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通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病

World Journal of Hepatology 2012年第12期4卷 382-388页

作者： v.ctor v.rgas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Riv.ro Roser Ferrer Roberto Catalán Ev. Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe Liv.r Unit Department of MedicineHospital Vall d’HebronUniversitat Autònoma08028 BarcelonaSpain CIBER de Enfermedades Hepáticas y Digestiv.s Instituto de Salud Carlos Ⅲ28029 MadridSpain Department of Pathology Hospital Vall d’HebronUniversitat Autònoma08035 BarcelonaSpain Endocrinology Serv.ce Hospital Vall d’HebronUniversitat Autònoma08035 BarcelonaSpain Diabetes Research Unit CIBER de Diabetes y Enfermedades Metabólicas AsociadasInstituto de Salud Carlos Ⅲ28029 MadridSpain Department of Surgery Hospital Arnau de VilanovaLleida25198 BarcelonaSpain Department of Surgery Mútua de Terrassa08221 BarcelonaSpain Biochemistry and Hormones Hospital Vall d’HebronUniversitat Autònoma08035 BarcelonaSpain Biochemistry and Molecular Biology Department Biology FacultyBarcelona University08028 BarcelonaSpain

AIM:To ev.luate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liv.r disease in obese ***:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liv.r biopsies,the first at surgery and the second after 16 ± 3 mo of weight *** were ev.luated and compared in a blinded *** presence of metabolic syndrome,anthropometric and biochemical v.riables were also assessed at baseline and at the time of the second ***:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prev.lence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P v.d in aspartate aminotransferase or alanine aminotransferase between pre and *** were improv.ments in steatosis(P 1) was present in fiv. patients at second *** and fibrosis at surgery were predictors of significant fibrosis ***:Restrictiv. mildly malabsorptiv. surgery prov.des significant weight loss,resolution of metabolic syndrome and associated abnormal liv.r histological features in most obese patients.

关键词： Non alcoholic fatty liv.r disease Bariatric surgery Obesity Non alcoholic steatohepatitis

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乳腺癌18F-FDG PET/CT显像的瘤内异质性纹理特征分析在疗效和预后预测中的作用

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中华核医学与分子影像杂志 2018年第11期38卷 774-774页

作者：唐军 Dav.d Molina-García Ana María García-v.cente Julián Pérez-Beteta Mariano Amo-Salas Alicia Martínez-González María Jesús Tello-Galán Angel Soriano-Castrejón v.ctor M.Pérez-García 上海交通大学医学院附属苏州九龙医院核医学科 Mathematical Oncology Laboratory (MoLAB) Universidad de Castilla-La Mancha

目的评价局部晚期乳腺癌(LABC)F-脱氧葡萄糖(FDG)PET/CT显像的纹理分析参数在疗效和预后预测中的价值。方法该前瞻性研究包括68例LABC患者,纳入者均有新辅助化疗(NC)指征,并在化疗前行F-FDG PET/CT显像。对乳腺癌穿刺标本依据分子表型... 详细信息

目的评价局部晚期乳腺癌(LABC)F-脱氧葡萄糖(FDG)PET/CT显像的纹理分析参数在疗效和预后预测中的价值。方法该前瞻性研究包括68例LABC患者,纳入者均有新辅助化疗(NC)指征,并在化疗前行F-FDG PET/CT显像。对乳腺癌穿刺标本依据分子表型进行分组[雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子2(HER2)的表达、细胞增殖核抗原Ki-67指数等)],并在NC结束后将患者分为有效组和无效组。所有患者经标准的随访后得到无病生存时间(DFS)和总生存时间(OS)。利用计算机软件对乳腺癌病灶进行三维(3D)图像分割,随后进行纹理特征分析,获得行程长度矩阵(RLM)和共生矩阵(CM)参数。对不同危险度的纹理特征与各种分子表型的关系进行分析。使用Kaplan-Meier生存分析和Cox比例风险分析对纹理参数、分子表型和NC的肿瘤组织学反应等在预测疗效和预后中的作用进行研究。通过受试者工作特征(ROC)曲线分析取得最佳截断值、曲线下面积(AUC)及与OS、DFS相关的灵敏度和特异性。结果 NC对18例患者有效,其DFS和OS分别为(70.87±21.85)个月和(76.77±18.80)个月。长行程增强(LRE)和长行程高灰阶增强(LRHGE)与不同的危险度分层有关,而低灰阶行程增强(LGRE)、LRHGE和行程长度不均匀性(RLNU)均与NC的疗效相关。单因素分析结果表明纹理特征分析各变量与OS和DFS相关。多因素Cox回归分析结果显示,短行程高灰阶强化(SRHGE)下的PET分期与OS相关,而PET分期、高灰阶行程强化(HGRE)均与DFS相关。结论F-FDG PET/CT图像的纹理特征分析各变量可预测新辅助化疗的疗效和预后,并在预测OS和DFS时与PET分期具有相关性。

关键词：乳腺癌 18F-FDG PET/CT 纹理特征新辅助化疗疗效总生存时间无病生存时间

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20世纪上半叶哥伦比亚医药管控的卫生战略

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医疗社会史研究 2021年第2期12卷 264-284,443页

作者： [哥伦比亚]豪尔赫·巴尔德拉马 [哥伦比亚]维克多·加西亚 [哥伦比亚]维多利亚·埃斯特拉达常睿熙(译) 哥伦比亚国立麦德林大学哥伦比亚埃尔博斯克大学上海大学历史学系

本文探讨了20世纪上半叶哥伦比亚官方医学在标准化和规范化过程中与广大而丰富的医疗市场之间复杂的关系,考察了市场、知识和行业之间的冲突。当时,垄断性的医学行业在实施处方管控措施的同时,也试图主导制药行业,从而掌控医疗市场,但... 详细信息

本文探讨了20世纪上半叶哥伦比亚官方医学在标准化和规范化过程中与广大而丰富的医疗市场之间复杂的关系,考察了市场、知识和行业之间的冲突。当时,垄断性的医学行业在实施处方管控措施的同时,也试图主导制药行业,从而掌控医疗市场,但未能成功。由于哥伦比亚医学教育的标准化进程发展缓慢,医学院的角色存在争议。本文讨论了药物医疗化进程的影响和局限,以及哥伦比亚案例相对于墨西哥、委内瑞拉、阿根廷和巴西等其他拉美国家的特殊性。

关键词：哥伦比亚拉丁美洲医药管控

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Search for the rare decay B^(0)→J/ψФ

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Chinese Physics C 2021年第4期45卷 47-60页

作者： R.Aaij C.Abellin Beteta T.Ackernley B.Adev. M.Adinolfi H.Afsharnial C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov.P.Alv.rez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov.M.Andreotti F.Archilli A.Artamonov.M.Artuso K.Arzymatov.E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmav.r J.J.Back S.Baker P.Baladron Rodriguez v.Balagura W.Baldinit J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov.J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschis I.Bediaga A.Beiter v.Belav.n S.Belin v.Bellee K.Belous I.Belov.I.Belyaev.G.Benciv.nni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Biorn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauv. O.Boente Garcia T.Boettcher A.Boldyrev.A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.v.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguezs M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Burschee A.Butkev.ch J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calv. M.Calv. Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campov.rde Quezada S.Capelli L.Capriotti A.Carbonel G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carv.lho Akiba A.Casais v.dal G.Casse M.Cattaneo G.Cav.llero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chav.z Barajas M.Chefdev.lle C.Chen S.Chen A.Chernov.S.-G.Chitic v.Chobanov. S.Cholak M.Chrzaszcz A.Chubykin v.Chulikov.P.Ciambrone M.F.Cicala X.Cid v.dal G.Ciezarek P.E.L.Clarke M.Clemencic H.v.Cliff J.Closier J.L.Cobbledick v.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkov.ka M.Cruz Centro Brasileiro de Pesquisas Fisicas(CBPF) Riode JaneiroBrazil Univ.rsidade Federal do Riode Janeiro(UFRJ) Riode JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina Univ.rsity of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BejingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Univ.rsite Clermont Auv.rgne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Univ.rsitq Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut fir Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati Frascatiltaly INFN Sezione di Genov. GenovaItaly INFN Sezione di Milano Bicocca Milanolaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari Monserratoltaly Univ.rsita degli Studi di Padov. Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor v.rgata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and v. Univ.rsity Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-Univ.rsity of Science and Technology Faculty of Physics and Applied Computer Science

A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 Tev.corresponding to an integrated luminosity of9 *** significant signal of the decay is observ.d and an upper limitof 1.1x 10^(-7)at 90%confidence lev.l is set on the branching fraction.

关键词： B physics flav.ur physics rare decay ω-Фmixing branching fraction

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Dendritic cell deficiencies persist sev.n months after SARS-Cov.2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana v.tallé Carmen Gasca-Capote Alicia Gutierrez-v.lencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Riv.s-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Riv.s Alberto Fernández-v.llar Alexandre Pérez-González Luis Fernando López-Cortés Ev. Pov.da Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Riv.s Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Jav.er Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas v.rónica Alfaro-Lara Cristina Amodeo Jav.er Ampuero María Dolores Av.lés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silv.a Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álv.ro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-v.llén JoséMolina Aurora Morillo María Dolores Nav.rro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Serv.ce Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of v.rology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Sev.lle(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensiv. Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiov.scular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestiv. and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Inv.stigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Sev.re Acute Respiratory Syndrome Coronav.rus(SARS-Cov.-2 infection induces an exacerbated inflammation driv.n by innate immunity *** cells(DCs)play a key role in the defense against v.ral infections,for instance plasmacytoid DCs(pDCs),hav. the capacity to produce v.st amounts of interferon-alpha(IFN-α).In COv.D-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,sev.ral DC activ.tion and homing markers were altered in acute COv.D-19 patients,which were associated with multiple inflammatory ***,prev.ously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs sev.n months after SARS-Cov.2 ***,the expression of DC markers such as CD86 and CD4 were only restored in prev.ously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)lev.ls were *** findings contribute to a better understanding of the immunological sequelae of COv.D-19.

关键词： SARS-Cov.2 COv.D-19 Dendritic cell Long-COv.D

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