Risk of second primary malignancies in a population-based study of adult patients with essential thrombocythemia

作     者：Rajesh Shrestha Smith Giri Ranjan Pathak Vijaya Raj Bhatt 

作者机构：Division of Hospital MedicineDepartment of MedicineRhode Island HospitalBrown University Department of MedicineUniversity at Tennessee Department of MedicineReading Health System Division of Hematology and OncologyDepartment of Internal MedicineUniversity of Nebraska Medical Center 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2016年第7卷第4期

页      面：324-330页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by The University of Nebraska Medical Center College of Medicine Physician-Scientist Training Program Grant 2015-2016(to Bhatt VR) 

主　　题：Essential thrombocythemia Second primary malignancy Survival 

摘      要：AIM:To determine the risk of second primary malignancy(SPM) and survival of patients with essential thrombocythemia(ET).METHODS:We identified all patients with ET diagnosed during 2001 to 2011 from the Surveillance,Epidemiology and End Results(SEER) 18 *** and relative survival methods were used to calculate the survival *** utilized the SEER 13 database to calculate *** used multiple primary standardized incidence ratio(SIR) session of the SEER*Stat software(version 8.1.5) to calculate SIR and excess risk of SPM for ET ***:Age standardized five-year cause-specific survival was greater for patients 50 years vs those ≥ 50 years(99.4% vs 93.5%,P 0.01).Five-year causespecific survival was lower for men vs women(70.2% vs 79.7%).A total of 201 patients(2.46%) developed SPM at a median age of 75 *** occurred at an observed/expected(O/E) ratio of 1.26(95%CI:1.09-1.45,P = 0.002) with an absolute excess risk(AER) of 37.44 per 10000 population.A significantly higher risk was noted for leukemia(O/E 3.78; 95%CI:2.20-6.05,P 0.001; AER 11.28/10000).CONCLUSION:ET patients have an excellent causespecific five-year survival but are at an increased risk of SPM,particularly leukemia,which may contribute to excess deaths.