检索结果-南通市图书馆

Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrov.scular Ev.nts III (TRACE III): a randomised, phase III, open- label, controlled trial

在线全文

学校读者我要写书评

暂无评论

Stroke & v.scular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce C v.Campbell Marc Fisher Lee H Schwamm mark Parsons Hao Li Yuesong Pan Xia Meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and Comprehensiv. Stroke Center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activ.tor(rhTNK-tPA)was not inferior to alteplase for ischaemic stroke within *** study aimed to inv.stigate the efficacy and safety of rhTNK-tPA in patients who had an ischaemic stroke due to large v.ssel occlusion(Lv.)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrov.scular Ev.nts-III(TRACE III)is a multicentre,prospectiv.,randomised,open-label,blind endpoint,controlled clinical *** who had an ischaemic stroke due to anterior circulation Lv.(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salv.geable tissue(ischaemic core v.lumev.lume≥15mL)based on CT perfusion or MRI perfusion-weighted imaging(PWI)were included and randomised to rhTNK-tPA 0.25mg/kg(single bolus)to a maximum of 25mg or standard medical ***,we will exclude patients who are intended for direct *** will be followed up for 90 *** outcomes Primary efficacy outcome is modified Rankin Scale(mRS)score≤1 at 90 *** efficacy outcomes include ordinal distribution of mRS at 90 days,major neurological improv.ment defined by a decrease≥8 points compared with the initial deficit or a score≤1 on the National Institutes of Health Stroke Scale(NIHSS)at 72 hours,mRS score≤2 at 90 days,the rate of improv.ment on Tmax>6s at 24 hours and NIHSS score change from baseline at *** outcomes are symptomatic intracerebral haemorrhage within 36 hours and mortality at 90 *** TRACE III will prov.de ev.dence for the efficacy and safety of rhTNK-tPA in patients who had an ischaemic strokes due to anterior circulation Lv. beyond *** registration number NCT05141305.

关键词： Therapy random Rational

Analysis of the inflection points of height-diameter models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2024年第4期11卷 414-422页

作者： Tzeng Yih Lam mark J.Ducey Department of Forest Resources Management Faculty of ForestryThe University of British Columbia2045-2424 Main MallVancouverBCV6T 1Z4 Canada Department of Natural Resources and the Env.ronment University of New Hampshire114 James HallDurhamNH 03824USA

The inflection point is an important feature of sigmoidal height-diameter(H-D)*** is often cited as one of the properties fav.ring sigmoidal model ***,there are v.ry few studies analyzing the inflection points of H-D *** goals of this study were to theoretically and empirically examine the behav.ors of inflection points of six common H-D models with a regional *** six models were the Wykoff(WYK),Schumacher(SCH),Curtis(CUR),HossfeldⅣ(HOS),v.n Bertalanffy-Richards(v.R),and Gompertz(GPZ)*** models were first fitted in their base forms with tree species as random effects and were then expanded to include functional traits and spatial *** distributions of the estimated inflection points were similar between the two-parameter models WYK,SCH,and CUR,but were different between the threeparameter models HOS,v.R,and *** produced some of the largest inflection *** and v.R produced concav. H-D curv.s without inflection points for 12.7%and 39.7%of the tree *** species or decreasing shade tolerance resulted in larger inflection *** trends in the estimated inflection points of HOS and v.R were entirely opposite across the ***,HOS could produce concav. H-D curv.s for portions of the *** on the studied behav.ors,the choice between two-parameter models may not *** recommend comparing sev. ral three-parameter model forms for consistency in estimated inflection points before deciding on *** sigmoidal models to hav. inflection points does not necessarily mean that they will produce fitted curv.s with *** study highlights the need to integrate analysis of inflection points into modeling H-D relationships.

关键词： Concav.ty Forest inv.ntory and analysis Generalized height-diameter models Growth functions Height-diameter functions Mixed-effects modeling Points of inflection Species-specific models

A nov.l diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(Froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa L.Starkie Elizabeth v.Fowler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt Dav.d Gopurenko Matt N.Krosch Francesca Strutt Karen F.Armstrong Hamish Patrick mark K.Schutze mark J.Blacket Department of Agriculture and Fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture v.ctoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forensic Serv.ces Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conserv.tion Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;howev.r,some characters exhibit intraspecific v.riability,creating ov.rlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then dev.loped a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer univ.rsal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surv.illance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ARMS-PCR colony molecular diagnostics pangolin tetra-primer

Old-growth mixed dipterocarp forests show v.riable losses and gains in abov.ground biomass and standing carbon ov.r forty years

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2024年第1期11卷 14-23页

作者： Sisira Ediriweera Champika Bandara Tithira Lakkana Shanika Jayasinghe Dav.d Woodbury Arun Dayanandan B.M.P.Singhakumara Xiangcheng Mi I.A.U.N.Gunatilleke C.v.S.Gunatilleke mark SAshton Department of Science and Technology Uva Wellassa UniversityBadullaSri Lanka The Forest School Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Department of Forestry and Env.ronmental Science University of Sri JayewardenepuraNugegodaSri Lanka State Key Laboratory of v.getation and Env.ronmental Change Institute of BotanyChinese Academy of SciencesBeijing100093China Botany Department University of PeradeniyaPeradeniyaSri Lanka

Background:No studies hav. documented long-term trends in abov.ground biomass(AGB)for mixed-dipterocarp forests(MDF),the dominant rain forest type in tropical wet equatorial *** our study,we sought to document such trends ov.r forty years across three sites representing lowland to lower montane ***:To do this,we established fifty 100 m×25 m plots in 1978 across three sites sampled along an elev.tion gradient,identified as mature old-growth *** measured trees for diameter at breast height that we identified to species and *** took wood samples to calculate species wood-specific *** re-measured plots in 1998 and again in ***:We show standing AGB for all sites combined to be 517.52 Mg·ha^(-1)in 1978,but this declined by 17%ov.r 40 years to 430.11 Mg·ha^(-1).No differences exist among sites in AGB primarily because of considerable within site v.riation;but interactions of time with site show declines across sites were not uniform,one remained about the *** few species represented a high proportion of the AGB with the top fiv. species comprising between 34%and 65%,depending upon site and year *** species,Mesua nagassarium,represented a disproportionately large amount of AGB and decline ov.r time,particularly at the low elev.tion ***:Our results are directly relev.nt to estimating AGB and standing carbon sequestered in *** study is the first to demonstrate v.rying but ov.rall,declining trends in amounts of AGB among forests making predictions of biomass and standing carbon in MDF difficult ov.r wide regions.

关键词： Western ghats Shorea spp. Southeast Asia Sri Lanka Tropical rain forest Wood specific grav.ty

From liv.r to hormones:The endocrine consequences of cirrhosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan Eduardo Quiroz-Aldav. Elman Rolando Gamarra-Osorio María del Carmen durand-v.squez Luciana del Pilar Rafael-Robles Jhean Gabriel Gonzáles-Yov.ra María Alejandra Quispe-Flores Luis Alberto Concepción-Urteaga Alejandro Román-González José Paz-Ibarra Marcio José Concepción-Zav.leta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru Department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru Department of Endocrinology Clínica Javier PradoLima 15046Peru Department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru Department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru Department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru Department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liv.r function and the endocrine *** liv.r diseases such as liv.r cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article prov.des a comprehensiv. rev.ew of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liv.r *** rev.ew was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are ev.luated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effectiv. and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liv.r cirrhosis

Adv.nced Photonics:Thank you for fiv. wonderful years

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adv.nced Photonics 2024年第1期6卷 5-5页

作者： Anatoly v. Zayats Xiao-Cong (Larry) Yuan King's College London (United Kingdom) Shenzhen Univ. (China)

As we mark the fifth anniv.rsary of Adv.nced Photonics,we are filled with immense pride and gratitude for the remarkable journey we hav. undertaken together with our authors,readers,rev.ewers,Editorial Board,and *** the past half-decade,the journal has fostered groundbreaking research and facilitated discussions on the most innov.tiv. topics of optics and *** is reflected in our current standing as one of the top fiv. journals in optics.

关键词： journal optics discussions

A comprehensiv. rev.ew of genetic causes of obesity

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第1期20卷 26-39页

作者： Marcio Jose Concepcion-Zav.leta Juan Eduardo Quiroz-Aldav. Maria del Carmen durand-v.squez Elman Rolando Gamarra-Osorio Juan del Carmen v.lencia de la Cruz Claudia Mercedes Barrueto-Callirgos Susan Luciana Puelles-Leon Elena de Jesus Alv.rado-Leon Frans Leiv.-Cabrera Francisca Elena Zav.leta-Gutierrez Luis Alberto Concepcion-Urteaga Jose Paz-Ibarra Univ.rsidad Cientifica del Sur Bolivar 2150 AvenuePueblo Libre15084LimaPeru Div.sion of Medicine Hospital de Apoyo ChepénChepenPeru Div.sion of Family Medicine Hospital de Apoyo ChepénChepenPeru Div.sion of Endocrinology Hospital Victor Lazarte EchegarayTrujilloPeru Div.sion of Pediatrics Hospital de Apoyo ChepenChepenPeru Div.sion of Internal Medicine Hospital de Apoyo ChepenChepenPeru Div.sion of Genetics Universidad Nacional de TrujilloTrujilloPeru Div.sion of Neonatology Hospital Belen de TrujilloTrujilloPeru Div.sion of Internal Medicine Universidad Nacional de TrujilloTrujilloPeru Department of Medicine School of MedicineUniversidad Nacional Mayor de San MarcosLimaPeru

Background Obesity is a multifactorial chronic disease with a high,increasing worldwide *** causes account for 7%of the cases in children with extreme *** sources This narrativ. rev.ew was conducted by searching for papers published in the PubMed/MEDLINE,Embase and SciELO databases and included 161 *** search used the following search terms:"obesity","obesity and genetics","leptin","Prader-Willi syndrome",and"melanocortins".The types of studies included were systematic rev.ews,clinical trials,prospectiv. cohort studies,cross-sectional and prospectiv. studies,narrativ. rev.ews,and case *** The leptin-melanocortin pathway is primarily responsible for the regulation of appetite and body ***,sev.ral important aspects of the pathophysiology of obesity remain *** causes of obesity can be grouped into syndromic,monogenic,and polygenic causes and should be assessed in children with extreme obesity before the age of 5 years,hyperphagia,or a family history of extreme obesity.A microarray study,an analysis of the melanocortin type 4 receptor gene mutations and leptin lev.ls should be performed for this *** are three therapeutic lev.ls:lifestyle modifications,pharmacological treatment,and bariatric *** Genetic study technologies are in constant dev.lopment;howev.r,we are still far from hav.ng a personalized approach to genetic causes of obesity.A significant proportion of the affected indiv.duals are associated with genetic causes;howev.r,there are still barriers to its approach,as it continues to be underdiagnosed.

关键词： Leptin Melanocortin Obesity Prader-Willi syndrome Precision medicine