How do serotonergic psychedelics treat depression:The potential role of neuroplasticity

作     者：Hewa Artin Sidney Zisook Dhakshin Ramanathan 

作者机构：Department of PsychiatryUC San DiegoLa JollaCA 92093United States Department of PsychiatryUC San DiegoSan DiegoCA 92093United States Department of PsychiatryVA San Diego Healthcare SystemSan DiegoCA 92161United States 

出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)

年 卷 期：2021年第11卷第6期

页      面：201-214页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：Department of Veteran's Affairs, Veteran's Health Administration [7IK2BX003308] UCSD Department of Psychiatry Burroughs Welcome Fund 

主　　题：Serotonergic psychedelics Psychedelics Depression Antidepressants Neuroplasticity Ketamine Hallucinogens 

摘      要：Depression is a common mental disorder and one of the leading causes of disability around the *** antidepressants often take weeks to months to work and are not effective for all *** has led to a search for a better understanding of the pathogenesis of depression as well as to the development of novel *** such novel antidepressant is ketamine,which has demonstrated both clinically promising results and contributed to new explanatory models of depression,including the potential role of neuroplasticity in *** clinical trials are now showing promising results of serotonergic psychedelics for depression;however,their mechanism of action remains poorly *** paper seeks to review the effect of depression,classic antidepressants,ketamine,and serotonergic psychedelics on markers of neuroplasticity at a cellular,molecular,electrophysiological,functional,structural,and psychological level to explore the potential role that neuroplasticity plays in the treatment response of serotonergic psychedelics.