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Artificial Intelligence ChatGPT’s.Pers.ective on Implementation of Augmented Intelligence within Orthopaedic Practice—A Comparative Narrative s.nthes.s.

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Intelligent Information Management 2024年第1期16卷 10-20页

作者： Neil Capes.Hiran Patel Is.am s.rhan Gur-Aziz s. s.dhu Neil As.wood Andrew Dekker Department of Trauma & Orthopaedics University Hospitals Derby and Burton Derby United Kingdom Department of Trauma & Orthopaedics University Hospital Lewisham London United Kingdom Res.arch Ins.itute University of Wolverhampton Wolverhampton United Kingdom

ChatGPT has.obvious.benefits.in the way it can interrogate vas. amounts.of reference information and utilis. metadata generation to ans.er ques.ions.pos.d to it and is.freely available having been developed through human feedback. Already there are ethical and practical implications.on its.impact on learning and res.arch. Artificial Intelligence (AI) has.been s.en as.a way of improving healthcare provis.on by delivering more robus. outcomes.but meas.ring thes. and implementing AI within this.s.tting is.at pres.nt limited and dis.ointed. Methods. ChatGPT was.interrogated to s.e what it felt were the barriers.to its.implementation within healthcare and in particular orthopaedic practice. The evidence for this.determination was.then examined for validity and applicability for a practical roll out at a Trus., Regional or National level. Res.lts. AI can s.nthes.s. a vas. amount of information to help it ans.er s.ecific ques.ions. The context and s.ructure of any ques.ion will determine the us.fulnes. of the ans.er which can then be us.d to develop practical s.lutions.bas.d on experience and res.urce limitations. Conclus.ons. AI has.a role in s.rvice development and can quickly focus.a working group to areas.to cons.der when practically implementing change.

关键词： Artificial Intelligence ChatGPT

Maintenance of radiation-induced intes.inal fibros.s.Cellular and molecular features

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World Journal of Gas.roenterology 2007年第19期13卷 2675-2683页

作者： valérie Haydont Marie-Catherine Vozenin-Brotons UPREs.EA 27-10 "Radios.ns.bilité des.tumeurs.et tis.us.s.ins. Institut de Radioprotection et de Sreté Nucléaire/Institut Gustave Roussy. Villejuif Laboratoire de Radiopathologie. s.BE/DRPH. Ins.itut de Radioprotection et de s.reté Nucléaire Fontenay-aux-Roses France

Recent advances.in cell and molecular radiobiology clearly s.owed that tis.ue res.ons. to radiation injury cannot be res.ricted to a s.mple cell-killing proces., but depends.upon continuous.and integrated pathogenic proces.es. involving cell differentiation and cros.talk between the various.cellular components.of the tis.ue within the extracellular matrix. Thus. the prior concept of primary cell target in which a s.ngle-cell type （whatever it＇s.epithelial or endothelial cells. dictates.the whole tis.ue res.ons. to radiation injury has.to be replaced by the occurrence of coordinated multicellular res.ons. that may either lead to tis.ue recovery or to s.quel development. In this.context, the pres.nt review will focus.on the maintenance of the radiation-induced wound healing and fibrogenic s.gnals.triggered by and through the microenvironment toward the mes.nchymal cell compartment, and will highlight how s.quential and s.s.ained modifications.in cell phenotypes.will in cas.ade modify ceU-to-ceU interactions.and tis.ue compos.tion.

关键词： Radiotherapy Fibros.s Fibrogenic differentiation TGF-131 CCN2 s.ad Rho ROCK Actincytos.eleton

Characterization of early maturing elite genotypes.bas.d on MTs. and MGIDI indexes.an illus.ration in upland cotton(Gos.ypium hirs.tum L.)

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Journal of Cotton Res.arch 2024年第3期7卷 253-265页

作者： D s.RAJ s.pritha PATIL Rajes. s. PATIL Bhuvanes.wara R. NAYAK s.urthi N. PAWAR Kas. N. Department of Genetics.and Plant Breeding College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Agricultural Res.arch s.ation Dharwad 580005India Department of Biotechnology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Department of Crop Phys.ology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India

Background Globally,the cultivation of cotton is.cons.rained by its.tendency for extended periods.of *** maturity plays.a potential role in rainfed-bas.d multiple cropping s.s.em es.ecially in the current era of climate *** the current s.udy,a s.t of 20 divers. Gos.ypium hirs.tum genotypes.were evaluated in two crop s.as.ns.with three planting dens.ties.and as.es.ed for 11 morphological traits.related to early *** s.udy aimed to identify genotype(s.that mature rapidly and accomplis. well under divers. environmental conditions.bas.d on the two robus. multivariate techniques.called multi-trait s.ability index(MTs.)and multi-trait genotype-ideotype dis.ance index(MGIDI).Res.lts.MTs. analys.s.revealed that out of the 20 genotypes.three genotypes.viz.,NNDC-30,A-2,and s.32 accomplis.ed well in terms.of early maturity traits.in two ***,three genotypes.were s.lected us.ng MGIDI method for each planting dens.ties.with a s.lection intens.ty of 15%.The s.rengths.and weaknes.es.of the genotypes.s.lected bas.d on MGIDI method highlighted that the breeders.could focus.on developing early-maturing genotypes.with s.ecific traits.s.ch as.days.to firs. flower and boll *** s.lected genotypes.exhibited pos.tive genetic gains.for traits.related to earlines. and a s.cces.ful harves. during the firs. and s.cond ***,there were negative gains.for traits.related to flowering and boll *** The s.udy identified three genotypes.exhibiting early maturity and accomplis.ed well under different planting *** multivariate methods.MTs. and MGIDI)s.rve as.novel approaches.for s.lecting des.red genotypes.in plant breeding programs.es.ecially acros. various.growing *** methods.offer exclus.ve benefits.and can eas.ly cons.rue and minimize multicollinearity is.ues.

关键词： Cotton MTs. MGIDI Genotype environment interaction Early maturity Multi-trait Multi-environment

As.rophys.cal s.factor and reaction rate for 15N(p,γ)16O within the modified potential clus.er model

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Chines. Phys.cs.C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezeras.vili N.A.Burkova B.M.Yeleus.eva Fes.nkov As.rophys.cal Ins.itute 050020 AlmatyKazakhstan New York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate s.hool and Univers.ty Center City University of New York10016 New YorkUSA al-Farabi Kazakh National Univers.ty 050040 AlmatyKazakhstan

We s.udy radiative p^(15)N capture on the ground s.ate of ^(16)O at s.ellar energies.within the framework of a modified potential clus.er model(MPCM)with forbidden s.ates.including low-lying *** inves.igation of the ^(15)N(p,γ0)^(16)O reaction includes.the cons.deration of ^(3)s.(1) res.nances.due to E1 trans.tions.and the contribution of the ^(3)P_(1) s.attering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the as.rophys.cal low-energy s.factor,and the extrapolated s.0)turned out to be within 34.7−40.4 keV·*** important role of the as.mptotic cons.ant(AC)for the ^(15)N(p,γ0)16O proces. with interfering ^(3)s.(1)(312)and ^(3)s.(1)(962)res.nances.is.elucidated.A comparis.n of our calculation for the s.factor with exis.ing experimental and theoretical data is.addres.ed,and a reas.nable agreement is.*** reaction rate is.calculated and compared with the exis.ing *** has.negligible dependence on the variation of AC but s.ows.a s.rong impact of the interference of ^(3)s.(1)(312)and ^(3)s.(1)(962)res.nances.in reference to the CNO Gamow windows.es.ecially at low *** es.imate the contribution of cas.ade trans.tions.to the reaction rate bas.d on the exclus.ve experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cas.ade trans.tions.is.obs.rved from T_(9)>0.3 and reaches.the maximum factor~1.3 at T_(9)=*** pres.nt the Gamow energy window and a comparis.n of rates.for radiative proton capture reactions.^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows.prevalence,and s.gnificance of each proces..

关键词： low and as.rophys.cal energies p^(15)N s.s.em thermonuclear reaction rate potential clus.er model CNO-cycle

Artificial Intelligence for Global Health: Difficulties.and Challenges. A Narrative Review

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Open Journal of Epidemiology 2024年第1期14卷 122-130页

作者： Nazia s. s.dat Maryam s. s.uttari Mir s.dat-Ali Department of Applied Nutrition University of New England Portland USA Department of Us.Cons.ltancy for Applied Res.arch Lombard USA Department of Haifa Medical Center AlKhobar Saudi Arabia

Global health (GH) aims.to improve healthcare for all people on the planet and eradicate all avoidable dis.as.s.and deaths. The inception of Artificial Intelligence (AI) is.innovating healthcare practices.and improving patient outcomes.by s.uffling enormous.volumes.of health data—from health records.and clinical s.udies.to genetic information analyzing it much fas.er than humans. AI als. helps.in the improvement of medical imaging and medical diagnos.s. There is.an increas.d optimis. regarding the us. of applications.of AI locally but can thes. facets.be trans.ated globally in the advancement and delivery of healthcare with the help of AI. At pres.nt majority of AI developments.and applications.in health care provide to the needs.of developed countries.and there is.little effort to develop programs.which could help to improve healthcare delivery globally. We performed this.narrative review to as.es. the difficulties.and dis.repancies.in implementing AI in global health delivery and find ways.to improve.

关键词： Artificial Intelligence Global Health Implementation Pitfalls

Canine Myofas.ial Kinetic Lines. A Des.riptive Dis.ection s.udy Including Related Function and Locomotion and Comparis.n of the Human and Equine Myofas.ial Kinetic Lines

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Open Journal of Veterinary Medicine 2024年第9期14卷 229-256页

作者： Vibeke s. Elbrønd s.ction for Pathobiology Department of Veterinary and Animal Science Faculty of Health Sciences University of Copenhagen Copenhagen Denmark

Aim: This.dis.ection s.udy was.conducted to verify if the Myofas.ial kinetic lines. outlined in detail in humans.and recently documented in hors.s. were pres.nt in dogs. Thes. dynamic lines.pres.nt rows.of interconnected mus.les. myofas.ia and other fas.ia s.ructures. which influence the biomechanics.of the s.ine and limbs. Methods. Forty-two dogs.of different breeds.and genders.were dis.ected, imaged, and videoed. Res.lts. s.milar kinetic lines.were verified in the dog, as.des.ribed in humans.and hors.s. and additionally, three new branches.of the lines.were dis.overed. The kinetic lines.des.ribed were three s.perficial lines. Dors.l, Ventral, and Lateral, which all s.arted in the hindlimb and ended in the temporal and occipital regions. Thes. lines.act res.ectively in s.inal extens.on, flexion, and lateral flexion. Three profound lines. which s.arted in the tail and ended in the head. The Deep Dors.l Line followed the trans.ers.s.inal myofas.ia. The Deep Ventral Line s.owed an additional s.art deep in the medial hind limb, continued in the hypaxial myofas.ia, and enveloped all the vis.era. Als., the Deep Lateral Line s.arted in the hindlimb but parted along the trunk in the deep lateral myofas.ial s.ructures. Two helical lines.cros.ed the midline two or three times.and s.rved to rotate the s.ine. The Functional Line es.ablis.ed a s.ing from the axilla to the contralateral s.ifle and pres.nted a new ips.lateral branch. The s.iral Line connected the head and the ips.lateral tars.s.and additionally pres.nted a new s.raight branch. The four front limb lines.des.ribe their motion: the Front Limb Protraction and Retraction, Adduction, and Abduction Lines. Conclus.on: The canine lines.mirrored the equine and human lines.with exceptions.due to differences.in anatomy, foot pos.ure, lumbos.cral flexibility, and their biomechanical cons.itution as.predator vers.s.prey animals. Additionally, three new canine branches.were verified and des.ribed.

关键词： Myofas.ial Kinetic Lines Canis.Familiaris s.perficial Lines Deep Lines Locomotive Connections Vis.ero-s.matic Connections

Invers. relations.ip between platelet Akt activity and hippocampal atrophy:A pilot cas.-control s.udy in patients.with diabetes.mellitus

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World Journal of Clinical Cas.s 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamits. Hori Dais.ke Mizutani Tomoyuki Hioki Kumi Kojima Takas.i Onuma Yukiko Enomoto Tomoaki Doi rie Mats.s.ima-Nis.iwaki s.inji Ogura Hiroki Iida Toru Iwama Takas.i s.kurai Os.mu Kozawa Department of Metabolic Res.arch Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neuros.rgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anes.hes.ology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Dis.s.er Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Res.arch Ins.itute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays.divers. roles.in *** is.involved in the pathogenes.s.of type 2 diabetes.mellitus.T2DM),which is.caus.d by ins.lin *** als. plays.a vital role in human platelet ***,the hippocampus.is.clos.ly as.ociated with memory and learning,and a decreas. in hippocampal volume is.reportedly as.ociated with an ins.lin-res.s.ant phenotype in T2DM patients.without *** To inves.igate the relations.ip between Akt phos.horylation in uns.imulated platelets.and the hippocampal volume in T2DM *** Platelet-rich plas.a(PRP)was.prepared from the venous.blood of patients.with T2DM or age-matched *** pellet lys.te of the centrifuged PRP was.s.bjected to wes.ern blotting to analys. the phos.horylation of Akt,p38 mitogen-activated protein(MAP)kinas. and glyceraldehyde 3-phos.hate dehydrogenas.(GAPDH).Phos.horylation levels.were quantified by dens.tometric *** volume was.analys.d us.ng a voxel-bas.d s.ecific regional analys.s.s.s.em for Alzheimer’s.dis.as. on magnetic res.nance imaging,which propos.s.the Z-s.ore as.a parameter that reflects.hippocampal *** The levels.of phos.horylated Akt corrected with phos.horylated p38 MAP kinas. were invers.ly correlated with the Z-s.ores.in the T2DM s.bjects.whereas.the levels.of phos.horylated Akt corrected with GAPDH were ***,this.relations.ip was.not obs.rved in the control *** Thes. res.lts.s.gges. that an invers. relations.ip may exis. between platelet Akt activation and hippocampal atrophy in T2DM *** findings.provide ins.ght into the molecular mechanis.s.underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic res.nance imaging Diabetes.mellitus

Particle s.arm Optimization-Bas.d Hyperparameters.Tuning of Machine Learning Models.for Big COVID-19 Data Analys.s

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Journal of Computer and Communications 2024年第3期12卷 160-183页

作者： Hend s. s.lem Mohamed A. Mead Ghada s. El-Taweel Department of Computer s.iences Suez Canal University Ismailia Egypt

Analyzing big data, es.ecially medical data, helps.to provide good health care to patients.and face the ris.s.of death. The COVID-19 pandemic has.had a s.gnificant impact on public health worldwide, emphas.zing the need for effective ris. prediction models. Machine learning (ML) techniques.have s.own promis. in analyzing complex data patterns.and predicting dis.as. outcomes. The accuracy of thes. techniques.is.greatly affected by changing their parameters. Hyperparameter optimization plays.a crucial role in improving model performance. In this.work, the Particle s.arm Optimization (Ps.) algorithm was.us.d to effectively s.arch the hyperparameter s.ace and improve the predictive power of the machine learning models.by identifying the optimal hyperparameters.that can provide the highes. accuracy. A datas.t with a variety of clinical and epidemiological characteris.ics.linked to COVID-19 cas.s.was.us.d in this.s.udy. Various.machine learning models. including Random Fores.s. Decis.on Trees. s.pport Vector Machines. and Neural Networks. were utilized to capture the complex relations.ips.pres.nt in the data. To evaluate the predictive performance of the models. the accuracy metric was.employed. The experimental findings.s.owed that the s.gges.ed method of es.imating COVID-19 ris. is.effective. When compared to bas.line models. the optimized machine learning models.performed better and produced better res.lts.

关键词： Big COVID-19 Data Machine Learning Hyperparameter Optimization Particle s.arm Optimization Computational Intelligence

Accuracy Enhancement of the Folin-Ciocalteu Method for Propolis

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American Journal of Analytical Chemis.ry 2024年第8期15卷 253-267页

作者： Ros.lene s. N. Paganotti Paulo J. s. Barbeira Ins.ituto Federal de Educao Cincia e Tecnologia de Minas GeraisCampus Formiga Formiga MG Brazil Departamento de Qumica Instituto de Cincias Exatas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil

This.s.udy pres.nts.an optimization of the Folin-Ciocalteu s.ectrophotometric method for the determination of total phenol content. Multivariate optimization us.ng factorial planning 22 with a central point and central compos.te planning was.cons.ructed to evaluate the influence of variables.in the proces. and maximize radiation abs.rption with minimal radiation s.attering caus.d by s.lid formation. X-ray fluores.ence and X-ray diffraction s.ectrometry were us.d to evaluate the chemical compos.tion of s.lids.formed and nephelometric and s.ectrophotometric s.udies.were als. us.d to evaluate whether the type, origin, dilution and dry extract contents.of commercial propolis.extracts.would s.gnificantly influence the increas. in radiation s.attering and abs.rption. The optimized methodology added s.veral advantages. s.ch as.reduction of reagents. time analys.s. and higher accuracy.

关键词： Folin-Ciocalteu Multivariate Optimization Propolis Total Phenol