的相互作用密切相关。同时,在润湿试验前后,在Mo-Ni-Si涂层/SiC衬底界面没有发现明显的反应层。

关键词：表面金属化 Mo-Ni-Si涂层 SiC陶瓷润湿界面

How useful are biomarkers for the diagnosis of Alzheimer’s disease and especially for its therapy?

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Neural Regeneration Research 2022年第10期17卷 2205-2207页

作者： Marta valenza Caterina Scuderi Department of Physiology and Pharmacology“V.Erspamer” SAPIENZA University of RomeRomeItaly

Alzheimer’s disease key facts:Alzheimer’s disease(AD)is a slowly progressive neurodegenerative disease with no available effective *** is possible to distinguish an early-onset AD that affects a limited number of subjects of young age,and a sporadic or late-onset form of the disease that affects the vast majority of subjects who are diagnosed with *** life expectancy has increased considerably over the past century,the number of people diagnosed with AD has grown ***,AD and AD-related pathologies represent a huge social and economic *** number of individuals waiting for effective disease-modifying therapy is *** is estimated that 50 million people worldwide live with dementia,the majority of these cases are caused by AD(World Health Organization,2021).In the US about 6 million individuals are living with AD,and more than 9 million people are in EU member states(OECD and European Union,2020).The costs of health care and long-term care are *** this massive societal impact,enormous efforts have been made to understand the pathogenetic mechanisms of the disease with the hope of identifying new targets and,therefore,developing effective drugs.

关键词： Alzheimer diagnosis slowly

Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2019年第4期25卷 509-520页

作者： Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio valenza Antonio Gasbarrini Luca Miele Antonio Grieco Department of Gastroenterological Endocrine-Metabolic and Nefro-Urological Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS Institute of Special Medical Pathology and Medical Semeiotics Università Cattolica del Sacro Cuore Institute of Internal Medicine and Geriatrics Università Cattolica del Sacro Cuore Department of Image Diagnostics Oncological Radiotherapy and Hematology Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS Nuclear Medicine Institute Università Cattolica del Sacro Cuore

BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver *** hypothesize that, diet could be able to modulate intestinal permeability in patients with *** To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat *** The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat *** Mediterranean diet is an effective strategy for treating overweight, visceral obesit

关键词： Liver steatosis Gut-liver axis Nutrition Personalized medicine Visceral obesity

Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation

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World Journal of Gastroenterology 2019年第33期25卷 4814-4834页

作者： Alberto Nicoletti Francesca Romana Ponziani Marco Biolato Venanzio valenza Giuseppe Marrone Gabriele Sganga Antonio Gasbarrini Luca Miele Antonio Grieco Fondazione Policlinico Universitario A Gemelli IRCCS Rome 00168Italy UniversitàCattolica del Sacro Cuore Rome 00168Italy

The intimate connection and the strict mutual cooperation between the gut and the liver realizes a functional entity called gut-liver *** integrity of intestinal barrier is crucial for the maintenance of liver *** this mutual relationship,the liver acts as a second firewall towards potentially harmful substances translocated from the gut,and is,in turn,is implicated in the regulation of the *** evidence has highlighted the relevance of increased intestinal permeability and consequent bacterial translocation in the development of liver *** particular,in patients with non-alcoholic fatty liver disease recent hypotheses are considering intestinal permeability impairment,diet and gut dysbiosis as the primary pathogenic *** advanced liver disease,intestinal permeability is enhanced by portal *** clinical consequence is an increased bacterial translocation that further worsens liver ***,this pathogenic mechanism is implicated in most of liver cirrhosis complications,such as spontaneous bacterial peritonitis,hepatorenal syndrome,portal vein thrombosis,hepatic encephalopathy,and hepatocellular *** liver transplantation,the decrease in portal pressure should determine beneficial effects on the gut-liver axis,although are incompletely understood data on the modifications of the intestinal permeability and gut microbiota composition are still *** the modulation of the intestinal permeability could prevent the initiation and progression of liver disease is still an uncovered area,which deserves further attention.

关键词： Bacterial translocation Gut microbiota Gut-liver axis Liver disease Cirrhosis Mediterranean diet Personalized medicine

Interferon β-1a alone or in combination with ribavirin: A randomized trial to compare efficacy and safety in chronic hepatitis C

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World Journal of Gastroenterology 2005年第29期11卷 4484-4489页

作者： Rinaldo Pellicano Antonio Craxì Piero Luigi Almasio Mario valenza Giovanna Venezia Alfredo Alberti Silvia Boccato Luigi Demelia Orazio Sorbello Antonino Picciotto Francesco Torre Gaetano Ideo Carlo Cattaneo Mara Berrutti Mario Rizzetto U.O.A.D.U. Gastro-Hepatology S. Giovanni Battista (Molinette) Hospital Turin Italy Venezia Department of Gastroenterology and Hepatology University of Palermo Italy Department of Internal Medicine University of Padua Italy Institute of Clinical Medicine University of Cagliari Italy Department of Internal Medicine University of Genoa Italy Department of Hepatology San Giuseppe Hospital Milan Italy U.O.A.D.U. Gastro-Hepatoiogy S. Giovanni Battista (Molinette) Hospital Turin Italy

AIM： To compare the efficacy and safety of recombinant human IFN β-la alone or in combination with ribavirin in treatment-naive subjects with chronic hepatitis C. METHODS： Open, randomized trial was performed in 6 Italian tertiary centers： 102 of the 108 patients screened were randomized to receive 6 MIU of recombinant human IFN β-la subcutaneously daily for 24 wk, alone （Group 1, n = 51） or in combination with ribavirin 1 000 to 1 200 mg/d （Group 2, n = 51）. RESULTS： The end-of-treatment virologic response rate was 29.4% in Group 1 and 41.2% in Group 2 （nonsignificant）. Twenty-four weeks after stopping therapy, sustained virologic response rate was 21.6% in Group 1 and 27.4% in Group 2 （non-significant）. All subjects in Group 1 completed treatment, while two subjects in Group 2 stopped therapy due to treatment-related adverse events. CONCLUSION： Recombinant human IFN β-la, alone or in combination with ribavirin, has an excellent safety profile and, may represent an alternative for chronic hepatitis C patients who are unable to tolerate pegylated α-interferon.

关键词： Chronic hepatitis C IFN β-1a Ribavirin

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意大利的地震地球化学前兆

世界地震译丛 1994年第4期25卷 73-77页

作者： M.valenza P.M.Nuccio 李彤起王非吕英国家地震局兰州地震研究所

本文展示了近几年在意大利西西里岛东部的武尔卡诺、埃特纳火山及地震地区进行的地球化学观测结果。结果表明,一些地质参数可以作为有效的地震前兆,但这些参数的选择都和该地区的地球化学性质密切相关。为了实现地震预报的目标,本文提... 详细信息

本文展示了近几年在意大利西西里岛东部的武尔卡诺、埃特纳火山及地震地区进行的地球化学观测结果。结果表明,一些地质参数可以作为有效的地震前兆,但这些参数的选择都和该地区的地球化学性质密切相关。为了实现地震预报的目标,本文提出应在世界不同地区实施的一种多学科、形式单一的预报方法。

关键词：地震地球化学异常地震前兆

Reduced exercise capacity and self-perceived health status in highrisk patients undergoing lung resection

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World Journal of Critical Care Medicine 2021年第5期10卷 232-243页

作者： Janet Rodríguez-Torres Irene Cabrera-Martos Laura López-López Florencio Quero-Valenzuela Lawrence Patrick Cahalin Marie Carmen valenza Fisioterapia University of GranadaGranada 18016Spain Cardiothoracic Surgery Department Virgen de las Nieves HospitalGranada 18016Spain Physical Therapy University of MiamiMiamiFL 33124United States

BACKGROUND Lung resection represents the main curative treatment modality of non-small cell lung *** with high-risk to develop postoperative pulmonary complications have been classified as“high-risk patients.”Characterizing this population could be important to improve their approach and *** To identify the differences between high and low-risk patients in exercise capacity and self-perceived health status after *** A longitudinal observational prospective cohort study was carried *** undergoing lung resection were recruited from the“Hospital Virgen de las Nieves”(Granada)and divided into two groups according to the risk profile criteria(age≥70 years,forced expiratory volume in 1 s≤70%predicted,carbon monoxide diffusion capacity≤70%predicted or scheduled pneumonectomy).Outcomes included were exercise capacity(Fatigue Severity Scale,Unsupported Upper-Limb Exercise,handgrip dynamometry,Five Sit-to-stand test,and quadriceps hand-held dynamometry)and patient-reported outcome(Euroqol-5 dimensions 5 Levels Visual Analogue Scale).RESULTS In total,115 participants were included in the study and divided into three groups:high-risk,low-risk and control *** discharge high-risk patients presented a poorer exercise capacity and a worse self-perceived health status(P<0.05).One month after discharge patients in the high-risk group maintained these differences compared to the other *** Our results show a poorer recovery in high-risk patients at discharge and 1 mo after surgery,with lower self-perceived health status and a poorer upper and lower limb exercise *** results are important in the rehabilitation field.

关键词： Non-small cell lung cancer Exercise tolerance health status Patient-reported outcomes Postoperative quality of life Exercise test

A Preliminary Study on the Effect of TCM on Gastric Emptying in Obese Patients: Evaluation with a Standard Meal

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A Preliminary Study on the Effect of TCM on Gastric Emptying...