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Asian pacific Journal of Tropical Biomedicine 2024年第9期14卷 401-409页

作者： B.prathap v.satyanarayanan K.Duraipandian p.subashree Department of pharmacology Karpaga Vinayaga Institute of Medical Sciences and Research CenterMaduranthakam 603308Tamil NaduIndia Department of pharmacology SRM Medical College Hospital and Research CenterKattankulathur 603211Tamil NaduIndia Department of Anatomy Karpaga Vinayaga Institute of Medical Sciences and Research CenterMaduranthakam 603308Tamil NaduIndia Department of Ophthalmology Karpaga Vinayaga Institute of Medical Sciences and Research CenterMaduranthakam 603308Tamil NaduIndia

Objective:To evaluate the effect of asiaticoside on streptozotocin(sTZ)and nicotinamide(NAD)-induced carbohydrate metabolism abnormalities and deregulated insulin signaling pathways in ***:Asiaticoside(50 and 100 mg/kg body weight)was administered to sTZ-NAD-induced diabetic rats for 45 days,and its effects on hyperglycaemic,carbohydrate metabolic,and insulin signaling pathway markers were ***:Asiaticoside increased insulin production,lowered blood glucose levels,and enhanced glycolysis by improving hexokinase activity and suppressing glucose-6-phosphatase and fructose-1,6-bisphosphatase *** in glycogen metabolism were mitigated by increasing glycogen synthase activity and gluconeogenesis was decreased by decreasing glycogen phosphorylase ***,asiaticoside upregulated the mrNA expressions of Irs-1,Irs-2,and GLUT4 in sTZ-NAD-induced diabetic rats and restored the beta cell morphology to ***:Asiaticoside has the potential to ameliorate type 2 diabetes by improving glycolysis,gluconeogenesis,and insulin signaling pathways.

关键词： Asiaticoside Type 2 diabetes mellitus Metabolic disorders Carbohydrate metabolism Insulin signaling

Managing type 2 diabetes:targeting a microbial enzyme as a novel treatment option

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signal Transduction and Targeted Therapy 2024年第1期9卷 3-5页

作者： Anikó Keller-pintér Tamás Korcsmáros Tibor vellai Department of Biochemistry Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzeged6720Hungary Department of Metabolism Digestion and ReproductionImperial College LondonLondonW120NNUK Quadram Institute Bioscience Norwich Research ParkNorwichNR47UQUK Department of Genetics Eötvös Loránd University(ELTE)Budapest1117Hungary Hungarian research Network HUN-rEN-ELTE Genetics research Group Budapest1117Hungary

In a recent science article,Wang and colleagues showed that the dipeptidyl peptidase 4(Dpp4)enzyme produced by the gut microbiota can interfere with the effect of host glucagon-like peptide-1(GLp-1)involved in stimulating insulin secretion,and the specific inhibitor of microbial Dpp4(mDpp4),combined with clinical inhibitors of host Dpp4 isoenzymes,further promotes blood glucose homeostasis.1 These results point out why certain patients respond inadequately to an antidiabetic medication.

关键词： homeostasis stimulating clinical

synthesis of coral-like structures of pr-Yb co-doped YIG: structural,optical, magnetic and antimicrobial properties

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Journal of rare Earths 2024年第3期42卷 543-554,I0004页

作者： A.Fernandez Francisca p.Araujo Y.Guerra s.Castro-Lopes J.Matilla-Arias Idglan s.de Lima Edson C.silva-Filho Josy A.Osajima F.Guerrero r.pena-Garcia Federal University of piau Graduate Program in Materials Science and EngineeringTeresinaPIBrazil Federal rural University of pernambuco Academic Unit of Cabo de Santo AgostinhoCabo de Santo AgostinhoPEBrazil Federal University of piaui Department of PhysicTeresinaPBrazil Federal University of pernambuco Graduate Program in Materials ScienceRecifePEBrazil University of Granma Departmentof Basic Sciences and Applied InformaticsFaculty of Technical SciencesBayamoCuba Federal University of Amazonas Department of PhysicManausAMBrazil Federal University of pernambuco Department of PhysicRecifePEBrazil

Coral-like structures of the Y_(3-x)pr_(x)Fe_(5-y)Yb_(y)O_(12),(0.00 ≤ x ≤ 0.04, 0.00 ≤ y ≤ 0.02) compound were synthesized using the sol-gel method. structural investigation certified the YIG cubic crystal structure formation, without any secondary phase. It is shown that, the relatively large ionic radius of the dopant cations results in an expansion of the lattice parameter, variations in the Iona-O-Iondangle, Iona-O,Iond-O and Ionc-O bond distances and decrease in the average crystallite size. Fourier transform infrared(FTIr) and raman measurements are essential to testify the single-phase formation of YIG crystal structure and are observed changes in the stretching and vibrational modes, respectively. The morphological study, energy dispersive spectroscopy(EDs) spectra and textural properties show corallike structures, peaks associated with pr^(3+) and Yb^(3+) atoms and the effect of dopants on surface area,diameter, and pore volume, respectively. The optical analysis from diffuse reflectance spectra witnessed an increase in the optical gap band, a decrease in Urbach energy and blue shift in the charge transfer,correlated with the expansion of the unit cell due to the dopant's insertion in the YIG structure. A typical ferrimagnetic behavior is exhibited by the Y_(3-x)pr_(x)Fe_(5-y)Yb_(y)O_(12)compound. The saturation magnetization(M_(s)), cubic anisotropy constant(K_(1)) and coercive field(H_(c)) increase with the pr^(3+)cations content, as consequence of their magnetic nature and distribution around of Fe^(3+)ions due to the coexistence with the Yb^(3+). Finally, for the first time, antibacterial tests by mean of the direct contact method were performed for YIG co-doped with pr^(3+)and Yb^(3+)and it is shown that, relatively high dosages of pr^(3+) cations favored the activity against s. aureus, therefore, a new biological property for YIG doped with rare earths is presented.

关键词： Yttrium iron garnet(YIG) Coral-like structures rare earths Band gap energy Magnetic properties Antimicrobial properties

Fast efficient photon deceleration in plasmas by using two laser pulses at different frequencies

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Matter and radiation at Extremes 2024年第3期9卷 11-18页

作者： Y.X.Wang X.L.Zhu s.M.Weng p.Li X.F.Li H.Ai H.r.pan Z.M.sheng Key Laboratory for Laser plasmas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IFsA Shanghai Jiao Tong UniversityShanghai 200240China research Center of Laser Fusion of China Academy of Engineering physics MianyangSichuan 621900China state key Laboratory of High Field Laser physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of ultrashort high-power light sources in the mid-infrared(mid-Ir)to terahertz(THz)range is of interest for applications in a number of fields,from fundamental research to biology and *** conventional laser technology,photon deceleration in plasma wakes provides an alternative approach to the generation of ultrashort mid-Ir or THz ***,we present a photon deceleration scheme for the efficient generation of ultrashort mid-Ir or THz pulses by using an intense driver laser pulse with a relatively short wavelength and a signal laser pulse with a relatively long *** signal pulse trails the driver pulse with an appropriate time delay such that it sits at the front of the second wake bubble that is driven by the driver *** to its relatively long wavelength,the signal pulse will be subjected to a large gradient of the refractive index in the plasma wake ***,the photon deceleration in the plasma wake becomes faster and more efficient for signal pulses with longer *** greatly enhances the capacity and efficiency of photon deceleration in the generation of ultrashort high-power light sources in the long-wavelength Ir and THz spectral ranges.

关键词： laser ultrashort photon

There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of sport and Health science 2024年第4期13卷 521-536页

作者： Helder s.Lopes Marina C.Waiteman Liliam B.priore Neal r.Glav.a.o David M.Bazett-Jones ronaldo v.Briani Fabio M.Azevedo school of science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA school of Exercise and rehabilitation sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MEDLINE,Embase,CINAHL,spOrTDiscus,and Web of science)were searched from inception to september *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(pFp),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(sMD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(sMD=-0.97,95%CI:-1.49 to-0.45).Individuals with pFp presented with reduced hamstring strength compared to painfree controls during isometric(sMD=-0.48,95%CI:-0.82 to-0.14),concentric(sMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(sMD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with pFp presented with reduced hamstring flexibility when compared to pain-free controls(sMD=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis patellar tendinopathy patellofemoral pain

Interindividual Age-Independent Differences in Human CX43 Impact ventricular Arrhythmic risk

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research 2024年第3期6卷 417-432页

作者： Laura García-Mendívil María pérez-Zabalza Antoni Oliver-Gelabert JoséMaría vallejo-Gil Javier Fañanás-Mastral Manuel vázquez-sancho Javier AndréBellido-Morales Alexánder sebastián vaca-Núñez Carlos Ballester-Cuenca Emiliano Diez Laura Ordovás Esther pueyo Biomedical signal Interpretation and Computational simulation group(BsICos) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BsICos Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental Medicine and Biology of Cuyo(IMBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ArAID) Zaragoza 50018Spain. Biomedical research Networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

Metrology for sub-rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High power Laser science and Engineering 2024年第3期12卷 90-105页

作者： E.A.vishnyakov.a.sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo C.D.Armstrong T.A.pikuz s.A.pikuz W.Yan T.M.Jeong s.singh p.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.velyhan T.Hayakawa Y.Fukuda J.K.Koga M.Ishino K.Kondo Y.Miyasaka A.Kon M.Nishikino Y.v.Nosach D.Khikhlukha I.p.Tsygvintsev D.Kumar J.Nejdl D.Margarone p.v.sasorov s.Weber M.Kando H.Kiriyama Y.Kato G.Korn K.Kondo s.v.Bulanov T.Kawachi A.s.pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for photon science(KpsI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFsA Shanghai Jiao Tong UniversityShanghaiChina Institute of plasma physics AsCr PragueCzech Republic FZU-Institute of physics AsCr PragueCzech Republic Czech Technical University in prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of physics National Academy of Sciences of UkraineKyivUkraine IsTEQ Ar YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

Cr-induced fusion reactions to synthesize superheavy elements

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Nuclear science and Techniques 2024年第5期35卷 122-130页

作者： s.Madhu H.C.Manjunatha N.sowmya B.M.rajesh L.seenappa r.s.susheela Department of physics R V College of EngineeringBangalore 560074India visvesvaraya Technological University BelagaviKarnataka 590018India Department of physics Government First Grade CollegeSrinivasapurKarnataka 563135India Department of physics Government First Grade CollegeDevanahallyKarnataka 562110India Department of physics Government First Grade CollegeMulbagalKarnataka 563131India Department of physics Government First Grade collegeNanjangudOoty RoadMysore 571301India

We investigated ^(50,52-54)Cr-induced fusion reactions for the synthesis of the superheavy element in the 104≤Z≤122 *** cross sections produced in this investigation using ^(54)Cr projectiles were compared with those obtained in prior *** estimated cross sections from this analysis are consistent with the findings of prior *** the current study,the predicted cross section was found to be 42fb at 236 Mev for ^(53)Cr+^(243)Am,23.2 fb at 236 Mev for ^(54)Cr+^(247)Cm,95.6 fb at 240 Mev for ^(53)Cr+248Bk,and 1.33 fb at 242 Mev for ^(53)Cr+***,these projected cross sections with excitation energy and beam energy will be useful in future Cr-induced fusion reaction investigations.

关键词： Fusion cross sections Compound nucleus formation probability survival probability Evaporation residue cross sections

structural build-up model for three-dimensional concrete printing based on kinetics theory

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Frontiers of structural and Civil Engineering 2024年第7期18卷 998-1014页

作者： prabhat ranjan prEM p.s.AMBILY shankar KUMAr Greeshma GIrIDHAr Dengwu JIAO Advanced Materials Laboratory CSIR-Structural Engineering Research CentreChennai 600113India Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

The thixotropic structural build-up is crucial in extrusion-based three-dimensional(3D)concrete *** paper uses a theoretical model to predict the evolution of static and dynamic yield stress for printed *** model employs a structural kinetics framework to create a time-independent constitutive link between shear stress and shear *** model considers flocculation,deflocculation,and chemical hydration to anticipate structural *** reversible and irreversible contributions that occur throughout the build-up,breakdown,and hydration are defined based on the proposed structural ***,detailed parametric studies are conducted to evaluate the impact of model *** is rev.a.ed that the proposed model is in good agreement with the experimental results,and it effectively characterizes the structural build-up of 3D printable concrete.

关键词： structural build-up rheology thixotropy 3D printable concrete kinetics theory ultra high performance concrete

Comparative analysis of microstructure,mechanical,and corrosion properties of biodegradable Mg-3Y alloy prepared by selective laser melting and spark plasma sintering

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Journal of Magnesium and Alloys 2024年第4期12卷 1496-1510页

作者： p.Minárik M.Zemková s.Šašek J.Dittrich M.Knapek F.Lukáˇc D.Koutný J.Jaroš r.Král Faculty of Mathematics and physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic research Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of plasma physics of the Czech Academy of sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of Machine and Industrial Design Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work explored possibilities of biodegradable magnesium alloy Mg-3Y preparation by two modern powder metallurgy techniques–spark plasma sintering(sps)and selective laser melting(sLM).The powder material was consolidated by both methods utilising optimised parameters,which led to very low porosity(∼0.3%)in the sLM material and unmeasurably low porosity in the sps *** main aim of the study was the thorough microstructure characterisation and interrelation between the microstructure and the functional properties,such as mechanical strength,deformability,and corrosion *** materials showed comparable strength of∼110 Mpa in tension and compression and relatively good deformability of∼9%and∼21%for the sLM and sps materials,*** corrosion resistance of the sps material in 0.1 M NaCl solution was superior to the sLM one and comparable to the conventional extruded *** digital image correlation during loading and the cross-section analysis of the corrosion layers rev.a.ed that the residual porosity and large strained grains have the dominant negative effect on the functional properties of the sLM *** the other hand,one of the primary outcomes of this study is that the sps consolidation method is very effective in the preparation of the W3 biodegradable alloy,resulting in material with convenient mechanical and degradation properties that might find practical applications.

关键词： Magnesium Yttrium powder metallurgy Microstructure Mechanical strength Corrosion resistance