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Contribution of functional KIR3DL1 to ankylosing spondylitis

Cellular & Molecular Immunology 2010年第6期7卷 471-476页

作者： Ivan v zvyagin Ilgar z Mamedov Olga v Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna v Chkalina Alexei A Kotlobay Dmitriy O Korostin denis v Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry RASMoscowRussia Institute of Rheumatology RAMSMoscowRussia DNA-Technology JSC MoscowRussia vavilov Institute of General Genetics MoscowRussia

Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune *** particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several ***,none of the studies analyzed these associations in the context of functionality of polymorphic *** better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)*** genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 *** the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low ***3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1**** finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating ***,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1**** activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective ***,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS.

关键词： ankylosing spondylitis autoimmune disease HLA-B27 KIR KIR3DL1 KIR3DS1 KIR3DL1*004 NK cell T cell

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Monoribbed-Functionalized Macrobicyclic Iron(Ⅱ) Complexes decorated with Terminal Reactive and vector Groups: Synthetic Strategy, Chemical Transformations and Structural Characterization

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Chinese Journal of Chemistry 2022年第17期40卷 2089-2105页

作者： Ilya P.Limarev Genrikh E.zelinskii Svetlana A.Belova Pavel v.Dorovatovskii Anna v.vologzhanina Ekaterina G.Lebed Yan z.voloshin Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences 28 Vavilova stMoscow119991 Russia Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences 31 Leninsky prMoscow119991 Russia National Research Center Kurchatov Institute 1 Kurchatova plMoscow123098 Russia

General and straightforward synthetic strategy towards the iron(Ⅱ)clathrochelates with functionalizing substituents in their apical capping and one of the three chelate ribbed fragments was *** hexachloroclathrochelate precursors were prepared by the direct template condensation of dichloroglyoxime with a suitable boronic acid on the Fe^(2+) ion as a matrix and underwent a stepwise nucleophilic substitution with S_(2)-,N_(2)- or O_(2)-bis-nucleophiles,forming the alicyclic or aromatic N_(2)-,S_(2)-or O_(2)-six-membered *** on the reaction conditions and precursor-to-dinucleophile molar ratios,iron(Ⅱ)clathrochelates with one(S,O and N),two(S,O and N)or three(S and O)X_(2)-six-membered ribbed substituent(s)were *** reactivity substantially decreases in a row:Cl_(6)-Cage>Cl_(4)X_(2)-Cage(where X=S,O or,especially,N)>Cl_(2)X_(4)-Cage(where X=S or O).The reactive monoribbed-functionalized clathrochelates underwent further chemical transformations giving the target macrobicyclic complexes with terminal vector *** follows from the single crystal XRD data,their FeN_(6)-coordination polyhedra possess the geometry intermediate between a trigonal prism and a trigonal antiprism(φ=21.3°—25.20°).Fe-N distances vary from 1.887(6)to 1.933(8)Å.Their 3D-molecules,the hydrophobic–hydrophilic balance in which can be tuned using a ribbed functionalization,form in the crystals the intermolecular specific halogen bonds and/or hydrophobic interactions.

关键词： Macrocyclic compounds Clathrochelates Iron complexes Ligand reactivity Targetdelivery

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device-based neuromodulation for cardiovascular diseases and patient’s age

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Journal of Geriatric Cardiology 2022年第11期19卷 876-893页

作者： Evgeny N Mikhaylov Nigar z Gasimova Natalia N Belyaeva Heber Ivan Condori Leandro Aleksandr D vakhrushev Evgeny v Shlyakhto Almazov National Medical Research Centre Saint-PetersburgRussia

The autonomic nervous system plays an important role in the pathogenesis of cardiovascular *** aging,autonomic activity changes,and this impacts the physiological reactions to internal and external *** sympathetic and parasympathetic responses seem to decline,reflecting functional and structural changes in nervous *** some investigators suggested that both the sympathetic and parasympathetic activities were suppressed,others found that only the parasympathetic activity was suppressed while the sympathetic activity *** addition,cardiac innervation progressively diminishes with ***,one may suggest that neuromodulation interventions may have different effects,and older age groups can express an attenuated *** article aims to discuss the effect of device-based neuromodulation in different cardiovascular diseases,depending on the patient’s ***,we cover renal denervation,pulmonary artery denervation,baroreceptor activation therapy,vagus nerve stimulation,spinal cord stimulation,ganglionated plexi ablation for the management of arterial and pulmonary hypertension,heart failure,angina and *** results of many clinical studies appeared to be *** view of the low rate of positive findings in clinical studies incorporating neuromodulation approaches,we suggest the underestimation of advanced age as a potential contributing factor to poorer *** of outcomes between different age groups in clinical trials may shed more light on the true effects of neuromodulation when neutral/ambiguous results are obtained.

关键词： stimulation cardiovascular diseases

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Operating limits and features of direct air capture on K_(2)CO_(3)/zrO_(2) composite sorbent

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Chinese Journal of Chemical Engineering 2022年第6期35卷 11-20页

作者： vladimir S.derevschikov Janna v.veselovskaya Anton S.Shalygin Dmitry A.Yatsenko Andrey z.Sheshkovas Oleg N.Martyanov Boreskov Institute of Catalysis SB RAS Akademika Lavrentieva Av.5630090 NovosibirskRussia Novosibirsk State University Pirogova Str.1630090 NovosibirskRussia

Potassium carbonate-based sorbents are prospective materials for direct air capture(DAC).In the present study,we examined and revealed the influence of the temperature swing adsorption(TSA)cycle conditions on the CO_(2) sorption properties of a novel aerogel-based K_(2)CO_(3)/zrO_(2) sorbent in a DAC *** was shown that the humidity and temperature drastically affect the sorption dynamic and sorption capacity of the *** a temperature at the sorption stage was 29℃ and a water vapor pressure P_(H2O) in the feed air was 5.2 mbar(1 bar=105 Pa),the composite material demonstrated a stable CO_(2) sorption capacity of 3.4%(mass).An increase in sorption temperature leads to a continuous decrease in the CO_(2) absorption capacity reaching a value of 0.7%(mass)at T=80℃.The material showed the retention of a stable CO_(2) sorption capacity for many cycles at each temperature in the *** PH2O in the inlet air from 5.2 to 6.8 mbar leads to instability of CO_(2) sorption capacity which decreases in the course of 3 consecutive TSA cycles from 1.7%to 0.8%(mass)at T=29℃.A further increase in air humidity only facilitates the deterioration of the CO_(2) sorption capacity of the material.A possible explanation for this phenomenon could be the filling of the porous system of the sorbent with solid reaction products and an aqueous solution of potassium salts,which leads to a significant slowdown in the CO_(2) diffusion in the composite sorbent *** investigate the regeneration step of the TSA cycle in situ,the macro ATRFTIR(attenuated total reflection Fourier-transform infrared)spectroscopic imaging was applied for the first *** was shown that the migration of carbonate-containing species over the surface of sorbent occurs during the thermal regeneration stage of the TSA *** movement of the active component in the porous matrix of the sorbent can affect the sorption characteristics of the composite *** revealed features make it possible

关键词： zirconia aerogel Potassium carbonate Carbon dioxide Direct air capture Fourier-transform infrared spectroscopic imaging

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Molecular pathways of liver regeneration:A comprehensive review

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World Journal of Hepatology 2021年第3期13卷 270-290页

作者： Yana v Kiseleva Sevak z Antonyan Tatyana S zharikova Kirill A Tupikin Dmitry v Kalinin Yuri O zharikov International School“Medicine of the Future” I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119435Russia department of Emergency Surgical Gastroenterology N.V.Sklifosovsky Research Institute for Emergency MedicineMoscow 129010Russia department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119048Russia Laboratory of Minimally Invasive Surgery A.I.Evdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia Pathology department A.V.Vishnevsky National Medical Research Center of Surgery of the Russian Ministry of HealthcareMoscow 117997Russia

The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its *** knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute *** liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver *** current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic *** studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases.

关键词： Liver regeneration Molecular pathways Hepatic progenitor cells Cytokines Micro ribonucleic acid Partial hepatectomy

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Nanofluid Flow across aMoving Plate under Blasius-Rayleigh-Stokes(BRS)variable Transport Fluid Characteristics

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Frontiers in Heat and Mass Transfer 2024年第1期22卷 65-78页

作者： Hanumesh vaidya Fateh Mebarek-Oudina K.v.Prasad Rajashekhar Choudhari Neelufer z.Basha Sangeeta Kalal department of Mathematics Vijayanagara Sri Krishnadevaraya UniversityBallariKarnatakaIndia department of Physics Faculty of SciencesUniversity of 20 Aout 1955-SkikdaSkikda21000Algeria department of Mathematics Manipal Institute of Technology BengaluruManipal Academy of Higher EducationManipalIndia

This investigation aims to analyze the effects of heat transport characteristics in the unsteady flow of nanofluids over a moving plate caused by a moving slot *** BRS variable is utilized for the purpose of analyzing these *** process of mathematical computation involves converting the governing partial differential equations into ordinary differential equations that have suitable similarity *** Keller-Box technique is employed to solve the ordinary differential equations(Odes)and derive the corresponding mathematical *** and tables present the relationship between growth characteristics and various parameters such as temperature,velocity,skin friction coefficient,concentration,Sherwood number,and Nusselt *** results are assessed by comparing them to previous *** observation reveals that higher dimensionless reference temperature and variable values of the moving slot parameter have a suppressing effect on the velocity and temperature patterns of *** values of the dimensionless reference temperature and moving slot parameter lead to enhancements in the Sherwood number,skin friction coefficient,and Nusselt *** conductivity of the nanofluid is ultimately affected by these enhancements.

关键词： Blasius-Rayleigh-Stokes stretching sheet variable viscosity boundary layer flow variable thermal conductivity moving slot

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Endoscopic anti-reflux therapy for gastroesophageal reflux disease

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World Journal of Gastroenterology 2021年第39期27卷 6601-6614页

作者： Enrique Rodríguez de Santiago Eduardo Albéniz Fermin Estremera-Arevalo Carlos Teruel Sanchez-vegazo vicente Lorenzo-zúñiga department of Gastroenterology and Hepatology Hospital Universitario Ramón y CajalInstituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Madrid 28034Spain Endoscopy Unit Gastroenterology DepartmentHospital Universitario de Navarra.Gastrointestinal Endoscopy Research UnitNavarrabiomed Biomedical Research Center.PamplonaSpain Endoscopy Unit Gastroenterology DepartmentHospital Universitari i Politècnic La FeInstituto de Investigación Sanitaria La Fe(IIS La Fe)Valencia 46026Spain

Gastroesophageal reflux disease has an increasing incidence and prevalence worldwide.A significant proportion of patients have a suboptimal response to proton pump inhibitors or are unwilling to take lifelong medication due to concerns about long-term adverse *** anti-reflux therapies offer a minimally invasive option for patients unwilling to undergo surgical treatment or take lifelong *** best candidates are those with a good response to proton pump inhibitors and without a significant sliding hiatal *** incisionless fundoplication and nonablative radiofrequency are the techniques with the largest body of evidence and that have been tested in several randomized clinical ***-assisted ligation techniques,anti-reflux mucosectomy,antireflux mucosal ablation,and new plication devices have yielded promising results in recent noncontrolled ***,the role of endoscopic procedures remains controversial due to limited long-term and comparative data,and no consensus exists in current clinical *** review provides an updated summary focused on the patient selection,technical details,clinical success,and safety of current and future endoscopic anti-reflux techniques.

关键词： Treatment Gastroesophageal reflux Transoral incisionless fundoplication Anti-reflux mucosectomy Anti-reflux mucosal ablation Stretta

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Scaling behavior of the thermopower of the archetypal heavy-fermion metal YbRh2Si2

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Frontiers of physics 2016年第2期11卷 89-95页

作者： v. R. Shaginyan A. z. Msezane G. S. Japaridze K. G. Popov J. W. Clark v. A. Khodel Petersburg Nuclear Physics Institute NRC Kurchatov Institute Gatchina 188300 Russia Clark Atlanta University Atlanta GA 30314 USA Komi Science Center Ural Division RAS Syktyvkar 167982 Russia department of Physics St. Petersburg State University Russia McDonnell Center for the Space Sciences 8J department of Physics Washington University St. Louis MO 63130 USA Centro de Ciencias Matemdticas Universidade de Madeira 9000-390 Funchal Madeira Portugal Russian Research Center Kurchatov Institute Moscow 123182 Russia

We reveal and explain the scaling behavior of the thermopower S/T exhibited by the archetypal heavy-fermion （HF） metal YbRh2Si2 under the application of magnetic field B at temperature T. We show that the same scaling is demonstrated by different HF compounds such as/3-YbA1B4 and the strongly correlated layered cobalt oxide [BiBa0.66K0.3602]CoO2. Using YbRh2Si2 as an example, we demonstrate that the scaling behavior of SIT is violated at the antiferromagnetic phase transition, while both the residual resistivity Po and the density of states, N, experience jumps at the phase transition, causing the thermopower to make two jumps and change its sign. Our elucidation is based on flattening of the single-particle spectrum that profoundly affects Po and N. To depict the main features of the SIT behavior, we construct a T-B schematic phase diagram of YbRh2Si2. Our calculated SIT for the HF compounds are in good agreement with experimental facts and support our observations.

关键词： thermoelectric and thermomagnetic effects quantum phase transition flat bands,non-Fermi-liquid states strongly correlated electron systems heavy fermions

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Correcting the Gutenberg–Richter b-value for effects of rounding and noise

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Earthquake Science 2015年第2期28卷 129-134页

作者： v.H.Márquez-Ramírez F.A.Nava F.R.zúiga UNAM Campus Querétaro México Centro de GeocienciasBlvd.Juriquilla No 3001 76230 México Querétaro México Seismology department CICESE Carretera Ensenada-Tijuana No 3918 Zona Playitas 22860 Ensenada BC México

The effects of magnitude rounding and of the presence of noise in the rounded magnitudes on the estimation of the Gutenberg-Richter b-value are explored, and the ways to correct for these effects are proposed. For typical values, b = 1 and rounding interval △M = 0.1, the rounding error is approximately -10^-3 and it can be corrected to a negligible approximately -10^-5. For the same typical values, the effect of noise can be larger, depending on the characteristics of the noise distribution; for normally distributed noise with standard deviation σ = 0.1, the correct b-value may be underestimated by a factor - 0.97.

关键词： b-value Noise Magnitude

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design and thermodynamic analysis of a pathway enabling anaerobic production of poly-3-hydroxybutyrate in Escherichia coli

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Synthetic and Systems Biotechnology 2023年第4期8卷 629-639页

作者： Karel Olavarria Marco v.Becker Diana z.Sousa Mark C.M.van Loosdrecht S.Aljoscha Wahl Laboratory of Microbiology Wageningen University and ResearchStippenenweg 46708 WEWageningenThe Netherlands Centre for Living Technologies Eindhoven-Wageningen-Utrecht AlliancePrincetonlaan 63584 CBUtrechtThe Netherlands department of Biotechnology Applied Sciences FacultyDelft University of Technologyvan der Maasweg 92629 HZDelftThe Netherlands Lehrstuhl für Bioverfahrenstechnik Friedrich-Alexander-Universit¨atPaul-Gordan-Strasse 391052ErlangenGermany

Utilizing anaerobic metabolisms for the production of biotechnologically relevant products presents potential advantages,such as increased yields and reduced energy ***,lower energy dissipation may indicate that certain reactions are operating closer to their thermodynamic *** stoichiometric analyses and genetic modifications are frequently employed in metabolic engineering,the use of thermodynamic tools to evaluate the feasibility of planned interventions is less *** this study,we propose a novel metabolic engineering strategy to achieve an efficient anaerobic production of poly-(R)-3-hydroxybutyrate(PHB)in the model organism Escherichia *** approach involves re-routing of two-thirds of the glycolytic flux through non-oxidative glycolysis and coupling PHB synthesis with NADH *** complemented our stoichiometric analysis with various thermodynamic approaches to assess the feasibility and the bottlenecks in the proposed engineered *** to our calculations,the main thermodynamic bottleneck are the reactions catalyzed by the acetoacetyl-CoAβ-ketothiolase(EC 2.***.1.9)and the acetoacetyl-CoA reductase(EC 1.***.1.36).Furthermore,we calculated thermodynamically consistent sets of kinetic parameters to determine the enzyme amounts required for sustaining the conversion *** the case of the engineered conversion route,the protein pool necessary to sustain the desired fluxes could account for 20%of the whole cell dry weight.

关键词： Pathway feasibility analysis Protein cost Anaerobic metabolism Engineered pathways Metabolite concentrations

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