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Comparative study of two bowel preparaton regimens for colonoscopy: Senna tablets vs sodium phosphate solution

World Journal of Gastroenterology 2006年第34期12卷 5536-5539页

作者： Savit Kositchaiwat Weerapat Suwanthamma Ronnarat Suvikapakornkul vaewvadee tiewthanom Prisna Rerkpatanakit Chaowalitr Tinkornrusmee Department of Surgery Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Province Thailand Department of Nursing Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Province Thailand

AIM: To compare the efficacy and acceptance of senna tablet and sodium phosphate solution for bowel preparation before ***: One hundred and thirty four patients, who needed elective colonoscopy, were randomly allocated to take 180 mg senna tablet or 95 mL sodium phosphate solution on the day before colonoscopy. The effi cacies of both laxatives were compared using the mean difference of colon-cleanliness score of the rectum, sigmoid segments, descending colon, transverse colon and cecum. The scores were rated by two observers who were blinded to the laxatives administered. The higher score means that the colon is cleaner. The efficacy of both laxatives were equivalent if the 95% confidence interval of the mean difference of the score of colon lie within -1 to +1. RESULTS: On intention-to-treat analysis, the mean cleanliness scores in the four segments of colon except the cecum were higher in the sodium phosphate group than those in senna group (7.9 ± 1.7 vs 8.3 ± 1.5, 8.0 ± 1.8 vs 8.5 ± 1.4, 7.9 ± 2.0 vs 8.5 ± 1.3, 7.9 ± 2.0 vs 8.2 ± 1.4 and 7.2 ± 1.7 vs 6.9 ± 1.4, respectively). The 95% conf idence intervals (95% CI) of mean difference in each segment of colon were not found to lie within 1 point which indicated that their effi cacies were not equivalent. The taste of senna was better than sodium phosphate solution. Also, senna had fewer side effects. CONCLUSION: The effi cacy of senna is not equivalentto sodium phosphate solution in bowel preparation for colonoscopy, but senna may be considered an alternative laxative.

关键词： Senna tablet Sodium phosphate solution Colonoscopy

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Evaluation of corporal fibrosis in cadaveric pericardium and vein grafts for tunica albuginea substitution in rats

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Asian Journal of Andrology 2003年第4期5卷 295-299页

作者： Somboon Leungwattanakij vaewvadee tiewthanom Wayne J.G. Hellstrom Department of Urology Ramathibodi Hospital Mahidol University Bangkok 10400 ThailandDepartment of Nursing Ramathibodi Hospital Mahidol University Bangkok 10400 ThailandDepartment of Urology Tulane University Health Sciences Center New Orleans Louisiana USA

Abstract Aim: To evaluate the degree of corporal fibrosis in rats with cadaveric pericardium or vein as grafting materials for tunica albuginea substitution. Materials and methods: Thirty male Sprague-Dawley rats (300 g-325 g) were divided at random into 3 groups of 10 animals each: group 1 was the sham-operated controls and groups 2 and 3 underwent wedge excision of tunica albuginea and replacement with cadaveric pericardium and vein grafts, respectively. Four months later, rats were sacrificed and the penis removed to assess the degree of fibrosis using RT PCR technique for TGP-β1 mRNA expression. The tissues were fixed in 10 % formalin, paraffin-embedded and stained with Masson's trichrome and Verhoff's van Giesen for collagen and elastic fibers. Results: Four months after grafting, there was minimal fibrosis surrounding the patch in the vein graft rats and moderate fibrosis in the pericardial graft rats. The degree of penile fibrosis in the pericardial graft rats was significantly higher than that in the controls (P0.05). Conclusion: The degree of penile fibrosis of cadaveric pericardial graft was significantly higher than that of the control group, while in the vein graft group it was comparable to the latter. The authors believe that the vein graft may be a more ideal substance to be used as the tunica albuginea substitute than the pericardial graft in the surgical treatment of Peyronie's disease.

关键词： Peyronie's disease pericardial graft vein graft

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