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Science China Materials 2019年第6期62卷 790-796页

作者： Yukun Wang Dezhi Yang Dongge Ma Dong Ha Kim Tansir Ahamad Saad M. Alshehri Agafbnv vadim Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of Technology Department of Chemistry and Nano Science Ewha Womans University Department of Chemistry College of ScienceKing Saud University Moscow Institute of Physics and Technology Dolgoprudny

Organic-inorganic hybrid perovskites are ideal materials for photodetection owing to their high charge carrier mobility, long charge carrier diffusion length, low dark current density and sharp absorption edge. However, a relatively small band gap(1.6 e V) limits their photonharvesting efficiency in the near-infrared region. In the present work, we demonstrate a hybrid methylamine iodide and Pb-Sn binary perovskite as the light absorption layer in photodetectors. Experimentally, the wavelength of photoresponse onset for the photodetectors can be extended to as great as 1,000 nm when the Sn content of the hybrid perovskite is increased to 30 mol%. In addition, the photodetectors exhibit a photoresponsivity of 0.39 A W^-1, a specific detectivity of 7×10^12 Jones, a fast photoresponse with rise and decay time constants and an external quantum efficiency greater than 50% in the wavelength range of350–900 nm, with a maximum value of about 80% at 550 nm.

关键词： organic-inorganic hybrid perovskite photodetector external quantum efficiency spectral response specific detectivity

Age-dependent peculiarities modulation of activity of aldehyde scavenger enzymes in mitochondria of rat thigh muscle during stress

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Frontiers in Biology 2016年第1期11卷 28-31页

作者： vadim V. Davydov Evgenya R. Grabovetskaya Amjad Hamdallah Chair of Biochemistry State Academican LP.Pavlov Medical University Ryazan 390026 Russia Chair of Medical Chemistry Kharkov National Medical University Kharkov 61022 Ukraine Chair of Biochemistry EN. Karazin Kharkov National University Kharkov 61077 Ukraine

The purpose of this study was a comparative investigation of activity of aldehyde scavenger enzymes in mitochondrial fraction of a thigh muscle in intact and immobilized rats of different ages. It has been shown that 12- month-old （adult） rats have high basal levels of aldehyde dehydrogenase, aldehyde reductase and glutathione transferase activity in mitochondrial fraction of thigh muscle. Aldehyde dehydrogenase activity increases during immobilization stress in adult rats. This change promote to enhance the effectiveness of utilization of carbonyl products of free radical oxidation in mitochondria of skeletal muscle of 12-month-old rats during stress. Immobilization of old and pubertal rats is accompanied by metabolic preconditions leading to accumulation of endogenous aldehydes in mitochondria, and, as a result, to the injury of muscular fibers and intensification of sarcopenia manifestations.

关键词： aldehydes mitochondria muscle immobilization stress aging

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Frontiers in Biology 2014年第4期9卷 283-286页

作者： vadim V. DAVYDOV Amjad HAMDALLAH Evgenya R. GRABOVETSKAYA Laboratory of Age Biochemistry State Institution institute of Children and Adolescent Health NAMS of Ukraine Kharkov 61154 Ukraine Chair of biochemistry V.N. Karazin Kharkov National University Kharkov 61077 Ukraine Chair of medical chemistry Kharkov National Medical University Kharkov 61022 Ukraine

The age-dependent peculiarities of stimulation of free radical processes in subcellular fractions of skeletal muscle of rats subjected to long-term immobilization stress were studied in order to improve knowledge about changes of muscular tissue during ontogenesis. It is found that adult animals do not show accumulation of proteins carbonyls, TBA-reactive substances, and Schiff bases in subcellular fractions of the thigh muscle when immobUized. Long-term immobilization causes apparent manifestation of oxidative stress only in mitochondrial fraction in pubertal rats. Mitochondrial oxidative stress defense systems are sufficiently effective, however, direction of pathways of free radical oxidation carbonyl products catabolism alters in the cytoplasm of myocytes in old rats under long-term immobilization conditions.

关键词： ontogenesis stress skeletal muscle free radical oxidation

Liver regeneration is associated with lipid reorganization in membranes of the endoplasmic reticulum

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Frontiers in Biology 2016年第5期11卷 396-403页

作者： Anatoly I. Bozhkov Natalia G. Menzyanova vadim V. Davydov Natalia I. Kurguzova vadim I. Sidorov Anastasia S. Vasilieva Research Institute of Biology of V.N. Karazin Kharkov National University sq. Svobody 4 61022 Kharkov Ukraine Institute of Fundamental Biology and Biotechnology of Siberian Federal University pr. Svobodny 79 660041 Krasnoyarsk Russia Ryazan State Medical University named after academician I.P.. Pavlov Visokovoltnaya 9 390026 Ryazan Russia

BACKGROUND： In recent years, an adaptive endoplasmic reticulum （ER） stress response has been actively investigated. The ER membrane, isolated from the intact and regenerating liver, may be an appropriate model for investigating the association between structural and functional characteristics of ER in vivo and their corresponding behavioral characteristics in vitro. The rate of lipid synthesis and that of intracellular lipid exchange between the ER and cytosol were investigated in the intact and regenerating liver （13 h after partial hepatectomy）. Particularly, membrane characteristics, surface potential, and glucose 6- phosphatase （G6Pase） activity were investigated, along with the degradation rate of G6Pase in vitro, which was estimated by the loss of G6Pase activity, formation of lipid peroxides, and size of excreted membrane vesicles. METHODS： The rate of lipid synthesis was determined by measuring the intensity of radioactive precursor （C^14-sodium acetate） in different fractions of lipids （phospholipids, non-esterified fatty acids, and triacylglycerides） after 30 min exposure. The rate of lipid metabolism was assessed by measuring the quantity oflipids with radioactive labels emerging in the cytosol of hepatocytes （CPM）. Viscosity and surface potential were determined by fluorescent probes. RESULTS： It was observed that after 13 h of partial hepatectomy, the rate of lipid synthesis in the ER of hepatocytes in the regenerating liver was 3 times lower than that in ER ofhepatocytes in the intact liver, wherein the rate of incorporation of newly synthesized lipids in cytosol was several times higher in the regenerating liver. Increase in the rate of exchange of neutral lipids in cells of the regenerating liver was accompanied by lipid reconstruction in the ER, changing the structural and functional characteristics of the membrane. Such membrane rebuilding also contributed to the rate of degradation of the ER in vitro, which that must be taken into account during d

关键词： regeneration neutral lipids microsomes in vitro

Titanium oxide artificial synaptic device:Nanostructure modeling and synthesis,memristive cross-bar fabrication,and resistive switching investigation

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Nano Research 2023年第7期16卷 10222-10233页

作者： vadim I.Avilov Roman V.Tominov Zakhar E.Vakulov Lev G.Zhavoronkov Vladimir A.Smirnov Research Laboratory Neuroelectronics and Memristive Nanomaterials(NEUROMENA Lab) Southern Federal UniversityTaganrog 347922Russia Institute of Nanotechnologies Electronics and Electronic Equipment EngineeringSouthern Federal UniversityTaganrog 347922Russia

The paper shows the results of the mathematical model development and the numerical simulation of the oxygen vacancies,and the distribution of TiO,Ti_(2)O_(3),and TiO_(2)oxides in the titanium oxide nanostructure obtained by local anodic oxidation(anodization).The effect of the anodization voltage pulse duration and amplitude on the titanium oxide composition distribution and the conduction channel formation was *** device prototypes based on electrochemical titanium oxide are fabricated and *** was shown that forming free resistive switching between the low resistances state(LRS)1.43±0.54 kΩand the high resistance state(HRS)28.75±9.75 kΩwere observed during 100,000 switching cycles and LRS 1.49±0.23 kΩwas maintained for 10,000 *** resistive switching of the synaptic device prototype was *** was shown that increasing Uset from 0.5 to 1.5 V leads to different LRS from 3.96±0.19 to 0.71±0.10 kΩ.The results obtained can be used in the development of technological foundations for the formation of high-performance multilevel artificial synapses for elements of neuroelectronics and hardware neural networks.

关键词： artificial intelligence neuromorphic systems memristive cross bar resistive switching scanning probe microscopy titanium oxide

Improving the efficiency of transport systems using simulation

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系统仿真学报 2020年第2期32卷 340-345页

作者： Bushuev Sergey Valentinovich Kovalev Igor Alexandrovich Permikin vadim Yurievich Anashkina Nataliia Yurievna Technical Sciences Associate ProfessorUSURT

The article describes the possibilities of application of simulation modeling for the analysis of infrastructure and technology of transport services of enterprises. The main technological and possible economic effect... 详细信息

关键词： service Improving the efficiency of transport systems using simulation

Fluorine-containing pharmaceuticals approved by the FDA in 2020:Synthesis and biological activity

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Chinese Chemical Letters 2021年第11期32卷 3342-3354页

作者： Yingjie Yu Aiyao Liu Gagan Dhawan Haibo Mei Wei Zhang Kunisuke Izawa vadim A.Soloshonok Jianlin Han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Department of Biomedical Science Acharya Narendra Dev CollegeUniversity of DelhiIndia Department of Chemistry University of Massachusetts Boston100 Morrissey BoulevardBostonMA 02125United States Hamari Chemical Ltd. 1-4-29 KunijimaHigashi-Yodogawa-kuOsaka 533-0024Japan Department of Organic Chemistry I Faculty of ChemistryUniversity of the Basque Country UPV/EHUPaseo Manuel Lardizabal 320018 San SebastianSpain IKERBASQUE Basque Foundation for ScienceMaría Díaz de Haro 3Plaza Bizkaia48013 BilbaoSpain

Thirteen new fluorine-containing drugs,which have been granted approval by the US Food and Drug Administration(FDA)in 2020,are profiled in this *** areas of these new fluorinated pharmaceuticals include medicines and diagnostic agents for Cushing's disease,neurofibromatosis,migraine,Alzheimer's disease,myelodysplastic syndromes,hereditary angioedema attacks,and various *** of these approved drugs feature aromatic fluorine(Ar-F)(11 compounds),aromatic Ar-CF_(3)(1),aliphatic CHF(1)and CF_(2)(1)*** each compound,we provide a spectrum of biological activity,medicinal chemistry discovery,and synthetic approaches.

关键词： Fluorine and compounds Blockbuster drugs Modern pharmaceuticals Synthesis Drug design and development Asymmetric synthesis

The bactericidal effect of continuous wave laser with strongly absorbing coating at the fiber tip

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Journal of Innovative Optical Health Sciences 2018年第5期11卷 51-58页

作者： vadim Elagin Anton Smirnov Vladimir Yusupov Alexey Kirillov Nadezhda Ignatova Olga Streltsova Evgeniy Grebenkin Vladislav Kamensky Institute of Biomedical Technologies Privolzhsky Research Medical University 10/1 Minina Square Nizhny Novgorod 603005Russia Laboratory of Laser Nanomodification of Materials Institute of Applied Physics Russian Academy of Sciences 46 Ulyanova Street Nizhny Novgorod 603950Russia Institute of Photon Technologies of Federal Scientific Research Centre"Crystallography and Photonics"of the Russian Academy of Sciences 2 Pionerskaya Street MoscowTroitsk 108840Russia Department of Innovative Program Institute of Applied Physics Russian Academy of Sciences 46 Ulyanova Street Nizhny Novgorod 603950Russia

The bactericidal effect of laser radiation with a quartz fiber-based transmission system with a strong absorption coating converter against bacteria associated with urological stones has been *** am-negative rod Escherichia coli and the Gram-positive coccus Staphylococcus epi-dermidis,Staphylococcus aureus,Enterococcus faecalis and Enterococcus faecium were used in this *** bacterial species was treated by continuous-wave near infrared laser coupled with bare fiber tip or strongly absorption coating fiber *** treatment,the temperature of bacterial suspension was *** addition,the temperature dist ribution was *** has been shown that using laser with a strongly absorption coating fiber tip results in significant bactericidal *** decrease of the amount of *** and *** was 100%after treatment with an output power of6 W of radiation at a wavelength of 0.97 pum for *** of *** and *** colony-forming unit was reduced to 70%after same *** peak temperature of bacterial suspension was 86℃ after treatment by laser with a strongly absorption coating fiber *** with a strongly absorpt ion coating fiber tip provides large scale hydrodynamic flows directed away from the fiber *** laser with a strongly absorption coating fiber tip has bactericidal *** main role is associated with the effect of high temperature,which,in the form of flow in a liquid medium,afects bacteria.

关键词： Laser strongly absorbing coating bacteria bacterididal efect laserinduced hydrodynamic

Fluorine-containing drugs approved by the FDA in 2019

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Chinese Chemical Letters 2020年第9期31卷 2401-2413页

作者： Haibo Mei Attila Mario Remete Yupiao Zou Hiroki Moriwaki Santos Fustero Lorand Kiss vadim ASoloshonok Jianlin Han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China University of Szeged Institute of Pharmaceutical Chemistry6720 SzegedEotvos u.6Hungary Hamari Chemicals Ltd. 1-4-29 KunijimaHigashi-Yodogawa-kuOsaka 533-0024Japan Departamento de Quimica Organica Universidad de Valencia46100 BurjassotValenciaSpain Department of Organic Chemistry 1 Faculty of ChemistryUniversity of the Basque Country UPV/EHUPaseo Manuel Lardizabal 320018 San SebastianSpain IKERBASQUE Basque Foundation for Science.Maria Diaz de Haro 3Plaza Bizkaia48013 BilbaoSpain

Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their discovery and preparation are *** areas include schizophrenia,migraine,multiple sclerosis,insomnia,rheumatoid arthritis,anti-tuberculosis,breast cancer,lymphoma kinase inhibitor,serotonin receptor *** pharmaceuticals feature four examples of aromatic fluorine,three aromatic CF3 group,three aliphatic CF3 and one compound with aromatic CF3O ***,among the new compounds,six are chiral and seven are derived from tailor-made amino acids.

关键词： Fluorine Pharmaceuticals Synthesis Medicinal chemistry Marketed medicinal drugs

Physiological significance of oxidative stress and its role in adaptation of the human body to deleterious factors

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Frontiers in Biology 2018年第1期13卷 19-27页

作者： vadim V. Davydov Alexander V. Shestopalov Evgenya R. Grabovetskaya Chair of biochemistry and molecular biology Pirogov Russian National Research Medical University Moscow 117997 Russia Chair of biochemistry V.N. Karazin Kharkov National University Ukraine Kharkov 61077 Ukraine

BACKGROUND： Oxidative stress is an extremely widespread condition manifested in an increased rate of free-radical processes and accumulation of reactive oxygen species （ROS） in the tissues. It appears in different physiologic states and pathological processes accompanied by stimulation of the sympathetic adrenal system or tissue hypoxia or under stress. However, until now, there is still no clarity on the issue of the significance of oxidative stress in the development of adaptation processes in the organism. OBJECTIVE： In the present work we will review the most recent finding about physiologic role of oxidative stress and its participation in adaptation of an organism to effect of different adverse factors. METHODS： A systematic literature search was performed using the Pubmed search engine. Studies published over past 18 years, i.e. between 1998 and 2015 were considered for review. Followed keywords were used：＂oxidative stress,＂＂free radical oxidation,＂＂ROS,＂＂endogenous aldehydes,＂＂adaptation.＂ RESULTS： The article cites arguments supporting the notion that oxidative stress serves as a nonspecific link in the adaptation of the human body to the effects of injurious factors. Oxidative stress exerts regulatory effects by changing the redox state of the cell. Oxidative stress affects on various intracellular proteins containing cysteine residues, e.g., enzymes, chaperones, and transcription factors, etc. For this reason, the use of antioxidants for the treatment and prophylaxis of a wide range of diseases is not recommended. CONCLUSION： Further investigation is needed in this field. The most attention should be paid to careful experimental verification aimed at quantitative assessment of the ROS level in tissues under oxidative stress, as well as at the study of possibility of enhancing the catabolism of free radical oxidation carbonyl products in order to prevent tissue damage under oxidative stress.

关键词： oxidative stress free radical oxidation ROS adaptation endogenous aldehydes