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Production and mechanical properties of nano SiC particle reinforced Ti-6Al-4v matrix composite

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Transactions of Nonferrous Metals Society of China 2017年第1期27卷 82-90页

作者： G.SIvAKUMAR v.ANANTHI S.ramanathan CISL Department of PhysicsAnnamalai UniversityTamilnadu 608002India Physics Section FEATAnnamalai UniversityTamilnadu 608002India Manufacturing Engineering Department Annamalai UniversityTamilnadu 608002India

Different mass fractions （0, 5%, 10%, and 15%） of the synthesized nano SiC particles reinforced Ti-6Al-4v （Ti64） alloy metal matrix composites （MMCs） were successfully fabricated by the powder metallurgy method. The effects of addition of SiC particle on the mechanical properties of the composites such as hardness and compressive strength were investigated. The optimum density （93.33%） was obtained at the compaction pressure of 6.035 MPa. Scanning electron microscopic （SEM） observations of the microstructures revealed that the wettability and the bonding force were improved in Ti64 alloy/5% nano SiCp composites. The effect of nano SiCp content in Ti64 alloy/SiCp matrix composite on phase formation was investigated by X-ray diffraction. The correlation between mechanical parameter and phase formation was analyzed. The new phase of brittle interfaced reaction formed in the 10% and 15% SiCp composite specimens and resulted in no beneficial effect on the strength and hardness. The compressive strength and hardness of Ti64 alloy/5% nano SiCp MMCs showed higher values. Hence, 5% SiCp can be considered to be the optimal replacement content for the composite.

关键词： titanium alloy nano SiC particle powder metallurgy hardness compressive strength

How do serotonergic psychedelics treat depression:The potential role of neuroplasticity

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World Journal of Psychiatry 2021年第6期11卷 201-214页

作者： Hewa Artin Sidney Zisook Dhakshin ramanathan Department of Psychiatry UC San DiegoLa JollaCA 92093United States Department of Psychiatry UC San DiegoSan DiegoCA 92093United States Department of Psychiatry VA San Diego Healthcare SystemSan DiegoCA 92161United States

Depression is a common mental disorder and one of the leading causes of disability around the *** antidepressants often take weeks to months to work and are not effective for all *** has led to a search for a better understanding of the pathogenesis of depression as well as to the development of novel *** such novel antidepressant is ketamine,which has demonstrated both clinically promising results and contributed to new explanatory models of depression,including the potential role of neuroplasticity in *** clinical trials are now showing promising results of serotonergic psychedelics for depression;however,their mechanism of action remains poorly *** paper seeks to review the effect of depression,classic antidepressants,ketamine,and serotonergic psychedelics on markers of neuroplasticity at a cellular,molecular,electrophysiological,functional,structural,and psychological level to explore the potential role that neuroplasticity plays in the treatment response of serotonergic psychedelics.

关键词： Serotonergic psychedelics Psychedelics Depression Antidepressants Neuroplasticity Ketamine Hallucinogens

A computational approach to explore the functional missense mutations in the spindle check point protein Mad1

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Frontiers in Biology 2013年第6期8卷 618-625页

作者： Merlin LOPUS Rao SETHUMADHAvAN P. CHANDRASEKARAN K. SREEvISHNUPRIYA A.W. vARSHA v. SHANTHI K. ramanathan R. RAJASEKARAN Bioinformatics Division School of Biosciences and Technology Vellore Institute of Technology Vellore 632014 Tamil Nadu India Industrial Biotechnology Division School of Biosciences and Technology Vellore Institute of Technology Vellore 632014 Tamil Nadu India

In this work, the most detrimental missense mutations of Madl protein that cause various types of cancer were identified computationally and the substrate binding efficiencies of those missense mutations were analyzed. Out of 13 missense mutations, I Mutant 2.0, SIFT and PolyPhen programs identified 3 variants that were less stable, deleterious and damaging respectively. Subsequently, modeling of these 3 variants was performed to understand the change in their conformations with respect to the native Madl by computing their root mean squared deviation （RMSD）. Furthermore, the native protein and the 3 mutants were docked with the binding partner Mad2 to explain the substrate binding efficiencies of those detrimental missense mutations. The docking studies identified that all the 3 mutants caused lower binding affinity for Mad2 than the native protein. Finally, normal mode analysis determined that the loss of binding affinity of these 3 mutants was caused by altered flexibility in the amino acids that bind to Mad2 compared with the native protein. Thus, the present study showed that majority of the substrate binding amino acids in those 3 mutants displayed loss of flexibility, which could be the theoretical explanation of decreased binding affinity between the mutant Madl and Mad2.

关键词： missense mutation Madl Mad2 spindle check point cancer

Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer

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World Journal of Clinical Cases 2016年第7期4卷 155-164页

作者： Kazuki Moro Masayuki Nagahashi Rajesh ramanathan Kazuaki Takabe Toshifumi Wakai Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Division of Surgical Oncology Department of Surgery Virginia Commonwealth University School of Medicine and the Massey Cancer Center

Inflammation is a central process in several disorders and contributes to cancer progression. Inflammation involves a complex cascade of pro-inflammatory and anti-inflammatory signaling events with protein and lipid mediators. Recent advances in lipid detection have revealed the importance of lipid mediators in inflammation. Omega three polyunsaturated fatty acids(ω-3 PUFA) are found naturally in fish oil and have been extensively studied in multiple inflammatory diseases with improved outcomes. Resolvins are thought to be the active metabolites of ω-3 PUFA, and are responsible for facilitating the resolving phase of acute inflammation. Clinically, resolvins have been associated with resolution of acute kidney injury and acute lung injury, micro and macro vascular response to injury, and inhibition of microglia-activated inflammation in neurodegenerative disorders. In addition to inflammatory diseases, ω-3 PUFA and resolvins appear to modulate cancer progression. ω-3 PUFA intake has been associated with reduced inflammation in colorectal cancer, and favorable phenotype in breast cancer. Resolvins offer promising therapeutic potential as they may modulate inflammation with minimal side-effects, in contrast to currently available anti-inflammatory medications. This review describes the roles of ω-3 PUFA and resolvins in the inflammatory cascade, various inflammatory diseases, and specific cancers. Additionally, it will discuss the clinical therapeutic potential of resolvins astargets in inflammatory diseases and cancers.

关键词： Anti-inflammatory lipid mediators Resolvin Omega three polyunsaturated fatty acids Inflammatory diseases Cancer

Endoscopic ear surgery in middle ear cholesteatoma

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第1期4卷 24-29页

作者： Satish Nair J.G.Aishwarya Nagamani Warrier v Pavithra Aditya Jain Mehrin Shamim Krishna ramanathan Pooja K.vasu Department of ENT-HNS Apollo HospitalsBangaloreKarnatakaIndia

Objective:Endoscope has been used as diagnostic tool for recidivism and as an adjunct to microscopic technique in the management of *** present transcanal endoscopic ear surgery(TEES)is being used as a minimally invasive alternative for microscopic *** aim to evaluate the feasibility,structural,functional and quality of life outcomes of endoscopic technique in middle ear ***:This prospective study was conducted at a tertiary care hospital from January 2017 to January 2018 including 32 adult patients who were treated by TEES for middle ear *** of endoscopic technique was assessed by the conversion rates,visualization of middle ear structures and *** outcomes were evaluated in terms of graft uptake at the third month follow-up and presence of residual or recurrent *** outcomes were evaluated in terms of postoperative air-bone gap closure at third month *** outcomes in terms of post-operative pain,cosmetic score,day of return to daily activities and patient comfort scores were *** quality of life outcomes were evaluated using chronic ear survey(CES)and short form questionnaire12 version 2(SF-12v2)which are disease specific and general quality of life assessment tools ***:Out of 32 patients,endoscopic intact canal wall mastoidectomy was done for 28 and endoscopic canal wall down mastoidectomy in 4 ***(3.1%)patient had to be converted to microscopic *** follow-up period was 32.8 months(9e46 months).There were no post-operative complications in any of our *** mean middle ear structural visibility index score was 8.4±1.4 with the use of zero-degree *** uptake rate at third month follow-up was 100%.Two(6.3%)patients had recurrent disease at 6 months follow-up and were treated by revision endoscopic *** air conduction(51.3±20.2 dB vs.34.5±20.4 dB,pvs.16

关键词： Middle ear cholesteatoma Endoscopic technique Transcanal endoscopic ear surgery

Computational analysis of deleterious missense mutations in aspartoacylase that cause Canavan's disease

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Science China(Life Sciences) 2012年第12期55卷 1109-1119页

作者： SREEvISHNUPRIYA K. CHANDRASEKARAN P. SENTHILKUMAR A. SETHUMADHAvAN R. SHANTHI v. DAISY P. NISHA J. ramanathan K. RAJASEKARAN R. Bioinformatics Division School of Biosciences and Technology Vellore Institute of TechnologyVellore 632014 Tamil Nadu India Department of Biotechnology Holy Cross CollegeTrichy 620002 Tamil Nadu India

In this work, the most detrimental missense mutations of aspartoacylase that cause Canavan's disease were identified computationally and the substrate binding efficiencies of those missense mutations were analyzed. Out of 30 missense mutations, I-Mutant 2.0, SIFT and PolyPhen programs identified 22 variants that were less stable, deleterious and damaging respectively. Subsequently, modeling of these 22 variants was performed to understand the change in their conformations with respect to the native aspartoacylase by computing their root mean squared deviation (RMSD). Furthermore, the native protein and the 22 mutants were docked with the substrate NAA (N-Acetyl-Aspartic acid) to explain the substrate binding efficiencies of those detrimental missense mutations. Among the 22 mutants, the docking studies identified that 15 mutants caused lower binding affinity for NAA than the native protein. Finally, normal mode analysis determined that the loss of binding affinity of these 15 mutants was caused by altered flexibility in the amino acids that bind to NAA compared with the native protein. Thus, the pre- sent study showed that the majority of the substrate-binding amino acids in those 15 mutants displayed loss of flexibility, which could be the theoretical explanation of decreased binding affinity between the mutant aspartoacylases and NAA.

关键词： missense mutation Canavan's disease aspartoacylase NAA flexibility

Coronary artery calcium data and reporting system: Strengths and limitations

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World Journal of Radiology 2019年第10期11卷 126-133页

作者： Subramaniyan ramanathan Department of Clinical Imaging Al-Wakra Hospital Hamad Medical Corporation Department of Radiology Weil Cornell Medical College Qatar Foundation-Education City

Coronary artery calcium data and reporting system(CAC-DRS)is a recently introduced standardized reporting system for calcium scoring on computed ***-DRS provides four risk categories(0,1,2 and 3)along with treatment recommendations for each *** with any other new reporting platform,CAC-DRS has both advantages and *** communication,better clarity of details,organized management recommendations and utility in future research and education are the major strengths of *** has many limitations such as questionable need for a new system,few missing components,use of a less accurate visual method and treatment suggestions based on expert opinion instead of clinical *** this contemporary review,we discuss the new reporting system CAC-DRS,its application,strengths and limitations and conclude with some remarks for the future.

关键词： Coronary artery calcium Reporting system Agatston score Strengths Limitations Management

临床出现麻风反应的LL病人体内CMS持续降低的免疫病理学意义

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地方病译丛 1992年第4期13卷 54-56页

作者： v.D.ramanathan 李永赞

麻风反应是潜在的麻风慢性炎症过程中的急性表现,它常见于开始治疗以后,并由于严重的神经炎、葡萄膜炎、肾炎或关节炎而导致产生严重的后遗症。一般认为,免疫复合物(IC)通常主动地参与瘤型麻风反应。

关键词：麻风免疫学病理学

Post-operative morbidity after neoadjuvant chemotherapy and resection for gallbladder cancer: A national surgical quality improvement program analysis

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 95-102页

作者： Minha Kim Stephanie Stroever Krist Aploks Alexander Ostapenko Xiang Da Dong ramanathan Seshadri Department of General Surgery Danbury HospitalDanburyCT 06810United States Department of Research and Innovation Nuvance HealthDanburyCT 06810United States Division of Surgical Oncology/Hepato-Pancreato-Biliary Surgery Danbury HospitalDanburyCT 06810United States

BACKGROUND Gallbladder cancer is the most common malignancy of the biliary ***-adjuvant chemotherapy(NACT)has improved overall survival by enabling R0 ***,there is no consensus of guidelines for neoadjuvant therapy in gallbladder *** investigations continue to analyze the regimen and benefit of NACT for ongoing care of gallbladder cancer patients,we examined American College of Surgeons National Surgical Quality Improvement Program(NSQIP)database to determine if there was higher morbidity among the neo-adjuvant group within the 30-day post-operative *** hypothesized patients who underwent NACT were more likely to have higher post-operative *** To investigate the 30-day post-operative morbidity outcomes between patients who received NACT and underwent surgery and patients who only had *** A retrospective analysis of the targeted hepatectomy NSQIP data between 2015 and 2019 was performed to determine if NACT in gallbladder cancer increased the risk for post-operative morbidity(bile leak,infection rate,rate of converting to open surgery,etc.)compared to the group who only had *** calculate the odds ratio for the primary and secondary outcomes,a crude logistic regression was *** Of the 452 patients,52 patients received NACT prior to *** were no statistically significant differences in the odds of morbidity between the two groups,including bile leak[odds ratio(OR),0.69;95%confidence interval(95%CI):0.16-2.10;P=0.55],superficial wound infection(OR,0.58;95%CI:0.03-3.02;P=0.61),and organ space wound infection(OR,0.63;95%CI:0.18-1.63;P=0.61).CONCLUSION There was no significant difference in the risk of 30-day post-operative morbidity between the NACT and surgery group and the surgery only group.

关键词： Gallbladder cancer Neoadjuvant chemotherapy Radical cholecystectomy National Surgery Quality Improvement Program Postoperative outcome