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Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates

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World Journal of Stem Cells 2021年第5期13卷 452-469页

作者： vladimir P Baklaushev Oleg V Durov vladimir A Kalsin Eugene V Gulaev Sergey V Kim Ilya L Gubskiy Veronika A Revkova Ekaterina m Samoilova Pavel A melnikov Dzhina D Karal-Ogly Sergey V Orlov Alexander V Troitskiy vladimir P Chekhonin Alexander V Averyanov Jan-Eric Ahlfors Biomedical Research Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Neurosurgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBAMoscow 115682MoskvaRussia Department of Anesthesiology N.N.Blokhin Russian Cancer Research CentreMoscow 115478MoskvaRussia Radiology and Clinical Physiology Scientific Research Center Federal center of brain research and neurotechnologies of the Federal Medical Biological AgencyMoscow 117997Russia Department of Neurobiology Serbsky National Medical Research Center for Psychiatry and NarcologyMoscow 119992MoskvaRussia Department of Primatology Russian Acad Med SciResearch Institute of Medical PrimatologySochi 119992SochiRussia Department of Vascular Surgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Basic and Applied Neurobiology V.P.Serbsky Federal Medical Research Center for Psychiatry and NarcologyRussia Department of medical Nanobiotechnology Pirogov Russian National Research Medical University(RNRMU)Moscow 115682MoskvaRussia New World Laboratories Laval H7V 4A7QuebecCanada

BACKGROUND The development of regenerative therapy for human spinal cord injury(SCI)is dramatically restricted by two main challenges:the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical *** reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first *** use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human *** To investigate the safety and efficacy of intraspinal transplantation of directly reprogrammed neural precursor cells(drNPCs).mETHODS Seven non-human primates with verified complete thoracic SCI were divided into two groups:drNPC group(n=4)was subjected to intraspinal transplantation of 5 million drNPCs rostral and caudal to the lesion site 2 wk post injury,and lesion control(n=3)was injected identically with the equivalent volume of *** Follow-up for 12 wk revealed that animals in the drNPC group demonstrated a significant recovery of the paralyzed hindlimb as well as recovery of somatosensory evoked potential and motor evoked potential of injured *** resonance diffusion tensor imaging data confirmed the intraspinal transplantation of drNPCs did not adversely affect the morphology of the central nervous system or cerebrospinal fluid *** immunohistochemical analysis showed that drNPCs maintained SOX2 expression characteristic of multipotency in the transplanted spinal cord for at least 12 wk,migrating to areas of axon growth *** Our data demonstrated that drNPC transplantation was safe and contributed to improvement of spinal cord function after acute SCI,based on neurological status assessment and neurophysiological recovery within 12 wk after *** functional improvement described was not associated with neuronal differentiation of th

关键词： Direct cell reprogramming Neural precursor cells Directly reprogrammed neural precursor cells Spinal cord injury Nonhuman primates Regenerative therapy,Evoked potentials

A new kinetic model for the common juniper essenstial oil extraction by microwave hydrodistillation

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Chinese Journal of Chemical Engineering 2019年第3期27卷 605-612页

作者： miljana S. markovi? Svetomir ?. milojevi? Nevenka m. Bo?kovi?-Vragolovi? vladimir P. Pavi?evi? Ljiljana М. Babincev Vlada B. Veljkovi? Faculty of Technical Sciences University of Pri?tina Faculty of Technology and metallurgy University of Belgrade Faculty of Technology University of Ni?

The main objective of the present study was to model the kinetics of essential oil extraction from swelled ground juniper berries by classic hydrodistillation(HD) and microwave-assisted hydrodistillation(mAHD). A new phenomenological kinetic model was developed on the basis of the juniper essential oil extraction mechanism that assumed three mass transfer processes occurring simultaneously: washing, unhindered diffusion and hindered diffusion. The new model was compared to the existing kinetic models. Among the tested models,the new model had the smallest mean relative percentage deviation and the highest corrected Akaike information criterion value. In addition, that, the new model was verified for HD and mAHD of essential oils from some other plant materials. On the basis of the above-mentioned facts, the new model can be recommended for modeling the kinetics of essential oil extraction by both HD and mAHD.

关键词： Juniperus communis L Essential oil Kinetics microwave-assisted hydrodistillation modeling

modeling challenges and potential solutions for integration of emerging DERs in DmS applications: power flow and short-circuit analysis

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Journal of modern Power Systems and Clean Energy 2019年第6期7卷 1365-1384页

作者： Luka V.STREZOSKI Nikola R.VOJNOVIC vladimir C.STREZOSKI Predrag m.VIDOVIC marija D.PRICA Kenneth A.LOPARO Case School of Engineering Case Western Reserve UniversityClevelandUSA Faculty of Technical Sciences University of Novi SadNovi SadSerbia

We aim to systematically review challenges imposed by emerging distributed energy resources(DERs)to model in two basic distribution management system(DmS)online applications—power flow and short-circuit analysis,as well as to offer a systematic review of potential *** the last decade,electronically coupled DERs became increasingly *** can employ a wide range of control strategies for power,current,or voltage control,in both normal and faulted ***,DERs cannot be modeled with the traditional PQ(load or generator bus)or PV(generator bus)bus types used for modeling synchronous and induction machines in online power flow ***,since fault currents of DERs are limited to predefined maximal values,electronically coupled DERs cannot be represented with traditional voltage source behind impedance models for online short-circuit calculation(SCC).However,most of the DmS software packages still use the traditional models to represent all DER types,including those that are electronically *** paper shows that there will be large calculation errors in such practice,which make the system model an inadequate representation of the *** will lead to serious errors in the management,control,and operation of distribution ***,potential solutions to the challenges are systematically ***,the calculation results on a distribution test system with all DER types are used to prove the claim.

关键词： Distributed energy resources(DERs) Distribution management system(DmS) Power flow modeling Short-circuit modeling

How minor structural changes generate major consequences in photophysical properties of RE coordination compounds;resonance effect,LmCT state

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Journal of Rare Earths 2020年第5期38卷 552-563页

作者： Ewa Kasprzycka Albano N.Carneiro Neto Viktor A.Trush Lucjan Jerzykiewicz vladimir m.Amirkhanov Oscar L.malta Janina Legendziewicz Paula Gawryszewska University of Applied Sciences-Fachhochschule münster Department of ChemicalEngineeringStegerwaldstr.39Steinjurt48565Germany Physics Department and CICECO-Aveiro Institute of materials University of Aveiro38 JO-193AveiroPortugal Department o f Chemistry Taras Shevchenko National University of Kyivul.Volodymyrska 64Kyiv01601 Ukraine Faculty of Chemistry University of Wroclaw14 F.Joliot-Curie Street50-383WroclawPoland Departamento de Quimica Fundamental Universidade Federal de Pernambuco Cidade Universitaria RecifePE50740-560Brazil

Lanthanide coordination compounds of the formula Na[Ln(L)4](1 Ln),where Ln=La^3+,Eu^3+,Gd^3+,Tb^3+,L=[L]-and HL=dimethyl(4-methylphenylsulfo nyl)amidophosphate,were *** structural and spectro scopic properties were discussed in detail based on X-ray diffraction measurements,IR spectroscopy,absorption and emission spectroscopy at 293 and 77 K and theoretical calculations of the intramolecular energy transfer(IET)*** calculations were used to investigate the 1 Ln electronic properties re quired to calculate the transition rates.30 and 22 pathways of intramolecular nonradiative energy transfer were examined in the case of 1 Eu and 1 Tb,*** is shown that the main pathway for sensitization of the lanthanide emission is either the triplet(1 Eu)or singlet(1 Tb)transfer,occurring mainly through the exchange *** energy rates for energy transfer from S1 and T1 equal WS=1.53×10^5 s^-1(1 Eu),WT=5.14×10^6 s^-1(1 Eu)and WS=4.09×10^7 s^-1(1 Tb),WT=6.88×10^5 s^-1(1 Tb).The crucial role of the 7 F5 level in the energy transfer process of 1 Tb and the participation of the LmCT state in the depopulation of the ligand singlet state of 1 Eu were *** influence of the resonance effect on the splitting of the7 F1 level in 1 Eu was *** comparing the properties of 1 Ln with the properties of 2 Ln coordination compounds,sharing the same ligand and crystallizing in the same crystallographic system(monoclinic),but with a different space group,it is demonstrated how slight structural changes can affect the photophysical properties of Ln compounds.

关键词： Lanthanide Phosphorylated sulfonamides Energy transfer Antenna effect Crystal structure Resonance effect

Vascularization and osteogenesis in ectopically implanted bone tissue-engineered constructs with endothelial and osteogenic differentiated adipose-derived stem cells

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World Journal of Stem Cells 2021年第1期13卷 91-114页

作者： Jelena G Najdanović vladimir J Cvetković Sanja T Stojanović marijaĐVukelić-Nikolić Jelena mŽivković Stevo J Najman Department of Biology and Human Genetics Department for Cell and Tissue Engineering Faculty of MedicineUniversity of NišNiš18108Serbia Department of Biology and Ecology Faculty of Sciences and MathematicsUniversity of NišNiš18106Serbia

BACKGROUND A major problem in the healing of bone defects is insufficient or absent blood supply within the *** overcome this challenging problem,a plethora of approaches within bone tissue engineering have been developed *** in mind that the interplay of various diffusible factors released by endothelial cells(ECs)and osteoblasts(OBs)have a pivotal role in bone growth and regeneration and that adjacent ECs and OBs also communicate directly through gap junctions,we set the focus on the simultaneous application of these cell types together with platelet-rich plasma(PRP)as a growth factor reservoir within ectopic bone tissue engineering *** To vascularize and examine osteogenesis in bone tissue engineering constructs enriched with PRP and adipose-derived stem cells(ASCs)induced into ECs and *** ASCs isolated from adipose tissue,induced in vitro into ECs,OBs or just expanded were used for implant construction as followed:BPEO,endothelial and osteogenic differentiated ASCs with PRP and bone mineral matrix;BPUI,uninduced ASCs with PRP and bone mineral matrix;BC(control),only bone mineral *** 1,2,4 and 8 wk after subcutaneous implantation in mice,implants were extracted and endothelial-related and bone-related gene expression were analyzed,while histological analyses were performed after 2 and 8 *** The percentage of vascularization was significantly higher in BC compared to BPUI and BPEO constructs 2 and 8 wk after *** had the lowest endothelial-related gene expression,weaker osteocalcin immunoexpression and Spp1 expression compared to BPUI and ***-related gene expression and osteocalcin immunoexpression were higher in BPUI compared to BC and *** had a higher percentage of vascularization compared to BPUI and the highest CD31 immunoexpression among examined *** Vwf,endothelial-related gene expression in BPEO had a later onset and was upregulated and well-balanced during in viv

关键词： Adipose-derived stem cells Endothelial-related genes Bone-related genes Ectopic osteogenesis Vascularization Platelet-rich plasma

Enhancing the graphene photocurrent using surface plasmons and a p-n junction

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Light(Science & Applications) 2020年第1期9卷 793-802页

作者： Di Wang Andres E.Llacsahuanga Allcca Ting-Fung Chung Alexander V.Kildishev Yong P.Chen Alexandra Boltasseva vladimir m.Shalaev School of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47907USA Birck Nanotechnology Center Purdue UniversityWest LafayetteIN 47907USA Department of Physics and Astronomy Purdue UniversityWest LafayetteIN 47907USA Purdue Quantum Science and Engineering Institute(PQSEI) Purdue UniversityWest LafayetteIN 47907USA

The recently proposed concept of graphene photodetectors offers remarkable properties such as unprecedented compactness,ultrabroadband detection,and an ultrafast response ***,owing to the low optical absorption of pristine monolayer graphene,the intrinsically low responsivity of graphene photodetectors significantly hinders the development of practical *** address this issue,numerous efforts have thus far been made to enhance the light–graphene interaction using plasmonic *** approaches,however,can be significantly advanced by leveraging the other critical aspect of graphene photoresponsivity enhancement-electrical junction *** has been reported that the dominant photocarrier generation mechanism in graphene is the photothermoelectric(PTE)***,the two energy conversion mechanisms involved in the graphene photodetection process are light-to-heat and heat-to-electricity *** this work,we propose a meticulously designed device architecture to simultaneously enhance the two conversion ***,a gap plasmon structure is used to absorb a major portion of the incident light to induce localized heating,and a pair of split gates is used to produce a p-n junction in graphene to augment the PTE current *** gap plasmon structure and the split gates are designed to share common key components so that the proposed device architecture concurrently realizes both optical and electrical *** experimentally demonstrate the dominance of the PTE effect in graphene photocurrent generation and observe a 25-fold increase in the generated photocurrent compared to the un-enhanced *** further photocurrent enhancement can be achieved by applying a DC bias,the proposed device concept shows vast potential for practical applications.

关键词： electrical plasmon hinder

Circulating tumor cells in pancreatic cancer patients:Enrichment and cultivation

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World Journal of Gastroenterology 2014年第45期20卷 17163-17170页

作者： vladimir Bobek Robert Gurlich Petra Eliasova Katarina Kolostova Department of Laboratory Genetics University Hospital Kralovske Vinohrady Department of Histology and Embryology Wroclaw Medical University 3rd Department of Surgery First Faculty of Medicine Charles University in Prague and University Hospital Motol Department of Surgery University Hospital Kralovske Vinohrady

AIm: To investigate the feasibility of separation and cultivation of circulating tumor cells (CTCs) in pancreatic cancer (PaC) using a filtration device.

关键词： Pancreatic cancer Circulating tumor cells Biomarker Cultivation

A positron source using an axially oriented crystal associated to a granular amorphous converter

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Chinese Physics C 2012年第9期36卷 871-878页

作者：徐成海 Robert Chehab Peter Sievers Xavier Artru michel Chevallier Olivier Dadoun 裴国玺 vladimir m.Strakhovenko Alessandro Variola Institute of High Energy Physics Chinese Academy of Sciences Laboratoire de l'Accélérateur Linéaire IN2P3/CNRS et Université de Paris-SudBP 34-91898Orsay cedexFrance Institut de Physique Nucléaire de Lyon IN2P3/CNRS et Université Lyon 169622 VilleurbanneFrance CERN CH-1211Genéve 23Switzerland Budker Institute of Nuclear Physics Av.Lavrentyeva11630090 NovosibirskRussia

A non-conventional positron source using the intense y radiation from an axially oriented monocrys- tal which materializes into e^＋e^- pairs in a granular amorphous converter is described. The enhancement of photon radiation by multi-GeV electrons crossing a tungsten crystal along its 〈111〉 axis is reported. The resulting enhancement of pair production in an amorphous converter placed 2 meters downstream, is also re- ported. Sweeping off the charged particles from the crystal by a bending magnet upstream of the converter allows a significant reduction of the deposited energy density. Substituting a granular target made of small spheres for the usual compact one, makes the energy dissipation easier. The deposited energy and correspond- ing heating are analyzed and solutions for cooling are proposed. The configurations studied here for this kind of positron source allow its consideration for unpolarized positrons for the ILC.

关键词： channeling effect crystal positron source ILC

Improving the performance of power system protection using wide area monitoring systems

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Journal of modern Power Systems and Clean Energy 2016年第3期4卷 319-331页

作者： Arun G.PHADKE Peter WALL Lei DING vladimir TERZIJA Virginia Polytechnic Institute and State University 900 N.Glebe Rd.ArlingtonVA 22203USA Department of Electrical and Electronic Engineering University of ManchesterManchester M139PLUK School of Electrical Engineering Shandong University17923 Jingshi RoadJinan 250061Shandong ProvinceChina

Wide area monitoring(WAm) offers many opportunities to improve the performance of power system protection. This paper presents some of these opportunities and the motivation for their development. This methods include monitoring the suitability of relay characteristics,supervisory control of backup protection, more adaptive and intelligent system protection and the creation of novel system integrity protection scheme. The speed of response required for primary protection means that the role WAm in enhancing protection is limited to backup and system protection. The opportunities offered by WAm for enhancing protection are attractive because of the emerging challenges faced by the modern power system protection. The increasingly variable operating conditions of power systems are making it ever more difficult to select relay characteristics that will be a suitable compromise for all loading conditions and contingencies. The maloperation of relays has contributed to the inception and evolution of 70 % of blackouts,thus the supervision of the backup protection may prove a valuable tool for preventing or limiting the scale of blackouts. The increasing interconnection and complexity of modern power systems has made them more vulnerable to wide area disturbances and this has contributed to several recent blackouts. The proper management of these wide area disturbances is beyond the scope of most of the existing protection and new, adaptive system integrity protection schemes are needed to protect power system security.

关键词： Backup protection Blackouts Hidden failures Power system protection System integrity protection schemes Wide area monitoring Wide area protection