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Research status and hotspots of tight junctions and colorectal cancer:A bibliometric and visualization analysis

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3705-3715页

作者： Hui-Min li Yin liu Meng-Di Hao Xiao-Qing liang Da-Jin Yuan Wen-Bin Huang Wen-Jie li Lei Ding Department of Gastrointestinal Oncology Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide and the second leading cause of cancer-related *** the past two decades,numerous researchers have provided important evidence regarding the role of tight junction(TJ)proteins in the occurrence and progression of *** causal relationship between the presence of specific TJ proteins and the development of CRC has also been *** the large number of publications in this field,a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been *** To analyze research on TJs and CRC,summarize the field’s history and current status,and predict future research *** We searched the Science Citation Index Expanded database for all literature on CRC and TJs from *** used bibliometrics to analyze the data of these papers,such as the authors,countries,institutions,and ***-authorship,co-citation,and co-occurrence analyses were the main methods of *** and vOSviewer were used to visualize the *** A total of 205 studies were ultimately *** number of publications on this topic has steadily increased since *** and the United States have made the largest contributions to this *** Research was the most prolific journal,publishing 8 articles,while the journal Oncogene had the highest average citation rate(68.33).Professor Dhawan P was the most prolific and cited author in this ***-occurrence analysis of keywords revealed that“tight junction protein expression”,“colorectal cancer”,“intestinal microbiota”,and“inflammatory bowel disease”had the highest frequency of occurrence,revealing the research hotspots and trends in this *** This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC,providing valuable research perspectives and future directions for studying the connection between th

关键词： Colorectal cancer Tight junctions Bibliometric analysis Research trends Hot spots

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Effects of cathode potentials and nitrate concentrations on dissimilatory nitrate reductions by Pseudomonas alcaliphila in bioelectrochemical systems

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Journal of Environmental Sciences 2014年第4期26卷 885-891页

作者： Wenjie Zhang Yao Zhang Wentao Su Yong Jiang Min Su Ping Gao Daping li College of life Sciences Sichuan University Key Laboratory of Environmental and Applied Microbiology Chengdu Institute of Biology Chinese Academy of Sciences Environmental Microbiology Key Laboratory of Sichuan Province

The effects of cathode potentials and initial nitrate concentrations on nitrate reduction in bio- electrochemical systems （BESs） were reported. These factors could partition nitrate reduction between denitrification and dissimilatory nitrate reduction to ammonium （DNRA）. Pseudomonas alcaliphilastrain MBR utilized an electrode as the sole electron donor and nitrate as the sole electron acceptor. When the cathode potential was set from -0.3 to -I.1 v （vs. Ag/AgC1） at an initial nitrate concentration of 100 mg NO^-N/L, the DNRA electron recovery increased from （10.76 ± 1.6）% to （35.06 ± 0.99）%; the denitrification electron recovery decreased from （63.42 ± 1,32）% to （44.33 ± 1.92）%. When the initial nitrate concentration increased from （29.09 ± 0.24） to （490.97 ± 3.49） mg NO3-N/L at the same potential （-0.9 v）, denitrification electron recovery increased from （5.88 ± 1.08）% to （50.19 ±2.59）%; the DNRA electron recovery declined from （48.79 ±1.32）% to （16.02 ± 1.41）%. The prevalence of DNRA occurred at high ratios of electron donors to acceptors in the BESs and denitrification prevailed against DNRA under a lower ratio of electron donors to acceptors. These results had a potential application value of regulating the transformation of nitrate to N2 or ammonium in BESs for nitrate removal.

关键词： bioelectrochemical systems cathode potential Pseudomonas alcaliphila MBR denitrification dissimilatory nitrate reduction

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A Furan-based Phosphaphenanthrene-containing Derivative as a Highly Efficient Flame-retardant Agent for Epoxy Thermosets without Deteriorating Thermomechanical Performances

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Chinese Journal of Polymer Science 2022年第3期40卷 233-240,I0005页

作者： Hao-Xin Niu Hong-liang Ding Jia-li Huang Xin Wang Lei Song Yuan Hu State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

In order to reduce greenhouse gas emissions, developing flame retardants from bio-based resources has aroused extensive interest in recent years. In this work, we utilized furfural(biomass) and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide(DOPO) to synthesize a biobased co-curing agent(FGD) to combine with 4,4'-diaminodiphenyl methane(DDM) for obtaining a low-phosphorus loading flame-retardant epoxy thermosets. The introduction of FGD decreased the activation energy of the curing progress, enhanced the mechanical properties of the epoxy thermosets, and did not affect the glass transition temperature of the epoxy thermosets. EP-5.0 had a lower thermal degradation rate and a doubled char yield compared with EP-0. The phosphorus content of EP-5.0 was only 0.45 wt%, while EP-5.0 reached the UL-94 v-0 rating with a high LOI value of 32%. Compared with EP-0, the PHRR of EP-2.5 and EP-5.0 decreased by 22.3% and 31.3%, respectively. The SEM results showed that the addition of FGD made the char residues more uniform and denser, which could effectively prevent combustible volatiles from escaping from the degradation area to the flame area and isolate the heat transfer so that the epoxy thermosets had an excellent flame-retardant performance.

关键词： Furfural DOPO Bio-based co-curing agent Flame-retardant performance

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Potent bromodomain and extraterminal domain inhibitor JAB-8263 suppresses MYC expression and exerts anti-tumor activity in colorectal cancer models

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World Journal of Gastrointestinal Oncology 2023年第2期15卷 332-342页

作者： Xin-Mo liu Shao-You Xia Wei Long Hai-Jun li Gui-Qun Yang Wen Sun Song-Yan li Xiao-Hui Du Department of General Surgery Chinese PLA General HospitalBeijing 100039China Medical School of Chinese PLA Beijing 100039China Department of Chemistry Jacobio PharmaceuticalsBeijing 102600China Department of Pharmacology Jacobio PharmaceuticalsBeijing 102600China Department of Anesthesiology the Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China

BACKGROUND The overexpression of the MYC gene plays an important role in the occurrence,development and evolution of colorectal cancer(CRC).Bromodomain and extraterminal domain(BET)inhibitors can decrease the function BET by recognizing acetylated lysine residues,thereby downregulating the expression of *** To investigate the inhibitory effect and mechanism of a BET inhibitor on CRC *** The effect of the BET inhibitor JAB-8263 on the proliferation of various CRC cell lines was studied by CellTiter-Glo method and colony formation *** effect of JAB-8263 on the cell cycle and apoptosis of CRC cells was studied by propidium iodide staining and Annexin v/propidium iodide flow assay,*** effect of JAB-8263 on the expression of c-MYC,p21 and p16 in CRC cells was detected by western blotting *** anti-tumor effect of JAB-8263 on CRC cells in vivo and evaluation of the safety of the compound was predicted by constructing a CRC cell animal tumor *** JAB-8263 dose-dependently suppressed CRC cell proliferation and colony formation in *** MYC signaling pathway was dose-dependently inhibited by JAB-8263 in human CRC cell ***-8263 dose-dependently induced cell cycle arrest and apoptosis in the MC38 cell ***837 xenograft model was treated with JAB-8263(0.3 mg/kg for 29 d),and the average tumor volume was significantly decreased compared to the vehicle control group(Pverage tumor volume was significantly decreased compared to the vehicle control group(P=0.003).CONCLUSION BET could be a potential effective drug target for suppressing CRC growth,and the BET inhibitor JAB-8263 can effectively suppress c-MYC expression and exert anti-tumor activity in CRC models.

关键词： Bromodomain Bromodomain and extraterminal domain inhibitor Colorectal cancer JAB-8263 MYC p21

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淮北煤田朱庄煤矿煤中微量元素地球化学特征

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煤炭科学技术 2023年第8期51卷 178-191页

作者：李祥李伍中国矿业大学煤层气资源与成藏过程教育部重点实验室江苏徐州221116 洛阳钼业集团股份有限公司河南栾川471000

随着工业发展和产业革新,以稀有元素为主体的关键金属矿产需求量与日俱增。更多的专家认为煤系矿产资源具有获取关键金属矿产的潜在可能,此类资源也因此受到了国内外的高度关注。我国淮北煤田煤炭资源丰富,为研究其煤中微量元素地球化... 详细信息

随着工业发展和产业革新,以稀有元素为主体的关键金属矿产需求量与日俱增。更多的专家认为煤系矿产资源具有获取关键金属矿产的潜在可能,此类资源也因此受到了国内外的高度关注。我国淮北煤田煤炭资源丰富,为研究其煤中微量元素地球化学特征,并判断稀有金属工业潜力,选取朱庄矿5煤、8煤、10煤作为研究对象,采用工业分析、XRF和ICP-MS等测试手段对样品进行了煤质分析和主微量元素含量测试。结果表明:与世界煤相比,朱庄矿煤中大部分微量元素富集程度较高,如li、Cr、Co等属于高度富集。与5煤和8煤相比,10煤中微量元素的富集程度较低,其中v、Mn、Rb、Cs的含量属于正常范围。通过w(Al_(2)O_(3))/w(TiO_(2))比值、元素地球化学特征,分析得出研究区沉积源区为长英质岩,从山西组到下石盒子组古盐度由海相向咸水相转变,古气候为温暖潮湿的还原环境。另外,稀土元素表现为轻中稀土富集型,且Eu、Y正异常和Ce负异常都显示出朱庄矿沉积环境受到了海水和岩浆热液的影响。因此,朱庄矿煤中微量元素异常富集可能是受到了沉积环境、海水和热液的共同影响。另外,研究区稀土元素较为富集,其总含量接近甚至高于工业品位,经REY展望系数(Coutl)和多种沉积物矿产比较,认为研究区样品中5煤和8煤稀土元素有希望作为REY原料,10煤则效果较差。

关键词：地球化学微量元素烟煤淮北煤田富集程度

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Modeling the gene delivery process of the needle array-based tissue nanotransfection

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Nano Research 2022年第4期15卷 3409-3421页

作者： Zhigang li Yi Xuan Subhadip Ghatak Poornachander RGuda Sashwati Roy Chandan K.Sen Indiana Center for Regenerative Medicine and Engineering Indiana University Health Comprehensive Wound CenterDepartment of SurgeryIndiana University School of MedicineIndianapolisIN 46202USA Birck Nanotechnology Center and Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteIN 47907USA

Hollow needle array-based tissue nanotransfection(TNT)presents an in vivo transfection approach that directly translocate exogeneous genes to target tissues by using electric *** this work,the gene delivery process of TNT was simulated and experimentally *** adopted the asymptotic method and cell-array-based model to investigate the electroporation behaviors of cells within the skin *** distribution of nonuniform electric field across the skin results in various electroporation behavior for each *** underneath the hollow microchannels of the needle exhibited the highest total pore numbers compared to others due to the stronger localized electric *** percentage of electroporated cells within the skin structure,with pore radius over 10 nm,increases from 25%to 82%as the applied voltage increases from 100 to 150 v/***,the gene delivery behavior across the skin tissue was investigated through the multilayer-stack-based *** delivery distance increased nonlinearly as the applied voltage and pulse number increased,which mainly depends on the diffusion characteristics and electric conductivity of each *** was also found that the skin is required to be exfoliated prior to the TNT procedure to enhance the delivery *** work provides the foundation for transition from the study of murine skin to translation use in large animals and human settings.

关键词： tissue nanotransfection silicon needle array hollow needle array electroporation electrophoresis gene delivery

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Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 29-35页

作者： Shi-Qiong Zhou Peng Wan Seng Zhang Yuan Ren Hong-Tao li Qing-Hua Ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor *** it metastasizes to the liver,treatment options become particularly limited and *** treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves ***,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on *** study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic *** To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic *** Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer *** in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable *** in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight *** June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy *** The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,Pvival(9.6 months vs 5.4 months,Pvere adverse events did not differ sign

关键词： Immunotherapy Programmed cell death 1 inhibitor Sintilimab Chemotherapy Metastatic Pancreatic ductal adenocarcinoma

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Spark plasma sintering of tungsten-based WTavCr refractory high entropy alloys for nuclear fusion applications

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 146-154页

作者： Yongchul Yoo Xiang Zhang Fei Wang Xin Chen Xing-Zhong li Michael Nastasi Bai Cui Department of Mechanical&Materials Engineering University of Nebraska-LincolnLincolnNE 68588USA Nebraska Center for Materials and Nanoscience University of Nebraska-LincolnLincolnNE 68588USA Department of Nuclear Engineering Texas A&M UniversityCollege StationTX 77843USA

W-based WTavCr refractory high entropy alloys (RHEA) may be novel and promising candidate materials for plasma facing components in the first wall and diverter in fusion reactors. This alloy has been developed by a powder metallurgy process combining mechanical alloying and spark plasma sintering (SPS). The SPSed samples contained two phases, in which the matrix is RHEA with a body-centered cubic structure, while the oxide phase was most likely Ta2vO6through a combined analysis of X-ray diffraction (XRD),energy-dispersive spectroscopy (EDS), and selected area electron diffraction (SAED). The higher oxygen affinity of Ta and v may explain the preferential formation of their oxide phases based on thermodynamic calculations. Electron backscatter diffraction (EBSD) revealed an average grain size of 6.2μm. WTavCr RHEA showed a peak compressive strength of 2997 MPa at room temperature and much higher micro-and nano-hardness than W and other W-based RHEAs in the literature. Their high Rockwell hardness can be retained to at least 1000°C.

关键词： refractory high entropy alloy plasma-facing material fusion reactor spark plasma sintering

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Facet effects on bimetallic ZnSn hydroxide microcrystals for selective electrochemical CO_(2)reduction

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Green Energy & Environment 2024年第8期9卷 1314-1320页

作者： liu Han Cheng-wei Wang Shan-shan Luo Ying-tang Zhou Bing li Ming liu School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHeilongjiang Province150000China National Engineering Research Center for Marine Aquaculture Marine Science and Technology CollegeZhejiang Ocean UniversityZhoushanZhejiang Province316004China

Employing crystal facets to regulate the catalytic properties in electrocatalytic carbon dioxide reduction reaction(eCO_(2)RR)has been well demonstrated on electrocatalysts containing single metals but rarely explored for bimetallic ***,we synthesize ZnSn(OH)_(6)(ZSO)microcrystals(MCs)with distinct facets and investigate the facet effects in eCO_(2)*** studies and in situ Fourier Transform Infrared Spectroscopy(in situ-FTIR)reveal that ZSO MCs produce mainly C1 products of HCOOH and ***{111}facet of the ZSO MCS exhibits higher selectivity and faradaic efficiency(FE)than that of the{100}facet over a wide range of potentials(-0.9 v∼-1.3 v versus RHE).Density Functional Theory(DFT)calculations elucidate that the{111}facet is favorable to the adsorption/activation of CO_(2)molecules,the formation of intermediate in the rate-determining step,and the desorption of C1 products of CO and HCOOH molecules.

关键词： ZnSn(OH)_(6) Crystal facets Electrochemical carbon dioxide reduction C1 product Density functional theory

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Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis

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World Journal of Gastroenterology 2017年第8期23卷 1367-1374页

作者： Yu-Mei Zhang Hong-Yu Ren Xian-lin Zhao Juan li Jun-Yi li Fu-Sheng Wu Hang Su Wen-Fu Tang Sichuan Provincial Pancreatitis Center Department of Integrative Medicine West China Hospital Sichuan University Department of Integrative Medicine Chengdu Integrated TCM and Western Medicine Hospital School of Acupuncture Chengdu University of Traditional Chinese Medicine

AIM To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction (DCQD) in the liver of rats with severe acute pancreatitis (SAP) based on an herbal recipe tissue pharmacology hypothesis. METHODS Healthy male Sprague-Dawley rats were randomly divided into a sham operation group (SOG); a model group (MG); and low-, median- and high-dose treatment groups (LDG, MDG, and HDG, respectively). Different dosages (6, 12 and 24 g/kg for the LDG, MDG, and HDG, respectively) of DCQD were administered to the rats with SAP. The tissue concentrations of aloeemodin, rhein, emodin, chrysophanol, honokiol, rheo chrysophanol, magnolol, hesperidin, naringenin and naringin in the liver of the treated rats were detected by high-performance liquid chromatography tandem mass spectrometry. Alanine transaminase (ALT) and aspartate transaminase (AST) in serum, inflammatory mediators in the liver and pathological scores were evaluated. RESULTS The major components of DCQD were detected in the liver, and their concentrations increased dose-dependently. The high dose of DCQD showed a maximal effect in ameliorating the pathological damages, decreasing the pro-inflammatory mediators tumor necrosis factor-a and interleukin (IL)-6 and increasing anti-inflammatory mediators IL-4 and IL-10 in the liver. The pathological scores in the pancreas for the MG were significantly higher than those for the SOG (P liver of the rats with SAP, especially in the HDG. Compared to the SOG, the ALT and AST levels in serum were higher in the MG (P viate liver damage by altering the inflammatory response in rats with SAP based on the liver distribution of its components.

关键词： Pharmacokinetics Pharmacodynamics Da-Cheng-Qi decoction Acute pancreatitis Acute liver injury

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