检索结果-南通市图书馆

Anti-cancer effects of sitagliptin,vildagliptin,and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation

引用

BIOCELL 2022年第12期46卷 2645-2657页

作者： POOJA JAISWAL versha tripathi ANSHUL ASSAIYA DHARMENDRA KASHYAP RAHUL DUBEY ANAMIKA SINGH JANESH KUMAR HEM CHANDRA JHA RAJESH SHARMA AMIT KUMAR DIXIT HAMENDRA SINGH PARMAR School of Biotechnology Devi Ahilya UniversityIndore452001India Laboratory of Membrane Protein Biology National Centre for Cell SciencePune411007India Department of Biosciences and Biomedical Engineering Indian Institute of TechnologyIndore452020India Department of Biotechnology IPS AcademyIndore452012India School of Pharmacy Devi Ahilya UniversityIndore452001India Central Council for Research in Ayurvedic Sciences Kolkata263645India

Triple-negative breast cancer(TNBC)cell line MDA-MB-231 is known for Warburg metabolism and defects in *** the other hand,dipeptidyl peptidase-IV(DPP-IV)inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis,but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell *** have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase(AMPK),which activates the downstream transcription factors PGC-1α,PGC-1β,or FOXO1 for mitochondrial biogenesis;above-mentioned incretin-based therapies are also known to activate *** study evaluated the effects of sitagliptin,vildagliptin,and exendin-4 on MDA-MB-231 cells and the underlying changes in mitochondrial biogenesis,were *** with sitagliptin(100μM),vildagliptin(100μM),and exendin-4(10 nM)for 72 h to MDA-MB-231 cells led to a decrease in viability indicated by MTT assay,cell migration by scratch,and transwell migration assays,accompanied with marginal reduction in cell numbers along with the apoptotic appearance,the rate of apoptosis,and decreased lactate content in conditioned *** changes in the cancer phenotype were accompanied by an increase in the mitochondrial DNA to nuclear DNA ratio,increased MitoTracker green and red staining,and increased expression of transcription factors PGC-1α,NRF-1,NRF-2,TFAM,and ***-treatment of cells with these incretin-based drugs followed by 48 h treatment with 1μM doxorubicin increased doxorubicin sensitivity as observed by a decrease in viability by MTT ***,sitagliptin,vildagliptin,and exendin-4 exert their beneficial effects on TNBC cells via an increase in mitochondrial biogenesis that helps to switch Warburg metabolism into anti-Warburg *** response was in the order of:sitagliptin>vildagliptin>ex

关键词： Sitagliptin Vildagliptin Exendin-4 Apoptosis Migration Viability Chemo-sensitivity Mitochondrial biogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel slot scheduling technique for duty-cycle based data transmission for wireless sensor network

引用

Digital Communications and Networks 2022年第3期8卷 351-358页

作者： Yogesh tripathi Arun Prakash Rajeev tripathi Department of Electronics and Communication Engineering Motilal Nehru National Institute of Technology AllahabadPrayagraj211004India

The duty cycling process involves turning a radio into an active and dormant state for conserving energy. It is a promising approach for designing routing protocols for a resource-constrained Wireless Sensor Networks (WSNs). In the duty cycle-based WSNs, the network lifetime is improved and the network transmission is increased as compared to conventional routing protocols. In this study, the active period of the duty cycle is divided into slots that can minimize the idle listening problem. The slot scheduling technique helps determine the most efficient node that uses the active period. The proposed routing protocol uses the opportunistic concept to minimize the sender waiting problem. Therefore, the forwarder set will be selected according to the node's residual active time and energy. Further, the optimum routing path is selected to achieve the minimum forwarding delay from the source to the destination. Simulation analysis reveals that the proposed routing scheme outperforms existing schemes in terms of the average transmission delay, energy consumption, and network throughput.

关键词： Duty cycle Energy model Wireless sensor network Slot scheduling technique

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Mathematical Study on Three Layered Oscillatory Blood Flow Through Stenosed Arteries

引用

Journal of Bionic Engineering 2012年第1期9卷 119-131页

作者： Dharmendra tripathi Department of Mathematics Indian Institute of Technology Ropar Punjab-140001 India

A mathematical model is constructed to examine the characteristics of three layered blood flow through the oscillatory cylindrical tube （stenosed arteries）. The proposed model basically consists three layers of blood （viscous fluids with different viscosities） named as core layer （red blood cells）, intermediate layer （platelets/white blood cells） and peripheral layer （plasma）. The analysis was restricted to propagation of small-amplitude harmonic waves, generated due to blood flow whose wave length is larger compared to the radius of the arterial segment. The impacts of viscosity of fluid in peripheral layer and intermediate layer on the interfaces, average flow rate, mechanical efficiency, trapping and reflux are discussed with the help of numerical and computational results. This model is the generalized form of the preceding models. On the basis of present discussion, it is found that the size of intermediate and peripheral layers reduces in expanded region and enhances in contracted region with the increasing viscosity of fluid in peripheral layer, whereas, opposite effect is observed for viscosity of fluid in intermediate layer. Final conclusion is that the average flow rate and mechanical efficiency increase with the increasing viscosity of fluid in both layers, however, the effects of the viscosity of fluid in both layers on trapping and reflux are opposite to each other.

关键词： mathematical model three layered oscillatory blood flow stenosed arteries mechanical efficiency trapping reflux

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A two-dimensional analytical model for channel potential and threshold voltage of short channel dual material gate lightly doped drain MOSFET

引用

Chinese Physics B 2014年第11期23卷 620-625页

作者： Shweta tripathi Department of Electronics & Communication Engineering Motilal Nehru National Institute of Technology

An analytical model for the channel potential and the threshold voltage of the short channel dual-material-gate lightly doped drain （DMG-LDD） metal-oxide-semiconductor field-effect transistor （MOSFET） is presented using the parabolic approximation method. The proposed model takes into account the effects of the LDD region length, the LDD region doping, the lengths of the gate materials and their respective work functions, along with all the major geometrical parameters of the MOSFET. The impact of the LDD region length, the LDD region doping, and the channel length on the channel potential is studied in detail. Furthermore, the threshold voltage of the device is calculated using the minimum middle channel potential, and the result obtained is compared with the DMG MOSFET threshold voltage to show the improvement in the threshold voltage roll-off. It is shown that the DMG-LDD MOSFET structure alleviates the problem of short channel effects （SCEs） and the drain induced barrier lowering （DIBL） more efficiently. The proposed model is verified by comparing the theoretical results with the simulated data obtained by using the commercially available ATLASTM 2D device simulator.

关键词： dual-material-gate MOSFET lightly doped drain short channel effect threshold voltage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A two-dimensional analytical modeling for channel potential and threshold voltage of short channel triple material symmetrical gate Stack(TMGS) DG-MOSFET

引用

Chinese Physics B 2016年第10期25卷 518-524页

作者： Shweta tripathi Department of Electronics & Communication Engineering Motilal Nehru National Institute of Technology

In the present work, a two-dimensional（2D） analytical framework of triple material symmetrical gate stack（TMGS）DG-MOSFET is presented in order to subdue the short channel effects. A lightly doped channel along with triple material gate having different work functions and symmetrical gate stack structure, showcases substantial betterment in quashing short channel effects to a good extent. The device functioning amends in terms of improved exemption to threshold voltage roll-off, thereby suppressing the short channel effects. The encroachments of respective device arguments on the threshold voltage of the proposed structure are examined in detail. The significant outcomes are compared with the numerical simulation data obtained by using 2D ATLAS;device simulator to affirm and formalize the proposed device structure.

关键词： triple material symmetrical gate stack(TMGS) DG MOSFET gate stack short channel effect drain induced barrier lowering threshold voltage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel approach towards molecular memory device in gate tunable structure of MoS_(2)-graphene

引用

Nano Research 2021年第1期14卷 177-184页

作者： Rahul tripathi Abha Misra Department of Instrumentation and Applied Physics Indian Institute of Sciencey BangaloreKarnataka 560012India

Molecular interaction in two-dimensional(2D)van der Waals(vdW)interfaces has drawn tremendous attention for extraordinary materials *** sensing characteristics of molecular interaction has been exploited extensively to reach the detection limit to a few parts-per-billion(ppb)of molecules and far less attention is given to the evolution of persistent current state due to the molecular *** study focuses on molecular memory operation of MoS_(2)-graphene heterostructure based field effect *** resistance state of the device due to the external perturbation of molecules is tuned to get a nearly relaxation free current state at much lower molecular concentration of 10 ppb tofacilitate non-volatile memory features for molecular memory *** ultrafast switching operation in milli-second order is achieved at room temperature for the fastest recovery obtained sofar in any molecular *** process is co-controlled both by molecular as well as external charge density.

关键词： MoS_(2) graphene field effect transistor molecular memory trap charges

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermal Stability of Supercapacitor for Hybrid Energy Storage System in Lightweight Electric Vehicles:Simulation and Experiments

引用

Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 170-178页

作者： Vima Mali Brijesh tripathi Department of Electrical Engineering/Solar Energy Pandit Deendayal Petroleum UniversityGandhinagarIndia Department of Science Pandit Deendayal Petroleum UniversityGandhinagarIndia

Recent research findings indicate that the non-monotonic consumption of energy from lithium-ion(Li-ion)batteries results in a higher heat generation in electrical energy storage *** peak demands,a higher heat generation due to high discharging current increases the temperature from 80℃ to 120℃,thereby resulting in thermal *** address peak demands,an additional electrical energy storage component,namely supercapacitor(SC),is being investigated by various research *** paper provides insights into the capability of SCs in lightweight electric vehicles(EVs)to address peak demands using the worldwide harmonized light-duty driving test cycle(WLTC)driving profile in MATLAB/Simulink at different ambient *** results indicate that temperature imposes a more prominent effect on Li-ion batteries compared with SCs under peak demand *** effect of the discharging rate limit on the Li-ion battery current is *** result shows that SCs can accommodate the peak demands for a low discharging current limit on the battery,thereby reducing heat *** impedance spectroscopy and cyclic voltammetry are performed on SCs to analyze their thermal performance at different temperatures ranging from 0℃ to 75℃ under different bias values of-0.6,0,0.6,and 1 V,*** results indicate a higher specific capacitance of the SC at an optimum operation temperature of 25℃ for the studied *** study shows that the hybrid combination of the Li-ion battery and SC for a lightweight EV can address peak demands by reducing thermal stress on the Li-ion battery and increasing the driving range.

关键词： Electric vehicle lithium-ion battery supercapacitor thermal stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A high-capacity viologen-based anolyte for high energy density neutral pH aqueous redox-flow batteries

引用

Journal of Energy Chemistry 2023年第3期78卷 222-231,I0007页

作者： Anubhav Kumar Bijay P.tripathi Department of Materials Science and Engineering Indian Institute of Technology DelhiHauz KhasNew Delhi 110016India

Redox-ﬂow batteries(RFBs)are a promising energy storage technology with remarkable scalability and safety for storing vast amounts of renewable energy and mitigating outputﬂuctuations of renewable power *** demonstrate a neutral pH aqueous RFB using a custom-designed 1’,1’’’,1’’’’’-(benzene-1,3,5-triyltris(methylene))tris(1-(3-(trimethyl ammonio)propyl)-[4’’,4’’’-bipyridine]-1,1’-diium)nonachloride(BTTMPB)as a 3 e-storage *** custom design with the high polarization in charge density has led to the excellent water solubility of 4.0 M in H_(2)O(321.6 A h L^(-1))and 2.4 M in 2.0 M NaCl(192.9 A h L^(-1)).The density functional theory(DFT)calculations and electrochemical experiments have shown 3 e-storage response of BTTMPB with a diffusion coefﬁcient of 3.1×10^(-6)cm^(2) s^(-1)and rate con-stant of 1.6×10^(-2)cm s^(-1) for theﬁrst reduction *** synthesized anolyte was paired with(Ferrocenylmethyl)trimethylammonium chloride(FcNCl)as catholyte enabling a 0.92 V aqueous RFB with 125.9 W h L^(-1)theoretical energy *** aqueous RFB has an excellent cycling performance from 10-30 m A cm^(-2),energy efﬁciency up to 80%,capacity retention of 99.96%per cycle at 20 m A cm^(-2),and a high demonstrated energy density of 29.1 W h L^(-1).

关键词： Energy storage Aqueous redox-ﬂow battery Redox-active organic material Viologen derivative Solvation energy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oral mucosal involvement in visceral leishmaniasis

引用

Asian Pacific Journal of Tropical Medicine 2013年第3期6卷 249-250页

作者： Sunny Garg Richik tripathi Kamlakar tripathi Department of General Medicine Institute of Medical SciencesBanaras Hindu UniversityIndia Consultant Oral and Maxillofacial Surgeon Heritage HospitalVaranasiIndia

Leishmaniasis affects both the visceral and cutaneous tissues in *** Mucosal involvement in leishmaniasis is rare and is often *** present a case 17 vear old boy from the north east region of Bihar who has a hislorv of visceral leishmaniasis one year back,came to the department of oral surgery for treatment of persistent oral *** examination did not give any diagnostic information while systemic examination revealed enlarged spleen and low grade *** was screened for leishmaniasis by rK39 based immunochromatographic strip test which came to be *** of the ulcer as well as splenic and bone marrow aspirate confirmed the presence of *** was administered Amphotericin B for 20 days following which significant clinical and haematological improvement followed.

关键词： Oral Mucosal Leishmaniasis Visceral

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermally and Optical-Induced Effect on Optical and Electrical Parameters of Ag-Doped CdSe Thin Films

引用

Acta Metallurgica Sinica(English Letters) 2015年第5期28卷 591-599页

作者： Jagdish Kaur S.K.tripathi Department of Physics Panjab University

Thin films of Ag-doped CdSe are deposited on the glass substrates by thermal evaporation technique using inert gas condensation method. The elemental composition of the prepared thin film is confirmed by EDX spectra. SEM analysis reveals the uniform distribution of the grains over the substrate. TEM analysis reveals the spherical nature of nanoparticles having size in the range of 25-30 nm. X-ray diffraction study indicates an increase in the grain size after thermal annealing and the decrease in the grain size after light soaking treatment. Transmittance spectra are found to decrease with corre- sponding red shift after annealing and light soaking of as-deposited thin films. The value of the band gap is found to decreases and refractive index increases, after annealing and light soaking treatment. The dispersion of refractive index is described using the Wemple-DiDomenico single oscillator model and the effects of the annealing and the light soaking on the dispersion parameters are studied. The dark conductivity is found to change from 2.24 × 10^-8 to 1.54 × 10^-7 and 1.45 ×10^-9 Ω-1 cm-1 after annealing and light soaking of thin films, respectively. Hall effect measurement reveals n-type behavior of as-deposited, annealed and light-soaked thin films.

关键词： CdSe Thin film Surface treatment Electrical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：