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光学相干断层扫描评估未发病的Leber遗传性视神经病变基因突变携带者的视网膜神经纤维层厚度

世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 56-57页

作者： Savini G. Barboni P. valentino M.L. 张少娟

To study retinal nerve fiber layer (RNFL) thickness by optical coherence tomog raphy (OCT) in unaffected carriers with Leber’s hereditary optic neuropathy (LH ON) mutations. Crosssectional study. Sixty-six unaffected carriers (44 females and 22 males) were analyzed and compared with an age-matched control group of 7 0 patients (40 females and 30 males). The statistical analysis was performed aft er grouping both the patients and the control group on the basis of gender and, for unaffected carriers only, mitochondrial DNA mutation. The Fast RNFL Thicknes s (3.4) scan acquisition protocol was used. Retinal nerve fiber layer thickness as measured by OCT. With respect to the control group, unaffected male carriers showed a thicker RNFL in the temporal and inferior quadrants and in the 360°ave rage measurement (P=0.025, P=0.03, and P=0.018, respectively). These differences reached statistical significance in subjects carrying the 11 778 mutation, wher eas only a trend was detected in those with the 3 460 mutation. Unaffected femal e carriers had an increased thickness in the temporal quadrant when compared wit h the control group (P=0.003) and no differences in the other measurements. The increase in temporal sectors was statistically significant in females with the 1 1 778 mutation, whereas a trend was detected in those with the 3 460 mutation. A thickening of the temporal fibers was detected in all subgroups of unaffected c arriers. This is the first evidence indicating the preferential involvement of t he papillomacular bundle in subclinical LHON. This notion previously was based o n the early loss of fibers from the temporal quadrant in acute LHON and the sele ctive loss of small-caliber fibers at histopathology. Our study also revealed t hat males have a more diffuse involvement than females.

关键词：遗传性视神经病 Leber 携带者基因突变乳头黄斑束主要评价指标横断面研究亚临床组织病理学亚组

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Python深度学习从原理到应用

Python深度学习从原理到应用

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作者： (美)瓦伦蒂诺·佐卡(valentino Zocca)[等]

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神经节苷脂对神经母细胞瘤细胞粘附于胶原蛋白作用的影响

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中国当代儿科杂志 2001年第4期3卷 359-362,455-460页

作者：文飞球陈亦欣吴本清 Tamara Kazarian Leonard A.valentino 暨南大学医学院附属二院儿科广东深圳518020 暨南大学医学院附属二院肿瘤研究所广东深圳518020 美国RUSH大学医学院儿童医院

目的　以胶原蛋白 (CN)作为底物 ,探讨内生肿瘤神经节苷脂 (GS)对神经母细胞LA N5细胞株粘附功能的影响。方法　用葡萄糖苷神经酰氨合成酶抑制剂 (D PDMP)抑制LA N5细胞株GS合成 ,观察该细胞对包被CN粘附作用的变化。结果　暴露于D PDMP... 详细信息

目的　以胶原蛋白 (CN)作为底物 ,探讨内生肿瘤神经节苷脂 (GS)对神经母细胞LA N5细胞株粘附功能的影响。方法　用葡萄糖苷神经酰氨合成酶抑制剂 (D PDMP)抑制LA N5细胞株GS合成 ,观察该细胞对包被CN粘附作用的变化。结果　暴露于D PDMP 6d后 ,细胞GS几乎完全清除 ,但细胞的活力、增殖率及凋亡率较对照组无明显变化 ;暴露于D -PDMP的细胞 ,其粘附能力仅为对照组的 3 5 % :OD570 分别为 0 .0 7± 0 .0 1和 0 .2 1± 0 .0 3 (P 0 .0 5 )。结论　内生肿瘤GS调节肿瘤细胞对CN的粘附作用 ,提示GS在肿瘤细胞的迁移 ,侵入和转移中可能起重要作用。

关键词：神经节苷脂神经母细胞瘤胶原蛋白粘附作用

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器之肌理,物之温度

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现代装饰 2018年第3期 108-115页

作者： vij5 Meike Harde Clella valentino peca Sverre Uhnger Woud 范嘉苑 Raw-Edges Design Studio Jin Kuramoto Studio

日本策展人祥见知生在《日日之器》一书中提到,＂对于器皿好恶的判断应该相信自己内心的声音。亲自拜访,亲手抚摸,亲身感受,喜爱器皿的第一步就是从相信自己双手的触感与内心的感受开始。＂好的器物会有一种平凡却能打动人的力量,透过... 详细信息

日本策展人祥见知生在《日日之器》一书中提到,＂对于器皿好恶的判断应该相信自己内心的声音。亲自拜访,亲手抚摸,亲身感受,喜爱器皿的第一步就是从相信自己双手的触感与内心的感受开始。＂好的器物会有一种平凡却能打动人的力量,透过触摸其材质和肌理,能感受到它们传递给用户的暖意与温度。我相信,不只是手作器皿,所有产品皆如此。小至一个首饰盒,大至一件家具,它们都蕴藏了设计师的信念,每一个设计背后都有着自己的独特故事。

关键词： Studio 设计师

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OPA1相关的显性视神经萎缩患者活体线粒体ATP产生不足

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世界核心医学期刊文摘(眼科学分册) 2005年第4期 6-7页

作者： Lodi R.,Tonon C. ,valentino M.L. ,秦雪娇 Dipto. Med. Clin./Biotecnol. A. D.C. Universita di Bologna Policlinico S. Orsola Via Massarenti 9 40138 Bologna Italy Dr

Dominant optic atrophy has been associated with mutations in the OPA1 gene, which encodes for a dyna- min- related GTPase, a mitochondrial protein implicated in the formation and maintenance of mitochondrial network and morphology. We used phosphorus magnetic resonance spectroscopy to assess calf muscle oxidative metabolism in six patients from two unrelated families carrying the c.2708- 2711delTTAG deletion in exon 27 of the OPA1 gene. The rate of postexercise phosphocreatine resynthesis, a measure of mitochondrial adenosine triphosphate production rate, was significantly delayed in the patients. Our in vivo results show for the first time to our knowledge a deficit of oxidative phosphorylation in OPA1- related DOA.

关键词：显性视神经萎缩线粒体粒线体 ATP OPA1 患者

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Orthopedic disorders of the knee in hemophilia:A current concept review

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World Journal of Orthopedics 2016年第6期7卷 370-375页

作者： E Carlos Rodriguez-Merchan Leonard A valentino Department of Orthopedic Surgery La Paz University Hospital-Idi Paz Rush University Medical Center

The knee is frequently affected by severe orthopedic changes known as hemophilic arthropathy(HA) in patients with deficiency of coagulation factor Ⅷ or Ⅸ and thus this manuscript seeks to present a current perspective of the role of the orthopedic surgeon in the management of these *** factor replacement therapy(FRT) is optimal to prevent HA,however adherence to this regerous treatment is challenging leading to breakthrough *** patients with chronic hemophilic synovitis,the prelude to HA,radiosynovectomy(RS) is the optimal to ameliorate *** in people with hemophilia(PWH) is associated with a high risk of bleeding and infection,and must be performed with FRT.A coordinated effort including orthopedic surgeons,hematologists,physical medicine and rehabilitation physicians,physiotherapists and other team members is key to optimal ***,orthopedic procedures should be performed in specialized hospitals with experienced *** we are able to prevent orthopedic problems of the knee in PWH will have to continue performing orthopedic procedures(arthrocentesis,RS,arthroscopic synovectomy,hamstring release,arthroscopic debridement,alignment osteotomy,and total knee arthroplasty).By using the aforementioned procedures,the quality of life of PWH will be improved.

关键词： Hemophilia Knee Orthopedic problems Prevention Surgical treatment

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Synthesis and Characterization of Aluminum/Carbon Nanotubes Composites： Study of Interfacial Interaction

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Journal of Chemistry and Chemical Engineering 2013年第4期7卷 313-318页

作者： Mananna Barbeno Pasquale Barone valentino Pingitore Assunta Bonanno Mariano Davoli FangXu Physics Department University of Calabria Rende (CS) 87036 Italy Earth Science Department University of Calabria Rende (CS) 87036 Italy

In this work, the authors present a study of growth and characterization of composite based on Al and CNT (carbon nanotubes. The composites were prepared by a chemical mixing method and characterized by SEM analysis, energy dispersed X-ray measurements, X-ray photoelectron spectroscopy and cathodoluminescence spectroscopy. The analysis showed that the composites are formed by macro-cluster of aluminum oxide on a network of CNT without formation of chemical bonds at interface between particles. The results are compared with those obtained for a sample of CNT with Al traces (< 0.5%). They show that only the presence of metal traces changes the nanotubes optical properties, with a luminescence signal centered at about 380 nm. These luminescence signals are caused by the adhesion between CNT and Al micro-clusters that promote the formation of band gap with some local energy levels.

关键词：碳纳米管复合材料界面相互作用铝颗粒表征 X射线光电子能谱合成发光光谱 SEM分析

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Laser Ablation of Silver Artifacts in Vacuum： Solution to Silver Tarnishing Problem

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Journal of Earth Science and Engineering 2012年第12期2卷 697-703页

作者： Fabio Stranges Marianna Barberio Pasquale Barone valentino Pingitore Fang Xu Assunta Bonanno Department of Physics University of Calabria Rende 87036 ltaly Department of Biology Ecology and Earth Sciences University of Calabria Rende 8703 Italy

This work is a study of effect of laser ablation in different medium on silver artifacts. The effectiveness of laser ablation cleanness methods was evaluated in air, water and vacuum condition. The samples were subjected to HCl treatment for several hours to simulate the formation of chloride patina on marine archeological artifacts. Laser ablation removes the patina in all medium, reducing its thickness from 300 to few microns in air and water and eliminating completely the chlorine in vacuum conditions. However, it was observed the formation, during cleanness of a white patina in air and water and an increasing of oxygen amount on surface. This indicate that in ambient reach in oxygen laser ablation favorite the oxygen absorbance on surface and the formation of a thin layer of AgO which dulls the surface. This hypothesis is confirmed by the results of laser ablation in vacuum conditions where surface tarnishing was not observed. So, laser ablation in vacuum condition was indicated as the most effective procedure to clean silver artifacts.

关键词：激光烧蚀表面变色文物真空度银真空条件题解激光消融

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Optical and Structural Properties of Carbon Nanotube-Rutile Heterostructures

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Journal of Chemistry and Chemical Engineering 2012年第10期6卷 942-950页

作者： Marianna Barbeno Pasquale Barone Alessandra Imbrogno Fang Xu valentino Pingitore Assunta Bonanno Physics Department University of Calabria Arcavacata 87036 Italy

The paper presents a study of the growth and characterization of carbon nanotube–rutile nanocomposites. The heterostructures were obtained with a chemical mixing method. Scanning electron microscope images show that the samples appear as a homogeneous powder of rutile with carbon nanotubes intercalated in interspaces between the TiO2 grains. Characterization by both X-ray photoelectron spectroscopy and cathodo-luminescence analysis show the formation of CO-Ti chemical bonds with a decrease of 0.8 eV in the band gap compared to pure rutile. The consequence of this band gap modification is a strong change in optical properties. Luminescence emission is drastically reduced and absorption in the visible range is increased of about 6% at very low concentration (1%) of carbon nanotubes.

关键词：金红石型碳纳米管异质结构光学性质结构特性 X-射线光电子能谱二氧化钛颗粒扫描电子显微镜

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局部过氧化钡治疗顽固开放性创口

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国外医学.护理学分册 1987年第3期08卷 136-136页

作者： valentino 郭光宇

过氧化钡疗法:开放性创口在许多传统疗法中以局部过氧化钡(THO)疗法效果为最佳。Kanfman等进行了临床研究,认为它能使烧伤、创口表皮细胞核分裂、移动,胶质合成,缩小创口,同样发现组织愈合需过多的氧来保护组织;Tan等报告应用高压空气(... 详细信息

过氧化钡疗法:开放性创口在许多传统疗法中以局部过氧化钡(THO)疗法效果为最佳。Kanfman等进行了临床研究,认为它能使烧伤、创口表皮细胞核分裂、移动,胶质合成,缩小创口,同样发现组织愈合需过多的氧来保护组织;Tan等报告应用高压空气(21%氧)及THO使家兔皮瓣小岛存活率增加;Fischer报告用THO25毫米汞柱压力使顽固性皮肤溃疡(烧伤、褥疮、静脉郁积性溃疡及创口感染)完全愈合;Kaamda认为THO容易掌握,病人舒服,过氧化钡腔(Chamber)围住溃疡、创口应用加压(环形压力80毫米汞柱)。给THO前应当移去创口的坏死组织,则效果更好;Kaufman等认为THO腔是根据正在愈合的组织,如果得到大量的氧创口愈合的较快原理。THO使外面组织与氧饱和而有利于愈合;Sa-urifman等认为THO促使肉芽组织增生,形成新的毛

关键词：创口 cm 胫前过氧化钡开放性

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