Non-peptidyl low molecular weight radical scavenger IAC attenuates DSS-induced colitis in rats

作     者：Valentina Vasina Massimiliano Broccoli Maria Grazia Ursino Donatella Canistro Luca Valgimigli Antonio Soleti Moreno Paolini Fabrizio De Ponti 

作者机构：Department of PharmacologyUniversity of Bologna Department of Organic Chemistry "A.Mangini"University of Bologna Medestea Research 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第29期

页      面：3642-3650页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by A Grant from the University of Bologna (Ricerca Fondamentale Orientata) 

主　　题：Dextran sodium sulphate-induced colitis Oxidative damage Inflammatory bowel disease Bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioate Radical scavenger Animal models 

摘      要：AIM:To investigate the effects of the free radical scavenger bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl) decandioate(IAC) in the dextran sodium sulphate(DSS) experimental model of ulcerative ***:Colitis was induced in Sprague Dawley male rats by administration of 5% DSS in drinking ***(30 mg/kg,lipophilic or hydrophilic form) was administered daily(orally or ip) for 6 d until *** damage was assessed by means of indirect(Disease Activity Index score) and direct measures(macroscopic and microscopic scores) and myeloperoxidase(MPO)*** infiltration within the tissue and glutathione S-transferase activity were also ***:DSS-induced colitis impaired body weight gain and markedly increased all inflammatory ***-day treatment with lipophilic IAC significantly reduced intestinal damage caused by inflammation,induced a down-regulation in MPO activity(0.72 ± 0.12 and 0.45 ± 0.12 with lipophilic IAC po and ip,respectively,vs 1.10 ± 0.27 in untreated DSS colitis animals) and minimized DSS-induced neutrophil infiltration,while hydrophilic IAC administered orally did not ameliorate DSS-induced ***:These results support the hypothesis that reactive oxygen metabolites contribute to inflammation and that the radical scavenger IAC has therapeutic potential in inflammatory bowel disease.