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Approaches to identifying drug resistance mechanisms to clinically relevant treatments in childhood rhabdomyosarcoma

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Cancer Drug Resistance 2022年第1期5卷 80-89页

作者： samson Ghilu Christopher L.Morton Angelina v.vaseva siyuan Zheng Raushan T.Kurmasheva Peter J.Houghton Department of Molecular Medicine Greehey Children’s Cancer Research InstituteUT HealthSan AntonioTX 78229USA Department of surgery St.Jude Children’s Research HospitalMemphisTN 38105USA Department of Epidemiology and Biostatistics Greehey Children’s Cancer Research InstituteUT HealthSan AntonioTX 78229USA

Aim:Despite aggressive multiagent protocols,patients with metastatic rhabdomyosarcoma(RMs)have poor *** a recent high-risk trial(ARsT0431),25% of patients failed within the first year,while on therapy and 80% had tumor progression within 24 ***,the mechanisms for tumor resistance are essentially *** we explore the use of preclinical models to develop resistance to complex chemotherapy regimens used in ***:A single Mouse Testing(sMT)protocol was used to evaluate the sensitivity of 34 RMs xenograft models to one cycle of vincristine,actinomycin D,cyclophosphamide(vAC)*** response was determined by caliper measurement,and tumor regression and event-free survival(EFs)were used as endpoints for *** tumors at regrowth were transplanted into recipient mice,and the treatment was repeated until tumors progressed during the treatment period(i.e.,became resistant).At transplant,tumor tissue was stored for biochemical and omics ***:The sensitivity to vAC of 34 RMs models was *** varied from 3 weeks to>20 *** models were classified as having intrinsic resistance,intermediate sensitivity,or high sensitivity to vAC *** to vAC was developed in multiple models after 2-5 cycles of therapy;however,there were examples where sensitivity remained unchanged after 3 cycles of ***:The sMT approach allows for in vivo assessment of drug sensitivity and development of drug resistance in a large number of RMs *** such,it provides a platform for assessing in vivo drug resistance mechanisms at a“population”level,simulating conditions in vivo that lead to clinical *** vAC-resistant models represent“high-risk”tumors that mimic a preclinical phase 2 population and will be valuable for identifying novel agents active against vAC-resistant disease.

关键词： Rhabdomyosarcoma patient-derived xenografts combination therapy intrinsic drug resistance acquired drug resistance

吉兰-巴雷综合征患者的生动梦境、幻觉、精神病和REM睡眠

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 23-24页

作者： Cochen v. Arnulf I. Demeret s. 赵天智 Dr Fédération des Pathologies du sommeil H?pital Pitié -salpêtrière 47- 83 Boulevard de l’H?pital 75013 Paris France

We conducted a prospective controlled study of the clinical and biological determinants of the mental status abnormalities in 139 patients with Guillain-Barré syndrome (GBs) and 55 patients without GBs placed in the intensive care unit (ICU controls). There were mental status changes in 31% of GBs patients and in 16% of controls (odds ratio = 2.3; P = 0.04). In GBs patients, they included vivid dreams (19% ), illusions (30% , including an illusory body tilt), hallucinations (60% , mainly visual) and delusions (70% , mostly paranoid). They appeared a median 9 days after disease onset (range 1- 40 days, during the progression or the plateau of the disease), and lasted a median 8 days. seven (16% ) patients experienced the symptoms before their admission to the ICU. Hallucinations were frequently hypnagogic, occurring as soon as the patients closed their eyes. Autonomic dysfunction, assisted ventilation and high CsF protein levels were significant risk factors for abnormal mental status in GBs patients. CsF hypocretin- 1 (a hypothalamic neuropeptide deficient in narcolepsy) levels, measured in 20 patients, were lower in GBs patients with hallucinations (555 ± 132 pg/ml) than in those without (664 ± 71 pg/ml, P = 0.03). since the mental status abnormalities had dream-like aspects, we examined their association with rapid eye movement sleep (REM sleep) using continuous sleep monitoring in 13 GBs patients with (n = 7) and without (n = 6) hallucinations and 6 tetraplegic ICU controls without hallucinations. Although sleep was short and fragmented in all groups, REM sleep latency was shorter in GBs patients with hallucinations (56 ± 115 min) than in GBs patients without hallucinations (153 ± 130 min) and in controls (207 ± 179 min, P sleep structure was highly abnormal in hallucinators, with sleep onset in REM sleep periods (83% ), abnormal eye movements during non-REM sleep (57% ), high percentages of REM sleep without atonia (92 ± 22% ), REM sleep be

关键词：巴雷吉兰患者 REM 梦境幻觉感觉障碍综合征综合病症

Plasmonic metasurface Luneburg lens

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Photonics Research 2019年第10期7卷 1112-1118页

作者： C.E.GARCIA-ORTIZ R.CORTEs J.E.GOMEZ-CORREA E.PIsANO J.FIUTOWsKI D.A.GARCIA-ORTIZ v.RUIZ-CORTEs H.-G.RUBAHN v.COELLO CICEsE Unidad MonterreyAlianza Centro 504PIITApodacaNL 66629Mexico Catedras CONACYT-Centro de Investigaciones enoptica Alianza Centro 504PIITApodacaNL 66629Mexico Mads Clausen Institute University of Southern DenmarkNanoSYDAlsion 2 DK6400S?nderborgDenmark CICFIM-UANL Av Universidad S/NSan Nicolas de los GarzaNL 66450Mexico Departamento deoptica CICESEEnsenadaBC 22860Mexico

We present a new design of a plasmonic Luneburg lens made from a gradient-index metasurface that was constructed with an array of nanometer-sized holes in a dielectric thin film. The fabricated structure consists of a planar lens with a diameter of 8.7 μm composed of a rectangular array of holes with a periodicity of 300 nm. The experimental characterization includes leakage-radiation microscopy imaging in the direction and frequency space. The former allows for characterization of the point spread function and phase distribution,whereas the latter grants access to qualitative measurements of the effective mode indices inside the plasmonic lens. The experimental results presented here are in good agreement with the expected average performance predicted by the numerical calculations. Nevertheless, the robustness of the characterization techniques presented here is also exploited to determine deviations from the design parameters.

关键词： space. film. characterization

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视网膜色素瘤和残余中心视野患者的全视野视网膜电图、多焦视网膜电图及多焦诱发电位研究

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 18-19页

作者： Ponjavic v. Andr'Gr■asson s. L. Granse 程燕 Department of Ophthalmology University Hospital of Lund S-221 85 Lund Sweden Dr.

Purpose: To evaluate (with three different electrophysiological methods) the r esidual retinal function in a selected group of patients with retinitis pigmento sa and remaining small central visual fields. Methods: Fourteen patients from se veral different genetic subgroups, who had been followed with visual acuity and visual field testing for periods up to 32 years, were examined. Ophthalmological examination included full-field electroretinography (ERG), multifocal electror etinography (mfERG) and multifocal visual evoked potential (mfvEP). Results: The ERGs were severely reduced in all patients. The mfERGs demonstrated the residua l central retinal function in five of the patients. The mfvEPs showed measurable amplitudes centrally in most of the patients. The follow-up examinations demon strated the slowly progressive course of the disease with preservation or only s light further loss of visual fields over a period of 7-32 years. Conclusion: Pa tients with retinitis pigmentosa may not always follow the typical natural cours e with progressive loss of visual fields, which may in some patients remain unaf fected over several decades. Multifocal ERG and mfvEP may be clinically useful f or evaluating remaining visual function in these patients.

关键词：视网膜电图中心视野诱发电位视网膜功能眼科检查视功能电位波幅电生理方法临床评估亚组

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第四代移动通信

网络电信 2005年第10期7卷 17-21页

作者： D. Rouffet s. Kerboeuf L. Cai v. Capdevielle

话音业务是第二代移动通信系统的驱动力量，并已取得了巨大的成功。当前，视频和电视业务正推动着第三代移动通信系统（3G）的部署。将来，随着短距离通信的出现，低成本高速数据业务将进一步驱动第四代移动通信系统（4G）的发展。不同... 详细信息

话音业务是第二代移动通信系统的驱动力量，并已取得了巨大的成功。当前，视频和电视业务正推动着第三代移动通信系统（3G）的部署。将来，随着短距离通信的出现，低成本高速数据业务将进一步驱动第四代移动通信系统（4G）的发展。不同种类用户设备的高度个性化及其之间的同步性使得各种业务和应用无所不在，这将成为40发展的另外一个驱动力。同时，无线接入网还将很可能从集中式的结构向分布式的结构演进。

关键词：第四代移动通信系统第三代移动通信系统高速数据业务话音业务短距离通信无线接入网驱动力电视业务用户设备

印度芥菜(Brassica juncea L.)硫甙含量的遗传分析(英文)

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印度芥菜(Brassica juncea L.)硫甙含量的遗传分析(英文)

热发射应力图形分析技术及其应用(二)——汽车发动机连杆的热弹性应力分析

第十二届国际油菜大会

作者： J.s.Chauhan Manju singh v.P.s.Bhadauria Arvind Kumar National Research Centre on Rapeseed-Mustard Bharatpur 3231 303 (Rajasthan)

印度油菜-芥菜种植面积和产量分别占世界的25.2%和13.8%。在印度国内,油菜-芥菜的种植面积和产量分别占总油料作物的21.6%和23.2%。印度芥菜(Brassica juncea L.)在整个国家的油菜-芥菜种植中具有主导地位,其种植面积占到了80%。印度芥... 详细信息

印度油菜-芥菜种植面积和产量分别占世界的25.2%和13.8%。在印度国内,油菜-芥菜的种植面积和产量分别占总油料作物的21.6%和23.2%。印度芥菜(Brassica juncea L.)在整个国家的油菜-芥菜种植中具有主导地位,其种植面积占到了80%。印度芥菜栽培品种的硫甙含量较高(8025μmol/g脱脂菜籽粕),高硫甙是国际贸易中的一个强有力的非关税壁垒,导致价格较低。目前,我国育种工作正努力降低硫甙含量,使其达到国际可接受的标准(小于30μmol/g脱脂菜籽粕)。对某一性状遗传知识的研究对育种工作的成功是必不可少的,但印度芥菜硫甙含量方面的遗传知识是比较缺乏的。本研究试图利用3个杂交组合(NUDHYJ-3×varuna、NUDHYJ–3×RL1359和NUDHYJ-3×PCR7)的6个世代材料(P1、P2、F1、F2、BC1和BC2)研究硫甙含量的遗传规律。NUDHYJ-3是双低品系,varuna、RL1359和PCR7是重要的印度芥菜品种。由F1平均值可知,所有3个杂交组合中,高硫甙含量对低硫甙含量具有部分显性。亲本NUDHYJ-3和3个高产品种硫甙含量至少存在4对主基因的差异。广义遗传力估计值较高(0.8.9),但狭义遗传力中等(0.4.5)。在所有3个杂交组合中,简单加性-显性模型不足以解释在不同杂交组合的不同世代硫甙性状总的遗传变异性,非等位基因互作对硫甙含量的遗传控制起主导作用。尽管加性和显性效应都很显著,但是显性效应的普遍性以及显性效应间的互作表明,早期世代对低硫甙进行选择并不是十分有效的。要想进行有效的选择,就必须推迟到较高世代,到显性效应大幅度降低的时候再进行选择。双亲杂交后至F3/F4世代的时候,再进行系谱选择,也许是选择低硫甙含量更合适的方法。

关键词： Indian mustard Brassica juncea glucosinolate content genetics

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机械强度 1989年第2期 78-80页

作者： v.sarihan D.Oliver s.Russell 吴宗岱

热弹性应力分析是一种比较新的和灵敏的实验应力分析技术。它是用于测量结构或零件动应力的一种非接触式和易于使用的技术。只需极少的表面准备工作,无需进一步的数据处理,即可快速地直接获得整个结构或某一部分的应力图。这一技术是用... 详细信息

热弹性应力分析是一种比较新的和灵敏的实验应力分析技术。它是用于测量结构或零件动应力的一种非接触式和易于使用的技术。只需极少的表面准备工作,无需进一步的数据处理,即可快速地直接获得整个结构或某一部分的应力图。这一技术是用图形来表示承受机械循环载荷的结构表面的主应力之和。热弹性应力分析仪利用从结构表面的红外辐射检测出由于所加应力循环产生的温度循环。

关键词：热弹性应力图连杆杆(机械元件) 试验夹具汽车

Modelling the impact of antimalarial quality on the transmission of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum

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Infectious Disease Modelling 2017年第2期2卷 161-187页

作者： Aleisha R.Brock Joshua v.Ross scott Greenhalgh David P.Durham Alison Galvani sunil Parikh Adrian Esterman school of Nursing&Midwifery University of South AustraliaAdelaideSAAustralia school of Mathematical sciences The University of AdelaideAdelaideSAAustralia Department of Mathematics and statistics Queen's UniversityKingstonONCanada Center for Infectious Disease Modeling and Analysis Yale School of Public HealthNew HavenCTUSA Yale school of Public Health New HavenCTUSA sansom Institute for Research Health University of South AustraliaAdelaideSAAustralia Australian Institute of Tropical Health and Medicine James Cook UniversityCairnsQLDAustralia

Background:The use of poor quality antimalarial medicines,including the use of nonrecommended medicines for treatment such as sulfadoxine-pyrimethamine(sP)monotherapy,undermines malaria control and elimination ***,the use of subtherapeutic doses of the active ingredient(s)can theoretically promote the emergence and transmission of drug resistant ***:We developed a deterministic compartmental model to quantify the impact of antimalarial medicine quality on the transmission of sP resistance,and validated it using sensitivity analysis and a comparison with data from Kenya collected in *** modelled human and mosquito population dynamics,incorporating two Plasmodium falciparum subtypes(sP-sensitive and sP-resistant)and both poor quality and good quality(artemether-lumefantrine)antimalarial ***:The model predicted that an increase in human malaria cases,and among these,an increase in the proportion of sP-resistant infections,resulted from an increase in poor quality sP antimalarial use,whether it was full-or half-dose sP ***:Our findings suggest that an increase in poor quality antimalarial use predicts an increase in the transmission of *** highlights the need for stricter control and regulation on the availability and use of poor quality antimalarial medicines,in order to offer safe and effective treatments,and work towards the eradication of malaria.

关键词： Deterministic compartmental model Falsified antimalarial medicine substandard antimalarial treatments Antimalarial quality Plasmodium falciparum malaria Drug resistance

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冠状动脉搭桥手术患者出院后结局的性别差异

世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 21-22页

作者： Guru v. Fremes s.E. Austin P.C. 郭俊 Institute for Clinical Evaluative sciences G106 2075 Bayview Ave Toronto Ont. M4N 3M5 Canada Dr.

Background -There are few comparative data regarding long-term nonfatal outcomes for women versus men after coronary artery bypass grafting(CABG). This study compares gender differences in cardiac events in a population of hospital survivors up to 11 years after isolated CABG surgery in Ontario, Canada. Methods and Results -A population-based cohort study(n=68 774 patients, 15 043 women) between september 1, 1991, and April 1, 2002, was assembled with linked clinical and administrative databases. Cox modeling and propensity score matching were used to compare death, cardiac readmission(angina, heart failure, myocardial infarction), repeat revascularization(angioplasty or CABG), and stroke readmission between men and women. Women were older(65±17 versus 62±13 years), more likely to present with urgent or emergent status(64%versus 56%), and less likely to receive arterial grafts(70%versus 78%). Women had a higher rate of cardiac readmission in the first year after surgery(hazard ratio[HR] of 1.5, 95%confidence interval[CI] 1.36 to 1.56), and this increased risk persisted after 1 year(HR 1.2, 95%CI 1.14 to 1.31). This was primarily due to readmissions for unstable angina(HR 1.3, 95%CI 1.24 to 1.38) and congestive heart failure(HR 1.1, 95%CI 1.06 to 1.21). Propensity-matched women had similar rates of death(HR 0.9, 95%CI 0.83 to 0.98) and repeat revascularization(HR 1.0, 95%CI 0.91 to 1.06). Conclusions -Women have a more complex clinical preoperative presentation and are more likely to be readmitted with unstable angina and congestive heart failure after CABG but experience survival similar to those seen in men. Gender differences in outcomes may be improved through durable revascularization strategies and close postoperative follow-up care targeted to women.

关键词：性别差异冠状动脉搭桥血运重建不稳定型心绞痛非致死性血管成形术心脏事件充血性心力衰竭患

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