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Bedrock outcropping in the accumulation zone of the largest glacier in Mexico(Glaciar Norte of Citlaltépetl),as evidence of a possible accelerated extinction

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Journal of Mountain Science 2023年第2期20卷 338-354页

作者： SOTO víctor Colegio de Geografía Facultad de EconomíaUniversidad VeracruzanaAv.Xalapa s/nObrero Campesina91020XalapaVer.México

The highest volcano in Mexico,at the same time the third largest mountain in North America(Citlaltépetl,5610 m a.s.l.),is home to the largest glacier in the *** of the extinction of the Popocatépetl glacier(5500 m a.s.l.)caused by eruptive activity,and the almost disappearance of the Iztaccíhuatl glaciers(5220 m a.s.l.)due to the lower elevation of the mountain,the Glaciar Norte of Citlatépetl has been the only glacier that has shown a certain degree of stability as a response to the altitude in which it is ***,as occurs in almost all glaciers on the planet,the retreat of its glacier terminus has been ***,during the last years the thickness of its upper part began to decrease rapidly until its bedrock was exposed for the first time in *** to its ecosystem importance and because it is the main glacier in Mexico,as well as the only one in the world located at latitude 19°N,in this work its current dimensions are updated,as well as the local climatology that governs the current state of the glacier is pointed *** study was based on the analysis of high-resolution Sentinel-2 optical images,as well as through Sentinel-1 SAR images,with the support of climatological information from the study ***,the outcropping of the bedrock in the accumulation zone and the consequent horizontal retreat of the upper part of the glacier are documented;at the same time,the decrease in the thickness of the ice along it is *** rocky outcrop in the accumulation zone suggests that the flow dynamics of the ice towards the ablation zone will be considerably less,accelerating the retreat of the glacier ***,the ascent of the glacial front to 5102 m *** the modelled altitude of the equilibrium line to 5276 m *** reported as a warning signal in terms of snow catchment and mass balance;likewise,the decrease of 23%of its surface is also indicated regarding the surface reduction monitoring that has been done

关键词： Bedrock outcrop Citlaltépetl glacier Glacial accumulation zone Glacier retreat Glacial thickness

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Endosomal escape of protein nanoparticles engineered through humanized histidine-rich peptides

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Science China Materials 2020年第4期63卷 644-653页

作者： Hector lopez-Laguna Rafael Cubarsi Ugutz Unzueta Ramon Mangues Esther vazquez Antonio villaverde Institut de Biotecnologia i de Biomedicina Universitat Aut6noma de BarcelonaBellaterra08193 BarcelonaSpain Departament de Genetica i de Microbiologia Universitat Aut6noma de BarcelonaBellaterra08193 BarcelonaSpain CIBER de Bioingenieria Biomateriales y Nanomedicina(CIBER-BBN)C/Monforte de Lemos 3-528029 MadridSpain Departament de Matematiques Universitat Politecnica de Catalunya08034BarcelonaSpain Institut d'Investigacions Biomediques Sant Pau Hospital de la Santa Creu i Sant Pau08025 BarcelonaSpain

Poly-histidine peptides such as H6(HHHHHH)are used in protein biotechnologies as purification tags,protein-assembling agents and endosomal-escape *** pleiotropic properties of such peptides make them appealing to design protein-based smart materials or nanoparticles for imaging or drug delivery to be produced in form of recombinant ***,the clinical applicability of H6-tagged proteins is restricted by the potential immunogenicity of these *** this study,we have explored several humanized histidine-rich peptides in tumor-targeted modular proteins,which can specifically bind and be internalized by the target cells through the tumoral marker *** were particularly interested in exploring how protein purification,self-assembling and endosomal escape perform in proteins containing the variant histidine-rich *** the tested candidates,the peptide H5 E(HEHEHEHEH)is promising as a good promoter of endosomal escape of the associated fulllength protein upon endosomal *** numerical modelling of cell penetration and endosomal escape of the tested proteins has revealed a negative relationship between the amount of protein internalized into target cells and the efficiency of cytoplasmic *** fact demonstrates that the His-mediated,proton sponge-based endosomal escape saturates at moderate amounts of internalized protein,a fact that might be critical for the design of protein materials for cytosolic molecular delivery.

关键词： protein materials nanoparticles genetic design endosomal escape poly-histidines

Current status of the genetic susceptibility in attenuated adenomatous polyposis

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World Journal of Gastrointestinal Oncology 2019年第12期11卷 1101-1114页

作者： víctor Lorca Pilar Garre Laboratorio de Oncología Molecular Grupo de Investigación Clínica y Traslacional en OncologíaHospital Clínico San CarlosMadrid 28040Spain Laboratorio de Oncología Molecular Servicio de OncologíaHospital Clínico San CarlosMadrid 28040Spain

Adenomatous polyposis(AP)is classified according to cumulative adenoma number in classical AP(CAP)and attenuated AP(AAP).Genetic susceptibility is the major risk factor in CAP due to mutations in the known high predisposition genes APC and ***,the contribution of genetic susceptibility to AAP is lower and less *** predisposition genes have been recently proposed,and some of them have been validated,but their scarcity hinders accurate risk estimations and prevalence *** is a heterogeneous condition in terms of severity,clinical features and ***,clinicians do not have strong discriminating criteria for the recommendation of the genetic study of known predisposition genes,and the detection rate is *** and knowledge of new AAP high predisposition genes are of great importance to offer accurate genetic counseling to the patient and family *** review aims to update the genetic knowledge of AAP,and to expound the difficulties involved in the genetic analysis of a highly heterogeneous condition such as AAP.

关键词： Attenuated adenomatous polyposis Genetic susceptibility High predisposition gene Genetic heterogeneity Colorectal cancer

Complete fuzzy scheduling and fuzzy earned value management in construction projects

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第1期13卷 56-68页

作者： José Luís PONZ-TIENDA Eugenio PELLICER víctor YEPES School of Building Engineering Universitat Politècnica de València School of Civil Engineering Universitat Politècnica de València Department of Construction Engineering ICITECHUniversitat Politècnica de València

This paper aims to present a comprehensive proposal for project scheduling and control by applying fuzzy earned *** goes a step further than the existing literature:in the formulation of the fuzzy earned value we consider not only its duration,but also cost and production,and alternatives in the scheduling between the earliest and latest *** mathematical model is implemented in a prototypical construction project with all the estimated values taken as fuzzy *** findings suggest that different possible schedules and the fuzzy arithmetic provide more objective results in uncertain environments than the traditional *** proposed model allows for controlling the vagueness of the environment through the adjustment of the α-cut,adapting it to the specific circumstances of the project.

关键词： Construction Earned value method(EvM) Fuzzy logic Fuzzy set Project management Scheduling

Discretized Miller approach to assess effects on boundary layer ingestion induced distortion

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Chinese Journal of Aeronautics 2017年第1期30卷 235-248页

作者： Esteban valencia víctor Hidalgo Devaiah Nalianda Laskaridis Panagiotis Riti Singh Departamento de Ingeniería Mecánica Facultad de Ingeniería Mecánica Escuela Politécnica Nacional Ladron de Guevara E11-253 Quito 17-01-2759 Ecuador School of Engineering Cranfield University Bedford MK430AL United Kingdom

The performance of propulsion configurations with boundary layer ingestion（BLI） is affected to a large extent by the level of distortion in the inlet flow field. Through flow methods and parallel compressor have been used in the past to calculate the effects of this aerodynamic integration issue on the fan performance; however high-fidelity through flow methods are computationally expensive, which limits their use at preliminary design stage. On the other hand, parallel compressor has been developed to assess only circumferential distortion. This paper introduces a discretized semi-empirical performance method, which uses empirical correlations for blade and performance calculations. This tool discretizes the inlet region in radial and circumferential directions enabling the assessment of deterioration in fan performance caused by the combined effect of both distortion patterns. This paper initially studies the accuracy and suitability of the semiempirical discretized method by comparing its predictions with CFD and experimental data for a baseline case working under distorted and undistorted conditions. Then a test case is examined,which corresponds to the propulsor fan of a distributed propulsion system with BLI. The results obtained from the validation study show a good agreement with the experimental and CFD results under design point conditions.

关键词： BLI Correlations Distortion Embedded propulsors Empirical Mean-line analysis Turbomachinery

Soil-vegetation relationships in Mediterranean forests after fire

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Forest Ecosystems 2021年第2期8卷 240-252页

作者： víctor Fernández-García Elena Marcos Sara Huerta Leonor Calvo Area of Ecology Department of Biodiversity and Environmental ManagementFaculty of Biological and Environmental SciencesUniversidad de León24071 LeónSpain

Background:Wildfires are one of the major environmental concerns in Mediterranean ***,many studies have addressed wildfire impacts on soil and vegetation in Mediterranean forests,but the linkages between these ecosystem compartments after fire are not well *** aim of this work is to analyze soil-vegetation relationships in Mediterranean burned forests as well as the consistency of these relationships among forests with different environmental conditions,at different times after fire,and among vegetation with different functional ***:Our results indicate that study site conditions play an important role in mediating soil-vegetation ***,we found that the nature of soil-vegetation relationships may vary over time as fire effects are less dominant in both ecosystem *** this,we detected several common soil-vegetation relationships among study sites and times after *** instance,our results revealed that available P content and stoichiometry(C:P and N:P)were closely linked to vegetation growth,and particularly to the growth of *** found that enzymatic activities and microbial biomass were inversely related to vegetation growth rates,whereas the specific activities of soil enzymes were higher in the areas with more vegetation height and ***,our results suggest that resprouters may influence soil properties more than seeders,the growth of seeders being more dependent on soil ***:We provide pioneer insights into how vegetation is influenced by soil,and vice-versa,in Mediterranean burned *** results reflect variability in soil-vegetation relationships among study sites and time after fire,but consistent patterns between soil properties and vegetation were also *** research is highly relevant to advance in forest science and could be useful to achieve efficient post-fire management.

关键词： Wildfires Soil nutrients Enzymatic activities Microbial biomass Growth forms Regenerative strategies

Adenosine A2A-dopamine D2 receptor heteromers operate striatal function:impact on Parkinson's disease pharmacotherapeutics

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Neural Regeneration Research 2018年第2期13卷 241-243页

作者： víctor fernández-duenas sergi ferré francisco ciruela unitat de farmacologia departament patologia i terapèutica experimentalfacultat de medicinaidibelluniversitat de barcelonal’hospitalet de llobregatBarcelonaSpain institut de neurociències universitat de barcelonaBarcelonaSpain integrative neurobiology section national institute on drug abuseintramural research programnational institutes of healthBaltimoreMDUSA

The basal ganglia （BG） assemble a series of deep gray matter structures forming recurrent loops that include the cortex and thalamus, and that participate in the regulation of a plethora of brain functions, including elicitation and learning of reward-and aversive stimuli-associated behaviors, motor activity control and sensorimotor gating （Brom- berg-Martin et al., 2010）.

关键词： AR Adenosine A impact on Parkinson’s disease pharmacotherapeutics Figure

Biomaterial engineering strategies for modeling the Bruch's membrane in age-related macular degeneration

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Neural Regeneration Research 2024年第12期19卷 2626-2636页

作者： Blanca Molins Andrea Rodríguez víctor Llorenç Alfredo Adán Group of Ocular Inflammation:Clinical and Experimental Studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain Institut Clínic d’Oftalmologia(ICOF) Hospital Clínic BarcelonaSpain

Age-related macular degeneration,a multifactorial inflammatory degenerative retinal disease,ranks as the leading cause of blindness in the ***,there is a scarcity of curative therapies,especially for the atrophic advanced form of age-related macular degeneration,likely due to the lack of models able to fully recapitulate the native structure of the outer blood retinal barrier,the prime to rget tissue of age-related macular *** in vitro systems rely on 2D monocultures unable to adequately reproduce the structure and function of the outer blood retinal barrier,integrated by the dynamic interaction of the retinal pigment epithelium,the Bruch's membrane,and the underlying *** Bruch's membrane provides structu ral and mechanical support and regulates the molecular trafficking in the outer blood retinal barrier,and therefo re adequate Bruch's membrane-mimics are key for the development of physiologically relevant models of the outer blood retinal barrie *** the last years,advances in the field of biomaterial engineering have provided novel approaches to mimic the Bruch's membrane from a variety of *** review provides a discussion of the integrated properties and function of outer blood retinal barrier components in healt hy and age-related macular degeneration status to understand the requirements to adequately fabricate Bruch's membrane biomimetic ***,we discuss novel materials and techniques to fabricate Bruch's membrane-like scaffolds for age-related macular degeneration in vitro modeling,discussing their advantages and challenges with a special focus on the potential of Bruch's membrane-like mimics based on decellularized tissue.

关键词： age-related macular degeneration Bruch's membrane decellularization retinal pigment epithelium scaffold