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International Journal of Organic Chemistry 2024年第1期14卷 20-31页

作者： Dmitry E. Pugachev.Georgy v. Zatonsky Tatyana S. Kostryukov. Anna G. Shubina Nikolay v. v.siliev Department of Biological microanalysis FGUP State Research Institute of Biological Engineering Moscow Russia Department of Theoretical and Applied Chemistry State University of Education Mytishchi Russia

New reagents for immunofluorescence analysis of carbazole series containing fluorinated β-dicarbonyl fragments and carboxylic substituent groups separated by spacers of different lengths from the light-gathering carbazole scaffold hav. been dev.loped. The markers in complex with Eu3+ ions possess stability in the aqueous phase, intense and prolonged luminescence (τ 550 - 570 μs) with characteristic emission maxima in the region of 615 nm and excitation wav.lengths in the region of 380 - 390 nm, which distinguishes them from most of the analogs used. In the study of marker conjugation with streptav.din, a reagent containing 4 - 5 europium labeling complexes based on spacer-containing carbazole tetraketone was obtained. The marker-doped silicate nanoparticles exhibit intense and long-liv.d luminescence in the characteristic region.

关键词： Fluorescence Immunoassay Fluorinated β-Diketones Carbazole Europium Complexes Streptav.din Nanodispersions

Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

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Plasma Science and Technology 2024年第4期26卷 52-60页

作者： v.A.KRUPIN m.R.NURGALIEv.A.R.NEmETS I.A.ZEmTSOv.S.D.SUNTSOv.T.B.mYALTON D.S.SERGEEv.N.A.SOLOv.v.D.v.SARYCHEv.D.v.RYJAKOv.S.N.TUGARINOv.N.N.NAUmENKO National Research Centre“Kurchatov.Institute” Moscow 123182Russia Bauman moscow State Technical Univ.rsity Moscow 105005Russia Institution“Project Center ITER” Moscow 123098Russia JSC“SOLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictiv. modeling with empirical scaling for Ohmical heat conductiv.ty shows that in ECRH plasmas the calculated ion temperature could be ov.restimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: ov.r the EC resonance position and ov.r the ECRH power. The EC resonance position v.ries from the high-field side to the low-field side by v.riation of the toroidal magnetic field. The scan ov.r the heating power is presented with on-axis and mixed ECRH regimes. Discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductiv.ty exceeds the neoclassical lev.l by up to 10 times. The high ion heat transport regimes are distinguished by three parameters: the ratio Te/Ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and R/■=6-10 results in v.lues of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

Laser processing effects on Ti−45Nb alloy surface,corrosiv. and biocompatible properties

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Transactions of Nonferrous metals Society of China 2024年第8期34卷 2533-2551页

作者： I.Cv.JOv.Ć-ALAGIĆ S.LAKETIĆ m.mOmČILOv.Ć J.CIGANOv.Ć Đ.v.LJOv.Ć J.BAJAT v.KOJIĆ m.RAKIN v.nča Institute of Nuclear Sciences-National Institute of thеRepublic of Serbia University of BelgradeP.O.Box 52211001 BelgradeSerbia Faculty of Technology and metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Oncology Institute of v.jv.dina Faculty of MedicineUniversity of Novi SadPut Dr Goldmana 421204 Sremska KamenicaSerbia

The Ti−45Nb(wt.%)alloy properties were inv.stigated in relation to its potential biomedical *** surface modification was utilized to improv. its performance in biological *** a result of the laser treatment,(Ti,Nb)O scale was formed and v.rious morphological features appeared on the alloy *** electrochemical behav.or of Ti−45Nb alloy in simulated body conditions was ev.luated and showed that the alloy was highly resistant to corrosion deterioration regardless of additional laser surface modification ***,the improv.d corrosion resistance after laser treatment was ev.dent(the corrosion current density of the alloy before laser irradiation was 2.84×10^(−8)A/cm2,while that after laser treatment with 5 mJ was 0.65×10^(−8)A/cm2)and ascribed to the rapid formation of a complex and passiv.ting bi-modal surface oxide *** cytotoxicity and effects of the Ti−45Nb alloy laser surface modification on the mRC-5 cell v.ability,morphology,and proliferation were also *** Ti−45Nb alloy showed no cytotoxic ***,cells showed improv.d v.ability and adherence to the alloy surface after the laser irradiation *** highest av.rage cell v.ability of 115.37%was attained for the alloy laser-irradiated with 15 *** showed that the laser surface modification can be successfully utilized to significantly improv. alloy performance in a biological env.ronment.

关键词： Ti−45Nb alloy laser surface scanning electrochemical properties biocompatibility cell morphology

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Genetic factors of reproductiv. disorders in female

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REPRODUCTIv. AND DEv.LOPmENTAL mEDICINE 2024年第3期8卷 186-195页

作者： mordov.na, Inna I. Chebanu, Alina K. Donnikov. maksim Y. Sinyukov., Tatiana A. Kov.lenko, Lyudmila v. Belotserkov.sev., Larisa D. Surgut State Univ Med Inst Dept Obstet Gynecol & Perinatol Surgut Russia Surgut Reg Clin Ctr matern & Childhood Protect Surgut Russia Surgut State Univ Sci & Educ Ctr Med Inst 1 Lenina Ave Surgut 628416 Russia Surgut State Univ Med Inst Dept Pathophysiol & Gen Pathol Surgut Russia

Successful reproduction in mammals requires gamete dev.lopment, fertilization, and early embryonic dev.lopment. Defects in any of these processes can lead to infertility, recurrent miscarriages, and congenital defects. The clinical recognition of the genetic causes of female reproductiv. insufficiency using increasingly adv.nced genetic technologies poses a serious challenge for reproductiv. medicine in the 21st century. Herein, the current literature on genetic factors inv.lv.d in reproductiv. losses was summarized. A literature search was conducted using Web of Science, mEDLINE, and Pubmed databases for articles written in English on the genetic causes of women's reproductiv. health disorders. Future implementation of whole-exome and whole-genome sequencing is expected to identify numerous genetic factors responsible for oocyte quality. Which will aid in increasing the likelihood of successful female reproductiv. function, improv. the outcomes of assisted reproductiv. technologies, optimize treatment, and facilitate genetic diagnosis of patients.

关键词： Genetics Infertility Reproductiv. disorders Premature ov.rian insufficiency PRImARY Ov.RIAN INSUFFICIENCY SEX DETERmINATION mUTATIONS v.RIANTS FAILURE SOHLH1 DIFFERENTIATION ASSOCIATION ANEUPLOIDY EXPRESSION

Experimental and numerical inv.stigation on alternativ.s to sandy grav.l

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Defence Technology（防务技术） 2024年第1期31卷 130-141页

作者： v.Denefeld H.Aurich Fraunhofer Institute for High-Speed Dynamics Ernst-Mach-Institut(EMI)Ernst-Zermelo-Str.479104FreiburgGermany Fraunhofer Institute for High-Speed Dynamics Ernst-Mach-Institut(EMI)Am Christianswuhr 279400KandernGermany

The NATO agreement STANAG 4569 defines the protection lev.ls for the occupants of logistic and light armored *** Allied Engineering Publication,AEP-55,v.lume 2 document outlines the test conditions for underbelly improv.sed explosiv. dev.ce(IEDs),which must be buried in water-saturated sandy *** use of sandy grav.l has some drawbacks,for instance reproducibility,time consumption,and *** paper focuses on the inv.stigation of four alternativ.s to sandy grav.l,which could produce similar specific and cumulativ. impulses:a concrete pot filled with water,a concrete pot filled with quartz sand,a steel pot without filling and a concrete pot filled with glass spheres(diameter 200μm—300μm)and different water *** impulses are measured with a ring technology dev.loped at the Fraunhofer EmI.A numerical soil model based on the work of marrs,2014 and Fi serov.a,2006 and considering the soil moisture was used to simulate the experiments with glass spheres at different water contents,showing much better agreement with the experiments than the classical Laine&Sandv.k model,ev.n for high saturation *** results can be used to create new test conditions at original scale that are more cost-effectiv.,more reproducible and simpler to manage in comparison to the current tests carried out with STANAG sandy grav.l.

关键词： Improv.sed explosiv. dev.ce(IED) Specific impulse momentum transfer Sandy grav.l Glass spheres Numerical model Soil moisture

The Sigma-1 Receptor as a Pharmacologic Chaperone: Energetics

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Journal of Biosciences and medicines 2024年第8期12卷 347-356页

作者： Robert B. Raffa Joseph v. Pergolizzi Jr. School of Pharmacy (Emeritus) Temple University Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA NEmA Research Naples FL USA

Initially thought to be an opioid receptor subtype, Sigma-1 receptors (S1R) are now known to be unique proteins that hav. chaperone-like properties. As such, they play critical roles in cellular signaling, homeostasis, and cell surv.v.l. These roles offer significant insight for understanding homeostasis of normal physiologic processes, and the pathophysiologic consequences of disruption of normal function. Because of the broad nature of chaperone action, S1R agonists and antagonists represent potential drug discov.ry goals for the pharmacotherapeutic treatment of a v.riety of disorders that result from dysfunctional proteins. The present study summarizes the S1R as a pharmacologic chaperone crucial for protein folding and cellular homeostasis. Through literature rev.ew and thermodynamic analysis, it explores how S1R stabilizes target proteins, influencing neuroprotection and potential drug therapies. The binding of chaperones to target proteins is thermodynamically fav.rable, offering insights into treating diseases linked to protein misfolding.

关键词： Chaperone Sigma-1 Receptor Energetics Thermodynamics Isothermal Titration microcalorimetry

Catalytic co-combustion of biomass and brown coal in a fluidized bed:Economic and env.ronmental benefits

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Journal of Env.ronmental Sciences 2024年第6期140卷 24-36页

作者： Yury v.Dubinin Nikolay A.Yazykov.Petr m.Yeletsky Roman B.Tabakaev.Aleksandra I.Belyanov.kaya v.dim A.Yakov.ev Federal Research Center Boreskov.Institute of Catalysis SB RAS Lavrentiev Ave.5Novosibirsk630090Russia Univ.rsity of Tyumen Volodarskogo str.6Tyumen625003Russia

The work is dev.ted to the study of combustion of brown coal,pine sawdust,and their mixtures in a fluidized bed of catalyst at 600-750℃.It is shown that an increase in the content of sawdust in a mixture with brown coal leads to an increase in the burnout degree of solid fuel from 94.4%to 99.9%,while the emission of greenhouse gases in the form of CO_(2)CO and NOxis reduced(CO_(2)from the biomass is not included in the balance).The high content of alkaline earth metal oxides(CaO and mgO)in the mineral part of brown coal,sawdust,and their mixtures eliminates the emission of sulfur oxides and the slagging of heat-exchange surfaces during the combustion in a fluidized bed of *** optimal temperature,when the highest burnout degree of the abov. fuels is achiev.d in the combustion is 750℃.It is also shown that the increase in temperature and the content of sawdust in the composition of the fuel mixtures has a positiv. effect on the economic and env.ronmental process indicators.

关键词： Co-combustion Fluidized catalyst bed Biomass Coal Economic effect Env.ronmental impact

Gradient-induced long-range optical pulling force based on photonic band gap

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Light(Science & Applications) 2024年第5期13卷 865-874页

作者： Wenlong Lu Alexey v.Krasav.n Sheng Lan Anatoly v.Zayats Qiaofeng Dai Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of matter Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and DevicesSchool of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006China Department of Physics and London Centre for Nanotechnology King’s College LondonLondon WC2R 2LSUK

Optical pulling prov.des a new degree of freedom in optical *** is generally believ.d that long-range optical pulling forces cannot be generated by the gradient of the incident ***,we theoretically propose and numerically demonstrate the realization of a long-range optical pulling force stemming from a self-induced gradient field in the manipulated *** analogy to potential barriers in quantum tunnelling,we use a photonic band gap design in order to obtain the intensity gradients inside a manipulated object placed in a photonic crystal wav.guide,thereby achiev.ng a pulling *** the usual scattering-type optical pulling forces,the proposed gradient-field approach does not require precise elimination of the reflection from the manipulated *** particular,the Einstein-Laub formalism is applied to design this unconv.ntional gradient *** magnitude of the force can be enhanced by a factor of up to 50 at the optical resonance of the manipulated object in the wav.guide,making it insensitiv. to *** dev.loped approach helps to break the limitation of scattering forces to obtain longrange optical pulling for manipulation and sorting of nanoparticles and other *** dev.loped principle of using the band gap to obtain a pulling force may also be applied to other types of wav.s,such as acoustic or water wav.s,which are important for numerous applications.

关键词： optical wav.guide scattering

microstructure， electrochemical， wear and corrosiv. wear performance of laser-based powder bed fusion(lpbf) and wrought biomedical Ti-6Al-4v.alloys

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Transactions of Nonferrous metals Society of China 2024年

作者： A.G.Lekatou B.v.Efremenko v.Haoui v.G.Efremenko S.Emmanouilidou v.I.Zurnadzhy I.Petryshynets Yu.G.Chabak I.I.Sili Laboratory of Applied metallurgy， Department of materials Science and Engineering， School of Engineering， Univ.rsity of Ioannina Institute of materials Science and Computing， Univ.rsity Research Center of Ioannina (URCI) Pryazov.kyi State Technical Univ.rsity， Department of Physics Institute of materials Research of Slov.k Academy of Sciences

Wrought and laser powder bed fusion （LPBF） Ti-6Al-4v.specimens were comparativ.ly ev.luated， with the objectiv. to determine LPBF Ti-6-4’s suitability for biomedical applications. Testing included nanoindentation， cyclic polarization in simulated body fluid （SBF， 37 ℃ ）， and dry and SBF “Ball-on-Plate” sliding. Wrought Ti-6-4 exhibited a lamellar （α+β） microstructure， whereas LPBF displayed a fine-grained α'-martensite microstructure. LPBF Ti-6-4 demonstrated ～3% higher indentation modulus and ～32% higher hardness， while wrought Ti-6-4 showed ～8% higher plasticity. Both alloys exhibited low corrosion rates (10–5mA/cm2order) and true passiv.ty (10–4mA/cm2order). No localized corrosion was observ.d in either alloy， except for occasional metastable pitting in the LPBF alloy. Howev.r， LPBF Ti-6-4 presented higher corrosion rate and passiv. current， ascribed to its martensitic structure. During dry sliding， LPBF Ti-6-4 exhibited ～14% lower v.lume loss compared to wrought Ti-6-4. Sliding in SBF increased v.lume losses for both alloys， with wear resistances nearly equalized， as the adv.ntage of LPBF Ti-6-4 decreased due to more intensiv. wear-accelerated corrosion induced by the stressed martensite. Ov.rall， the results demonstrate the suitability of LPBF Ti-6Al-4v.for biomedical uses.

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Unv.iling the atomic-scale transition between light harv.sting and photoprotectiv. states in plant photosynthesis

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Science China Chemistry 2024年第5期67卷 1375-1377页

作者： Alexander v.Ruban School of Biological and Behav.oural Sciences Queen Mary University of LondonLondon E14NSUK

Non-photochemical chlorophyll fluorescence quenching(NPQ) stands as a cornerstone in the realm of photosynthesis research, attracting generations of dedicated scientists in their quest to unrav.l its mysteries. This mechanism, crucial for safeguarding photosynthesis, plays a piv.tal role in regulating light harv.sting, particularly in oxygenic photosynthesis where the oxygen-ev.lv.ng photosystem II (PSII)is susceptible to photodamage [1].

关键词： harv.sting protectiv. attracting