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Photometric and Spectroscopic Study of Ten Low Mass Ratio Contact Binary Systems:Orbital Stability,O'Connell Effect and Infrared Calcium Line Filling

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Research in Astronomy and Astrophysics 2024年第8期24卷 212-222页

作者： Surjit S.wadhwa Adam Popowicz Raúl Michel Petar Kostić Oliver Vince Nick F.H.Tothill Ain Y.De Horta Miroslav D.Filipović School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Department of Electronics Electrical Engineering and MicroelectronicsSilesian University of TechnologyAkademicka 1644120 GliwicePoland Instituto de Astronomía UNAM.A.P.87722800 EnsenadaBCMéxico Astronomical Observatory Volgina 711060 BelgradeSerbia

Low mass ratio contact binary systems are more likely to have unstable orbits and potentially *** addition,such systems exhibit characteristics such as starspots and high energy emissions(UV)suggestive of chromospheric and magnetic *** curve modeling of ten contact binary systems is *** were found to be of extreme low mass ratio ranging from 0.122 to 0.24 and three were found to be potentially unstable and possible merger *** of the infrared calcium absorption lines is a marker of increased chromospheric *** use the available Large Sky Area Multi-Object Fiber Spectroscopic Telescope spectra along with matched standard spectra(broadened for rotation)to measure the excess filling of the central core depression flux of the two main infrared calcium absorption linesλ8542 andλ*** find that all reported contact binaries have excess filling of the core flux in the infrared calcium *** of the systems reported were also observed by the Galaxy Evolution Explorer mission and we find that all three have features of excess ultraviolet emissions further adding evidence for increased chromospheric activity in low mass ratio contact *** of both orbital stability and absorption line filling is dependent on the determination of geometric and absolute parameters from light curve *** an insignificant number of contact binary light curves exhibit the O’Connell effect,usually attributed to *** discuss the inclusion of starspots in light curve solutions and how they influence the geometric and absolute parameters.

关键词： (stars)binaries eclipsing-techniques photometric-stars chromospheres

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Recent advances in managing obstructive sleep apnea

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World Journal of Clinical Cases 2024年第24期12卷 5456-5461页

作者： Deb Sanjay Nag Abhishek Chatterjee Roushan Patel Biswajit Sen Bappa Ditya Pal Gunjan wadhwa Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JharkhandIndia Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

Obstructive sleep apnea(OSA)is a rapidly increasing global *** it remains untreated,it can lead to cardiovascular,metabolic,and psychiatric complications and may result in premature *** efficient and effective management of OSA can have a beneficial effect and help reduce the financial burden on the health *** has been constant development in OSA management,and numerous options are *** mainstay of therapy is still the conventional measures and behavioral ***,in cases of failure of these modalities,surgical therapy is the only *** studies have shown that proper management of OSA has beneficial effects with good long-term outcomes.

关键词： Sleep apnea Obstructive Continuous positive airway pressure Concepts Pharmacological

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Clinical Evidence on the Effects of Saffron(Crocus Sativus L.)in Anxiety and Depression

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World Journal of Traditional Chinese Medicine 2022年第2期8卷 181-187页

作者： Vanktesh Kumar Navjot Kaur Pankaj wadhwa Department of Pharmaceutical Chemistry School of Pharmaceutical ScienceLovely Professional UniversityPhagwaraPunjabIndia

Crocus sativus L.,a member of the Iridaceae family,commonly known as saffron has very much popular as both medicine and *** saffron was used as one of the important constituents in opioid preparations for pain *** uses in the treatment of mild-to-moderate depression are well *** can affect the quality of life of individuals by causing headaches,difficulty in thinking,and loss of *** clinical trials have been conducted for evaluating the efficacy of saffron in depression *** fifty constituents of *** L are well *** of the major constituents include crocin,picrocrocin,and *** the present review,the main focus is on the antidepressant effects of saffron and its major constituents,in which it was found that saffron has substantial effects on depression and anxiety because of double-blind study the data can be trusted.

关键词： Anxiety Crocus sativus L depression double blind saffron safranin

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A study of knowledge,attitude and practices about otitis media in parents in Navi-Mumbai

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Journal of Otology 2021年第2期16卷 89-94页

作者： Yogesh G.Dabholkar Anmol wadhwa Atul Deshmukh Department of ENT School of MedicineD.Y.Patil UniversityNavi MumbaiIndia Centre for Interdisciplinary Research D.Y.Patil UniversityNavi MumbaiIndia

Although otitis media poses a serious health risk in developing countries,being a frequent occurrence in children below five years of age,parental awareness and practices about otitis media have not been adequately *** cross-sectional study was undertaken in Navi Mumbai schools,from October 2019 to December 2019,wherein parents with children<5 years of age answered a questionnaire which gathered data on their knowledge,attitude and practices about otitis media in their ***-square tests,Cramer’s V were used to study association between gender,age-group and education of parents with their knowledge,practice and attitude about otitis *** of 425 valid responses,overall most parents displayed adequate knowledge(77%),positive attitude(61%)and good care-seeking practices(70%).There was a positive correlation of knowledge and practice with level of *** study shows acceptable levels of knowledge,attitude and practices in parents about otitis *** who did not seek treatment from health centre attributed the behaviour to poverty,ignorance and lack of health *** positive correlation of knowledge and practices with level of education highlights the importance of role of education in modifying parental awareness and care seeking *** findings call for a need to further strengthen community-based healthcare and improve parental confidence in healthcare services for early detection and adequate treatment of otitis media.

关键词： Otitis media Middle ear infections Children Knowledge Attitude Practices

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Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome

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World Journal of Gastroenterology 2017年第13期23卷 2443-2447页

作者： Sanya wadhwa Tae Hun Kim Leah Lin Gary Kanel Takeshi Saito Department of Medicine Keck School of MedicineUniversity of Southern California Department of Pathology University of Southern CaliforniaKeck School of Medicine Department of Radiology University of Southern CaliforniaKeck School of Medicine Department of Medicine Molecular Microbiology and Immunologyand PathologyDivision of Gastrointestinal and Liver DiseasesKeck School of Medicine of USCUniversity of Southern California

Hepatic angiosarcoma is a mesenchymal tumor originating from liver sinusoidal endothelial cells. It is an extremely rare malignant neoplasm accounting for less than 1% of primary malignant liver tumors. The deregulated coagulopathy that can be seen in hepatic angiosarcoma fulfills the clinical diagnostic criteria of disseminated intravascular coagulation. However, the mechanism that governs this coagulopathy has been poorly understood. This case report provides histological evidence of the consumption of coagulation factors along with trapped platelets occurring within the tumor, which is the foundation for the concept of Kasabach-Merritt syndrome(KMS). KMS is characterized by thrombocytopenia and hyperconsumption of coagulation factors within a vascular tumor. However, KMS associated with angiosarcoma has not been well recognized. This case report describes, for the first time, the histological evidence of KMS that occurred in an extremely rare mesenchymal malignant tumor of the liver.

关键词： Hepatic angiosarcoma Kasabach-Merritt syndrome Vascular tumor

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Mortalin imaging in normal and cancer cells with quantum dot immuno conjugates

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Cell Research 2003年第6期13卷 503-507页

作者： ZEENIA KAUL,TOMOKO YAGUCHI,SUNIL C KAUL,TAKASHI HIRANO,RENU wadhwa,KAZUNARI TAIRA National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan National Institute of Advanced Industrial Science and Technology (AIST) 1-1-1 Higashi Tsukuba Ibaraki3058562 Japan

Quantum dots are the nanoparticles that are recently emerging as an alternative to organic fluorescence probes in cell biology and biomedicine, and have several predictive advantages. These include their i) broad absorption spectra allowing visualization with single light source, ii) exceptional photo-stability allowing long term studies and iii) narrow and symmetrical emission spectrum that is controlled by their size and material composition. These unique properties allow simultaneous excitation of different size of quantum dots with a single excitation light source, their simultaneous resolution and visualization as different colors. At present there are only a few studies that have tested quantum dots in cellular imaging. We describe here the use of quantum dots in mortalin imaging of normal and cancer cells. Mortalin staining pattern with quantum dots in both normal and cancer cells mimicked those obtained with organic florescence probes and were considerably stable.

关键词： quantum dots immunofluorescence mortalin visualization.

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Sphere-forming corneal cells repopulate dystrophic keratoconic stroma:Implications for potential therapy

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World Journal of Stem Cells 2020年第1期12卷 35-54页

作者： Himanshu wadhwa Salim Ismail Jennifer J McGhee Bert Van der Werf Trevor Sherwin Department of Ophthalmology Faculty of Medical and Health SciencesThe University of AucklandAuckland 1023New Zealand Department of Epidemiology and Biostatistics School of Population HealthFaculty of Medical and Health SciencesThe University of AucklandAuckland 1023New Zealand

BACKGROUND Keratoconus is a degenerative corneal disease characterised by aberrant cell behaviour and loss of matrix that can result in vision *** extracted from peripheral corneas can form stem cell-enriched spheres,which have shown the potential to repopulate the normal peripheral corneal stroma in vitro upon sphere implantation but have not been previously studied in keratoconic *** To investigate the therapeutic potential of stem cell-enriched spheres formed from extracted peripheral human corneal cells when introduced to keratoconic *** Stem cell-enriched spheres were formed from extracts of normal cadaveric human peripheral corneal *** spheres were implanted into incisions created in full thickness and onto the surface of 10μm thin sections of keratoconic and normal stromal tissues in *** sections were used to maximise use of limited keratoconic tissue available for *** cells were stained with Calcein-AM and visualised with stereo and fluorescence microscopy to assess survival and behaviours between the time of implantation day 0 and 14 d(D14)from *** cells in implanted tissues were characterised for stem cell and differentiation markers using immunohistochemistry and droplet digital PCR to assess the potential implications of these characteristics in the use of spheres in keratoconus *** Spheres were successfully implanted into full-thickness central corneal tissue and onto the surface of 10μm thin en face tissue *** observable differences were seen in sphere migration,proliferation or differentiation in keratoconic tissue compared to normal between day 0 and *** stained positively with Calcein-AM up to *** migration increased from day 0 to D14,occurring radially in three dimensions from the sphere and in alignment with tissue *** proliferation marker,EdU,was detected at day *** spheres stained positively for putative stem cell markersΔNp63

关键词： Keratoconus Cell culture Immunohistochemistry Quantitative PCR Digital PCR Spheroid Holoclone Neurosphere Regeneration

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Photometric analysis of two extreme low mass ratio contact binary systems

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Research in Astronomy and Astrophysics 2021年第9期21卷 217-223页

作者： Surjit S.wadhwa Nick F.H.Tothill Ain Y.De Horta Miroslav Filipovié School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia

Multi-band photometry and light curve analysis for two newly recognized contact binary systems,TYC 6995-813-1 and NSVS 13602901,are *** were found to be of extreme low mass ratios 0.11 and 0.17,*** secondary components of both systems show evidence of considerable evolution with elevated densities as well as both luminosity and radii well above their main sequence *** in the absence of significant spot activity,at least one of the systems,TYC 6995-813-1,displays features of magnetic and chromospheric *** 6995-813-1 is also determined to be a potential merger candidate with its current separation near the theoretical instability separation.

关键词： stars:binaries:eclipsing stars:evolution stars:low-mass techniques:photometric

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Designed fabrication of active tumor targeting covalent organic framework nanotherapeutics via a simple post-synthetic strategy

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Nano Research 2023年第5期16卷 7085-7094页

作者： Yue Yu Guoxin Zhang Zhongping Li Jia Wang Yang Liu Rahul Bhardwaj Renu wadhwa Yuki Nagao Mototada Shichiri Ran Gao Biomedical Research Institute National Institute of Advanced Industrial Science and Technology(AIST)Osaka 563-8577Japan AIST-INDIA DAILAB DBT-AIST International Center for Translational&Environmental Research(DAICENTER)AISTTsukubaIbaraki 305-8565Japan Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases NHC Key Laboratory of Human Disease Comparative MedicineNational Human Diseases Animal Model Resource CenterInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollageBeijing 100021China School of Materials Science Japan Advanced Institute of Science and TechnologyIshikawa 923-1211Japan Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 120-749Republic of Korea Flexible 3D System Integration Laboratory SANKENOsaka UniversityOsaka 567-0047Japan

Developing agents that can accurately differentiate tumors from normal healthy tissues is of utmost importance for safe cancer *** targeting has been considered as an effective technique for tumor *** this work,we demonstrate a folate-functionalized nanoscale covalent organic framework(FATD nCOF)highly specific to cancer cells through active targeting of their enriched folate receptors(FRs).The FATD nCOF prepared by simple post-synthetic modification of the COF surface defeats disperses well in water and exhibits a high loading capacity for various anticancer *** biocompatible FATD nCOF is selectively internalized by FR-harboring cancer cells and consequently augments the efficacy of the loaded drug,Withaferin A(Wi-A),for targeted cancer cell *** biomolecular mechanism studies,Wi-A-loaded FATD(FATD@Wi-A)nanocomposites show remarkably a higher rate of apoptosis in FR-enriched cancer *** analyses of FR-positive and FR-negative tumor xenografts reveal enhanced selective antitumor activity of FATD@Wi-A *** together,the study findings suggest that FATD nCOF holds great promise for active targeting of tumors in *** simple yet effective technology might be valuable for creating new state-of-the-art COFs for chemical and biomedical applications.

关键词： covalent organic framework active targeting folate receptor drug delivery cancer therapy

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Femoroacetabular impingement with chronic acetabular rim fracture- 3D computed tomography, 3D magnetic resonance imaging and arthroscopic correlation

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World Journal of Orthopedics 2015年第6期6卷 498-504页

作者： Avneesh Chhabra Shaun Nordeck Vibhor wadhwa Sai Madhavapeddi William J Robertson Department of Radiology University of Texas Southwestern Medical Center Department of Orthopaedics University of Texas Southwestern Medical Center

Femoroacetabular impingement is uncommonly associated with a large rim fragment of bone along the superolateral acetabulum. We report an unusual case of femoroacetabular impingement(FAI) with chronic acetabular rim fracture. Radiographic, 3D computed tomography, 3D magnetic resonance imaging and arthroscopy correlation is presented with discussion of relative advantages and disadvantages of various modalities in the context of FAI.

关键词： 3D computed tomography 3D magnetic resonance imaging Femoroacetabular impingement Rim fracture

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