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Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines

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World Journal of Gastroenterology 2016年第16期22卷 4109-4119页

作者： Gursimran Chandhok Judit Horvath Annu Aggarwal mohit bhatt Andree Zibert Hartmut HJ Schmidt Klinik fur Transplantationsmedizin Universitatsklinikum Munster D-48149 Munster Germany Institut fur Humangenetik Westfalische Wilhelms-Universitat D-48149 Munster Germany Kokilaben Dhirubhai Ambani Hospital and medical Research Institute Mumbai 400103 India

AIm: To study the effect of anti-copper treatment for survival of hepatic cells expressing different ATP7 B mutations in cell culture. mETHODS: The most common Wilson disease(WD) mutations p.H1069 Q, p.R778 L and p.C271*, found in the ATP7 B gene encoding a liver copper transporter, were studied. The mutations represent major genotypes of the United States and Europe, China, and India, respectively. A human hepatoma cell line previously established to carry a knockout of ATP7 B was used to stably express WD mutants. m RNA and protein expression of mutant ATP7 B, survival of cells, apoptosis, and protein trafficking were ***: Low temperature increased ATP7 B protein expression in several mutants. Intracellular ATP7 B localization was significantly impaired in the mutants. mutants were classified as high, moderate, and no survival based on their viability on exposure to toxic copper. Survival of mutant p.H1069 Q and to a lesser extent p.C271* improved by D-penicillamine(DPA) treatment, while mutant p.R778 L showed a pronounced response to zinc(Zn) treatment. Overall, DPA treatment resulted in higher cell survival as compared to Zn treatment; however, only combined Zn + DPA treatment fully restored cell viability. CONCLUSION: The data indicate that the basic impact of a genotype might be characterized by analysis of mutant hepatic cell lines.

关键词： ATP7B D-penicillamine Zinc mutations Wilson disease Therapy

Design of mg-Zn-Si-Ca casting magnesium alloy with high thermal conductivity

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Journal of magnesium and Alloys 2020年第1期8卷 184-191页

作者： v.E.Bazhenov A.v.Koltygin m.C.Sung S.H.Park A.Yu.Titov v.A.Bautin S.v.matveev m.v.Belov v.D.Belov K.v.malyutin National University of Science and Technology“mISiS” Leninskiy pr.4Moscow 119049Russia LG Electronics Inc. Yeoui-daeroYeongdeungpo-gu.128LG Twin TowerSeoul 07336 Republic of Korea

magnesium alloys are commonly used to produce lightweight *** most magnesium alloys exhibit low thermal conductivities,high thermal conductivities are needed for electronic *** this study,we attempted to develop new magnesium casting alloys with high thermal *** mg-Zn-Si-Ca alloy compositions were chosen using CALPHAD(CALculation of PHAse Diagrams)calculations,and alloy samples were *** fluidity and hot-tearing resistance were *** results indicated that these properties were similar to those of AZ91 *** tests showed that high-pressure die casting could produce mg-Zn-Si-Ca alloys possessing mechanical properties 1.5-3 times higher than those produced via sand *** alloy thermal conductivity was 126 W/mK at room *** corrosion rates of the as-cast samples in NaCl/water solutions were two times higher than that of AZ91.

关键词： magnesium alloy Thermal conductivity Phase composition Corrosion rate Sand casting High-pressure die casting

Photon interaction with semiconductor and scintillation detectors

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Nuclear Science and Techniques 2016年第3期27卷 159-170页

作者： v.p.singh n.m.badiger Department of Physics Karnatak UniversityDharwad 580003India

mass attenuation coefficients,effective atomic numbers,and electron densities for semiconductor and scintillation detectors have been calculated in the photon energy range 1 kev-100 *** interaction parameters have been found to vary with detector composition and the photon *** variation in the parameters with energy is shown graphically for all the partial photon interaction *** effective atomic numbers of the detector were compared with the ZXCOm program,and the results were found to be *** of semiconductor and scintillation detectors are presented in terms of effective atomic *** study should be useful for comparing the detector performance in terms of gamma spectroscopy,radiation sensitivity,radiation measurement,and radiation *** results of the present investigation should stimulate research work for gamma spectroscopy and radiation measuring materials.

关键词：相互作用参数闪烁探测器半导体光子有效原子序数光谱探测器质量衰减系数能量变化

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动脉导管未闭的药物治疗

国际心血管病杂志 1989年第5期32卷 272-275页

作者： bhatt v Nahata mC 陈健夫

本文讨论了新生儿症状性动脉导管未闭的发生率、临床表现和药物治疗,重点讨论了消炎痛的作用机制、药物动力学、治疗和预防效果。

关键词：药物治疗药物动力学消炎痛作用机制首次剂量肺透明膜病心输出量心肌收缩力主动脉内径奔马律

Evaluation of influence of cold atmospheric pressure argon plasma operating parameters on degradation of aqueous solution of Reactive Blue 198(RB-198)

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Plasma Science and Technology 2020年第5期22卷 114-125页

作者： K NAvANEETHA PANDIYARAJ D vASU P v A PADmANABHAN m PICHUmANI R R DESHmUKH v KANDAvELU Research Division of Plasma Processing(RDPP) Department of PhysicsSri Shakthi Institute of Engineering and TechnologyChinniyam Palayam(post)Coimbatore-641062India Department of Nanoscience and Technology Sri Ramakrishna Engineering CollegeCoimbatore-641022India Department of Physics Institute of Chemical TechnologyMatungaMumbai 400019India Department of Chemistry Sri Shakthi Institute of Engineering and TechnologyL&T bypassChinniyam Palayam(post)Coimbatore-641062India

The intention of this work is to remove Reactive Blue 198(RB-198)dye components from simulated water solution using cold atmospheric pressure argon plasma *** solutions of RB-198 dye were treated as a function of various operating parameters such as applied potential,reaction time and distance between the plasma jet and surface of the *** efficiency of the degradation of RB-198 molecules was explored by means of Uv-vis *** reactive species involved during the treatment process were examined by optical emission spectra(OES).The present hydroxyl radicals(OH·radical)and hydrogen peroxide(H2O2)in the plasma-treated aqueous dye solutions were investigated using various spectroscopic *** other parameters such as total organic carbon(TOC),conductivity and p H were also *** toxicity of plasma-treated RB-198 solution was finally studied by diffusion bacterial analysis and by tracking seed germination *** results show that a higher degradation percentage of99.27%was acquired for the RB-198 treated at higher reaction time and applied potential,and shorter distance between the plasma jet and water *** may be due to the formation of various reactive oxygen(OH·radical,atomic oxygen(O)and H2O2)and nitrogen species(nitric oxide(NO)radicals and N2 second positive system(N2 SPS))during the processes as confirmed by OES analysis and other spectroscopy ***(17.7%-81.8%)and pH(7.5-3.4)values of the plasma-treated RB-198 decreased significantly with respect to various operation parameters,which indicates the decomposition of RB-198 molecules in the aqueous ***,the conductivity of plasma-treated RB-198 aqueous solutions was found to have increased linearly during the plasma treatment due to the formation of various ionic species in aqueous *** toxicity analysis clearly exhibits the non-toxic behavior of plasma-treated RB-198 aqueous solution towards the bacterial growth and germination of see

关键词： RB-198 degradation non-toxicity cold atmospheric pressure plasma jet

Controlled Wettability of Polymers via Environmental Crazing

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Chinese Journal of Polymer Science 2022年第10期40卷 1307-1314,I0012页

作者： Alena Yu.Yarysheva Larisa m.Yarysheva Fedor v.Drozdov Olga v.Arzhakova Aziz m.muzafarov Faculty of Chemistry Lomonosov Moscow State UniversityLeninskieGory 1-3Moscow 119991Russia Institute of Synthetic Polymer materials RAS ul.Profsoyuznaya 70Moscow 117393Rusia

This work highlights the benefits of environmental crazing for the control over the hydrophilic-lipophilic balance of glassy amorphous and semicrystalline polymers:poly(ethylene terephthalate)(PET)and biodegradable polycaprolactone(PCL).Task-oriented encapsulation of diverse commercial and natural hydrophilic(polyethyleneoxide,polyvinylpyrrolidone,gelatin)and hydrophobic guest additives(perfluoroorgano siloxanes,water-repellent impregnation)into mesoporous host polymer(PET,PCL)matrixes allows targeted control over the wettability of the resultant nanocomposite *** on the nature of the guest additive,the properties of the modified polymers can be varied from hydrophilic to hydrophobic:contact angle(CA)of PET can be adjusted from 47_(⊥)/38_(||)to 130_(⊥)/117_(||)°(for initial PET,CA=82°)and CA of PCL from 40°to 114°(for initial PCL CA=75°).The unique benefits of environmental crazing for structural modification are related to the universal character of this approach which can be applied to a broad range of polymers and allows preparation of diverse high-performance materials with tunable hydrophilic-lipophilic balance.

关键词： Wettability Hydrophilic-hydrophobic balance Contact angle Environmental crazing Poly(ethylene terephthalate) Polycaprolactone

Post-Late Paleozoic Collisional Framework of Southern Great Altai

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Acta Geologica Sinica(English Edition) 2012年第5期86卷 1093-1104页

作者： Boris m. CHIKOv Sergei v. ZINOvIEv Еugene v. DEYEv Institute of Geology Siberian Branch of Russian Academy of Sciences Novosibirsk 630090 Russia

We outline the post-Late Paleozoic （latest Permian to Cenozoic） collisional framework of the southern Great Altai （Central Asia） produced by the convergence between the Tuva-mongolia and Junggar continental terranes （microplates）. The collisional structures in the region classified on the basis of their geometry and deformation style, dynamic metamorphism, and compositions of tectonites are of three main types：（1） mosaic terranes made up of large weakly deformed Paleozoic blocks separated by younger shear zones; （2） contractional deformation systems involving structures formed in post-Late Paleozoic time, parallel faults oriented along collisional deformation systems, and relict lenses of Paleozoic orogenic complexes; and （3） isolated zones of dynamic metamorphism composed mostly of collisional tectonites different in composition and alteration grade.

关键词： continental collision post-Late Paleozoic events tectonic framework dynamic metamorphism Altai Central Asia

Risk of second primary malignancies in a population-based study of adult patients with essential thrombocythemia

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World Journal of Clinical Oncology 2016年第4期7卷 324-330页

作者： Rajesh Shrestha Smith Giri Ranjan Pathak vijaya Raj bhatt Division of Hospital medicine Department of MedicineRhode Island HospitalBrown University Department of medicine University at Tennessee Department of medicine Reading Health System Division of Hematology and Oncology Department of Internal MedicineUniversity of Nebraska Medical Center

AIm:To determine the risk of second primary malignancy(SPm) and survival of patients with essential thrombocythemia(ET).mETHODS:We identified all patients with ET diagnosed during 2001 to 2011 from the Surveillance,Epidemiology and End Results(SEER) 18 *** and relative survival methods were used to calculate the survival *** utilized the SEER 13 database to calculate *** used multiple primary standardized incidence ratio(SIR) session of the SEER*Stat software(version 8.1.5) to calculate SIR and excess risk of SPm for ET ***:Age standardized five-year cause-specific survival was greater for patients vs those ≥ 50 years(99.4% vs 93.5%,P ve-year causespecific survival was lower for men vs women(70.2% vs 79.7%).A total of 201 patients(2.46%) developed SPm at a median age of 75 *** occurred at an observed/expected(O/E) ratio of 1.26(95%CI:1.09-1.45,P = 0.002) with an absolute excess risk(AER) of 37.44 per 10000 population.A significantly higher risk was noted for leukemia(O/E 3.78; 95%CI:2.20-6.05,P ve an excellent causespecific five-year survival but are at an increased risk of SPm,particularly leukemia,which may contribute to excess deaths.

关键词： Essential thrombocythemia Second primary malignancy Survival

BDNF Overexpression Enhances the Preconditioning Effect of Brief Episodes of Hypoxia,Promoting Survival of GABAergic Neurons

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Neuroscience Bulletin 2020年第7期36卷 733-760页

作者： m.v.Turovskaya S.G.Gaidin m.v.vedunova A.A.Babaev E.A.Turovsky Institute of Cell Biophysics of the Russian Academy of Sciences Federal Research Center“Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”PushchinoRussia Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny NovgorodRussia

Hypoxia causes depression of synaptic plasticity,hyperexcitation of neuronal networks,and the death of specific populations of ***,brief episodes of hypoxia can promote the adaptation of *** preconditioning is well manifested in glutamatergic neurons,while this adaptive mechanism is virtually suppressed in GABAergic ***,we show that brain-derived neurotrophic factor(BDNF) overexpression in neurons enhances the preconditioning effect of brief episodes of *** amplitudes of the NmDAR-and AmPARmediated Ca2+ responses of glutamatergic and GABAergic neurons gradually decreased after repetitive brief hypoxia/reoxygenation cycles in cell cultures transduced with the(AAv)-Syn-BDNF-EGFP virus *** contrast,the amplitudes of the responses of GABAergic neurons increased in non-transduced cultures after *** decrease of the amplitudes in GABAergic neurons indicated the activation of mechanisms of hypoxic *** suppressed apoptotic or necrotic cell *** effect was most pronounced in cultures with BDNF overe *** of BDNF abolished the effect of preconditioning and promoted the death of GABAergic ***,the expression of the anti-apoptotic genes Stat3,Socs3,and Bcl-x1 substantially increased 24 h after hypoxic episodes in the transduced cultures compared to *** expression of genes encoding the pro-inflammatory cytokines IL-10 and IL-6 also *** turn,the expression of pro-apoptotic(Bax,Casp-3,and Fas) and proinflammatory(IL-1β and TNFα) genes decreased after hypoxic episodes in cultures with BDNF *** of vesicular BDNF release abolished its protective action targeting inhibition of the oxygen-glucose deprivation(OGD)-induced [Ca2+]i increase in GABAergic and glutamatergic neurons,thus promoting their *** A1,Brefeldin A,and tetanus toxin suppressed vesicular release(including BDNF) and shifted the gene expression pr

关键词： Hypoxia Neuron BDNF Preconditioning Calcium Receptors