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Contrast-enhanced ultrasound with sulphur-hexafluoride in diagnosis of early HCC in cirrhosis

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Hepatoma Research 2019年第6期5卷 16-24页

作者： Antonio giorgio Pietro Gatti Paolo Matteucci valentina giorgio Department of Medicine Interventional Ultrasound UnitAthena Clinical InstituteCaserta 81016Italy Department of Medicine Brindisi General HospitalBrindisi 72100Italy Radiation Oncology Institute Campus Biomedico UniversityRome 00128Italy Fondazione Policlinico A.Gemelli IRCCS Department of Woman and Child Health and Public HealthRoma 00168Italy

Contrast-enhanced ultrasound(CEUS)with pure blood stream contrast agents allow the study of blood supply of focal liver lesions and especially of hepatocellular carcinoma(HCC)in *** sensitivity and specificity in diagnosis of small tumors is very *** review summarizes the recent results on CEUS with SonoVue,which is one of the second generation contrast agents,in the diagnosis of early HCC in cirrhosis emphasizing its increasing role in routine clinical practice.

关键词： Hepatocellular carcinoma contrast-enhanced ultrasound cirrhosis early hepatocellular carcinoma

Editorial on "Role of thermal ablation in the management of colorectal liver metastasis"

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 62-64页

作者： Antonio giorgio Pietro Gatti Massimo De Luca Paolo Matteucci valentina giorgio Liver Unit and Interventional Ultrasound Unit Athena Clinical InstitutePiedimonte Matese(CE)Italy Internal Medicine Unit Brindisi General HospitalBrindisiItaly Liver Unit Cardarelli HospitalNaplesItaly Radiation Oncology Unit Campus BiomedicoRomaItaly Fondazione Policlinico A.Gemelli IRCCS Department of Woman and Child Health and Public HealthRomaItaly

The last 30 years have shown the increasing role of Ablation in the treatment of malignant liver tumors. By the introduction of percutaneous ethanol injection (PEI) as first ablation tool for percutaneous treatment of hepatocellular carcinoma (HCC) in cirrhosis that firstly showed very high efficacy (1), several ablation techniques (mainly thermal) have been introduced in clinical practice aimed at destroying primary and secondary hepatic tumors as alternative or substitute tools to surgery. Radiofrequency ablation (RFA) was the first thermal technique that showed a good efficacy to ablate liver metastases (2). Among the secondary liver tumors, colorectal liver metastases (CRLM) represent the unique indication for ablation (2). Unlike HCC in cirrhosis where the role of RFA is well defined as first line therapy for HCC nodules < or equal to 2 cm or as alternative to surgery in 1-3 HCC nodules with the maximum diameter<3 cm (3), in the case of CRLM it is not possible to reproduce the same paradigm. Liver resection remains the standard of care for CRLM and the indications to ablation remain confined to nonresectable patients (4). The review article by Takahashi and Berber recently published in HBSN wells illustrates the current role of ablation in treatment of CRLM (5).

关键词： colorectal metastasis surgery

Intrahepatic Cholangiocarcinoma and Thermal Ablation:Long-term Results of An Italian Retrospective Multicenter Study

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 287-292页

作者： Antonio giorgio Pietro Gatti Luca Montesarchio Bruno Santoro Andrea Dell’Olio Nicola Crucinio Carmine Coppola Ferdinando Scarano Fabio De Biase Emanuela Cirac Stefano Semeraro valentina giorgio Liver Unit and Interventional Ultrasound Unit Athena Clinical InstitutePiedimonte Matese(CE)Italy Internal Medicine Unit Brindisi General HospitalBrindisiItaly General Surgery Unit Polla General HospitalPolla(SA)Italy Department of Radiology Bisceglie Hospital-ASL BATBisceglieItaly Gastroenterology Unit Foggia General HospitalFoggiaItaly Department of Internal Medicine Hepatology Interventional UnitGragnano HospitalGragnano(NA)Italy Internal Medicine Unit Ostuni HospitalOstuni(BR)Italy Fondazione Policlinico A.Gemelli IRCCS Department of Woman and Child Health and Public HealthLargo A GemelliRomaItaly

Background and Aims: Despite resection being considered the treatment of choice for intrahepatic cholangiocarcinoma(ICC),percutaneous thermal ablation can be an alter-native treatment for patients unfit for *** aim was to compare long-term results of percutaneous sonographi-cally-guided radiofrequency ablation(RFA)with high-powered microwave ablation(MWSA)in treatment of ***: Results of 71 ICC patients with 98 nodules treated with RFA(36 patients)or MWSA(35 patients)between January 2008 and June 2018 in 5 Interventional Ultrasound centers of Southern Italy were retrospectively ***-mulative overall survival curves were calculated with the Ka-plan-Meyer method and differences with the log-rank *** possible factors affecting survival were ***: Overall survival of the entire series was 88%,65%,45%and 34%at 12,36,60 and 80 months,*** treated with MWSA survived longer than pa-tients treated with RFA(p 4 cm,no significant difference was ***-free sur-vival and progression-free survival were better in the MWSA group compared to the RFA group(p < 0.005).Diameter of nodules and MWSA were independent factors predicting a better *** major complications were ***: MWSA is superior to RFA in treating ICC unfit for surgery,achieving better long-term survival in small(≤3 cm)ICC nodules as well as nodules up to 4 cm of neo-plastic tumors and should replace RFA.

关键词： Intrahepatic cholangiocarcinoma Thermal ablation Microwaves Radiofrequency Percutaneous treatment

Feeding broiler chickens with arginine above recommended levels:effects on growth performance,metabolism,and intestinal microbiota

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1528-1541页

作者： giorgio Brugaletta Marco Zampiga Luca Laghi valentina Indio Chiara Oliveri Alessandra De Cesare Federico Sirri Department of Agricultural and Food Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly Department of Veterinary Medical Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly Department of Physics and Astronomy Alma Mater Studiorum-University of Bologna40127 BolognaItaly

Background Arginine is an essential amino acid for chickens and feeding diets with arginine beyond the recommended levels has been shown to influence the growth performance of broiler chickens in a positive ***,further research is required to understand how arginine supplementation above the widely adopted dosages affects metabolism and intestinal health of ***,this study was designed to assess the effects of arginine supplementation(i.e.,total arginine to total lysine ratio of 1.20 instead of 1.06-1.08 recommended by the breeding company) on growth performance of broiler chickens and to explore its impacts on the hepatic and blood metabolic profiles,as well as on the intestinal *** this purpose,630 one-day-old male Ross 308 broiler chicks were assigned to 2 treatments(7 replicates each) fed a control diet or a crystalline L-arginine-supplemented diet for 49 *** Compared to control birds,those supplemented with arginine performed significantly better exhibiting greater final body weight at D49(3778 vs.3937 g;P < 0.001),higher growth rate(76.15 vs.79.46 g of body weight gained daily;P < 0.001),and lower cumulative feed conversion ratio(1.808 vs.1.732;P < 0.05).Plasma concentrations of arginine,betaine,histidine,and creatine were greater in supplemented birds than in their control counterparts,as were those of creatine,leucine and other essential amino acids at the hepatic *** contrast,leucine concentration was lower in the caecal content of supplemented *** alpha diversity and relative abundance of Firmicutes and Proteobacteria(specifically Escherichia coli),as well as increased abundance of Bacteroidetes and Lactobacillus salivarius were found in the caecal content of supplemented *** The improvement in growth performance corroborates the advantages of supplementing arginine in broiler *** can be hypothesized that the performance enhancement found in this study is associated with the i

关键词： Arginine Broiler chicken Growth performance Metabolism Microbiota

Negative Feedback Regulation of Auxin Signaling by ATHB8/ACL5-BUD2 Transcription Module

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Molecular Plant 2014年第6期7卷 1006-1025页

作者： Simona Baima valentina Forte Marco Possenti Andres Penalosa Guido Leoni Sergio Salvi Barbara Felici Ida Ruberti giorgio Morelli Food and Nutrition Research Centre Agricultural Research Council Via Ardeatina 546 00178 Rome Italy Present address: Department of Physics Sapienza University of Rome Rle A Moro 5 00185 Rome Italy Present address: Soil-Plant System Studies Research Centre Agricultural Research Council Via della Navicella 2-4 00184 Rome Italy Institute of Biology Molecular Medicine and NanoBiotechnology National Research Council Rle A. Moro 5 00185 Rome Italy

The role of auxin as main regulator of vascular differentiation is well established, and a direct correlation between the rate of xylem differentiation and the amount of auxin reaching the （pro）cambial cells has been proposed. It has been suggested that thermospermine produced by ACAULIS5 （ACL5） and BUSHY AND DWARF2 （BUD2） is one of the factors downstream to auxin contributing to the regulation of this process in Arabidopsis. Here, we provide an in-depth characterization of the mechanism through which ACL5 modulates xylem differentiation. We show that an increased level of ACL5 slows down xylem differentiation by negatively affecting the expression of homeodomain-leucine zipper （HD- ZIP） III and key auxin signaling genes. This mechanism involves the positive regulation of thermospermine biosynthesis by the HD-ZIP III protein ARABIDOPSIS THALIANA HOMEOBOX8 tightly controlling the expression of ACL5 and BUD2. In addition, we show that the HD-ZIP III protein REVOLUTA contributes to the increased leaf vascularization and long hypocotyl phenotype of acl5 likely by a direct regulation of auxin signaling genes such as LIKE AUXIN RESISTANT2 （LAX2） and LAX3. We propose that proper formation and differentiation of xylem depend on a balance between positive and negative feedback loops operating through HD-ZIP III genes.

关键词： auxin procambium thermospermine autoregulation auxin influx transporters Arabidopsis.

Appendicular tuberculosis:The resurgence of an old disease with difficult diagnosis

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World Journal of Gastroenterology 2010年第4期16卷 518-521页

作者： Francesco Barbagallo Saverio Latteri Maria Sofia Agostino Ricotta giorgio Castello Andrea Chisari valentina Randazzo Gaetano La Greca Department of Surgical Sciences Transplantation and New TechnologiesUniversity of CataniaVia Messina 35495126 CataniaItaly

Gastrointestinal tuberculosis(TB) is quite rare,representing only 3% of all extra-pulmonary *** gut and ileum are the most common gastrointestinal localizations,while appendix involvement is *** involvement is usually related to symptoms of acute appendicitis since the caseous necrosis may lead to adhesions and surgical complications such as *** this reason patients with suspected appendicular TB usually undergo surgery even without a secure *** these cases,due to the absence of specific symptoms and signs,the diagnosis is delayed after surgery,thus resulting in a high percentage of important,and sometimes lethal,*** examination is often the only way to reach a diagnosis and to establish specific antibiotic therapy,while an early diagnosis could avoid surgical *** report a case of appendicular TB not only for its rarity but also todiscuss the difficulty in its diagnosis.

关键词： Appendicitis Peritoneal tuberculosis Peritonitis Tuberculosis

New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond

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World Journal of Gastroenterology 2017年第36期23卷 6593-6627页

作者： Emanuele Sinagra Gaetano Cristian Morreale Ghazaleh Mohammadian giorgio Fusco valentina Guarnotta Giovanni Tomasello Francesco Cappello Francesca Rossi Georgios Amvrosiadis Dario Raimondo Gastroenterology and Endoscopy Unit Fondazione Istituto Giuseppe GiglioContrada Pietra Pollastra Pisciotto Euro-Mediterranean Institute of Science and Technology Department of Experimental Biomedicine and Clinical Neuroscience Section of Human AnatomyUniversity of Palermo Unit of Gastroenterology Ospedali Riuniti Villa Sofia-Vincenzo Cervello Department of Medicine Division of Gastroenterology and HepatologyKarolinska InstitutetKarolinska University Hospital Unit of Internal Medicine Ospedali Riuniti Villa Sofia-Vincenzo Cervello Section of Cardio-Respiratory and Endocrine-Metabolic Diseases Biomedical Department of Internal and Specialist MedicineUniversity of Palermo

Irritable bowel syndrome(IBS)is a chronic,recurring,and remitting functional disorder of the gastrointestinal tract characterized by abdominal pain,distention,and changes in bowel *** there are several drugs for IBS,effective and approved treatments for one or more of the symptoms for various IBS subtypes are *** understanding of pathophysiological mechanisms such as the role of impaired bile acid metabolism,neurohormonal regulation,immune dysfunction,the epithelial barrier and the secretory properties of the gut has led to advancements in the treatment of *** regards to therapies for restoring intestinal permeability,multiple studies with prebiotics and probiotics are ongoing,even if to date their efficacy has been *** parallel,much progress has been made in targeting low-grade inflammation,especially through the introduction of drugs such as mesalazine and rifaximin,even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such *** literature review aims to summarize the findings related to new and investigational therapeutic agents for IBS,most recently developed in preclinical as well as Phase 1 and Phase 2clinical studies.

关键词： Therapy Low grade inflammation Motility Secretion Irritable bowel syndrome Immunoendocrine axis

Antidiabetic therapy and increased risk of hepatocellular carcinoma in chronic liver disease

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World Journal of Gastroenterology 2009年第20期15卷 2506-2511页

作者： Valter Donadon Massimiliano Balbi Michela Ghersetti Silvia Grazioli Antonio Perciaccante Giovanni Della valentina Rita Gardenal Maria Dal Mas Pietro Casarin giorgio Zanette Cesare Miranda Department of Medicine Internal Medicine 3rd Pordenone Hospital Diabetes Clinic Pordenone Hospital Via Montereale 24 Pordenone 33170 Italy

AIM:To explore the association between hepatocellular carcinoma(HCC) and type 2 diabetes mellitus, describe the temporal relations between the onset of diabetes and the development of HCC and evaluate the possible effects of antidiabetic therapy on HCC ***:We recruited 465 HCC patients, 618 with cirrhosis and 490 control *** evaluated the odds ratio(OR) for HCC by univariate and multivariate ***, OR for HCC in diabetic subjects treated with insulin or sulphanylureas and with metformin were ***:The prevalence of diabetes mellitus was 31.2% in HCC, 23.3% in cirrhotic patients and 12.7% in the Control *** univariate and multivariate analysis, the OR for HCC in diabetic patients were respectively 3.12(CI 2.2-4.4, P < 0.001) and 2.2(CI 1.2-4.4, P = 0.01).In 84.9% of cases, type 2 diabetes mellitus was present before the diagnosis of ***, we report an OR for HCC of 2.99(CI 1.34-6.65, P = 0.007) in diabetic patients treated with insulin or sulphanylureas, and an OR of 0.33(CI 0.1-0.7, P = 0.006) in diabetic patients treated with ***:Our study confi rms that type 2 diabetes mellitus is an independent risk factor for HCC and pre-exists in the majority of HCC ***, in male patients with type 2 diabetes mellitus, our data shows a direct association of HCC with insulin and sulphanylureas treatment and an inverse relationship with metformin therapy.

关键词：肝癌治疗风险降糖 2型糖尿病肝病慢性二甲双胍

Role of Mediterranean diet in preventing platinum based gastrointestinal toxicity in gynecolocological malignancies: A single Institution experience

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World Journal of Clinical Oncology 2019年第12期10卷 391-401页

作者： Eleonora Ghisoni valentina Casalone Gaia Giannone Gloria Mittica valentina Tuninetti giorgio Valabrega Candiolo Cancer Institute FPO-IRCCSTorino 10060 Italy University of Torino Torino 10060Italy

BACKGROUND Gynecological malignancies represent a major cause of death in women and are often treated with platinum-based *** undergoing chemotherapy suffer from alterations in nutritional status which may worsen gastrointestinal(GI)toxicities,quality of life and affect the overall ***,assuring a good nutritional status and limiting toxicities during treatment are still major goals for *** To assess the role of Mediterranean Diet(MD)in reducing GI toxicities in patients with gynecological cancers treated with platinum-based *** We conducted an observational study on 22 patients with gynecological tumors treated with a platinum-based chemotherapy at Candiolo Cancer Institute FPO/IRCCS between January 2018 and June *** food and frequency(FFQ)and the Patient-Reported Outcomes Common Terminology Criteria For Adverse Events(PRO-CTCAE)questionnaires were administered at baseline and at every Day 1 of each *** evaluate the differences in GI toxicities the study population was divided in two groups according to the currently validated Mediterranean Diet Serving Score(MDSS)at *** Patients with high MDSS reported a trend toward lower GI toxicities according to PRO-CTCAE at each timepoint(first evaluation:P=0.7;second:P=0.52;third:P=0.01).In particular,difference in nausea frequency and gravity(P<0.001),stomach pain frequency and gravity(P=0.01 and P=0.02),abdomen bloating frequency and gravity(P=0.02 and P=0.03),and interference with daily activities(P=0.02)were highly statistically significant at the end of *** than 60%of patients changed their food habits during chemotherapy mainly because of GI toxicities.A higher reduction of food intake,both in terms of caloric(P=0.29)and of single nutrients emerged in the group experiencing higher *** Our results show that adherence to MD possibly reduces GI toxicity and prevents nutritional status impairment during chemotherapy treatmen

关键词： Mediterranean diet Gynecological malignancies Gastrointestinal toxicities Platinum-based chemotherapy Nutritional status