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Revaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome

World Journal of Gastroenterology 2008年第30期14卷 4745-4752页

作者： Alessia Riva Paola Trombini Raffaella Mariani Alessandra Salvioni Sabina Coletti Silvia Bonfadini valentina paolini Matteo Pozzi Rita Facchetti Giorgio Bovo Alberto Piperno Department of Clinical Medicine University of Milano-Bicocca San Gerardo Hospital Department of Clinical and Preventive Medicine University of Milano-Bicocca Department of Clinical Pathology San Gerardo Hospital University of Milano-Bicocca

AIM： To re-evaluate the diagnostic criteria of insulin resistance hepatic iron overload based on clinical, biochemical and histopathological findings. METHODS： We studied 81 patients with hepatic iron overload not explained by known genetic and acquired causes. The metabolic syndrome （MS） was defined according to ATPⅢ criteria. Iron overload was assessed by liver biopsy. Liver histology was evaluated by Ishak＇s score and iron accumulation by Deugnier＇s score; steatosis was diagnosed when present in ≥ 5% of hepatooltes. RESULTS： According to transferrin saturation levels, we observed significant differences in the amount of hepatic iron overload and iron distribution, as well as the number of metabolic abnormalities. Using Receiving Operating Curve analysis, we found that the presence of two components of the MS differentiated two groups with a statistically significant different hepatic iron overload （P 〈 0.0001）. Patients with ≥2 metabolic alterations and steatosis had lower amount of hepatic iron, lower transferrin saturation and higher sinusoidal iron than patients with 〈 2 MS components and absence of steatosis. CONCLUSION： In our patients, the presence of ≥ 2 alterations of the MS and hepatic steatosis was associated with a moderate form of iron overload with a prevalent sinusoidal distribution and a normal transferrin saturation, suggesting the existence of a peculiar pathogenetic mechanism of iron accumulation. These patients may have the typical dysmetabolic iron overload syndrome. By contrast, patients with transferrin saturation ≥ 60% had more severe iron overload, few or no metabolic abnormalities and a hemochromatosis-like pattern of iron overload.

关键词： Iron overload Hepatic iron distribution Transferrin saturation Metabolic syndrome Hepatic steatosis

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Non-peptidyl low molecular weight radical scavenger IAC attenuates DSS-induced colitis in rats

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World Journal of Gastroenterology 2010年第29期16卷 3642-3650页

作者： valentina Vasina Massimiliano Broccoli Maria Grazia Ursino Donatella Canistro Luca Valgimigli Antonio Soleti Moreno paolini Fabrizio De Ponti Department of Pharmacology University of Bologna Department of Organic Chemistry "A.Mangini" University of Bologna Medestea Research

AIM:To investigate the effects of the free radical scavenger bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl) decandioate(IAC) in the dextran sodium sulphate(DSS) experimental model of ulcerative ***:Colitis was induced in Sprague Dawley male rats by administration of 5% DSS in drinking ***(30 mg/kg,lipophilic or hydrophilic form) was administered daily(orally or ip) for 6 d until *** damage was assessed by means of indirect(Disease Activity Index score) and direct measures(macroscopic and microscopic scores) and myeloperoxidase(MPO)*** infiltration within the tissue and glutathione S-transferase activity were also ***:DSS-induced colitis impaired body weight gain and markedly increased all inflammatory ***-day treatment with lipophilic IAC significantly reduced intestinal damage caused by inflammation,induced a down-regulation in MPO activity(0.72 ± 0.12 and 0.45 ± 0.12 with lipophilic IAC po and ip,respectively,vs 1.10 ± 0.27 in untreated DSS colitis animals) and minimized DSS-induced neutrophil infiltration,while hydrophilic IAC administered orally did not ameliorate DSS-induced ***:These results support the hypothesis that reactive oxygen metabolites contribute to inflammation and that the radical scavenger IAC has therapeutic potential in inflammatory bowel disease.

关键词： Dextran sodium sulphate-induced colitis Oxidative damage Inflammatory bowel disease Bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioate Radical scavenger Animal models

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